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1. 发明申请

WO2007100910A2 TRANSDERMAL PATCHES CONTAINING A NITRIC OXIDE-DONOR AND A SECOND ACTIVE AGENT AND ASSOCIATED METHODS 审中-公开
标题翻译：含有氮氧化物和第二活性剂及其相关方法的透皮胶条
公开(公告)号：WO2007100910A2
公开(公告)日：2007-09-07
申请号：PCT/US2007005395
申请日：2007-02-28
申请人： CURE THERAPEUTICS INC , ANG ROBERT , JACOBSON SVEN , WEIMMAN LUDWIG , MURRELL GEORGE ANTHONY CALVERT , GELIEBTER DAVID
发明人： ANG ROBERT , JACOBSON SVEN , WEIMMAN LUDWIG , MURRELL GEORGE ANTHONY CALVERT , GELIEBTER DAVID
IPC分类号： A61K31/21
CPC分类号： A61K9/7061 , A61K33/00 , A61K45/06
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitric oxide-donor and a second active agent. The patch can comprise a backing layer and an active agent-containing composition which is supported at least in part by the backing layer. The active agent-containing composition can include an amount of a nitric oxide-donor and an amount of a second active agent. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 µg/hour to about 85 µg/hour. The second active agent can be selected from a number of agents including NSAIDS, opioids, local anesthetics, menthol, salicylic acid, salicylic acid derivatives, vanilloid receptor- 1 activators, corticosteroids, vasoconstrictors, and combinations thereof.
摘要翻译：本发明涉及用于递送一氧化氮给体和第二活性剂的透皮贴片。贴剂可以包括背衬层和至少部分由背衬层支撑的含活性剂的组合物。含活性剂的组合物可以包括一定量的一氧化氮供体和一定量的第二活性剂。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区，并且透皮贴剂可以配制成以约5μg/小时至约约1μg/小时递送一氧化氮供体，例如硝酸甘油 85微克/小时。第二活性剂可以选自许多试剂，包括NSAIDS，阿片样物质，局部麻醉剂，薄荷醇，水杨酸，水杨酸衍生物，香草素受体-1激活剂，皮质类固醇，血管收缩剂及其组合。

2. 发明申请

WO2007124110A3 VASODIALATING DRESSING FOR USE WITH INTRAVENOUS CATHETERS 审中-公开
标题翻译： VASODIALATING DRESSING用于内窥镜
公开(公告)号：WO2007124110A3
公开(公告)日：2008-12-04
申请号：PCT/US2007009756
申请日：2007-04-19
申请人： CURE THERAPEUTICS INC , ANG ROBERT , GELIEBTER DAVID
发明人： ANG ROBERT , GELIEBTER DAVID
IPC分类号： A61F13/02 , A61F13/00 , A61M29/00
CPC分类号： A61L15/44 , A61K31/21 , A61L15/58 , A61L2300/204 , A61L2300/40 , A61L2300/602
摘要： The present invention is drawn to adhesive dressings and associated systems and methods for use in reducing the occurrence of phlebitis and extending the lifespan of intravenous catheters. The adhesive dressings can include a backing layer, and a nitroglycerin-containing composition supported at least in part by the backing layer. The adhesive dressing can have a drug delivery zone defined by the area where the nitroglycerin-containing composition contacts an intact human skin site. The drug delivery zone can have an area of at least 2.5 cm2 and can be configured such that when the adhesive dressing is applied to secure an intravenous catheter the drug delivery zone substantially overlays a vessel in which the intravenous catheter is inserted. The nitroglycerin-containing composition can be formulated to deliver nitroglycerin at from about 5 µg/hour to about 80 µg/hour.
摘要翻译：本发明涉及用于减少静脉炎发生并延长静脉内导管的寿命的粘合剂敷料和相关系统和方法。粘合剂敷料可以包括背衬层和至少部分由背衬层支撑的含有硝酸甘油的组合物。粘合敷料可以具有由含硝酸甘油的组合物接触完整的人皮肤部位的区域限定的药物递送区域。药物递送区可以具有至少2.5cm 2的面积，并且可以构造成使得当施加粘合剂敷料以固定静脉内导管时，药物递送区基本上覆盖其中插入静脉内导管的血管。含硝酸甘油的组合物可配制成以约5μg/小时至约80μg/小时递送硝酸甘油。

3. 发明申请

WO2007143185A3 TRANSDERMAL TREATMENT OF TENDINOPATHY USING GLYCERYL TRINITRITE 审中-公开
标题翻译：使用谷氨酸TRINITRITE的TENDINOPATHY的透皮治疗
公开(公告)号：WO2007143185A3
公开(公告)日：2008-06-26
申请号：PCT/US2007013117
申请日：2007-06-01
申请人： CURE THERAPEUTICS INC , MURRELL GEORGY ANTHONY CALVERT , ANG ROBERT , WEIMANN LUDWIG , JACOBSON SVEN
发明人： MURRELL GEORGY ANTHONY CALVERT , ANG ROBERT , WEIMANN LUDWIG , JACOBSON SVEN
IPC分类号： A61F13/00 , A61K31/21
CPC分类号： A61K9/0014 , A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy providing a durability of effect by administering nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. The use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过施用硝酸甘油来治疗提供耐久性的腱鞘的方法。这些方法包括减轻与这种腱病相关的疼痛的方法。使用透皮贴片，其配置为以5mcg / hr的速率将硝酸甘油酯输送至约85mcg / hr。

