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1. 发明申请

WO2004111190A3 IN VIVO HIGH THROUGHPUT SELECTION OF EFFECTIVE RNAi PROBES 审中-公开
标题翻译：有效的RNAi探针的高通量选择
公开(公告)号：WO2004111190A3
公开(公告)日：2005-04-14
申请号：PCT/US2004016844
申请日：2004-05-26
申请人： COLD SPRING HARBOR LAB , MITTAL VIVEK , KUMAR RAJEEV
发明人： MITTAL VIVEK , KUMAR RAJEEV
IPC分类号： C07H21/04 , C12N20060101 , C12N15/63 , C12Q1/68
CPC分类号： G01N33/5023
摘要： In mammalian systems, RNA interference (RNAi)-based suppression of target gene expression may be activated by delivery of RNAi probes such as double stranded small interfering RNA (siRNA) molecules or short hairpin RNAs (shRNAs), where the RNAi probe sequence is homologous to the target gene. A reliable and quantitative method is provided for the rapid and efficient identification of RNAi probes that are most effective in providing RNAi-mediated suppression of target gene expression. This method may be used for high-throughput screens to identify effective RNAi probes.
摘要翻译：在哺乳动物系统中，靶基因表达的RNA干扰（RNAi）抑制可以通过递送RNAi探针来激活，例如双链小干扰RNA（siRNA）分子或短发夹RNA（shRNA），其中RNAi探针序列是同源的到目标基因。提供了一种可靠和定量的方法，用于快速有效地鉴定提供RNAi介导的靶基因表达抑制最有效的RNAi探针。该方法可用于高通量筛选以鉴定有效的RNAi探针。

2. 发明申请

WO2012048201A2 LUBRICANTS CONTAINING NANOFIBERS 审中-公开
标题翻译：含有纳米纤维的润滑剂
公开(公告)号：WO2012048201A2
公开(公告)日：2012-04-12
申请号：PCT/US2011055228
申请日：2011-10-07
申请人： NANO TERRA INC , MAYERS BRIAN , MCLELLAN JOSEPH , KUMAR RAJEEV , STEWART MATTHEW , LI XINHUA , AGARWAL SANDIP
发明人： MAYERS BRIAN , MCLELLAN JOSEPH , KUMAR RAJEEV , STEWART MATTHEW , LI XINHUA , AGARWAL SANDIP
IPC分类号： C10M107/06
CPC分类号： C10M107/06 , C10M107/44 , C10M2205/024 , C10M2217/046 , C10N2220/086 , C10N2230/06 , C10N2270/00
摘要： Disclosed is a composition comprising one or more lubricants and one or more nanofibers. Also disclosed is an article having a surface disposed thereon the composition of the invention. Also disclosed is a method of reducing friction between two surfaces, comprising disposing the composition of the invention on at least one of the two surfaces that come into contact.
摘要翻译：公开了包含一种或多种润滑剂和一种或多种纳米纤维的组合物。还公开了在其上设置有本发明组合物的表面的制品。还公开了减少两个表面之间的摩擦的方法，包括将本发明的组合物设置在接触的两个表面中的至少一个表面上。

3. 发明申请

WO2010011957A3 ENZYMATIC HYDROLYSIS OF CELLULOSIC BIOMASS THROUGH ENHANCED REMOVAL OF OLIGOMERS 审中-公开
标题翻译：纤维素生物质通过增强去除低聚物酶水解
公开(公告)号：WO2010011957A3
公开(公告)日：2010-04-01
申请号：PCT/US2009051737
申请日：2009-07-24
申请人： UNIV CALIFORNIA , WYMAN CHARLES E , KUMAR RAJEEV
发明人： WYMAN CHARLES E , KUMAR RAJEEV
IPC分类号： C12P21/06 , C12P1/00 , C12P7/10
CPC分类号： C12P7/10 , C12P19/14 , Y02E50/16
摘要： The methods and composition of the disclosure are directed to the reducing cellulase inhibition by xylooligomers through adding hemicellulase enzymes that break xylooligomers down to monomeric sugars with a corresponding increase in glucose release. What was heretofore unknown is that xylobiose and higher xylooligomers inhibit enzymatic hydrolysis of any lignocellulosic biomass (plant material) used as feed stocks for commercial ethanol production, including, but not limited to, corn stover, birch wood, switchgrass, poplar wood, Miscanthus, aspen, other grasses and woody plants, and many other types of agricultural and forestry residues, as well as municipal solid waste. In addition, the examples herein show that xylobiose and xylotriose have progressively greater effects on hydrolysis rates. In accordance with the disclosure, the addition of one or more hemicellulase enzymes, such as xylanase and ß- xylosidase, to a lignocellulosic biomass significantly improves hydrolysis performance.
摘要翻译：本公开的方法和组合物涉及通过加入半纤维素酶来减少木聚糖寡聚体对纤维素酶的抑制作用，所述半纤维素酶将木聚糖寡聚体分解成单体糖，并相应增加葡萄糖释放。迄今未知的是，木二糖和较高木寡糖抑制用作商业乙醇生产的原料的任何木质纤维素生物质（植物材料）的酶促水解，包括但不限于玉米秸秆，桦木，柳枝稷，白杨木，芒草，白杨，其他草和木本植物，以及许多其他类型的农业和林业残余物，以及城市固体废物。此外，本文的实施例显示木二糖和木三糖对水解速率的影响逐渐增大。根据本公开内容，将一种或多种半纤维素酶例如木聚糖酶和β-木糖苷酶添加至木质纤维素生物质显着改善了水解性能。

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