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1. 发明申请

WO2007066116A1 PIEZOELECTRIC ACTUATOR 审中-公开
标题翻译：压电致动器
公开(公告)号：WO2007066116A1
公开(公告)日：2007-06-14
申请号：PCT/GB2006/004576
申请日：2006-12-07
申请人： DELPHI TECHNOLOGIES, INC. , COOKE, Michael , HARDY, Martin , KOLKMAN, Manfred , TAPIN, Christopher
发明人： COOKE, Michael , HARDY, Martin , KOLKMAN, Manfred , TAPIN, Christopher
IPC分类号： H01L41/04 , H01L41/083
CPC分类号： H01L41/083 , H01L41/04
摘要： A piezoelectric actuator comprises a stack (10) of piezoelectric elements (12) formed from a piezoelectric material, a plurality of positive internal electrodes (14) interdigitated with a plurality of negative internal electrodes (16) to define active regions of the piezoelectric material which are responsive to a voltage being applied across the internal electrodes (14, 16) , in use, an external positive electrode (18) for connection to the positive internal electrodes (14) , and an external negative electrode for connection to the negative internal electrodes (16) . The stack (10) includes an inactive stack region (22) that defines a resistive element (24, 24a, 26, 70, 74) in the form of a coating of resistive material applied to an outer peripheral surface (24, 26) and/or an inner peripheral surface of the inactive stack region (22) , wherein the resistive element is arranged to connect between the external positive electrode (18) and the external negative electrode (72) to allow charge to dissipate from the stack (10) .
摘要翻译：压电致动器包括由压电材料形成的压电元件（12）的堆叠（10），与多个负的内部电极（16）互相指向的多个正的内部电极（14），以限定压电材料的有源区域，响应于在使用中施加在内部电极（14,16）上的电压，用于连接到正内部电极（14）的外部正极（18）和用于连接到负极内部电极的外部负极（16）。堆叠（10）包括非活性堆叠区域（22），其限定施加到外周表面（24,26）上的电阻材料涂层形式的电阻元件（24,24,27a，74,74）和 /或非活性堆叠区域（22）的内周表面，其中电阻元件布置成在外部正极（18）和外部负极（72）之间连接，以允许电荷从堆叠（10）消散，。

2. 发明申请

WO2008093294A1 A CASING FOR AN ELECTRICAL COMPONENT 审中-公开
标题翻译：电气部件的试验
公开(公告)号：WO2008093294A1
公开(公告)日：2008-08-07
申请号：PCT/IB2008/050366
申请日：2008-01-31
申请人： Delphi Technologies, Inc. , GOAT, Christopher A , COOKE, Michael
发明人： GOAT, Christopher A , COOKE, Michael
IPC分类号： H01L41/053
CPC分类号： H01L41/053 , H01L41/0533
摘要： A casing for encapsulation of an electrical component, for example a piezoelectric actuator, comprising an outer layer (3) of a semipermeable material and an inner layer (5) comprising a chemically active, hydrophilic substance which chemically combines with water to form a compound.
摘要翻译：一种用于封装电气部件的壳体，例如压电致动器，其包括半透性材料的外层（3）和包含与水化学结合以形成化合物的化学活性的亲水物质的内层（5）。

