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1. 发明申请

WO2010078516A2 MULTIFUNCTIONAL NUCLEIC ACID NANO-STRUCTURES 审中-公开
标题翻译：多功能核酸纳米结构
公开(公告)号：WO2010078516A2
公开(公告)日：2010-07-08
申请号：PCT/US2009/069947
申请日：2009-12-31
申请人： CORNELL UNIVERSITY , LUO, Dan , LEE, Jong, Bum
发明人： LUO, Dan , LEE, Jong, Bum
IPC分类号： C12N15/11 , C12Q1/68 , B82B1/00 , C07H21/00
CPC分类号： C12N15/111 , C12N2310/351 , C12N2310/3517 , C12N2310/51 , C12N2310/52 , C12N2310/53 , C12Q1/6811 , C12Q1/682 , C12Q2565/401 , C12Q2525/313
摘要： Compositions and methods are provided for constructing multi-functional nucleic acid nano-structures. Nano-structures are provided incorporating a built-in modularity, including nucleic acid modules. Modules contain moieties including detectible labels, nanoparticles, reactive moieties and other functional groups. Nano-structures can be used for delivery of target compounds, as well as identification of target nucleic acid molecules.
摘要翻译：提供了构建多功能核酸纳米结构的组合物和方法。提供纳入结构的内置模块化，包括核酸模块。模块包含包含可检测标记，纳米颗粒，反应性部分和其他官能团的部分。纳米结构可用于递送靶化合物，以及靶核酸分子的鉴定。

2. 发明申请

WO2010147655A2 COMPOSITIONS AND METHODS RELATING TO NUCLEIC ACID DELIVERY VEHICLES 审中-公开
标题翻译：关于核酸递送车辆的组合物和方法
公开(公告)号：WO2010147655A2
公开(公告)日：2010-12-23
申请号：PCT/US2010/001743
申请日：2010-06-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , CORNELL UNIVERSITY , IRVINE, Darrell, J. , UM, Soong, Ho , LUO, Dan
发明人： IRVINE, Darrell, J. , UM, Soong, Ho , LUO, Dan
IPC分类号： A61K48/00 , C12P19/34 , C07H21/00
CPC分类号： A61K31/00 , A61K9/0019 , A61K9/06 , A61K9/127 , A61K9/1271 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K49/0002 , C07H21/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2310/3519 , C12N2310/52 , C12N2320/32 , C12N2330/30 , C12P19/34
摘要： The invention provides compositions and methods relating to delivery of agents in vivo or in vitro. In some instances, the invention provides nanoparticles synthesized from crosslinked nucleic acids, optionally having a lipid shell or coating, and may further comprise for example small molecule or high molecular weight compounds as therapeutic or diagnostic agents.
摘要翻译：本发明提供了与体内或体外递送试剂有关的组合物和方法。在一些情况下，本发明提供了由交联的核酸合成的纳米颗粒，任选地具有脂壳或涂层，并且还可包含例如作为治疗剂或诊断剂的小分子或高分子量化合物。

