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1. 发明申请

WO2019115635A1 FLAVIVIRUS VACCINE 审中-公开
公开(公告)号：WO2019115635A1
公开(公告)日：2019-06-20
申请号：PCT/EP2018/084607
申请日：2018-12-12
申请人： CUREVAC AG , SANOFI PASTEUR
发明人： BAUMHOF, Patrick , GROSSE, Wolfgang , JASNY, Edith , KRAMPS, Thomas , VOSS, Daniel , DANNENMAIER, Julia , LECOUTURIER, Valérie , GIRERD-CHAMBAZ, Yves
IPC分类号： A61K39/12 , C12N15/63 , A61P31/14
CPC分类号： A61K39/12 , A61K2039/53 , A61P31/14 , C12N2770/24111
摘要： The present invention is directed to an artificial nucleic acid and to a polypeptide suitable for use in the treatment or prophylaxis of an infection with a flavivirus, in particular an infection with yellow fever virus or with dengue virus, or of a disorder related to such an infection. The present invention is also directed to a composition, preferably an immunogenic composition, comprising the artificial nucleic acid or the inventive polypeptide. In particular, the present invention concerns an immunogenic composition against a flavivirus, such as yellow fever virus or dengue virus. Further, the invention concerns a kit, particularly a kit of parts, comprising the artificial nucleic acid, polypeptide or (immunogenic) composition. The invention is further directed to a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptide, composition, in particular the first and second medical uses of the immunogenic composition according to the invention.

2. 发明申请

WO2022023559A1 NUCLEIC ACID ENCODED ANTIBODY MIXTURES 审中-公开
公开(公告)号：WO2022023559A1
公开(公告)日：2022-02-03
申请号：PCT/EP2021/071479
申请日：2021-07-30
申请人： CUREVAC AG
发明人： GROßE, Hans Wolfgang , BAUMHOF, Patrick
IPC分类号： C07K16/00 , C07K16/10 , C07K16/1018 , C07K2317/14 , C07K2317/515 , C07K2317/526
摘要： The invention relates inter alia to a nucleic acid composition for the expression of at least two antibodies, preferably a mixture of assembled antibodies in a cell or subject, wherein at least one coding sequence of the nucleic acid composition encodes at least one antibody chain assembly promoter. Further, the invention relates to a nucleic acid sequence set for expression of at least one assembled antibody and to a combination of different nucleic acid sequence sets. Additionally, first and second medical uses, methods of treating or preventing diseases, disorders or conditions, and methods for the production of antibody mixtures are provided.

3. 发明申请

WO2020161342A1 CODING RNA ADMINISTERED INTO THE SUPRACHOROIDAL SPACE IN THE TREATMENT OF OPHTALMIC DISEASES 审中-公开
公开(公告)号：WO2020161342A1
公开(公告)日：2020-08-13
申请号：PCT/EP2020/053215
申请日：2020-02-07
申请人： CUREVAC AG
发明人： REJMAN, Joanna , BAUMHOF, Patrick
IPC分类号： A61K38/00 , A61K47/64 , A61K48/00 , A61P27/02
摘要： The invention relates inter alia to compositions comprising coding RNA for use in treatment of an ophthalmic disease, disorder or condition, wherein said composition is administered into the suprachoroidal space of a subject in need of treatment. Additionally, methods of treating or preventing ophthalmic diseases, disorders or conditions are provided.

4. 发明申请

WO2017212007A1 CATIONIC CARRIERS FOR NUCLEIC ACID DELIVERY 审中-公开
标题翻译：用于核酸递送的阳离子载体
公开(公告)号：WO2017212007A1
公开(公告)日：2017-12-14
申请号：PCT/EP2017/064057
申请日：2017-06-09
申请人： CUREVAC AG
发明人： BAUMHOF, Patrick , THIELE, Carolin
IPC分类号： A61K47/54 , A61K48/00 , C07C215/14 , A61P35/00 , A61P37/00 , A61P43/00
摘要： Compositions for nucleic acid delivery are provided which comprise a relatively low amount a permanently cationic lipid or lipidoid, such as a lipid comprising a quaternary ammonium group. The compositions are suitable for the delivery of chemically modified or unmodified DNA or RNA. Moreover, the compositions are suitable for local administration, such as by extravascular injection.
摘要翻译：提供用于核酸递送的组合物，其包含相对低量的永久性阳离子脂质或类脂质，例如包含季铵基团的脂质。该组合物适合于递送化学修饰的或未修饰的DNA或RNA。而且，该组合物适用于局部给药，例如通过血管外注射。

5. 发明申请

WO2021123332A1 LIPID NANOPARTICLES FOR DELIVERY OF NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2021123332A1
公开(公告)日：2021-06-24
申请号：PCT/EP2020/087254
申请日：2020-12-18
申请人： CUREVAC AG
发明人： NAVARRO, Gemma , BAUMHOF, Patrick
IPC分类号： A61P1/16 , A61P3/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , C07D211/22 , A61K31/445 , C07D405/12
摘要： The application relates to cationic lipids and to compositions comprising said cationic lipids useful for the delivery of nucleic acids into living cells.