3. 发明申请

WO2007031700A1 PIEZOELECTRIC ACTUATOR 审中-公开
标题翻译：压电致动器
公开(公告)号：WO2007031700A1
公开(公告)日：2007-03-22
申请号：PCT/GB2006/002519
申请日：2006-07-07
申请人： DELPHI TECHNOLOGIES, INC. , BOSCH, Russell , COOKE, Michael , GOAT, Christopher
发明人： BOSCH, Russell , COOKE, Michael , GOAT, Christopher
IPC分类号： H01L41/083
CPC分类号： H01L41/0471 , H01L41/0838 , H01L41/273 , Y10T29/42
摘要： A piezoelectric actuator comprises a co-fired stack (10) of piezoelectric elements (12) formed from a piezoelectric material and a plurality of positive internal electrodes (14) interdigitated with a plurality of negative internal electrodes (16) throughout the stack (10) to define active regions (22) of the piezoelectric material which are responsive to a voltage applied across the internal electrodes (14), in use. An external positive electrode (18) connects with the positive internal electrodes (14) and an external negative electrode (20) connects with the negative internal electrodes (16). The actuator is characterised in that the stack (10) further comprises means (34; 38a, 38b; 40) for deliberately creating artificial cracks (36) within the stack (10) at a location at which the artificial cracks do not give rise to a short circuit between the internal electrodes (14, 16) but serve to relieve stresses within the piezoelectric material.
摘要翻译：压电致动器包括由压电材料形成的压电元件（12）的共烧堆叠（10）和与整个堆叠（10）中的多个负内部电极（16）互相指向的多个正内部电极（14）以限定在使用中响应于施加在内部电极（14）上的电压的压电材料的有源区域（22）。外部正极（18）与正内部电极（14）连接，外部负极（20）与负极内部电极（16）连接。致动器的特征在于，堆叠（10）还包括用于在人造裂纹不引起的位置处故意地在堆叠（10）内产生人造裂纹（36）的装置（34; 38a，38b; 40）内部电极（14,16）之间的短路，但用于减轻压电材料内的应力。

4. 发明申请

WO2010133685A1 FLUID DOSING DEVICE 审中-公开
标题翻译：流体计量装置
公开(公告)号：WO2010133685A1
公开(公告)日：2010-11-25
申请号：PCT/EP2010/057001
申请日：2010-05-20
申请人： DELPHI TECHNOLOGIES HOLDING S.À.R.L. , WRIGHT, Keith , COOKE, Michael , THOMPSON, Phillip , COSTER, Simon , OLDFIELD, Nick , HARDY, Martin
发明人： WRIGHT, Keith , COOKE, Michael , THOMPSON, Phillip , COSTER, Simon , OLDFIELD, Nick , HARDY, Martin
IPC分类号： F01N3/20 , F01N13/18 , F01N3/36
CPC分类号： F01N3/2066 , F01N3/36 , F01N13/18 , F01N2610/02 , F01N2610/14 , F01N2610/1433 , F01N2610/1453 , Y02T10/24
摘要： A mounting arrangement for attaching a pump arrangement (10, 110, 210) to an exhaust pipe (12, 112) at a boss (14, 114) is disclosed. The pump arrangement (10, 110, 210) comprises a delivery nozzle section (22, 122) and a remaining section including a pump body (20, 120), and the mounting arrangement comprises packing means (66, 152, 252) for supporting the pump body (20, 120) at the remaining section of the pump arrangement (10, 110, 210). The packing means provides thermal insulation and reduces noise during operation of the pump. A dosing device (110) for an exhaust system of an internal combustion engine is also disclosed. The dosing device comprises a pump (118) comprising a pump body (120); a delivery nozzle (122) for receiving fluid from the pump (118) and having an outlet end (130) from which fluid is expelled into the exhaust system upon operation of the pump (118); and a mounting arrangement (124, 126, 144) for mounting the pump (118) to an exhaust chamber of the exhaust system, in use. The mounting arrangement (124, 126, 144) comprises a heat shield (148) that surrounds at least an outlet end (130) of the nozzle (122) so as to define an air gap (150) between the heat shield (148) and the nozzle (122). The heat shield (148) is thermally decoupled from the nozzle (122) and the pump body (120), to guard against overheating of the reagent in the pump.
摘要翻译：公开了一种用于将泵装置（10,110,210）附接到在凸台（14,114）处的排气管（12,112）的安装装置。泵装置（10,110,210）包括输送喷嘴部分（22,122）和包括泵体（20,120）的剩余部分，并且所述安装装置包括用于支撑的填料装置（66,152,252）在泵装置（10,110,210）的剩余部分处的泵体（20,120）。包装装置提供热绝缘，并减少泵运行期间的噪音。还公开了一种用于内燃机排气系统的计量装置（110）。所述计量装置包括包括泵体（120）的泵（118）; 用于从泵（118）接收流体并具有出口端（130）的输送喷嘴（122），在泵（118）的操作时，流体从该出口端排出到排气系统中; 以及用于在使用中将泵（118）安装到排气系统的排气室的安装装置（124,126,144）。安装装置（124,126,144）包括隔热罩（148），其围绕喷嘴（122）的至少一个出口端（130），以便限定在隔热罩（148）之间的空气间隙（150）和喷嘴（122）。热屏蔽（148）与喷嘴（122）和泵体（120）热分离，以防止泵中的试剂过热。