3. 发明申请

WO2009143157A2 SELF-ASSEMBLY OF NANOPARTICLES THROUGH NUCLEIC ACID ENGINEERING 审中-公开
标题翻译：通过核酸工程自组装纳米粒子
公开(公告)号：WO2009143157A2
公开(公告)日：2009-11-26
申请号：PCT/US2009/044526
申请日：2009-05-19
申请人： CORNELL UNIVERSITY , LUO, Dan , CHENG, Wenlong
发明人： LUO, Dan , CHENG, Wenlong
IPC分类号： C12Q1/68 , B82B3/00 , C07H21/00
CPC分类号： B82B1/00 , B82Y30/00
摘要： A self-assembly nanodevice formed through nucleic acid engineering is disclosed. The nanodevice may include an array of nanoparticles. The nanodevice may further include a substrate that supports the array of nanoparticles. Each of the nanoparticles may be coordinated with a plurality of nucleic acids that are substantially free of Watson-Crick base- paring with nucleic acids coordinated with other nanoparticles. Methods of forming the nanodevice, as well as the microscopic organization of the nanoparticles are also disclosed. By manipulating the nucleic acids as capping ligands, the inter-particle distance may be extended to a greater range than nanotechnology based on alkyl ligands or nucleic acids base- pairing.
摘要翻译：公开了通过核酸工程形成的自组装纳米器件。纳米器件可以包括纳米颗粒阵列。纳米器件还可以包括支撑纳米颗粒阵列的衬底。每个纳米颗粒可以与基本上不含与其他纳米颗粒配位的核酸碱基配对的Watson-Crick碱基的多个核酸配位。还公开了形成纳米器件的方法以及纳米颗粒的微观结构。通过将核酸作为封端配体进行操作，颗粒间距离可以延伸到比基于烷基配体或核酸碱基配对的纳米技术更大的范围。

4. 发明申请

WO2010017264A2 PHOTO-CROSSLINKED NUCLEIC ACID HYDROGELS 审中-公开
标题翻译：光交联核酸水凝胶
公开(公告)号：WO2010017264A2
公开(公告)日：2010-02-11
申请号：PCT/US2009/052795
申请日：2009-08-05
申请人： CORNELL UNIVERSITY , LUO, Dan , ROH, Young, Hoon
发明人： LUO, Dan , ROH, Young, Hoon
IPC分类号： C07H21/00 , C12N15/88 , A61K48/00 , A61K31/713
CPC分类号： A61K9/06 , A61K9/146 , A61K9/1641 , A61K47/34 , C12N15/10 , C12N15/88
摘要： Methods and compositions are provided for producing hydrogel nucleic acid structures using photo-crosslinking. Methods of using the photo-crosslmked hydrogels for cell-free protein production, and for encapsulating and delivering compounds, are also provided.
摘要翻译：提供了使用光交联产生水凝胶核酸结构的方法和组合物。还提供了使用光交联的水凝胶进行无细胞蛋白质生产以及用于包封和递送化合物的方法。

5. 发明申请

WO2007008838A3 PORTABLE KEY ASSEMBLY 审中-公开
公开(公告)号：WO2007008838A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026798
申请日：2006-07-07
申请人： LUO, Dan
发明人： LUO, Dan
IPC分类号： E05B19/04
摘要： A portable key assembly occupies less space and is attachable to certain attachment structures for providing a key-turning moment arm. The portable key assembly is set with a key body, a lock fastener, and an abbreviated key handle on one end of the key body. The portable key assembly can be connected and overlapped in face-to-face relation with other keys or key accessories so that the same may be well combined, easily located, and convenient to carry. A moment arm extension can be formed by connecting the portable key assembly with other keys or key accessories. The turning torque of the key handle may thus be enlarged so that the portable key assembly can function properly even if the key handle is shortened and the volume of the whole key is reduced.

6. 发明申请

WO2020206326A1 SYSTEM AND METHODS FOR GENERATING DYNAMIC MATERIALS HAVING ARTIFICIAL METABOLISM 审中-公开
公开(公告)号：WO2020206326A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/026680
申请日：2020-04-03
申请人： CORNELL UNIVERSITY
发明人： LUO, Dan , HAMADA, Shogo , VANCEY, Kenneth Gene
IPC分类号： C12M1/18 , C08J3/00 , C12N15/10
摘要： This disclosure relates to generation of dynamic materials having an ordered structure and artificial metabolism. The approach disclosed herein allows autonomous and dynamic generation of materials with structural hierarchy by simultaneously coupling both irreversible synthesis (and optionally decomposition) and dissipative assembly processes, but in an artificial fashion. As an exemplary embodiment, D NA-based A ssembly and S ynthesis of H ierarchical (or"DASH") materials have been generated. Systems, devices, reagents and methods for generating the materials, as well as additional applications of the present methodology, are disclosed.

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