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1. 发明申请

WO2012008810A3 MICROORGANISM WITH ENHANCED L-LYSINE PRODUCTIVITY AND METHOD FOR PRODUCING L-LYSINE USING THE SAME 审中-公开
标题翻译：具有增强的L-赖氨酸生产力的微生物及使用该生产L-赖氨酸的方法
公开(公告)号：WO2012008810A3
公开(公告)日：2012-05-24
申请号：PCT/KR2011005252
申请日：2011-07-15
申请人： CJ CHEILJEDANG CORP , LIM SANG JO , MOON JUN OK , KIM HYUNG JOON , JANG JAE WOO , CHO JAE YONG
发明人： LIM SANG JO , MOON JUN OK , KIM HYUNG JOON , JANG JAE WOO , CHO JAE YONG
IPC分类号： C12N1/21 , C12N15/54 , C12P13/08 , C12R1/15
CPC分类号： C12P13/08 , C12N9/1205
摘要： Disclosed is an L-lysine-producing microorganism having gluconate kinase activity weakened in comparison to the endogenous activity thereof, and methods provided for preparing the microorganism and for producing L-lysine using the same.
摘要翻译：公开了具有葡糖酸激酶活性的产生L-赖氨酸的微生物与其内源性活性相比减弱，并提供了用于制备该微生物和使用该微生物生产L-赖氨酸的方法。

2. 发明申请

WO2012008809A3 MICROORGANISM HAVING IMPROVED L-ORNITHINE PRODUCTIVITY, AND METHOD FOR PRODUCING L-ORNITHINE USING SAME 审中-公开
标题翻译：具有改进的L-ORNITHINE生产力的微生物和使用其生产L- ORN的方法
公开(公告)号：WO2012008809A3
公开(公告)日：2012-05-18
申请号：PCT/KR2011005251
申请日：2011-07-15
申请人： UNIV SANGJI INDUSTRY ACADEMIC COOPERATION FOUNDATION , CHO JAE YONG
发明人： CHO JAE YONG
IPC分类号： C12N1/21 , C12N15/54 , C12P13/10 , C12R1/15
CPC分类号： C12P13/10 , A23K20/142 , A23L33/175 , C12N9/1205
摘要： The present invention relates to an L-ornithine-producing microorganism, in which the gluconate kinase (GntK) activity is weakened relative to an intrinsic activity thereof, and to a method for producing L-ornithine from the L-ornithine-producing microorganism. According to the present invention, L-ornithine can be produced at a high yield rate and with high efficiency, and the thus-produced L-ornithine can be effectively used in the medical and pharmaceutical industry, the food industry, the feed industry, the chemical industry, etc.
摘要翻译：本发明涉及相对于其内在活性而使葡萄糖酸激酶（GntK）活性弱化的L-鸟氨酸生产微生物，以及L-赖氨酸生产微生物的L-鸟氨酸的制造方法。根据本发明，L-鸟氨酸可以以高产率和高效率生产，因此生产的L-鸟氨酸可以有效地用于医药工业，食品工业，饲料工业，化学工业等

3. 发明申请

WO2012161522A2 MICROORGANISM FOUND IN THE CORYNEBACTERIUM GENUS HAVING ENHANCED L-ORNITHINE PRODUCTION AND METHOD FOR PREPARING L-ORNITHINE USING SAME 审中-公开
标题翻译：在具有增强的L-选择素生产的CORYNBACTERIUM基因中发现的微生物和使用它们制备L-ORNITH的方法
公开(公告)号：WO2012161522A2
公开(公告)日：2012-11-29
申请号：PCT/KR2012004089
申请日：2012-05-23
申请人： GANGWON TECHNOLOGY HOLDINGS CO LTD , CHO JAE YONG , KO YOUNG WOONG
发明人： CHO JAE YONG , KO YOUNG WOONG
IPC分类号： C12N1/21 , C12N15/77 , C12P13/10 , C12R1/15
CPC分类号： C12N9/0006 , C12P13/10 , C12Y101/9901
摘要： The present invention relates to a microorganism found in the corynebacterium genus having enhanced L-ornithine production, and to a method for preparing L-ornithine using same. More particularly, the present invention relates to a microorganism found in the corynebacterium genus in which intrinsic glucose dehydrogenase (GDH) activity is reduced or becomes inert, thus enhancing L-ornithine production. The present invention also relates to a method for preparing said microorganism, and to a method for preparing L-ornithine, comprising the steps of: culturing said microorganism using glucose as a carbon source; and recovering L-ornithine from said culture. Using the microorganism found in the corynebacterium genus of the present invention in which intrinsic glucose dehydrogenase enzyme activity is reduced, not only is a pentose phosphate pathway activated but also the specific activities of G6PDH and 6PGD, which are enzymes related to the pentose phosphate pathway, are increased to improve NADPH production yields, thus increasing L-ornithine production yields using said NADPH. Therefore, the microorganism of the present invention may be widely utilized in the efficient and economical production of L-ornithine.
摘要翻译：本发明涉及具有增强的L-鸟氨酸生产的棒状杆菌属中发现的微生物以及使用其制备L-鸟氨酸的方法。更具体地说，本发明涉及其中内源性葡萄糖脱氢酶（GDH）活性降低或变成惰性的棒状杆菌属中发现的微生物，从而增强L-鸟氨酸生产。本发明还涉及一种制备所述微生物的方法和L-鸟氨酸的制备方法，包括以下步骤：使用葡萄糖作为碳源培养所述微生物; 并从所述文化中回收L-鸟氨酸。使用其中内在葡萄糖脱氢酶活性降低的本发明的棒状杆菌属中发现的微生物不仅活化戊糖磷酸途径，而且与作为与戊糖磷酸途径相关的酶的G6PDH和6PGD的比活性，增加NADPH生产产率，从而增加使用所述NADPH的L-鸟氨酸产量。因此，本发明的微生物可以广泛地用于L-鸟氨酸的有效和经济的生产。

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