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1. 发明申请

WO0200691A3 POLYNUCLEOTIDES AND POLYPEPTIDES ENCODED THEREBY 审中-公开
标题翻译：多核苷酸和编码的多核苷酸
公开(公告)号：WO0200691A3
公开(公告)日：2003-02-27
申请号：PCT/US0120510
申请日：2001-06-27
申请人： CURAGEN CORP , VERNET CORINE A M , TCHERNEV VELIZAR , PATTURAJAN MEERA , MALYANKAR URIEL M , GUSEV VLADIMIR , HERRMANN JOHN L , MACDOUGALL JOHN R , RASTELLI LUCA , ZHONG HAIHONG , SPYTEK KIMBERLY A , SHENOY SURESH , GERLACH VALERIE L , GANGOLLI ESHA A , STONE DAVID J , SMITHSON GLENNDA
发明人： VERNET CORINE A M , TCHERNEV VELIZAR , PATTURAJAN MEERA , MALYANKAR URIEL M , GUSEV VLADIMIR , HERRMANN JOHN L , MACDOUGALL JOHN R , RASTELLI LUCA , ZHONG HAIHONG , SPYTEK KIMBERLY A , SHENOY SURESH , GERLACH VALERIE L , GANGOLLI ESHA A , STONE DAVID J , SMITHSON GLENNDA
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/04 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P7/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/08 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P27/00 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/02 , A61P35/00 , A61P37/04 , A61P37/08 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/36 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/85
CPC分类号： C12N9/2462 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C12N2799/026
摘要： Disclosed herein are nucleic acid sequences. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

2. 发明申请

WO0206339A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO0206339A2
公开(公告)日：2002-01-24
申请号：PCT/US0121249
申请日：2001-07-03
申请人： CURAGEN CORP , SPADERNA STEVEN K , TCHERNEV VELIZAR , LIU XIAOHONG , SHENOY SURESH , SPYTEK KIMBERLY , ZERHUSEN BRYAN , PATTURAJAN MEERA , TAUPIER RAYMOND J , RASTELLI LUCA , GROSSE WILLIAM M , SZEKERES EDWARD S , ALSOBROOK JOHN II , LEPLEY DENISE M , SHEN LEI , BURGESS CATHERINE E , SHIMKETS RICHARD A , PADIGARU MURALIDHARA
发明人： SPADERNA STEVEN K , TCHERNEV VELIZAR , LIU XIAOHONG , SHENOY SURESH , SPYTEK KIMBERLY , ZERHUSEN BRYAN , PATTURAJAN MEERA , TAUPIER RAYMOND J , RASTELLI LUCA , GROSSE WILLIAM M , SZEKERES EDWARD S , ALSOBROOK JOHN II , LEPLEY DENISE M , SHEN LEI , BURGESS CATHERINE E , SHIMKETS RICHARD A , PADIGARU MURALIDHARA
IPC分类号： C07K14/47
CPC分类号： C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polpeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新型多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

3. 发明申请

WO02081517A3 NOVEL POLYPEPTIDES AND NUCLEIC ACIDS ENCODED THEREBY 审中-公开
标题翻译：新型多糖和核酸编码
公开(公告)号：WO02081517A3
公开(公告)日：2003-08-28
申请号：PCT/US0202064
申请日：2002-01-22
申请人： CURAGEN CORP , DECRISTOFARO MARC F , PADIGARU MURALIDHARA , MILLER CHARLES , TCHERNEV VELIZAR , ZHONG HAIHONG , ZHONG MEI , ANDERSON DAVID , BALLINGER ROBERT , GERLACH VALERIE , SPYTEK KIMBERLY A
发明人： DECRISTOFARO MARC F , PADIGARU MURALIDHARA , MILLER CHARLES , TCHERNEV VELIZAR , ZHONG HAIHONG , ZHONG MEI , ANDERSON DAVID , BALLINGER ROBERT , GERLACH VALERIE , SPYTEK KIMBERLY A
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , A61K38/16 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00
摘要： Disclosed are novel polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
摘要翻译：公开了编码它们的新型多肽和核酸。还公开了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

4. 发明申请

WO0202637A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO0202637A2
公开(公告)日：2002-01-10
申请号：PCT/US0121174
申请日：2001-07-02
申请人： CURAGEN CORP , SPADERNA STEVEN K , PADIGARU MURALIDHARA , SPYTEK KIMBERLY A , CASMAN STACIE , RASTELLI LUCA , MAYANKAR URIEL , TCHERNEV VELIZAR
发明人： SPADERNA STEVEN K , PADIGARU MURALIDHARA , SPYTEK KIMBERLY A , CASMAN STACIE , RASTELLI LUCA , MAYANKAR URIEL , TCHERNEV VELIZAR
IPC分类号： C07K14/705 , C07K14/72 , C12N15/12
CPC分类号： C07K14/705 , C07K14/723
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The inventio further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。本发明还公开了用于诊断，治疗和预防涉及这些新型人核酸和蛋白质中的任何一种的病症的治疗，诊断和研究方法。

