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2. 发明申请

WO2010099955A8 PROTEASE FOR WOUND CONDITIONING AND SKIN CARE 审中-公开
标题翻译：保护皮肤护理和皮肤护理
公开(公告)号：WO2010099955A8
公开(公告)日：2010-12-16
申请号：PCT/EP2010001328
申请日：2010-03-03
申请人： BRAIN BIOTECHNOLOGY RES & INFORMATION NETWORK AG , NIEHAUS FRANK , ECK JUERGEN , SCHULZE RENATE
发明人： NIEHAUS FRANK , ECK JUERGEN , SCHULZE RENATE
IPC分类号： C12N9/64 , A61K38/43 , C07K16/40 , C12N5/10 , C12N15/62
CPC分类号： C12N9/6408
摘要： We have identified by molecular cloning a protease which originates from the larvae of Lucilia sericata and which was termed debrilase due to its activities useful for debridement of wounds. Described is a nucleic acid molecule encoding a serine protease having the ability to cleave fibrin and casein which is (a) a nucleic acid molecule encoding the serine protease comprising or consisting of the amino acid sequence of SEQ ID NO: 4 as well as to nucleic acid molecules encoding precursors or fragments of said serine protease; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 3; (c) a nucleic acid molecule encoding a serine protease the amino acid sequence of which is at least 80 % identical to the amino acid sequence of (a), preferably at least 85 % identical, more preferably at least 90 % identical, and most preferred 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 80 % identical to the nucleotide sequence of (b), preferably at least 85 % identical, more preferably at least 90 % identical, and most preferred 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (b) or (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.
摘要翻译：我们已经通过分子克隆鉴定了源自丝蚕幼虫的蛋白酶，由于其可用于清创伤口的活性，所以被称为脱氨酶。描述了编码具有裂解纤维蛋白和酪蛋白的能力的丝氨酸蛋白酶的核酸分子，其是（a）编码包含或由SEQ ID NO：4的氨基酸序列组成的丝氨酸蛋白酶的核酸分子以及核酸编码所述丝氨酸蛋白酶的前体或片段的酸分子; （b）包含SEQ ID NO：3的核苷酸序列或由其组成的核酸分子; （c）编码丝氨酸蛋白酶的核酸分子，其氨基酸序列与（a）的氨基酸序列至少80％相同，优选至少85％相同，更优选至少90％相同，最多优选95％相同; （d）核酸分子，其包含与（b）的核苷酸序列至少80％相同的核苷酸序列或由其组成，优选至少85％相同，更优选至少90％相同，最优选95％相同; （e）相对于（b）或（d）的核酸分子简并的核酸分子; 或（f）对应于（a）至（d）中任一项的核酸分子的核酸分子，其中T被U.替代

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