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1. 发明申请

WO2004096979A2 METHODS AND SYSTEMS FOR ANNOTATING BIOMOLECULAR SEQUENCES 审中-公开
标题翻译：生物分子序列的方法和系统
公开(公告)号：WO2004096979A2
公开(公告)日：2004-11-11
申请号：PCT/IL2004000077
申请日：2004-01-27
申请人： COMPUGEN LTD , MINTZ LIAT , XIE HANQING , DAHARY DVIR , LEVANON EREZ , FREILICH SHIRI , BECK NILI , ZHU WEI-YONG , WASSERMAN ALON , CHERMESH CHEN , AZAR IDIT , BERNSTEIN JEANNE , SOREK ROTEM
发明人： MINTZ LIAT , XIE HANQING , DAHARY DVIR , LEVANON EREZ , FREILICH SHIRI , BECK NILI , ZHU WEI-YONG , WASSERMAN ALON , CHERMESH CHEN , AZAR IDIT , BERNSTEIN JEANNE , SOREK ROTEM
IPC分类号： C12N20060101 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00 , C12N
CPC分类号： G06F19/12 , G06F19/22
摘要： A method of annotating biomolecular sequences. The method comprises (a) computationally clustering the biomolecular sequences according to a progressive homology range, to thereby generate a plurality of clusters each being of a predetermined homology of the homology range; and (b) assigning at least one ontology to each cluster of the plurality of clusters, the at least one ontology being: (i) derived from an annotation preassociated with at least one biomolecular sequence of each cluster; and/or (ii) generated from analysis of the at least one biomolecular sequence of each cluster thereby annotating biomolecular sequences.
摘要翻译：注释生物分子序列的方法。该方法包括（a）根据渐进同源范围计算聚集生物分子序列，从而产生多个具有同源范围的预定同源性的簇; 所述至少一个本体是：（i）从与每个簇的至少一个生物分子序列预先相关联的注释导出的;以及（b）将至少一个本体分配给所述多个簇中的每个簇，和/或（ii）从每个簇的至少一个生物分子序列的分析产生，从而注释生物分子序列。

2. 发明申请

WO2004096980A3 NOVEL POLYNUCLEOTIDES ENCODING SOLUBLE POLYPEPTIDES AND METHODS USING SAME 审中-公开
标题翻译：编码可溶聚合物的新型多核苷酸及其使用方法
公开(公告)号：WO2004096980A3
公开(公告)日：2006-08-03
申请号：PCT/IL2004000078
申请日：2004-01-27
申请人： COMPUGEN LTD , AYALON-SOFFER MICHAL , POLLOCK SARAH , DIBER ALEX , LEVINE ZURIT , NEMZER SERGEY , DAHARY DVIR , SOREK ROTEM , LEVANON EREZ , ROTMAN GALIT , SAVITSKY KINERET , CHERMESH CHEN , MINTZ LIAT , FREILICH SHIRI , BECK NILI , ZHU WEI-YONG , WASSERMAN ALON , AZAR IDIT , BERNSTEIN JEANNE
发明人： AYALON-SOFFER MICHAL , POLLOCK SARAH , DIBER ALEX , LEVINE ZURIT , NEMZER SERGEY , DAHARY DVIR , SOREK ROTEM , LEVANON EREZ , ROTMAN GALIT , SAVITSKY KINERET , CHERMESH CHEN , MINTZ LIAT , FREILICH SHIRI , BECK NILI , ZHU WEI-YONG , WASSERMAN ALON , AZAR IDIT , BERNSTEIN JEANNE
IPC分类号： C12Q1/68 , C12N20060101 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G06F19/12 , G06F19/22
摘要： An isolated polynucleotide is provided. The isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide having an amino acid sequence at least 70 % identical to SEQ ID NO: 1, as determined using the LALIGN software of EMBnet switzerland (http://www.ch.embnet.org/index.html) using default parameters.
摘要翻译：提供了分离的多核苷酸。分离的多核苷酸包含编码具有与SEQ ID NO：1至少70％相同的氨基酸序列的多肽的核酸序列，使用EMBNET瑞士的LALIGN软件（http://www.ch.embnet.org/ index.html）使用默认参数。

3. 发明申请

WO0206315A3 NOVEL NUCLEIC ACID AND AMINO ACID SEQUENCES 审中-公开
标题翻译：新型核酸和氨基酸序列
公开(公告)号：WO0206315A3
公开(公告)日：2003-10-02
申请号：PCT/IL0100653
申请日：2001-07-17
申请人： COMPUGEN LTD , MINTZ LIAT , FREILICH SHIRI , BERNSTEIN JEANNE
发明人： MINTZ LIAT , FREILICH SHIRI , BERNSTEIN JEANNE
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N15/12 , A61K38/17 , A61K39/395 , C07K16/18 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： Novel nucleic acid sequences and amino acid sequences are provided. Some of the novel nucleic acid sequences are alternative splice variants of previously known transcripts. Others of these novel nucleic acid sequences are similar to a previously known expressed sequence. The novel nucleic acid and amino acid sequences have a variety of diagnostic and therapeutic applications.
摘要翻译：提供了新的核酸序列和氨基酸序列。一些新的核酸序列是先前已知的转录物的替代剪接变体。这些新型核酸序列中的其他核酸序列与先前已知的表达序列相似。新型核酸和氨基酸序列具有多种诊断和治疗应用。