5. 发明申请

WO2012095450A1 INJECTION DEVICE FOR REAGENT 审中-公开
标题翻译：注射装置用于试剂
公开(公告)号：WO2012095450A1
公开(公告)日：2012-07-19
申请号：PCT/EP2012/050366
申请日：2012-01-11
申请人： DELPHI TECHNOLOGIES HOLDING S.À.R.L. , COOKE, Michael
发明人： COOKE, Michael
IPC分类号： F01N3/20 , F02M61/08 , F02M61/18
CPC分类号： F16L41/02 , F01N3/2066 , F01N2610/02 , F01N2610/1453 , F02M61/08 , F02M61/18 , Y02T10/24 , Y10T137/87676
摘要： An injection device for administering a reagent into an exhaust passage of an internal combustion engine, the injection device having an axis (A) along its length and comprising an outwardly opening valve member (14) having a seating surface which is engageable with a valve seating region (30). A seating member provided with an internal bore (12) which defines the valve seating region (30), wherein the internal bore (12) further defines a flow re-directing region (32) downstream of the valve seating region (30). The seating member (10) has an end face (36; 136) provided with a feature (38; 138; 238; 338; 438; 538) which intersects with at least a portion of the flow re-directing region (32) to define, together with the flow re-directing region (32), a spray path for reagent exiting the injection device when the valve member (10) is moved outwardly from the bore (12) away from the valve seating region (30). The spray path has a variable spray angle, relative to the axis A, around the circumference of the valve seating region (30).
摘要翻译：一种用于将试剂施加到内燃机的排气通道中的注射装置，所述注射装置具有沿着其长度的轴线（A），并且包括向外打开的阀构件（14），其具有可与阀座接合的座面区域（30）。设置有限定所述阀座区域（30）的内孔（12）的座位构件，其中，所述内孔（12）还在所述阀座区域（30）的下游进一步限定流动引导区域（32）。座位构件（10）具有设置有特征（38; 138; 238; 338; 438; 538）的端面（36; 136），其与流动引导区域（32）的至少一部分相交到当所述阀构件（10）从所述孔（12）向外移动远离所述阀座区域（30）时，与所述流引导区域（32）一起限定出口离开所述注射装置的试剂的喷射路径。喷射路径相对于轴线A具有围绕阀座区域（30）的圆周的可变喷雾角度。

6. 发明申请

WO2010059401A2 COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译：化学干扰细胞扩增的化合物
公开(公告)号：WO2010059401A2
公开(公告)日：2010-05-27
申请号：PCT/US2009/062646
申请日：2009-10-29
申请人： IRM LLC , THE SCRIPPS RESEARCH INSTITUTE , BOITANO, Anthony , COOKE, Michael , PAN, Shifeng , SCHULTZ, Peter G. , TELLEW, John , WAN, Yongqin , WANG, Xing
发明人： BOITANO, Anthony , COOKE, Michael , PAN, Shifeng , SCHULTZ, Peter G. , TELLEW, John , WAN, Yongqin , WANG, Xing
IPC分类号： A61K35/28 , C07D473/34 , A61K31/52 , A61P35/02 , A61P35/00 , A61P7/06 , A61P37/00 , C12N5/0789 , C12N5/078
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