5. 发明申请

WO2004004668A3 IMMUNE MODULATORY ACTIVITY OF HUMAN RIBONUCLEASES 审中-公开
标题翻译：人类免疫调节剂的免疫调节活性
公开(公告)号：WO2004004668A3
公开(公告)日：2005-03-03
申请号：PCT/US0308824
申请日：2003-04-02
申请人： MOLECULAR STAGING INC , FU QIN , TCHERNEV VELIZAR , SATYARAJ EBENEZER , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F , SCHWEITZER BARRY
发明人： FU QIN , TCHERNEV VELIZAR , SATYARAJ EBENEZER , PATEL DHAVALKUMAR D , KINGSMORE STEPHEN F , SCHWEITZER BARRY
IPC分类号： A61K39/39 , G01N33/573 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/573 , A61K39/39 , A61K2039/55516 , G01N2333/922
摘要： Human extracellular ribonucleases (RNases) are widely distributed in various organs and body fluids and together with other members of the mammalian RNase A superfamily. In addition to their RNase activity, several RNases have been shown to have special biological actions, i.e., antitumor, antiviral and antigiogenic properties. However, the molecular mechanisms of such activities are unclear. Using protein microarrays amplified rolling circle amplification (RCA), we investigated the effects of EDN (Rnase 2), ECP (Rnase 3) and RNase 1om leukocytes cytokine production. We measured the levels of 78 different cytokines and growth factors in culture supernatants to determine the cytokine profiles of cells treated with different combinations of RNases and RNase inhibitors. Members of human ribonuclease family (such as Rnase 1, hEDN (Rnase 2) and Rnase 3 ) induced expression of certain sets of cytokines in human leukocytes, including ENA-78, EOT2, BLC, GDNF, I309, IFN-alpha, IFN-gamma, IL-10, IL-12p70, IL-13, IL-16, IL-18, IL1beta, IL-1ra, IL-2Sra, IL-3, IL-6, IL-6Sr, IL-7, IL-8, IP-10, MCP-1, MCP-2, MCP-3, MCSF, MIG, MDC, MIP-1alpha, MIP-1beta, MPIF-1, NAP-2, RANTES, sCD23, OSM, TARC, TNF-alpha, TNF-R1 and uPAR. Thus members of the Rnase superfamily are therapeutic targets for treatment of inflammatory diseases and clinical conditions. Inhibition or augmentation of Rnase expression is used to modulate the immune system and is beneficial for host defense against various diseases and is exploited as an adjuvant. The expression of Rnases is a diagnostic marker for inflammation related conditions and is used to determine various disease stages. In addition, expression of cytokines, chemokines, growth factors is used to monitor efficacy of Rnase-base therapies.
摘要翻译：人类细胞外核糖核酸酶（RNases）广泛分布在各种器官和体液中，并与哺乳动物核糖核酸酶A超家族的其他成员一起分布。除了它们的RNA酶活性外，已经显示出几种RNA酶具有特殊的生物学作用，即抗肿瘤，抗病毒和抗病毒性质。然而，这些活动的分子机制尚不清楚。使用蛋白质微阵列扩增滚环扩增（RCA），我们研究了EDN（Rnase 2），ECP（Rnase 3）和RNase 1om白细胞细胞因子产生的影响。我们测量培养上清液中78种不同细胞因子和生长因子的水平，以确定用不同RNA酶和RNA酶抑制剂组合处理的细胞的细胞因子谱。人类核糖核酸酶家族（如Rnase 1，hEDN（Rnase 2）和Rnase 3）的成员诱导人白细胞中某些细胞因子的表达，包括ENA-78，EOT2，BLC，GDNF，I309，IFN-α，IFN- γ，IL-10，IL-12p70，IL-13，IL-16，IL-18，IL1β，IL-1ra，IL-2Sra，IL-3，IL-6，IL-6Sr， 8，IP-10，MCP-1，MCP-2，MCP-3，MCSF，MIG，MDC，MIP-1alpha，MIP-1beta，MPIF-1，NAP-2，RANTES，sCD23，OSM，TARC， α，TNF-R1和uPAR。因此，Rnase超家族成员是治疗炎症性疾病和临床病症的治疗靶点。 Rnase表达的抑制或增加用于调节免疫系统，有利于宿主防御各种疾病，并被开发为佐剂。 Rnases的表达是炎症相关病症的诊断标记，用于确定各种疾病阶段。此外，细胞因子，趋化因子，生长因子的表达用于监测Rnase基疗法的疗效。

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