专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007002149A3 METHODS AND COMPOSITIONS RELATING TO A VACCINE AGAINST PROSTATE CANCER 审中-公开
公开(公告)号：WO2007002149A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/024076
申请日：2006-06-21
申请人： CYTO PULSE SCIENCES, INC. , LEDER, Christopher , KING, Alan, D. , PAVLENKO, Maxim , PISA, Pavel
发明人： LEDER, Christopher , KING, Alan, D. , PAVLENKO, Maxim , PISA, Pavel
IPC分类号： A61K39/00
摘要： An object of the invention is to provide methods and compositions relating to a vaccine against prostate cancer which includes a non- human -primate PSA for administration to humans to provide an immune response against human PSA. More generally, an object of the invention is to provide methods and compositions relating to using a non-human primate xenogeneic antigen (e. g. protein) in a human, wherein, with respect to the non-human primate xenogeneic antigen that is used, there are relatively few interspecies differences between the non-human primate xenogeneic antigen and the human self antigen in order to induce an optimal immune response in the human to its native self antigen.

2. 发明申请

WO2003020915A2 NON-LINEAR AMPLITUDE DIELECTROPHORESIS WAVEFORM FOR CELL FUSION 审中-公开
标题翻译：用于细胞融合的非线性放大电位放电波形
公开(公告)号：WO2003020915A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/008239
申请日：2002-04-05
申请人： CYTO PULSE SCIENCES, INC. , WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D.
发明人： WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D.
IPC分类号： C12N
CPC分类号： C12M35/02 , A61K2039/5152 , A61K2039/5154 , C12N5/16 , C12N13/00 , H01L2224/83856 , H01L2924/01019
摘要： An object of the invention is to provide a method of treating biological cells prior to subjecting the biological cells to cell fusion pulses which includes the step of treating the biological cells with pre-fusion electric field waveforms which change amplitude in a non-linear way with respect to time, such that the biological cells are first aligned with a relatively low amplitude, long duration pre-fusion electric field waveform and then compressed with a relatively high amplitude, short duration pre-fusion electric field waveform resulting in increased cell membrane contact prior to being subjected to cell fusion. The non-linear pre-fusion electric field waveforms can change in a stepped way, in a continuous way, in a sigmoidal way, with step-wise increasing waveforms in adjacent steps, with step-wise increasing waveforms in non-adjacent steps, and in accordance with non-linear algorithms.
摘要翻译：本发明的一个目的是提供一种在使生物细胞经历细胞融合脉冲之前处理生物细胞的方法，其包括用以非线性方式改变幅度的融合前电场波形来处理生物细胞的步骤，相对于时间，使得生物细胞首先用相对低幅度，长持续时间的预融合电场波形对准，然后用相对较高幅度，短持续时间的预融合电场波形压缩，导致增加的细胞膜接触先进行细胞融合。非线性预融合电场波形可以以连续的方式以S形方式以相邻步骤中逐步增加的波形以逐步增加的波形在非相邻步骤中逐步增加，并以按照非线性算法。

3. 发明申请

WO2003089046A1 METHOD OF TREATING BIOLOGICAL MATERIALS WITH TRANSLATING ELECTRICAL FIELDS AND ELECTRODE POLARITY REVERSAL 审中-公开
标题翻译：用电场和电极极性反转处理生物材料的方法
公开(公告)号：WO2003089046A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/009208
申请日：2003-04-11
申请人： CYTO PULSE SCIENCES, INC. , WALTERS, Richard, E. , KING, Alan, D. , DEBRUIN, Katherine, A.
发明人： WALTERS, Richard, E. , KING, Alan, D. , DEBRUIN, Katherine, A.
IPC分类号： A61N1/04
CPC分类号： A61N1/0412 , A61N1/0476 , A61N1/306 , A61N1/325 , A61N1/327
摘要： A method and apparatus are provided for treating biological cellular material with a treating agent using pulsed electrical fields provided by a waveform generator (12). The treatment method includes obtaining an electrode assembly which includes three or more parallel rows of individual electrodes (19). The electrode assembly is applied to a treatment area. Electrically conductive pathways are established between the electrodes (19) and the waveform generator (12) through an array switch (14). Successive electric fields are applied to the treatment area in the form of successive electric field waveforms from the waveform generator (12), through the array switch (14), to adjacent rows of electrodes (19), wherein each successive electric field has the same direction, and wherein polarities of rows of electrodes are reversed successively during the applying of the successive electric fields between adjacent successive rows of electrodes to the treatment area. As a result, the biological cellular material in the treatment area is treated with the treating agent unidirectionally with uniform electric fields with a minimization of the formation of deleterious electrochemistry products at the electrodes.
摘要翻译：提供了一种使用由波形发生器（12）提供的脉冲电场用处理剂处理生物细胞材料的方法和装置。处理方法包括获得包括三个或更多个平行的单独电极行（19）的电极组件。将电极组件施加到治疗区域。通过阵列开关（14）在电极（19）和波形发生器（12）之间建立导电通路。连续的电场以波形发生器（12），阵列开关（14）的相继电场（19）的连续电场波形的形式施加到处理区域，其中每个连续的电场具有相同的电场方向，并且其中在将相邻的连续的电极行之间的连续电场施加到治疗区域期间，电极行的极性依次反转。结果，处理区域中的生物细胞材料用均匀的电场单向地用处理剂处理，同时在电极处形成有害的电化学产物。

