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1. 发明申请

WO2011134621A3 METHOD FOR PRODUCING ALKYLPHOSPHONOUS ACID SALTS 审中-公开
标题翻译：用于生产ALKYLPHOSPHONIGSÄURESALZEN
公开(公告)号：WO2011134621A3
公开(公告)日：2012-04-26
申请号：PCT/EP2011002015
申请日：2011-04-20
申请人： CLARIANT FINANCE BVI LTD , HILL MICHAEL , KRAUSE WERNER , SICKEN MARTIN
发明人： HILL MICHAEL , KRAUSE WERNER , SICKEN MARTIN
IPC分类号： C07F9/48 , C08K5/5393 , C09K21/12
CPC分类号： C07F9/4816 , C08K5/5313 , C08K5/5393 , C09K21/04 , C09K21/12
摘要： The invention relates to a method for producing alkylphosphonous acid salts, characterised in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to obtain an alkylphosphonous acid, the salts or esters thereof (II), b) the thus obtained alkylphosphonous acid, the salts or esters thereof (II) are reacted with metal compounds of Mg, Ca, AI, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K and/or a protoned nitrogen base to obtain the corresponding alkylphosphonous acid salts (III) of said metals and/or a nitrogen compound, wherein R1, R2, R3, R4 are the same or different and independently of each other represent H, C1-C18-alkyl, C6-C18-aryl, C7-C18-arylalkyl, C7-C18-alkylaryl and Y represents Mg, Ca, AI, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K and/or a nitrogen compound and n represents 1/4, 1/3, 1/2, 1 and the catalyst A is a transition metal and/or transition metal compound and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand.
摘要翻译：本发明涉及一种用于Alkylphosphonigsäuresalzen的制备方法，其特征在于，烷基亚膦酸进行反应的盐或酯（II），b）将产生的）次膦酸（I）与烯烃反应，（IV）在催化剂A的存在烷基亚膦酸，其盐或酯（II）与Mg，Ca，铝，锑，锡，锗，钛，铁，锆，锌，铈，铋，锶，锰，锂，钠，钾和/或质子化的金属化合物氮碱反应，以形成这些金属和/或氮化合物，其中R1，R2，R3，R4相同或不同，且独立地为H，C1-C18烷基，C6-C18芳基，C7-C18的的相应Alkylphosphonigsäuresalzen（III）芳基烷基，代表C7-C18烷基芳基，并且Y是镁，钙，铝，锑，锡，锗，钛，铁，锆，锌，铈，铋，锶，锰，锂，钠，钾和/或氮化合物和 n为1/4，1/3，1/2，1，它是由过渡金属和/或过渡金属化合物和/或卡塔催化剂A lysatorsysteme是，过渡金属和/或过渡金属化合物和至少一种配体组成。