4. 发明申请

WO9967382A3 ANGIOPOIETIN-LIKE GROWTH FACTOR SEQUENCES 审中-公开
标题翻译：血管生成素样生长因子序列
公开(公告)号：WO9967382A3
公开(公告)日：2000-04-27
申请号：PCT/IL9900343
申请日：1999-06-23
申请人： COMPUGEN LTD , MINTZ LIAT , SAVITSKY KINNERET
发明人： MINTZ LIAT , SAVITSKY KINNERET
IPC分类号： A61K38/00 , A61K48/00 , C07K14/515 , C12N1/21 , C12N15/12 , A61K31/70 , A61K38/18 , C07K16/22 , C12N5/10 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C07K14/515 , A61K38/00 , A61K48/00
摘要： The present invention concerns novel nucleic acid and amino acid sequences, expression vectors, host cells and pharmaceutical compositions comprising same, as well as antibodies directed against said amino acid sequences and methods for detecting the amino acid sequences and the nucleic acid sequences in a sample.
摘要翻译：本发明涉及新的核酸和氨基酸序列，表达载体，宿主细胞和包含其的药物组合物，以及针对所述氨基酸序列的抗体以及用于检测样品中的氨基酸序列和核酸序列的方法。

5. 发明申请

WO0049158A3 PSA AND KLK-2 SPLICING VARIANTS 审中-公开
标题翻译： PSA和KLK-2分离变量
公开(公告)号：WO0049158A3
公开(公告)日：2000-12-21
申请号：PCT/IL0000102
申请日：2000-02-18
申请人： COMPUGEN LTD , SAVITZKY KINNERET , MINTZ LIAT , DAVID ANAT , AZAR IDIT
发明人： SAVITZKY KINNERET , MINTZ LIAT , DAVID ANAT , AZAR IDIT
IPC分类号： C12N9/64 , C12N15/55
CPC分类号： C12N9/6445
摘要： The invention concerns novel nucleic acid sequences, amino acid sequences coded thereby and method of detection using the above. The novel nucleic acid sequences are naturally occurring splice variants of a prostate specific antigen sequence (PSA) or of the KLK-2 gene.
摘要翻译：本发明涉及新的核酸序列，由此编码的氨基酸序列和使用上述的检测方法。新的核酸序列是前列腺特异性抗原序列（PSA）或KLK-2基因的天然存在的剪接变体。

6. 发明申请

WO2007126792A3 USE OF GHRELIN SPLICE VARIANT FOR TREATING HIGH CHOLESTEROL LEVELS OR HIGH PLASMA GLUCOSE LEVELS AND RELEATED DISEASES 审中-公开
标题翻译：使用GHRELIN SPLICE变量治疗高胆固醇水平或高等级葡萄糖水平和相关疾病
公开(公告)号：WO2007126792A3
公开(公告)日：2008-05-15
申请号：PCT/US2007007534
申请日：2007-03-27
申请人： MINTZ LIAT
发明人： MINTZ LIAT
IPC分类号： C07K14/47 , A61K38/17 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07K14/575 , A61K38/00
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of hypercholesterolemia and/or high cholesterol and/or high cholesterol complication and/or lipemia and/or lipemia complication and/or CHD and/or weight management and/or diabetes and/or hyperglycemia.
摘要翻译：本公开一方面涉及使用生长素释放肽剪接变体或其类似物来制备用于以下一种或多种的药物：治疗和/或预防高胆固醇血症和/或高胆固醇和/或高胆固醇并发症，和 /或脂血症和/或血脂并发症和/或CHD和/或体重管理和/或糖尿病和/或高血糖症。

7. 发明申请

WO2005014806A3 CONSERVED HBV AND HCV SEQUENCES USEFUL FOR GENE SILENCING 审中-公开
标题翻译：保留用于基因沉默的HBV和HCV序列
公开(公告)号：WO2005014806A3
公开(公告)日：2005-12-01
申请号：PCT/US2004019229
申请日：2004-06-10
申请人： NUCLEONICS INC , PACHUK CATHERINE J , SATISHCHANDRAN C , ZURAWSKI VINCENT R JR , MINTZ LIAT
发明人： PACHUK CATHERINE J , SATISHCHANDRAN C , ZURAWSKI VINCENT R JR , MINTZ LIAT
IPC分类号： A61K38/00 , A61K48/00 , C12N15/113 , C12N15/11 , A61K31/7088
CPC分类号： C12N15/1131 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans.
摘要翻译：提供了可用于抑制哺乳动物细胞中病毒表达的已知乙型肝炎病毒株和已知丙型肝炎病毒株的保守共有序列。这些序列对于使HBV和HCV的基因沉默是有用的，从而提供对人类HBV和HCV病毒感染的治疗效用。

