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1. 发明申请

WO2007036232A1 METHODS FOR DIFFERENTIATING STEM CELLS AND USE THEREOF IN THE TREATMENT OF DENTAL CONDITIONS 审中-公开
标题翻译：用于分化干细胞的方法及其在治疗牙齿病症中的应用
公开(公告)号：WO2007036232A1
公开(公告)日：2007-04-05
申请号：PCT/DK2006/000533
申请日：2006-09-28
申请人： COPYGENE A/S , OSTHER, Kurt , CLAUSEN, Christian , PEDERSEN, Klaus Riskær
发明人： OSTHER, Kurt , CLAUSEN, Christian , PEDERSEN, Klaus Riskær
IPC分类号： C12N5/06 , A61K6/00
CPC分类号： C12N5/0654 , A61K35/12 , C12N5/0664
摘要： The present invention relates to a method for propagating and/or differentiating mammalian cells, the method comprising exposing or co-culturing mammalian cells with one or more of periodontal ligament tissue, periodontal ligament proteins or factors derived from periodontal ligament tissue, to obtain cells having PDL characteristics and fulfilling at least one of the following: i) show periodontal characteristics as evidenced with Von Kossa method in which calcium phosphate deposits are stained brown to black, ii) show increased osteopontin and osteocalcin and at the same time decreased bone sialoprotein (bone sialoprotein Il or BSP), iii) are capable of being implanted to repair and/or regenerate periodontal tissue, iv) are capable of repairing disorders such as paradentitis also called paradentosis, or periodontitis by healing of the gum line towards the teeth, and v) are accepted by the host without significant immune reaction or cell rejection.
摘要翻译：本发明涉及一种用于繁殖和/或分化哺乳动物细胞的方法，所述方法包括将一种或多种牙周韧带组织，牙周韧带蛋白或源自牙周韧带组织的因子暴露或共培养哺乳动物细胞，以获得具有 PDL特征并满足以下至少一个：i）显示了Von Kossa方法证明的牙周特征，其中磷酸钙沉积物被染成棕色至黑色，ii）显示出增加的骨桥蛋白和骨钙素，同时降低骨涎蛋白（骨骼）唾液酸蛋白II或BSP），iii）能够被植入以修复和/或再生牙周组织，iv）能够通过牙龈愈合牙齿修复诸如也称为间盘突出症的症状或牙周病，v ）被宿主接受，没有显着的免疫反应或细胞排斥。

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