4. 发明申请

WO2007103190A3 TRANSDERMAL TREATMENT OF TENDINOP ATHY USING NO DONOR 审中-公开
标题翻译： TENDINOP ATHY使用无捐助物的转基因治疗
公开(公告)号：WO2007103190A3
公开(公告)日：2008-08-14
申请号：PCT/US2007005394
申请日：2007-02-28
申请人： CURE THERAPEUTICS INC , MURRELL GEORGE ANTHONY CALVERT , ANG ROBERT , WEIMMAN LUDWIG , JACOBSON SVEN
发明人： MURRELL GEORGE ANTHONY CALVERT , ANG ROBERT , WEIMMAN LUDWIG , JACOBSON SVEN
IPC分类号： A61F13/00 , A61K31/21
CPC分类号： A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy in the absence of inflammation by the transdermal administration of nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies. and the use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过透皮给药硝酸甘油来治疗不存在炎症的腱鞘炎的方法。这些方法包括减轻与这种腱病相关的疼痛的方法。以及使用透皮贴片，其被配置成以5mcg / hr的速率递送硝酸甘油酯至约85mcg / hr。

5. 发明申请

WO2007092284A3 LOW DOSE NO DONOR-CONTAINING TRANSDERMAL PATCH 审中-公开
标题翻译：低剂量不含复合透皮贴片
公开(公告)号：WO2007092284A3
公开(公告)日：2008-07-03
申请号：PCT/US2007002835
申请日：2007-02-02
申请人： CURE THERAPEUCTICS INC , ANG ROBERT , JACOBSON SVEN , WEIMANN LUDWIG
发明人： ANG ROBERT , JACOBSON SVEN , WEIMANN LUDWIG
IPC分类号： A61F13/02 , A61F13/00
CPC分类号： A61K9/7061 , A61K31/21 , A61K47/10
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitroglycerin or other NO donor. The patch can comprise a backing layer, and a nitroglycerin-containing composition or other NO donor-containing composition which is supported at least in part by the backing layer. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 µg/hour to about 70 µg/hour. In one embodiment, the transdermal patch can provide a delivery rate at the drug delivery zone of from about 1 µg/cm2/day to about 600 µg/cm2/day. In another embodiment, the transdermal patch can contain from 6 wt% to 18 wt% of the nitric oxide donor, e.g., nitroglycerin. In each embodiment, the patch can contain at least 450 µg/cm2 of nitroglycerin.
摘要翻译：本发明涉及用于递送硝酸甘油或其他NO供体的透皮贴片。贴剂可以包含背衬层和含硝酸甘油的组合物或至少部分由背衬层支撑的含NO供体的组合物。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区，并且透皮贴剂可以配制成以约5μg/小时至约约1μg/小时递送一氧化氮供体，例如硝酸甘油 70μg/小时。在一个实施方案中，透皮贴剂可以在药物递送区域提供约1μg/ cm 2 /天至约600μg/ cm 2 /天的递送速率。在另一个实施方案中，透皮贴剂可含有6重量％至18重量％的一氧化氮供体，例如硝酸甘油。在每个实施方案中，贴剂可含有至少450μg/ cm 2的硝酸甘油。

6. 发明申请

WO2008027203A3 MEDICATED ORTHOPEDIC SUPPORT STRUCTURES FOR TREATMENT OF DAMAGED MUSCULOSKELETAL TISSUE 审中-公开
标题翻译：用于治疗损伤的胶质细胞组织的药物治疗支持结构
公开(公告)号：WO2008027203A3
公开(公告)日：2008-11-06
申请号：PCT/US2007018199
申请日：2007-08-14
申请人： CURE THEREPAUTICS INC , ANG ROBERT , WEIMANN LUDWIG , MURRELL ANTHONY CALVERT
发明人： ANG ROBERT , WEIMANN LUDWIG , MURRELL ANTHONY CALVERT
IPC分类号： A61F13/00
CPC分类号： A61K9/7061 , A61K31/21
摘要： A system and method for treating damaged musculoskeletal tissue includes an orthopedic support structure and a nitroglycerin-containing composition. The orthopedic support structure provides mechanical support to the damaged tissue and maintains the nitroglycerin-containing composition in contact with the skin of a subject wearing using the system. The nitroglycerin- containing composition can be integrated into the orthopedic support structure or the support structure can be configured to contain removable doses of the nitroglycerin-containing composition. The system and method provides relief of pain and improved function of the musculoskeletal tissue.
摘要翻译：用于治疗损伤的肌肉骨骼组织的系统和方法包括矫形支撑结构和含硝酸甘油的组合物。矫形支撑结构为受损组织提供机械支撑，并使含硝酸甘油的组合物与使用该系统的受试者的皮肤接触。含硝酸甘油的组合物可以整合到整形外科支持结构中，或者支持结构可被配置成含有可除去剂量的含有硝酸甘油的组合物。该系统和方法提供减轻疼痛和改善肌肉骨骼组织的功能。

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