8. 发明申请

WO2007108990A2 USE OF GHRELIN SPLICE VARIANT FOR TREATING CACHEXIA AND/OR ANOREXIA AND/OR ANOREXIA-CACHEXIA AND/OR MALNUTRITION AND/OR LIPODYSTROPHY AND/OR MUSCLE WASTING AND/OR APPETITE STIMULATION 审中-公开
标题翻译：使用GHRELIN SPLICE变种用于治疗慢性乙型肝炎和/或异丙肾上腺素和/或异丙肾上腺素和/或雌激素和/或脂肪和/或肌肉的药物和/或外观刺激
公开(公告)号：WO2007108990A2
公开(公告)日：2007-09-27
申请号：PCT/US2007006189
申请日：2007-03-09
申请人： MINTZ LIAT
发明人： MINTZ LIAT
IPC分类号： A61K48/00 , C12N1/00
CPC分类号： C07K14/60 , A61K38/00 , A61K38/1754 , A61K38/27 , A61K38/30 , A61K38/465 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof for the preparation of a medicament for one or more of: treatment and/or prevention of loss of body weight and body fat, prophylaxis or treatment of cachexia, stimulation of appetite, stimulation of food intake, stimulation of weight gain, or increasingly body fat mass, or increasing body lean mass. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. Another aspect relates to the use of a ghrelin splice variant-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to the use of a ghrelin splice variant-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds.
摘要翻译：本公开一方面涉及使用生长素释放肽剪接变体或其类似物来制备用于以下一种或多种的药物：治疗和/或预防体重和体脂肪的丧失，预防或治疗恶病质刺激食欲，刺激食物摄入，刺激体重增加或身体脂肪量增加，或增加瘦体重。另一方面涉及使用生长素释放肽剪接变体样化合物来制备用于在需要这种治疗的个体中预防或治疗癌症恶病质的药物。另一方面涉及通过向个体施用皮下剂量的所述药物来制备用于预防或治疗个体恶病质的药物的生长素释放肽剪接变体样化合物的用途。另一方面涉及生长素释放肽剪接变体样化合物或其药学上可接受的盐在制备通过向个体施用皮下剂量的所述药物的个体中刺激个体食欲的药物中的用途。另一方面涉及许多新的生长素释放肽剪接变体样化合物及其用途，以及包含新的生长素释放肽剪接变体样化合物的药物组合物和医药包装。

9. 发明申请

WO2006069064A3 CONSERVED HBV AND HCV SEQUENCES USEFUL FOR GENE SILENCING 审中-公开
标题翻译：保留用于基因沉默的HBV和HCV序列
公开(公告)号：WO2006069064A3
公开(公告)日：2007-10-25
申请号：PCT/US2005046162
申请日：2005-12-20
申请人： NUCLEONICS INC , PACHUK CATHERINE , SATISHCHANDRAN CHANDRASEKHAR , ZURAWSKI VINCENT JR , MINTZ LIAT
发明人： PACHUK CATHERINE , SATISHCHANDRAN CHANDRASEKHAR , ZURAWSKI VINCENT JR , MINTZ LIAT
IPC分类号： A61K31/713 , C12N15/113
CPC分类号： C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the viruses in mammalian cells, are provided. These sequences are useful to silence the genes of HBV and HCV, thereby providing therapeutic utility against HBV and HCV viral infection in humans.
摘要翻译：提供了可用于抑制哺乳动物细胞中病毒表达的已知乙型肝炎病毒株和已知丙型肝炎病毒株的保守共有序列。这些序列对于使HBV和HCV的基因沉默是有用的，从而提供对人类HBV和HCV病毒感染的治疗效用。

10. 发明申请

WO2007055996A3 COMPOSITIONS, REAGENTS AND KITS FOR AND METHODS OF DIAGNOSING, MONITORING AND TREATING HORMONAL IMBALANCE 审中-公开
标题翻译：组成，试剂和试剂及其诊断，监测和治疗异常不平衡的方法
公开(公告)号：WO2007055996A3
公开(公告)日：2007-08-02
申请号：PCT/US2006042606
申请日：2006-11-01
申请人： MINTZ LIAT
发明人： MINTZ LIAT
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , A61K48/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/566 , G01N33/68 , G01N33/6845 , G01N2333/575
摘要： The present invention concerns ten novel variants of alternative splicing of the hormonal imbalance related genes.
摘要翻译：本发明涉及激素失调相关基因的选择性剪接的十个新变体。

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