2. 发明申请

WO2011134620A3 METHOD FOR PRODUCING MIXTURES OF ALKYLPHOSPHONOUS ACID SALTS AND DIALKYLPHOSPHINIC ACID SALTS 审中-公开
标题翻译：用于生产ALKYLPHOSPHONIGSÄURESALZEN作者和混合物二烷基次膦酸盐
公开(公告)号：WO2011134620A3
公开(公告)日：2012-03-29
申请号：PCT/EP2011002014
申请日：2011-04-20
申请人： CLARIANT FINANCE BVI LTD , HILL MICHAEL , HOEROLD SEBASTIAN , KRAUSE WERNER , SICKEN MARTIN
发明人： HILL MICHAEL , HOEROLD SEBASTIAN , KRAUSE WERNER , SICKEN MARTIN
IPC分类号： C07F9/38 , C07F9/48 , C08K5/5317 , C08K5/5393 , C09K21/12
CPC分类号： C09K21/12 , C07F9/3808 , C07F9/4816
摘要： The invention relates to a method for producing mixtures of alkylphosphonous acid and dialkylphosphinic acid salts, characterised in that a) a phosphinic acid source (I) is reacted with olefins (II) in the presence of a catalyst A to obtain a mixture of alkylphosphonous acid (III) and dialkylphosphinic acid (IV) or salts or esters thereof, and b) the thus obtained mixture of alkylphosphonous acid (III) and dialkylphosphinic acid (IV) or the salts or esters thereof is reacted with metal compounds of Mg, Ca, AI, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K and/or a protonated nitrogen base to obtain the corresponding mixtures of alkylphosphonous acid salt (V) and dialkylphosphinic acid salt (VI) of said metals and/or a nitrogen compound, (V) (VI), wherein Y represents Mg, Ca, AI, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K and/or a nitrogen compound and n represents ¼, ?, ½, 1.
摘要翻译：本发明涉及一种用于制备和二烷基次膦酸盐Alkylphosphonigsäure-的混合物，其特征在于：a）次膦酸的方法（I）（II与烯烃）A（在催化剂的存在下，得到烷基亚膦酸（III的混合物）和二烷基次膦IV）或它们的盐或酯进行反应，和b）将所得的烷基亚膦酸（III）和二烷基次膦酸的混合物（IV）或其盐或酯与Mg，Ca，铝，锑，锡，锗，钛，铁，锆的金属化合物，锌，铈，铋，锶，锰，锂，钠，钾和/或质子化的氮碱，以形成这些金属和/或含氮化合物（V）的Alkylphosphonigsäuresalz（V）和二烷基次膦酸盐（VI）的相应的混合物（VI）其中Y是镁，钙，铝，锑，锡，锗，钛，铁，锆，锌，铈，铋，锶，锰，锂，钠，钾和/或氮化合物，并且n是4,1'，½ ，1站。

3. 发明申请

WO2010051887A8 METHOD FOR PRODUCING DIALKYLPHOSPHINIC ACIDS AND ESTERS AND SALTS THEREOF BY MEANS OF VINYL COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：用于生产二烷基次膦酸，酯和盐乙烯基化合物及其使用方式
公开(公告)号：WO2010051887A8
公开(公告)日：2010-07-01
申请号：PCT/EP2009007127
申请日：2009-10-06
申请人： CLARIANT INT LTD , HILL MICHAEL , KRAUSE WERNER , SICKEN MARTIN
发明人： HILL MICHAEL , KRAUSE WERNER , SICKEN MARTIN
IPC分类号： C07F9/30 , C07F9/48 , C08K5/53 , C09K21/12
CPC分类号： C07F9/301 , C07F9/302 , C07F9/306 , C07F9/3211 , C07F9/3217 , C07F9/3241 , C07F9/3264 , C07F9/4816 , C07F9/4866 , C08K5/5313 , C08L21/00 , C09K21/12
摘要： The invention relates to a method for producing mono-carboxyfunctionalized dialkylphosphinic acids and esters and salts thereof by means of vinyl compounds, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with acetylenic compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted with carbon monoxide to yield a mono-carboxyfunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst C, wherein R1, R2, R3, R4, R5, R6 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, and X and Y are the same or different and stand independently of each other for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and the catalysts A, B, C and D are formed by transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand.
摘要翻译：本发明涉及一种方法，用于制备的单官能化的二烷基次膦酸，其酯和盐通过乙烯基化合物的手段，其特征在于：a）次膦酸（I）与烯烃（IV）在催化剂A存在于烷基亚膦酸，其盐或酯（II）中，b）将所得的烷基亚膦酸，其盐或酯反应（II）在催化剂b（单官能化的二烷基次膦酸衍生物VI）的存在下使式（V）的炔属化合物，以及c）该起源于单（VI） - 功能化在催化剂C的存在一氧化碳二烷基次膦酸衍生物的单羧基官能二烷基次膦酸衍生物（III），其中R1，R2，R3，R4，R5，R6相同或不同并且独立地为除其他外 H，C1-C18烷基，C6-C18芳基，C6-C18芳烷基，C6-C18烷芳基且X和Y相同或不同，并且各自独立地为H，C1-C18烷基，C6-C18芳基，C6-C18Aralkyl，C6-C18Alkylaryl，镁，钙，铝，锑，锡，锗，钛，铁，锆，锌，铈，铋，锶，锰，铜，镍，锂，钠，钾和/或一个质子化的氮碱是，它是在催化剂A，B，C和d的过渡金属和/或过渡金属化合物和/或催化剂体系，其由过渡金属和/或过渡金属化合物和至少一种配体的。