4. 发明申请

WO2003020915A3 NON-LINEAR AMPLITUDE DIELECTROPHORESIS WAVEFORM FOR CELL FUSION 审中-公开
公开(公告)号：WO2003020915A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/008239
申请日：2002-04-05
申请人： CYTO PULSE SCIENCES, INC. , WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D.
发明人： WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D.
IPC分类号： C12N15/87
摘要： An object of the invention is to provide a method of treating biological cells prior to subjecting the biological cells to cell fusion pulses which includes the step of treating the biological cells with pre-fusion electric field waveforms which change amplitude in a non-linear way with respect to time, such that the biological cells are first aligned with a relatively low amplitude, long duration pre-fusion electric field waveform and then compressed with a relatively high amplitude, short duration pre-fusion electric field waveform resulting in increased cell membrane contact prior to being subjected to cell fusion. The non-linear pre-fusion electric field waveforms can change in a stepped way, in a continuous way, in a sigmoidal way, with step-wise increasing waveforms in adjacent steps, with step-wise increasing waveforms in non-adjacent steps, and in accordance with non-linear algorithms.

5. 发明申请

WO2008144058A1 METHOD AND APPARATUS FOR THE DELIVERY OF POLYNUCLEOTIDE VACCINES TO MAMMALIAN SKIN 审中-公开
标题翻译：将多核苷酸疫苗递送给妈妈皮肤的方法和装置
公开(公告)号：WO2008144058A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006442
申请日：2008-05-20
申请人： CYTO PULSE SCIENCES, INC. , WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D. , ROOS, Anna-Karin
发明人： WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D. , ROOS, Anna-Karin
IPC分类号： A61K48/00 , A61N1/30
CPC分类号： A61N1/327 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/70 , A61N1/306 , C07K14/005 , C12N2770/24122 , C12N2770/24134
摘要： An object of the invention is to provide a method and apparatus for the delivery of polynucleotide vaccines into mammalian skin cells to increase T cell response and reduce pain and discomfort due to long electric waveform application and due to muscle contractions. The method includes administering a polynucleotide vaccine into the skin at an administration site, (b ) applying a needle electrode to the skin in the vicinity to the administration site, and (c ) applying a sequence of at least three single, operator-controlled, independently programmed, narrow interval electrical waveforms, which have pulse intervals that are less than 100 milliseconds, to deliver the 15 polynucleotide vaccine into the skin cells by electroporation.
摘要翻译：本发明的目的是提供一种用于将多核苷酸疫苗递送到哺乳动物皮肤细胞中以增加T细胞应答并减少由于长电波形应用引起的疼痛和不适以及由于肌肉收缩而引起的不适的方法和装置。该方法包括在给药部位向皮肤施用多核苷酸疫苗，（b）将针电极施用于给药部位附近的皮肤，以及（c）施用至少三个单独的，操作者控制的，具有脉冲间隔小于100毫秒的独立编程的窄间隔电波形，以通过电穿孔将15个多核苷酸疫苗递送到皮肤细胞中。

