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1. 发明申请

WO2008104635A1 METHOD FOR PREPARING SILICA COMPOSITIONS, SILICA COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：二氧化硅组合物的制备方法，二氧化硅组合物及其用途
公开(公告)号：WO2008104635A1
公开(公告)日：2008-09-04
申请号：PCT/FI2008/050085
申请日：2008-02-22
申请人： DELSITECH OY , JOKINEN, Mika , JALONEN, Harry , FORSBACK, Ari-Pekka , KOSKINEN, Mika
发明人： JOKINEN, Mika , JALONEN, Harry , FORSBACK, Ari-Pekka , KOSKINEN, Mika
IPC分类号： C01B33/152 , C01B33/157 , A61K9/00
CPC分类号： A61K47/02 , A23L29/06 , A23L29/294 , A23P10/47 , A61K9/0019 , A61K9/06 , A61K9/08 , A61K38/00 , C01B13/32 , C01B33/152 , C01B33/157 , C01G23/053 , C01G25/02 , C01P2006/22
摘要： The present invention relates to a method for producing a flowing silica composition comprising a sol-gel transfer, wherein redispersion is carried out. The redispersion comprises adding, after having reached gel point of said sol-gel transfer, liquid into the gel formed by the sol-gel transfer, and the adding being made within a sufficiently short time period after reaching the gel point, to result, after mixing to follow of the gel and the liquid, in a rheologically homogenous flowing silica composition, which is and remains injectable as such, or by short stirring
摘要翻译：本发明涉及一种生产流动二氧化硅组合物的方法，其包括溶胶 - 凝胶转移，其中进行再分散。再分散体包括在已经达到所述溶胶 - 凝胶转移的凝胶点之后，将液体加入通过溶胶 - 凝胶转移形成的凝胶中，并且在达到凝胶点之后在足够短的时间内进行添加，结果是在在流动性均匀的流动二氧化硅组合物中混合，随后可以流动地均匀流动的二氧化硅组合物，并且通过薄的22G针短暂搅拌30秒。本发明还涉及通过本发明的方法获得的流动二氧化硅组合物和凝胶。本发明还涉及流动二氧化硅组合物的用途。

2. 发明申请

WO2014207304A1 SILICA HYDROGEL COMPOSITE 审中-公开
标题翻译：硅胶复合材料
公开(公告)号：WO2014207304A1
公开(公告)日：2014-12-31
申请号：PCT/FI2014/050492
申请日：2014-06-18
申请人： DELSITECH OY
发明人： JOKINEN, Mika , JALONEN, Harry , FORSBACK, Ari-Pekka
IPC分类号： A61K9/00 , A61K47/02 , A61K9/14 , A61K9/16
CPC分类号： A61K9/0024 , A61K9/143 , A61K9/1611 , A61K9/19 , A61K31/455 , A61K49/0073
摘要： This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.
摘要翻译：本发明涉及一种二氧化硅水凝胶复合物，其通过将包含胶囊的二氧化硅颗粒与二氧化硅溶胶混合而获得，其中所得的水凝胶复合物是剪切稀化的。本发明还涉及根据本发明的二氧化硅水凝胶复合物用于可注射，流动或可挤压制剂的用途。本发明还涉及一种制备二氧化硅水凝胶的方法。

3. 发明申请

WO2017068245A1 HYDROGEL COMPOSITE DEPOT FORMULATION 审中-公开
标题翻译：水凝胶复合料制剂
公开(公告)号：WO2017068245A1
公开(公告)日：2017-04-27
申请号：PCT/FI2016/050745
申请日：2016-10-21
申请人： DELSITECH OY
发明人： LEINO, Lasse , JALONEN, Harry , FORSBACK, Ari-Pekka , JOKINEN, Mika , NOPPARI, Panu
IPC分类号： A61K47/02 , A61K9/16 , A61K31/522
CPC分类号： A61K9/0024 , A61K9/1611 , A61K31/522 , A61K47/02
摘要： This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analogue reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analogue reverse transcriptase inhibitor and having a maximum diameter of ≤ 1 000 μm, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.
摘要翻译：本发明涉及包含掺入核苷酸或核苷类似物逆转录酶抑制剂的生物可降解氧化硅水凝胶复合材料的贮库制剂，其中所述氧化硅水凝胶复合材料可通过将包含所述核苷酸或核苷类似物逆转录酶抑制剂并且具有≤1000μm的最大直径，原样或作为悬浮液，其中硅溶胶中水凝胶复合材料在静态储存时结构稳定且结构稳定并且当通过注射施加剪切应力时剪切稀化。本发明还涉及长效制剂用于治疗慢性病毒感染和预防慢性病毒再感染的用途。本发明进一步涉及包含所述储库制剂的预填充注射器。

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