4. 发明申请

WO2010069545A3 PROCESS FOR PREPARING ETHYLENEDIALKYLPHOSPHINIC ACIDS, ESTERS AND SALTS BY MEANS OF ACETYLENE AND USE THEREOF 审中-公开
标题翻译：用于生产ETHYLENDIALKYLPHOSPHINSÄUREN，酯类和盐类运用乙炔及其用途
公开(公告)号：WO2010069545A3
公开(公告)日：2010-08-26
申请号：PCT/EP2009008964
申请日：2009-12-15
申请人： CLARIANT INT LTD , HILL MICHAEL , KRAUSE WERNER , SICKEN MARTIN
发明人： HILL MICHAEL , KRAUSE WERNER , SICKEN MARTIN
IPC分类号： C07F9/30 , C07F9/48 , C08K5/53 , C09K21/12
CPC分类号： C09K21/12 , C07F9/305 , C07F9/3235 , C08K5/5313 , C08L77/00
摘要： The invention relates to a process for preparing ethylenedialkylphosphinic acids, ethylenedialkylphosphinic esters and ethylenedialkylphosphinic salts, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, its salt or ester (II), b) the resultant alkylphosphonous acid, its salt or ester (II) is reacted with an acetylenic compound (V) in the presence of a catalyst B, to give the ethylenedialkylphosphinic acid derivative (III), where R1, R2, R3, R4, R5, R6, R11, R12, R13 and R14 are identical or different and independently of one another inter alia are H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl and X is H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base, and the catalyst A comprises transition metals and/or transition-metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition-metal compound and at least one ligand, and the catalyst B comprises peroxide-forming compounds and/or peroxo compounds and/or azo compounds.
摘要翻译：本发明涉及一种方法，用于制备的Ethylendialkylphosphinsäuren，酯和盐，其特征在于：a）次膦酸（I）与烯烃（IV）在催化剂A存在于烷基亚膦酸进行反应的盐或酯（II） b）中得到的烷基亚膦酸，其盐或酯（II）在催化剂b存在下对Ethylendialkylphosphinsäurederivat（III），其中R1，R2，R3，R4，R5，R6，R11，R12炔属化合物（V）反应来，R13，R14相同或不同并且独立地为除其他外 H，C1-C18烷基，C6-C18芳基，C6-C18芳烷基，C6-C18烷基芳基，且X是H，C1-C18烷基，C6-C18芳基，C6-C18芳烷基，C6- C18烷基芳基，镁，钙，铝，锑，锡，锗，钛，铁，锆，锌，铈，铋，锶，锰，铜，镍，锂，钠，钾和/或质子化氮碱的立场和这是由过渡金属和/或过渡金属化合物和/或催化剂体系，其由过渡金属和/或过渡金属化合物和至少一种配体和所述的催化剂的催化剂B是形成过氧化物的化合物和/或过氧化合物和/或关注偶氮化合物。