7. 发明申请

WO2010145911A1 FUEL INJECTOR 审中-公开
标题翻译：喷油器
公开(公告)号：WO2010145911A1
公开(公告)日：2010-12-23
申请号：PCT/EP2010/057003
申请日：2010-05-20
申请人： DELPHI TECHNOLOGIES HOLDING S.À.R.L. , COOKE, Michael
发明人： COOKE, Michael
IPC分类号： F02M45/08 , F02M47/02 , F02M51/06 , F02M61/18
CPC分类号： F02M45/086 , F02M47/027 , F02M51/061 , F02M61/182 , F02M2200/46
摘要： A fuel injector (100) for use in an internal combustion engine comprising an injection nozzle (118) having a nozzle body (120) provided with a nozzle bore (130), a first valve needle (136) received within the nozzle bore and being engageable with a first seat region (137) to control fuel delivery through a first set of nozzle outlets (126), and a second valve needle (138) received within a valve bore (140) provided in the first valve needle and being engageable with a second seat region (144) arranged to control fuel delivery through a second set of nozzle outlets (128). A control chamber (184) for fuel is provided, preferably at least in part, between the first valve needle and the second valve needle, wherein movement of the first valve needle is responsive to fuel pressure in the control chamber, and wherein movement of the second valve needle is mechanically coupled to an armature of the first actuator arrangement (159), such that when the second valve needle lifts away from the second seating region, a fuel flow path is established between the control chamber and the second set of nozzle outlets. The fuel injector further includes a second actuator arrangement (200) that is operable to control fuel flow into the control chamber thereby regulating fuel pressure within the control chamber and, thus, movement of the first valve needle.
摘要翻译：一种用于内燃机的燃料喷射器（100），其包括具有喷嘴主体（120）的注射喷嘴（118），喷嘴主体（120）设置有喷嘴孔（130），第一阀针（136）容纳在喷嘴孔内，可与第一座位区域（137）接合以控制通过第一组喷嘴出口（126）的燃料输送;以及第二阀针（138），其容纳在设置在第一阀针中的阀孔（140）内并可与布置成控制通过第二组喷嘴出口（128）的燃料输送的第二座位区域（144）。优选地，至少部分地在第一阀针和第二阀针之间提供用于燃料的控制室（184），其中第一阀针的运动响应于控制室中的燃料压力，并且其中运动第二阀针机械地联接到第一致动器装置（159）的衔铁，使得当第二阀针从第二安置区域提升时，在控制室和第二组喷嘴出口之间建立燃料流动路径。燃料喷射器还包括第二致动器装置（200），其可操作以控制进入控制室的燃料流，从而调节控制室内的燃料压力，从而调节第一阀针的运动。

8. 发明申请

WO2020146432A1 USE OF AN ANTI-CD45 ANTIBODY DRUG CONJUGATE (ADC) IN CELL THERAPY 审中-公开
公开(公告)号：WO2020146432A1
公开(公告)日：2020-07-16
申请号：PCT/US2020/012637
申请日：2020-01-07
申请人： MAGENTA THERAPEUTICS, INC. , COOKE, Michael
发明人： COOKE, Michael , GILLARD, Geoffrey O. , BOITANO, Anthony
IPC分类号： A61K35/28 , A61K47/68 , A61K51/10 , A61P35/00
摘要： The invention provides methods of depleting CD45+ cells in human patients undergoing chimeric antigen receptor (CAR) immunotherapy in order to promote acceptance of CAR expressing immune cells. Anti-CD45 antibody drug conjugates (ADCs) are administered as a conditioning regimen to a human patient receiving autologous or allogeneic CAR expressing immune cells such that the CAR expressing immune cells are accepted by the human patient. Compositions and methods of the invention can be used in combination with CAR therapy to treat a variety of pathologies, including autoimmune diseases and cancer.