6. 发明申请

WO2010110910A1 METHOD AND APPARATUS FOR THE DELIVERY OF POLYNUCLEOTIDE CANCER VACCINES TO MAMMALIAN SKIN 审中-公开
标题翻译：将多核苷酸疫苗送给妈妈皮肤的方法和装置
公开(公告)号：WO2010110910A1
公开(公告)日：2010-09-30
申请号：PCT/US2010/000908
申请日：2010-03-26
申请人： CYTO PULSE SCIENCES, INC. , WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D. , MALTAIS, Anna-karin , WAHREN, Britta , HALLER, Kristian , BRAVE, Andreas
发明人： WALTERS, Richard, E. , WALTERS, Derin, C. , KING, Alan, D. , MALTAIS, Anna-karin , WAHREN, Britta , HALLER, Kristian , BRAVE, Andreas
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61K39/00 , A61K39/0011 , A61K2039/53 , A61K2039/54 , A61N1/327 , C12N2770/24134
摘要： The invention provides a method and apparatus for the delivery of polynucleotide cancer vaccines to increase T cell response and reduce pain due to long electric waveform application and muscle contractions. The method includes the steps of: (a.) administering a polynucleotide cancer vaccine into the skin at an administration site, (b.) applying a needle electrode to the skin in the vicinity of the administration site, and (c.) applying a sequence of at least three electrical waveforms to deliver the polynucleotide cancer vaccine into skin cells by electroporation. The sequence has at least one of the following characteristics {1} at least two of the waveforms differ in amplitude, {2} at least two of the waveforms differ in width, and (3) a first waveform interval for a first set of two of the waveforms is different from a second waveform interval for a second set of two of the waveforms.
摘要翻译：本发明提供了用于递送多核苷酸癌症疫苗以增加T细胞应答并减少由于长电波形应用和肌肉收缩引起的疼痛的方法和装置。该方法包括以下步骤：（a）在给药部位向皮肤施用多核苷酸癌症疫苗，（b）在施用部位附近向皮肤施用针电极，（c）至少三个电波形的序列，以通过电穿孔将多核苷酸癌症疫苗递送到皮肤细胞中。该序列具有以下特征{1}中的至少一个，振幅中至少两个波形不同，{2}至少两个波形的宽度不同，（3）第一组二分之一的第一波形间隔的波形与第二组波形的第二波形间隔不同。

7. 发明申请

WO2003013647A2 ELECTRODES COATED WITH TREATING AGENT AND USES THEREOF 审中-公开
标题翻译：用处理剂涂覆的电极及其用途
公开(公告)号：WO2003013647A2
公开(公告)日：2003-02-20
申请号：PCT/US2002/021314
申请日：2002-08-02
申请人： CYTO PULSE SCIENCES, INC.
发明人： KING, Alan, D. , WALTER, Richard, E.
IPC分类号： A61N
CPC分类号： A61N1/325 , A61H39/002 , A61N1/306
摘要： An object of the invention is to provide a method for delivery of macromolecules into biologicale cells in the tissues of a patient and includes the steps of: (a) providing electrodes (16) in an electrode assembly (12), whrein the electrodes have fixed electrode surfaces (42) wich are coated with at least one static layer of electrode releasable molecules (44) to be delivred; (b) providing a waveform generator (15) for generating electric fields; (c) establishing electrically conductive pathways between the electrodes (16) and the waveform generator (15); (d) locating the electrodes (16), such that the biological cells are situated therebetween, and (g) providing electric fields in the form of pulse waveforms from the waveform generator (15) to the electrodes (16), such that molecules in the at least one static layer of the electrode releasable molecules (44) on the electrodes (16) are delivered into the biological cells. The electrode releasable molecules (44) can be either electric field separable molecules and/or solvent separable material. Another object of the invention is to provide an apparatus for carrying out the method of the invention. The static-coated electrode assembly (12) can be provided in a sterile package (24), from wich the electrode assembly (12) is removed prior to use. The statically-coated electrode assembly (12) can be in a form of a disposable assembly (12) wich is removable and replaceable from an electrode assembly holder (13).
摘要翻译：本发明的一个目的是提供一种将大分子递送到患者组织中的生物细胞中的方法，该方法包括以下步骤：（a）在电极组件中提供电极（16） 12）中，电极具有固定的电极表面（42），所述固定的电极表面（42）涂覆有至少一个待传输的电极可释放分子（44）的静电层; （b）提供用于产生电场的波形发生器（15）; （c）在电极（16）和波形发生器（15）之间建立导电路径; （d）定位电极（16），使得生物细胞位于它们之间，以及（g）提供从波形发生器（15）到电极（16）的脉冲波形形式的电场，使得电极（16）上的电极可释放分子（44）的至少一个静电层被递送到生物细胞中。电极可释放分子（44）可以是电场可分离分子和/或溶剂可分离材料。本发明的另一个目的是提供一种用于实施本发明方法的设备。静电涂覆的电极组件（12）可以设置在无菌包装（24）中，在使用之前电极组件（12）被移除。静电涂覆的电极组件（12）可以是一次性组件（12）的形式，其可从电极组件保持器（13）移除和更换。

