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1. 发明申请

WO2008082198A1 ANTIFUNGAL TRIAZOLE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME 审中-公开
标题翻译：抗真菌三唑衍生物，其制备方法和含有其的药物组合物
公开(公告)号：WO2008082198A1
公开(公告)日：2008-07-10
申请号：PCT/KR2007/006961
申请日：2007-12-28
申请人： DAEWOONG PHARMACEUTICAL CO., LTD. , PARK, Joon Seok , YU, Kyung A , YOON, Yun Soo , HAN, Mi Ryeong
发明人： PARK, Joon Seok , YU, Kyung A , YOON, Yun Soo , HAN, Mi Ryeong
IPC分类号： C07D249/08 , A61P31/10
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14
摘要： The present invention relates to triazole derivaties, a method for the preparation thereof, and a pharmaceutical composition containing the same as an active ingredient. The inventive triazole derivaties have an excellent antifungal activity against various pathogens.
摘要翻译：本发明涉及三唑衍生物，其制备方法和含有该组合物作为活性成分的药物组合物。本发明的三唑衍生物对各种病原体具有优异的抗真菌活性。

2. 发明申请

WO2016175555A8 NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：WO2016175555A8
公开(公告)日：2016-11-03
申请号：PCT/KR2016/004411
申请日：2016-04-27
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： LEE, Chun Ho , LEE, Seung Chul , LEE, Yeon Im , EOM, Deok Ki , HAN, Mi Ryeong , KOH, Eun Ji
IPC分类号： C07D207/48 , A61K31/40 , A61K31/095 , C07D207/30 , C07D207/335 , C07D207/36
摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori . Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.

3. 发明申请

WO2018004306A1 PYRAZOLOPYRIMIDINE DERIVATIVES AS KINASE INHIBITOR 审中-公开
标题翻译：吡唑并嘧啶衍生物作为激酶抑制剂
公开(公告)号：WO2018004306A1
公开(公告)日：2018-01-04
申请号：PCT/KR2017/006980
申请日：2017-06-30
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： KIM, In Woo , HAN, Mi Ryeong , YOO, Jakyung , OH, Yun Ju , KIM, Ji Duck , KIM, Nam Youn , JUN, Sun Ah , LEE, Jun Hee , PARK, Joon Seok
IPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D401/14 , A61K31/519 , A61K31/496
摘要： The present invention relates to a pyrazolopyrirmidine derivative, or a pharmaceutically acceptable salt thereof. The compound according to the present invention can be usefully used for the prevention or treatment of diseases which are associated with kinase inhibitory actions.
摘要翻译：吡唑并嘧啶衍生物或其药学上可接受的盐本发明涉及吡唑并吡啶衍生物或其药学上可接受的盐。根据本发明的化合物可以有效地用于预防或治疗与激酶抑制作用有关的疾病。

4. 发明申请

WO2011099804A2 NOVEL ANTIFUNGAL TRIAZOLE DERIVATIVES 审中-公开
标题翻译：新型抗真菌三唑衍生物
公开(公告)号：WO2011099804A2
公开(公告)日：2011-08-18
申请号：PCT/KR2011/000925
申请日：2011-02-11
申请人： DAEWOONG PHARMACEUTICAL CO., LTD. , PARK, Joon Seok , YU, Kyung A , YOON, Yun Soo , HAN, Mi Ryeong , KIM, Ji Duck
发明人： PARK, Joon Seok , YU, Kyung A , YOON, Yun Soo , HAN, Mi Ryeong , KIM, Ji Duck
IPC分类号： C07D249/10 , A61K31/4196 , A61P31/10
CPC分类号： C07D401/14 , A61K31/4196 , C07D401/06 , C07D401/12
摘要： Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide spectrum of fungi.
摘要翻译：公开了新的三唑衍生物。展示优良的抗真菌活性和体内安全性，它们可用于治疗或预防由广谱真菌引起的真菌感染。