9. 发明申请

WO2011073004A1 FASTENING MEMBER 审中-公开
标题翻译：紧急会员
公开(公告)号：WO2011073004A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/068137
申请日：2010-11-24
申请人： DELPHI TECHNOLOGIES HOLDING S.à.r.l. , COOKE, Michael , GUERRATO, Diego , CALONNE, Jerome
发明人： COOKE, Michael , GUERRATO, Diego , CALONNE, Jerome
IPC分类号： F02M61/16 , F16B37/14 , F02M61/14
CPC分类号： F02M61/168 , F02M61/14 , F02M2200/8076 , F16B29/00
摘要： A fastening member (100) for fastening a first component (118) to a second component (110) in an end-to-end configuration along a common axis (A) is disclosed. The fastening member (100) comprises a first portion (124) having a threaded region for engagement with a corresponding threaded region (120) of the first component (118), a second portion (126) for applying a retaining force to the second component (110) to hold the first and second components (118, 110) in sealing engagement, and a deformable portion (130) intermediate the first and second portions (124, 126). The deformable portion (130) is plastically deformable so as to allow relative movement of the first and second portions (124, 126) in use of the fastening member (100), such that a location (129) on the fastening member can be brought into angular alignment with a location on the first or second component (118, 110) upon turning movement of the fastening member. The fastening member is particularly suitable for use as a cap nut in a fuel injector of the type having a cylinder pressure sensor integrated into the cap nut.
摘要翻译：公开了一种用于沿着公共轴线（A）以端对端配置将第一部件（118）紧固到第二部件（110）的紧固部件（100）。紧固构件（100）包括具有螺纹区域的第一部分（124），用于与第一部件（118）的对应的螺纹区域（120）接合，第二部分（126）用于向第二部件（110），以将第一和第二部件（118,110）保持在密封接合状态，以及在第一和第二部分（124,126）之间的可变形部分（130）。可变形部分（130）是可塑性变形的，以允许在使用紧固构件（100）时第一和第二部分（124,126）的相对运动，使得紧固构件上的位置（129）可以被带到当紧固构件转动时，与第一或第二构件（118,110）上的位置成角度对准。紧固构件特别适用于具有集成在盖螺母中的气缸压力传感器的类型的燃料喷射器中的盖帽螺母。

10. 发明申请

WO2010139997A3 MODIFIED ZEOLITES AND THEIR USE IN THE RECYCLING OF PLASTICS WASTE 审中-公开
公开(公告)号：WO2010139997A3
公开(公告)日：2010-12-09
申请号：PCT/GB2010/050932
申请日：2010-06-03
申请人： UNIVERSITY OF MANCHESTER , GARFORTH, Athur , HERNANDEZ-MARTINEZ, Jesus , AKAH, Aaron , COOKE, Michael , CRESSWELL, David
发明人： GARFORTH, Athur , HERNANDEZ-MARTINEZ, Jesus , AKAH, Aaron , COOKE, Michael , CRESSWELL, David
IPC分类号： B01J29/08 , B01J37/30 , C08J11/10 , C10G1/00
摘要： The present invention relates to a method for the recycling of plastics materials, in particular waste plastics materials, into chemical feed stocks and hydrocarbon fractions. The present invention also relates to novel zeolite based catalysts used in such methods. The present invention also relates to methods of manufacturing such zeolite based catalysts. Plastics waste is traditionally disposed of by land-fill, incineration or recycling by re- processing the waste into raw material for reuse. Each of these disposal methods has its disadvantages. The drawbacks of land-fill are self apparent. Although incineration may include energy recovery, there still remains the obvious problem of CO 2 emission and the emission of other toxic pollutants. Additionally, recycling the plastics requires sorting of the plastics waste because certain types of plastics materials are not recyclable, and mixtures of plastics can be problematic. The present invention provides an improved method for the recycling of waste plastics including mixed waste streams.

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