5. 发明申请

WO2009010188A2 ALKYLPHOSPHONOUS ACIDS, SALTS AND ESTERS, METHODS FOR THE PRODUCTION THEREOF, AND USE OF SAME 审中-公开
标题翻译：烷基亚膦酸，盐和酯，其制造方法相同，并且它们的用途
公开(公告)号：WO2009010188A2
公开(公告)日：2009-01-22
申请号：PCT/EP2008005382
申请日：2008-07-02
申请人： CLARIANT INT LTD , HILL MICHAEL , BAUER HARALD , KRAUSE WERNER
发明人： HILL MICHAEL , BAUER HARALD , KRAUSE WERNER
IPC分类号： C07F9/48 , C08K5/5393
CPC分类号： C07F9/4866 , C07F9/4816 , C07F9/485 , C08K5/5393
摘要： The invention relates to alkylphosphonous acids, salts and esters of formula (I) A-P(=O)(OX)-H (I) wherein A C2-C20 alkyl, C2-C20alkylene, and C8-C20 alkaryl are optionally substituted, and X is H, alkyl, aryl, alkylaryl, alkenyl, substituted alkyl, aryl, alkaryl, alkenyl, ammonium, primary, secondary, tertiary, quaternary alkyl and/or aryl ammonium, an alkali metal, an alkaline earth metal, a metal of the third and fourth main group and the second, fourth and eighth sub-group or a metal of the lanthanoid group. The invention also relates to methods for producing same and to the uses of said compounds.
摘要翻译：本发明涉及式（I）AP（= O）（OX）-H（I）其中A是C2-C20烷基，C2-C20亚烷基，C8-C20烷芳基的烷基亚膦酸，盐和酯，任选地取代，且X是H，烷基，芳基，烷基，烯基，取代的烷基，芳基，烷芳基，烯基，铵，伯，仲，叔，季烷基和/或芳基铵，碱金属，碱土金属，所述第三和第四金属装置的主要和第二，第四，第八子组，或镧系元素组的金属。本发明还涉及其制备方法和使用这些化合物的方法。

6. 发明申请

WO9903509A3 PHARMACEUTICAL PRODUCTS CONTAINING TRIIODOAROMATS CONTAINING PERFLUOROALKYL GROUPS, AND THE USE THEREOF IN THE TREATMENT OF TUMOURS AND INTERVENTIONAL RADIOLOGY 审中-公开
标题翻译：制药含全氟烷TRIJODAROMATEN和它们在肿瘤治疗和介入放射学
公开(公告)号：WO9903509A3
公开(公告)日：1999-05-14
申请号：PCT/EP9804130
申请日：1998-07-06
申请人： SCHERING AG , PLATZEK JOHANNES , NIEDBALLA ULRICH , BAUER MICHAEL , SCHLECKER WOLFGANG , WEINMANN HANNS JOACHIM , FRENZEL THOMAS , KRAUSE WERNER
发明人： PLATZEK JOHANNES , NIEDBALLA ULRICH , BAUER MICHAEL , SCHLECKER WOLFGANG , WEINMANN HANNS-JOACHIM , FRENZEL THOMAS , KRAUSE WERNER
IPC分类号： A61K31/03 , A61K31/165 , A61K31/40 , A61K31/70 , A61K33/24 , A61K47/48 , A61K49/00 , A61K49/04
CPC分类号： A61K31/03
摘要： The invention relates to pharmaceutical products containing triiodoaromats of general formula I containing perfluoroalkyl groups, and to their use in the treatment of tumours and in interventional radiology. The compounds of general formula I can be used preferably as combination preparations in conjunction with chemotherapeutical agents in the chemoembolisation of tumours.
摘要翻译：本发明涉及一种特征在于在权利要求的主体，也就是含全氟烷Trijodaromaten通式（I）和它们在肿瘤治疗和介入放射学用途的药物组合物。通式（I）的化合物可优选作为发现组合制剂在肿瘤应用的化疗栓塞化疗剂一起。

7. 发明申请

WO9725923A3 OPTIMIZING DOSES OF CONTRASTING AGENT FOR IMAGING DIAGNOSTIC METHODS 审中-公开
标题翻译：用于成像诊断方法的对比剂优化剂量
公开(公告)号：WO9725923A3
公开(公告)日：1997-08-28
申请号：PCT/DE9700116
申请日：1997-01-20
申请人： SCHERING AG , KRAUSE WERNER
发明人： KRAUSE WERNER
IPC分类号： A61B6/00
CPC分类号： A61B6/481 , A61B6/504 , G06F19/321 , G06F19/3468
摘要： The invention concerns a device by means of which the type of contrasting agent injection mode (volume, injection speed) and a diagnostic appliance, e.g. a computer tomograph (CT), a magnetic resonance tomograph (MRT) or an ultrasound appliance (US), can be controlled such that both parts of the diagnosis - the application of the contrasting agent and the "recording parameters" of the diagnostic appliance - are optimized for the individual patient, and/or the resultant time-density curves or the pharmacokinetic parameters derived therefrom are used for differential diagnosis.
摘要翻译：本发明涉及一种装置，借助于此装置，对比剂注射模式（体积，注射速度）和诊断装置的类型例如是不同的。可以控制计算机断层摄影机（CT），磁共振断层摄影机（MRT）或超声波设备（US），使诊断的两个部分 - 对比剂的应用和诊断设备的“记录参数” 针对个体患者进行了优化，和/或得到的时间密度曲线或其衍生的药代动力学参数用于鉴别诊断。