5. 发明申请

WO2016175555A3 NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新的4-甲氧基吡咯衍生物或其盐及包含该化合物的药物组合物
公开(公告)号：WO2016175555A3
公开(公告)日：2016-11-03
申请号：PCT/KR2016/004411
申请日：2016-04-27
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： LEE, Chun Ho , LEE, Seung Chul , LEE, Yeon Im , EOM, Deok Ki , HAN, Mi Ryeong , KOH, Eun Ji
IPC分类号： C07D207/48 , A61K31/40 , A61K31/095 , C07D207/30 , C07D207/335 , C07D207/36
摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori . Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.
摘要翻译：本发明提供4-甲氧基吡咯衍生物或其药学上可接受的盐，其制备方法和含有其的药物组合物。根据本发明的4-甲氧基吡咯衍生物或其药学上可接受的盐不仅具有优异的质子泵抑制活性，胃损伤抑制活性和防御因子增强作用，而且还具有优异的抗H的根除活性。因此，4-甲氧基吡咯衍生物或其药学上可接受的盐可以有效地用于预防和治疗由胃肠道溃疡，胃炎，反流性食管炎或H引起的胃肠道损伤。幽门螺杆菌的。此外，4-甲氧基吡咯衍生物或其药学上可接受的盐对GPCR具有抑制活性，因此可有效地用于预防和治疗5-HT受体介导的或毒蕈碱性乙酰胆碱受体介导的疾病。

6. 发明申请

WO2015034271A1 NOVEL ANTIFUNGAL PYRIDINYLHYDRAZIDE DERIVATIVES 审中-公开
标题翻译：新型抗真菌吡啶衍生物衍生物
公开(公告)号：WO2015034271A1
公开(公告)日：2015-03-12
申请号：PCT/KR2014/008287
申请日：2014-09-04
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： PARK, Joon Seok , YOON, Youn Jung , PARK, Chang Min , NA, Yun Soo , CHO, Min Jae , LEE, Ho Bin , HAN, Mi Ryeong , PARK, Yeon Jung , KIM, Ji Duck
IPC分类号： C07D213/72 , A61K31/4406 , A61P31/10 , A61P31/00
CPC分类号： C07D213/77 , A61K9/2059 , A61K9/2077 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to novel pyridinylhydrazide derivatives and a method for manufacturing the same. The pyridinylhydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections. Additionally, the pyridinylhydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.
摘要翻译：本发明涉及新的吡啶基肼衍生物及其制造方法。本发明的吡啶基酰肼衍生物具有优异的抗真菌和杀真菌活性，因此可用于预防和治疗各种真菌感染。另外，本发明的吡啶基酰肼衍生物与其他杀真菌剂不同，可以口服给药。

7. 发明申请

WO2016175555A2 NOVEL 4-METHOXY PYRROLE DERIVATIVES OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
标题翻译：新的4-甲氧基吡咯烷酮衍生物或其盐及其包含其的药物组合物
公开(公告)号：WO2016175555A2
公开(公告)日：2016-11-03
申请号：PCT/KR2016/004411
申请日：2016-04-27
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： LEE, Chun Ho , LEE, Seung Chul , LEE, Yeon Im , EOM, Deok Ki , HAN, Mi Ryeong , KOH, Eun Ji
IPC分类号： C07D207/48 , A61K31/40 , A61K31/095 , C07D207/30 , C07D207/335 , C07D207/36
CPC分类号： C07D207/48
摘要： The present invention provides a 4-methoxy pyrrole derivative or a pharmaceutically cceptable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof according to the present invention have not only excellent proton pump inhibitory activity, gastric damage-inhibiting activity and defensive factor-enhancing effects, but also excellent eradication activity against H. pylori. Therefore, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof can be effectively used for the prevention and treatment of gastrointestinal damage due to gastrointestinal tract ulcer, gastritis, reflux esophagitis or H. pylori . Moreover, the 4-methoxy pyrrole derivatives or pharmaceutically acceptable salts thereof, have inhibitory activities against GPCR and thus can be effectively used for the prevention and treatment of 5-HT receptor-mediated or muscarinic acetylcholine receptor-mediated diseases.
摘要翻译：本发明提供4-甲氧基吡咯衍生物或其药学上可接受的盐，其制备方法和含有该化合物的药物组合物。根据本发明的4-甲氧基吡咯衍生物或其药学上可接受的盐不仅具有优异的质子泵抑制活性，胃损伤抑制活性和防御因子增强作用，而且具有优异的针对幽门螺杆菌的根除活性。因此，4-甲氧基吡咯衍生物或其药学上可接受的盐可有效地用于预防和治疗胃肠道溃疡，胃炎，反流性食管炎或幽门螺杆菌引起的胃肠损伤。此外，4-甲氧基吡咯衍生物或其药学上可接受的盐对GPCR具有抑制活性，因此可有效地用于预防和治疗5-HT受体介导的或毒蕈碱性乙酰胆碱受体介导的疾病。