6. 发明申请

WO2018078053A1 LIPID NANOPARTICLE MRNA VACCINES 审中-公开
标题翻译：脂质纳米颗粒MRNA疫苗
公开(公告)号：WO2018078053A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077517
申请日：2017-10-26
申请人： CUREVAC AG , ACUITAS THERAPEUTICS INC.
发明人： BAUMHOF, Patrick , FOTIN-MLECZEK, Mariola , HEIDENREICH, Regina , HOPE, Michael J. , JASNY, Edith , LAZZARO, Sandra , LIN, Paulo Jia Ching , LUTZ, Johannes , MUI, Barbara , PETSCH, Benjamin , RAUCH, Susanne , SCHMIDT, Kim Ellen , TAM, Ying
IPC分类号： A61K39/12 , A61K39/39 , A61P31/16 , A61P31/14 , A61K9/51 , A61K31/225 , A61K9/16 , A61K47/18 , A61K9/127 , C07C219/06 , C07C229/16 , C07C233/18 , C07C255/24
摘要： The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
摘要翻译：本发明涉及包含脂质纳米颗粒的mRNA及其医学用途。本发明的脂质纳米颗粒包含根据式（I），（II）或（III）的阳离子脂质和/或根据式（IV）的PEG脂质，以及包含编码抗原肽或蛋白质。本发明进一步涉及所述脂质纳米颗粒作为疫苗或药物的用途，特别是关于流感或狂犬病疫苗。

7. 发明申请

WO2017212006A1 HYBRID CARRIERS FOR NUCLEIC ACID CARGO 审中-公开
标题翻译：用于核酸货物的混合载体
公开(公告)号：WO2017212006A1
公开(公告)日：2017-12-14
申请号：PCT/EP2017/064056
申请日：2017-06-09
申请人： CUREVAC AG
发明人： BAUMHOF, Patrick , THIELE, Carolin
IPC分类号： A61K47/54 , A61K47/59 , A61K47/64 , A61K47/69 , A61K48/00 , A61P35/00 , A61P37/00 , A61P43/00
摘要： The invention relates to carrier compositions for nucleic acid delivery which comprise a cationic peptide or polymer in combination with a cationic lipid. In a further aspect, the invention relates to nanoparticles comprising a complex of a bioactive cargo material with the peptide or polymer and the lipid. The invention further relates to the preparation and the uses of the nanoparticles.
摘要翻译：本发明涉及用于核酸递送的载体组合物，其包含与阳离子脂质组合的阳离子肽或聚合物。另一方面，本发明涉及包含生物活性货物材料与肽或聚合物和脂质的复合物的纳米颗粒。本发明还涉及纳米颗粒的制备和用途。

8. 发明申请

WO2016203025A1 VACCINE COMPOSITION 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2016203025A1
公开(公告)日：2016-12-22
申请号：PCT/EP2016/064093
申请日：2016-06-17
申请人： CUREVAC AG
发明人： HIPP, Madeleine , HEIDENREICH, Regina , FOTIN-MLECZEK, Mariola , BAUMHOF, Patrick , LUTZ, Johannes , KOWALCZYK, Aleksandra
IPC分类号： A61K39/39 , A61K39/00
CPC分类号： A61K39/12 , A61K39/00 , A61K39/39 , A61K2039/53 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , C12N2760/16134 , C12N2760/20134 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： A composition or combination comprising at least a first immunogenic component and at least a second adjuvant component, wherein the first immunogenic component comprises at least one nucleic acid molecule encoding at least one epitope of at least one antigen, and wherein the second adjuvant component comprises at least one immune potentiator compound and/or at least one delivery system compound.
摘要翻译：包含至少第一免疫原性组分和至少第二佐剂组分的组合物或组合，其中所述第一免疫原性组分包含编码至少一种抗原的至少一个表位的至少一个核酸分子，并且其中所述第二佐剂组分包含至少一种免疫增强剂化合物和/或至少一种递送系统化合物。

