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1. 发明申请

WO0228414B1 COMPOSITIONS AND METHODS FOR WT1 SPECIFIC IMMUNOTHERAPY 审中-公开
标题翻译： WT1特异性免疫治疗的组合物和方法
公开(公告)号：WO0228414B1
公开(公告)日：2002-07-18
申请号：PCT/US0131139
申请日：2001-10-03
申请人： CORIXA CORP , GAIGER ALEXANDER , MCNEILL PATRICIA D , SMITHGALL MOLLY , MOULTON GUS , VEDVICK THOMAS S , SLEATH PAUL R , MOSSMAN SALLY , EVANS LAWRENCE , SPIES A GREGORY , BOYDSTON JEREMY
发明人： GAIGER ALEXANDER , MCNEILL PATRICIA D , SMITHGALL MOLLY , MOULTON GUS , VEDVICK THOMAS S , SLEATH PAUL R , MOSSMAN SALLY , EVANS LAWRENCE , SPIES A GREGORY , BOYDSTON JEREMY
IPC分类号： G01N33/574 , A61K31/7088 , A61K35/14 , A61K38/00 , A61K39/00 , A61K39/39 , A61K39/395 , A61K45/00 , A61K48/00 , A61P35/00 , A61P35/02 , A61P37/04 , C07K14/47 , C07K14/82 , C07K16/32 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12Q1/68 , A61K38/16 , A61K38/17 , C07H21/02 , C07H21/04 , C07K14/435 , G01N33/53
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/515 , C07K2319/00
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
摘要翻译：披露了用于治疗恶性疾病例如白血病和癌症的组合物和方法。该组合物包含WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体中的一种或多种; 或与WT1多肽特异性反应的T细胞。这样的组合物可以用于例如预防和治疗转移性疾病。

2. 发明申请

WO0203961B1 MICROSPHERES AND ADJUVANTS FOR DNA VACCINE DELIVERY 审中-公开
标题翻译：用于DNA疫苗递送的微生物和调节物
公开(公告)号：WO0203961B1
公开(公告)日：2002-04-04
申请号：PCT/US0121780
申请日：2001-07-09
申请人： CORIXA CORP
发明人： JOHNSON MARK E , MOSSMAN SALLY , CECIL TRICIA , EVANS LAWRENCE
IPC分类号： A61K9/50 , A61K9/00 , A61K9/16 , A61K38/00 , A61K39/00 , A61K39/39 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61K48/00 , A61P31/06 , A61P35/00
CPC分类号： A61K9/1647
摘要： A nucleic acid delivery system that offers, in one system, a combination of high encapsulation efficiency, rapid release kinetics and preservation of DNA in supercoiled form is provided. The nucleic delivery system comprises nucleic acid molecules, such as deoxyribonucleic acid (DNA), encapsulated in biodegradable microspheres, and is particularly suited for delivery DNA vaccines. The ivnention futher provides a method for encapsulating nucleic acid molecules in microspheres. The invention additionally provides a composition comprising nucleic acid molecules encapsulated in microspheres produced by a method of the invention, and a method for delivering a nucleic acid molecule to a subject. The invention futher provides an adjuvant for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules comprising an aminoalkyl glucosaminide 4-phosphate (AGP). The invention also provides a method for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules.
摘要翻译：提供了在一个系统中提供高封装效率，快速释放动力学和超螺旋形式的DNA保存的组合的核酸递送系统。核酸递送系统包含核酸分子，例如包封在可生物降解的微球中的脱氧核糖核酸（DNA），特别适用于递送DNA疫苗。另外，提供了一种将核酸分子包封在微球体中的方法。本发明另外提供包含通过本发明的方法制备的包封在微球体中的核酸分子的组合物和将核酸分子递送至受试者的方法。本发明还提供了用于调节包含氨基烷基葡糖苷-4-磷酸（AGP）的核酸分子的微球的免疫刺激功效的佐剂。本发明还提供了调节包封核酸分子的微球的免疫刺激功效的方法。

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