8. 发明申请

WO2015060613A1 NOVEL ANTIFUNGAL OXODIHYDROPYRIDINECARBOHYDRAZIDE DERIVATIVE 审中-公开
标题翻译：新型反义寡核苷酸衍生物
公开(公告)号：WO2015060613A1
公开(公告)日：2015-04-30
申请号：PCT/KR2014/009876
申请日：2014-10-21
申请人： DAEWOONG PHARMACEUTICAL CO., LTD.
发明人： PARK, Joon Seok , YOON, Youn Jung , PARK, Chang Min , NA, Yun Soo , CHO, Min Jae , LEE, Ho Bin , HAN, Mi Ryeong , PARK, Yeon Jung , KIM, Ji Duck
IPC分类号： C07D213/63 , C07D401/12 , A61K31/4412 , A61P31/04
CPC分类号： C07D213/82 , C07D213/63 , C07D401/04 , C07D401/06 , C07D401/12 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/08
摘要： The present invention relates to novel oxodihydropyridinecarbohydrazide derivatives with excellent antifungal activities, an antifungal composition containing the same, and its use for the prevention and treatment of fungal infectious diseases. The oxodihydropyridinecarbohydrazide derivatives of the present invention have excellent antifungal and fungicidal activities, and thus will be useful for the prevention and treatment of various fungal infections by Candida spp. , Aspergillus spp ., Cryptococcus neoformans and Trichophyton spp., etc. Additionally, the oxodihydropyridinecarbohydrazide derivatives of the present invention, unlike other fungicidal preparations, can be orally administered.
摘要翻译：本发明涉及具有优异抗真菌活性的新型氧代二氢吡啶碳酰肼衍生物，含有它们的抗真菌组合物及其用于预防和治疗真菌感染性疾病的用途。本发明的氧代二氢吡啶碳酰肼衍生物具有优异的抗真菌和杀真菌活性，因此可用于预防和治疗念珠菌属，曲霉属（Aspergillus spp。），新隐隐球菌（Cryptococcus neoformans）和毛癣菌属（Trichophyton spp。）等各种真菌感染。另外，氧代二氢吡啶碳酰肼本发明的衍生物与其它杀真菌剂不同，可以口服给药。

9. 发明申请

WO2007052943A1 NOVEL ANTIFUNGAL TRIAZOLE DERIVATIVES 审中-公开
标题翻译：新型抗真菌三唑衍生物
公开(公告)号：WO2007052943A1
公开(公告)日：2007-05-10
申请号：PCT/KR2006/004495
申请日：2006-10-31
申请人： DAEWOONG PHARMACEUTICAL CO., LTD. , PARK, Joon Seok , YU, Kyung A , KIM, Sun Young , SONG, Yeon Jung , KIM, Kang-Pil , YOON, Yun Soo , HAN, Mi Ryeong
发明人： PARK, Joon Seok , YU, Kyung A , KIM, Sun Young , SONG, Yeon Jung , KIM, Kang-Pil , YOON, Yun Soo , HAN, Mi Ryeong
IPC分类号： C07D401/06 , A61K31/4196 , A61P31/10
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14
摘要： Disclosed herein are antifungal triazole derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. The triazole derivatives of Chemical Formula 1 or pharmaceutically acceptable salts thereof according to the present invention have excellent inhibitory activity against a broad spectrum of fungi, in addition to being safe to the body, and thus are very useful in the treatment and prevention of fungal infection.
摘要翻译：本文公开了抗真菌三唑衍生物或其药学上可接受的盐，其制备方法和包含其的药物组合物。根据本发明的化学式1的三唑衍生物或其药学上可接受的盐除了对身体安全以外，对广谱真菌具有优异的抑制活性，因此在治疗和预防真菌感染方面非常有用。

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