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    • 2. 发明申请
    • TWIST FLOW MICROFLUIDIC MIXER AND MODULE
    • WO2012166756A1
    • 2012-12-06
    • PCT/US2012/039916
    • 2012-05-30
    • CORNING INCORPORATEDCHIVILIKHIN, Mikhail Sergeevich
    • CHIVILIKHIN, Mikhail Sergeevich
    • B01F13/00B01F5/00B01F5/02
    • B01F5/0057B01F5/0275B01F13/0059B81B1/00
    • A multilayer microfluidic module (10) contains a micromixer (12) comprising, in order along an internal fluid path (14), a first fluid channel (16) lying within a first layer (51) of the module (10) along a first direction (15) with the first layer having a lower boundary (21); at least one additional fluid channel (17) lying within the first layer (51) of the module (10) along an additional direction (19); a first injection passage (20) extending from a first injection passage inlet (22) in the lower boundary (21) of the first layer (51) of the module (10) through a second layer (52) of the module (10) to a first injection passage outlet (24), the first injection passage inlet (22) being fluidically connected to the first fluid channel (16) and to the additional fluid channel (17) either individually through the lower boundary (21) of the first layer (51) or via a manifold (25) within the first layer (51); and a second fluid channel (26) lying within a third layer (53) of the module (10), the third layer (53) having an upper boundary (30), the second fluid channel having a width W 26 ; wherein the first direction (15) and the additional direction (19) are non-collinear, and wherein the first injection passage outlet (24) is centered within the second fluid channel (26) in the direction of the width W 26 , and has a length L 24 along the second fluid channel (26) and a width W 24 in the direction of the width W 26 , and wherein the width W 24 is narrower than the width W 26, and wherein the first injection passage outlet (24) has a length-to-width ratio L 24 / W 24 of greater than 1:1.
    • 多层微流体模块(10)包含微混合器(12),其沿着内部流体路径(14)依次包括位于模块(10)的第一层(51)内的第一流体通道(16) 方向(15)与第一层具有下边界(21); 至少一个额外的流体通道(17),沿着附加方向(19)位于模块(10)的第一层(51)内; 通过模块(10)的第二层(52)从模块(10)的第一层(51)的下边界(21)中的第一注入通道入口(22)延伸的第一注入通道(20) 到第一注射通道出口(24),第一注射通道入口(22)流体地连接到第一流体通道(16)和另外的流体通道(17),单独地通过第一流体通道的下边界(21) 层(51)或经由第一层(51)内的歧管(25)。 以及位于所述模块(10)的第三层(53)内的第二流体通道(26),所述第三层(53)具有上边界(30),所述第二流体通道具有宽度W26; 其中所述第一方向(15)和所述附加方向(19)是非共线的,并且其中所述第一喷射通道出口(24)在所述第二流体通道(26)内沿宽度W26的方向居中,并且具有 沿着第二流体通道(26)的长度L24和宽度W26的方向上的宽度W24,并且其中宽度W24比宽度W26更窄,并且其中第一注射通道出口(24)具有长度 - 宽度比L24 / W24大于1:1。