9. 发明申请

WO2017081082A2 OPTIMIZED NUCLEIC ACID MOLECULES 审中-公开
标题翻译：优化的核酸分子
公开(公告)号：WO2017081082A2
公开(公告)日：2017-05-18
申请号：PCT/EP2016/077145
申请日：2016-11-09
申请人： CUREVAC AG
发明人： BAUMHOF, Patrick , RAUCH, Susanne , KOWALCZYK, Aleksandra , LUTZ, Johannes , JASNY, Edith , PETSCH, Benjamin , THESS, Andreas , SCHLAKE, Thomas , FOTIN-MLECZEK, Mariola , HEIDENREICH, Regina , LAZZARO, Sandra , DÖNER, Fatma , GROßE, Wolfgang
IPC分类号： C12N15/00 , A61K48/00
CPC分类号： C12N15/00 , A61K48/00 , A61K2039/53 , C07K2319/00
摘要： The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g. selected among nucleic acid moieties encoding a polypeptide element, such as a secretory signal peptide (SSP), a multimerization element (dimerization, trimerization, tetramerization and oligomerization), a virus like particle (VLP) forming element, a transmembrane element, a dendritic cell targeting element, an immunological adjuvant element, an element promoting antigen presentation; a 2A peptide; a peptide linker element, elements that extend protein half-life, and/or any other polypeptide or protein. Non-coding nucleic acid moieties may be selected e.g. from the group comprising 3'-UTR, 5'-UTR, IRES element, miRNA moiety, histone stem loop, poly(C) sequence, polyadenylation signal, polyA-sequence. The optimized nucleic acid molecule can further be characterized by the presence of at least one modified nucleoside. The versatility of the present invention allows for rational design of a large variety of different nucleic acid molecules with desired properties.
摘要翻译：本发明提供了优化的核酸分子，用于优化核酸分子的方法和优化的核酸分子的用途。提供了模块化设计原理，其适合于产生针对相应应用定制的核酸，特别是mRNA。本发明的核酸分子可以通过在核酸水平上多种组件的多种组合来获得。这样的核酸，例如可以通过组合一种或多种模块来定制mRNA，所述模块包含（i）编码感兴趣的多肽（例如可能产生治疗结果的蛋白质）的核酸部分和（ii）至少一种另外的编码或非编码核酸部分，例如（SSP），多聚化元件（二聚化，三聚化，四聚化和低聚化），病毒样颗粒（VLP）形成元件，跨膜元件，树突状细胞等的编码多肽元件的核酸部分靶向元件，免疫佐剂元件，促进抗原呈递的元件; 2A肽; 肽接头元件，延长蛋白质半衰期的元件，和/或任何其他多肽或蛋白质。可以选择例如非编码核酸部分。来自包含3'-UTR，5'-UTR，IRES元件，miRNA部分，组蛋白茎环，聚（C）序列，聚腺苷酸化信号，聚A序列的组。优化的核酸分子可以进一步通过存在至少一种修饰的核苷来表征。本发明的多功能性允许合理设计具有期望特性的多种不同核酸分子。

10. 发明申请

WO2016170176A1 RNA CONTAINING COMPOSITION FOR TREATMENT OF TUMOR DISEASES 审中-公开
标题翻译：用于治疗肿瘤疾病的含RNA组合物
公开(公告)号：WO2016170176A1
公开(公告)日：2016-10-27
申请号：PCT/EP2016/059109
申请日：2016-04-22
申请人： CUREVAC AG
发明人： FOTIN-MLECZEK, Mariola , KOWALCZYK, Aleksandra , HEIDENREICH, Regina , BAUMHOF, Patrick , PROBST, Jochen , KALLEN, Karl-Josef
IPC分类号： A61K38/19 , C07K14/52 , A61K38/20 , A61K39/00 , C12N15/113 , C12N15/117 , A61P35/00
CPC分类号： A61K48/005 , A61K9/0019 , A61K38/177 , A61K38/1774 , A61K38/19 , A61K38/208 , A61K39/12 , A61K39/145 , A61K39/39 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K48/0041 , A61K2039/53 , A61K2039/54 , A61K2039/55511 , A61K2039/55522 , A61K2039/55538 , A61K2039/55561 , A61K2039/585 , C07K16/2818 , C07K16/2878 , C07K16/2896 , C07K16/30 , C07K16/34 , C07K2317/75 , C07K2317/76 , C12N7/00 , C12N15/117 , C12N2310/17 , C12N2320/30 , C12N2760/16034 , C12N2760/16134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/397 , A61K2300/00
摘要： The present invention relates to RNA containing compositions for use in the treatment or prophylaxis of tumor and/or cancer diseases, to a pharmaceutical composition, to a kit and to uses of the RNA containing compositions for the treatment or prophylaxis of tumor and/or cancer diseases
摘要翻译：本发明涉及用于治疗或预防肿瘤和/或癌症疾病的RNA含有组合物，药物组合物，试剂盒和用于治疗或预防肿瘤和/或癌症的含RNA组合物的用途疾病

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