8. 发明申请

WO2007098359A1 SEALING CATHETER HUB ATTACHMENT 审中-公开
标题翻译：密封导管座附件
公开(公告)号：WO2007098359A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/062191
申请日：2007-02-15
申请人： SMITHS MEDICAL ASD, INC. , DIEP, Nhut, M. , GORAL, David, J. , KING, Alan, D. , KOEHLER, Thomas, T.
发明人： DIEP, Nhut, M. , GORAL, David, J. , KING, Alan, D. , KOEHLER, Thomas, T.
IPC分类号： A61M25/00 , A61M25/06 , A61M39/06
CPC分类号： A61M39/06 , A61M25/0097 , A61M25/0612 , A61M39/0606 , A61M2039/062 , A61M2039/0633 , A61M2039/0646 , A61M2039/0686
摘要： A generally rigid molded plastic catheter hub attachment (16, 52, 74) includes one or more co-molded elastomeric gaskets (22, 58).
摘要翻译：通常刚性的模制塑料导管毂连接件（16,52,74）包括一个或多个共模塑弹性垫片（22,58）。

9. 发明申请

WO2007098355A1 ENCLOSED NEEDLE DEVICE WITH DUCKBILL RELEASE MECHANISM 审中-公开
标题翻译：具有DUCKILL释放机构的封闭针装置
公开(公告)号：WO2007098355A1
公开(公告)日：2007-08-30
申请号：PCT/US2007/062185
申请日：2007-02-15
申请人： SMITHS MEDICAL ASD, INC. , BIALECKI, Dennis, M. , DIEP, Nhut, M. , KING, Alan, D. , KOEHLER, Thomas, T.
发明人： BIALECKI, Dennis, M. , DIEP, Nhut, M. , KING, Alan, D. , KOEHLER, Thomas, T.
IPC分类号： A61M25/06 , A61M5/32
CPC分类号： A61M25/0631 , A61M5/3271 , A61M25/0606 , A61M2005/3247
摘要： An enclosed needle catheter insertion device (10) includes a catheter (12) and a needle insertion device (14) which are held together by cooperating arms (52, 53) with one or more detents (56) cooperating with a radially projecting surface (26) of the catheter hub (16). Insertion device (14) includes a guard housing (30) to enclose a needle (34) in a shielded position and a support housing (32) supporting the needle (34) for movement between a ready position, with the tip (36) of the needle (34) exposed, to the shielded position. Cooperating lock elements (47, 78) are provided for the housings (30, 32) which are positioned to define a lock actuation stage between the ready and shielded positions, whereat the needle is still within a passageway (54) defined by the cooperating arms (52, 53).
摘要翻译：封闭的针导管插入装置（10）包括导管（12）和针插入装置（14），它们通过配合的臂（52,53）与一个或多个与径向突出的表面配合的棘爪（56） 26）。插入装置（14）包括用于将针（34）封闭在屏蔽位置的保护壳体（30）和支撑针（34）的支撑壳体（32），用于在就绪位置与准备位置之间移动，该就绪位置与尖端针（34）暴露于屏蔽位置。为壳体（30,32）设置合作的锁定元件（47,78），所述壳体（30,32）被定位成在准备位置和屏蔽位置之间限定锁定致动台，其中针仍在由协作臂限定的通道（54）内（52,53）。

10. 发明申请

WO2007094841A1 ENCLOSED NEEDLE DEVICE WITH FLUID PATH ACCESS 审中-公开
标题翻译：带有流体路径接入的封闭针装置
公开(公告)号：WO2007094841A1
公开(公告)日：2007-08-23
申请号：PCT/US2006/045767
申请日：2006-11-28
申请人： SMITHS MEDICAL ASD, INC. , KING, Alan, D.
发明人： KING, Alan, D.
IPC分类号： A61M25/06
CPC分类号： A61M25/0606 , A61M5/158 , A61M5/3271 , A61M25/0631 , A61M25/0693 , A61M2005/3247
摘要： An enclosed needle catheter insertion device (10) includes an elongated needle guard housing (20) and an elongated needle support housing (22). The support housing (22) is received for movement in guard housing (20) to pull needle (24) in from catheter (12) to be enclosed by guard housing (20). Support housing (22) is of sufficient length that a proximal end (42) thereof is accessible at or beyond a proximal end (28) of guard housing (20) even with the needle (24) extended out of catheter (12) for use, so as to allow for access to the fluid path (44) of support housing (22) to needle lumen (49).
摘要翻译：封闭的针导管插入装置（10）包括细长的针护罩壳体（20）和细长的针支撑壳体（22）。支撑壳体（22）被接收用于在保护壳体（20）中移动以将针（24）从导管（12）拉出以被保护壳体（20）包围。支撑壳体（22）具有足够的长度，使得即使针（24）延伸出导管（12）以使用，其近端（42）也可在保护壳体（20）的近端（28）处或其外部接近，以允许将支撑壳体（22）的流体路径（44）接近针腔（49）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式