8. 发明申请

WO2005056058A3 RADIOSENSITIZER CONJUGATE TO IMPROVE THE EFFICACY OF RADIOLABELED DRUGS 审中-公开
标题翻译：放射增敏剂联合用于提高放射性药物的疗效
公开(公告)号：WO2005056058A3
公开(公告)日：2006-04-13
申请号：PCT/IB2004004428
申请日：2004-12-13
申请人： SCHERING AG , KRAUSE WERNER
发明人： KRAUSE WERNER
IPC分类号： A61K41/00 , A61K51/00 , A61K51/10 , A61P35/00
CPC分类号： A61K41/0038 , A61K51/1027 , A61K51/1069
摘要： Disclosed are radiolabeled drugs and methods to improve their efficacy by using a radiosensitizer such that the radiosensitizer is either part of the radiolabeled drug by directly attaching the radiosensitizer to the radiolabeled drug or by producing a mixture of the radiolabeled drug and an analogue of the drug with the radiosensitizer attached to the drug instead of the radiolabel.
摘要翻译：公开了通过使用放射增敏剂来提高其功效的放射性标记药物和方法，使得放射增敏剂是放射性标记药物的一部分，通过将放射增敏剂直接附着到放射性标记的药物或通过产生放射性标记的药物和药物的类似物的混合物与放射敏剂附着于药物而不是放射性标记物。

9. 发明申请

WO0018439A3 USE OF NEOANGIOGENESIS MARKERS FOR DIAGNOSING AND TREATING TUMOURS BY THERAPY 审中-公开
标题翻译：血管生成标志物的诊断和治疗肿瘤的用途
公开(公告)号：WO0018439A3
公开(公告)日：2000-09-14
申请号：PCT/EP9907198
申请日：1999-09-29
申请人： SCHERING AG , KRAUSE WERNER , MUSCHICK PETER
发明人： KRAUSE WERNER , MUSCHICK PETER
IPC分类号： A61K51/10 , A61P35/00 , A61K49/00 , A61K47/48 , A61K49/04
CPC分类号： A61K51/1093
摘要： The invention relates to the use of conjugates consisting of neoangiogenesis markers and active groups for diagnosing and/or treating tumours by therapy, to novel neoangiogenesis marker conjugates, to agents containing these compounds, and to methods for producing them.
摘要翻译：本发明涉及使用新血管发生标志物和用于肿瘤的诊断和/或治疗的活性基团的缀合物，以及新的新血管发生标记缀合物，含化合物和它们的制备方法这些。

10. 发明申请

WO9916416A3 COATED MEDICAL IMPLANTS, METHOD FOR PRODUCING THEM, AND USE OF THE SAME FOR PREVENTING RESTENOSIS 审中-公开
标题翻译：带涂层的医用植入物，方法为生产和它们用于预防再狭窄
公开(公告)号：WO9916416A3
公开(公告)日：1999-08-05
申请号：PCT/EP9806019
申请日：1998-09-24
申请人： SCHERING AG , KRAUSE WERNER
发明人： KRAUSE WERNER
IPC分类号： A61L31/00 , A61L27/00 , A61L31/10 , A61L31/16 , C09D175/08
CPC分类号： C09D175/08 , A61L31/08 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： The invention relates to agents for producing coated medical implants which release active substances, e.g., stents, to the implants themselves which are produced in this way, to a method for producing said implants and to the use of the same for preventing restenosis.
摘要翻译：本发明涉及一种装置，用于生产涂布，药物洗脱医学植入物，例如支架如此制备植入物，它们的制备方法以及它们用于再狭窄的预防用途。

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