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1. 发明申请

WO2009095226A2 NUCLEIC ACIDS OF FORMULA (I) (NUGLXMGNNV)A AND DERIVATIVES THEREOF AS AN IMMUNOSTIMULATING AGENT/ADJUVANT 审中-公开
标题翻译：制剂（I）（NUGLXMGNNV）的核酸及其作为免疫调节剂/调节剂的衍生物
公开(公告)号：WO2009095226A2
公开(公告)日：2009-08-06
申请号：PCT/EP2009000546
申请日：2009-01-28
申请人： CUREVAC GMBH , KRAMPS THOMAS , VOSS SOEHNKE , PROBST JOCHEN , HOERR INGMAR
发明人： KRAMPS THOMAS , VOSS SOEHNKE , PROBST JOCHEN , HOERR INGMAR
IPC分类号： C12N15/09 , A61K39/39 , C12N15/117
CPC分类号： A61K39/39 , A61K2039/53 , A61K2039/55561 , A61K2039/572 , C07H21/00 , C12N15/117 , C12N2310/17 , C12N2310/314 , C12N2310/315 , C12N2320/31
摘要： The present invention relates to nucleic acids of the general formula (I): (NuGlXmGnNv)a and derivatives thereof as an immunostimulating agent/adjuvant and to compositions containing same, optionally comprising an additional adjuvant. The present invention furthermore relates to a pharmaceutical composition or to a vaccine, each containing nucleic acids of formula (I) above and/or derivatives thereof as an immunostimulating agent, and optionally at least one additional pharmaceutically active component, e.g. an antigenic agent. The present invention relates likewise to the use of the pharmaceutical composition or of the vaccine for the treatment of cancer diseases, infectious diseases, allergies and autoimmune diseases etc. Likewise, the present invention includes the use of nucleic acids of the general formula (I): (NuGlXmGnNv)a and/or derivatives thereof for the preparation of a pharmaceutical composition for the treatment of such diseases.
摘要翻译：本发明涉及通式（I）的核酸：（NuG1XmGnNv）a及其衍生物作为免疫刺激剂/佐剂和含有其的组合物，任选地包含另外的佐剂。本发明还涉及药物组合物或疫苗，其各自含有上述式（I）核酸和/或其衍生物作为免疫刺激剂，以及任选的至少一种另外的药物活性成分，例如，抗原剂。本发明同样涉及药物组合物或疫苗用于治疗癌症疾病，感染性疾病，过敏症和自身免疫疾病等的用途。同样地，本发明包括通式（I）的核酸，：（NuGlXmGnNv）a和/或其衍生物，用于制备用于治疗这些疾病的药物组合物。

2. 发明申请

WO02077023A3 A NEW ESSENTIAL DOWNSTREAM COMPONENT OF THE WINGLESS SIGNALLING PATHWAY 审中-公开
标题翻译：无线信号通道的新的基本下放组件
公开(公告)号：WO02077023A3
公开(公告)日：2003-01-16
申请号：PCT/CH0200063
申请日：2002-02-01
申请人： UNIV ZUERICH , KRAMPS THOMAS , BASLER KONRAD
发明人： KRAMPS THOMAS , BASLER KONRAD
IPC分类号： A61K31/7105 , A61K31/711 , A61K31/713 , A61K38/00 , A61K45/00 , A61K48/00 , A61P7/00 , A61P35/00 , A61P43/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/16 , C12N9/38 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/574 , A61K38/18 , C12Q1/68
CPC分类号： G01N33/57407 , C07K14/43581 , C07K14/4702 , C07K2319/00 , G01N33/5082 , G01N2520/00
摘要： The present invention relates to a new essential downstream component of the wingless signaling pathway. In particular, the invention relates to nucleotide sequences of the Drosophila melanogaster daughter of legless (doll) gene, of its encoded proteins, as well as derivatives, fragments and analogues thereof. The invention includes vertebrate and invertebrate homologues of the Doll protein, comprising proteins that contain a stretch of amino acids with similarity to the Drosophila Doll gene. Methods for producing the Doll protein, derivatives and analogs, e.g. by recombinant means, and antibodies to Doll are provided by the present invention as well. The invention also relates to methods for performing high throughput screening assays for compounds modulating Doll function in the Wnt pathway.
摘要翻译：本发明涉及无翼信令通路的新的基本下游部件。特别地，本发明涉及无基因（洋娃娃）基因，其编码的蛋白质以及其衍生物，片段和类似物的黑腹果蝇的雌性核苷酸序列。本发明包括Doll蛋白的脊椎动物和无脊椎动物同系物，其包含含有与果蝇娃娃基因相似的一段氨基酸的蛋白质。生产Doll蛋白，衍生物和类似物的方法，例如通过重组方法，本发明也提供了对Doll的抗体。本发明还涉及用于在Wnt途径中调节Doll功能的化合物进行高通量筛选测定的方法。

3. 发明申请

WO2015024668A2 RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE 审中-公开
标题翻译：呼吸道合胞病毒（RSV）疫苗
公开(公告)号：WO2015024668A2
公开(公告)日：2015-02-26
申请号：PCT/EP2014002301
申请日：2014-08-21
申请人： CUREVAC GMBH
发明人： KRAMPS THOMAS , SCHNEE MARGIT , VOSS DANIEL , PETSCH BENJAMIN
IPC分类号： A61K39/155
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K48/00 , A61K2039/505 , A61K2039/53 , A61K2039/6031 , C07K16/1027 , C07K2317/24 , C12N7/00 , C12N2760/18534
摘要： The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Additionally the present invention relates to a composition comprising a plurality of mRNA sequences comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment, variant or derivative thereof. Furthermore it also discloses the use of the mRNA sequence or the composition comprising a plurality of mRNA sequences for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the prophylaxis or treatment of RSV infections Respiratory syncytial virus (RSV) infections. The present invention further describes a method of treatment or prophylaxis of RSV infections using the mRNA sequence.
摘要翻译：本发明涉及包含编码RSV感染的至少一种抗原性肽或蛋白质的编码区的mRNA序列。呼吸道合胞病毒（RSV）或其片段，变体或衍生物。另外，本发明涉及包含多个包含编码区的编码至少一种RSV感染的抗原性肽或蛋白质的mRNA序列的组合物。呼吸道合胞病毒（RSV）或其片段，变体或衍生物。此外，它还公开了mRNA序列或包含多个mRNA序列的组合物用于制备药物组合物，特别是疫苗例如人血清白蛋白的用途。用于预防或治疗RSV感染呼吸道合胞病毒（RSV）感染。本发明进一步描述了使用mRNA序列治疗或预防RSV感染的方法。

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