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1. 发明申请

WO2018222777A1 RFID MARKERS AND SYSTEMS AND METHODS FOR IDENTIFIFYING AND LOCATING THEM 审中-公开
公开(公告)号：WO2018222777A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035219
申请日：2018-05-30
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John E. , RULKOV, Nikolai
IPC分类号： A61B90/00 , A61B90/98 , G06K7/10 , A61B5/06
摘要： Systems and methods are provided for identifying or locating a tag within a patient's body that include a probe that transmits synchronized electromagnetic signals, e.g., RF energy, and optical signals, e.g., infrared light pulses into the patient's body, whereupon the tag converts the optical signals into electrical energy to open and close a switch in the tag to modulate signals, e.g., backscatter signals, transmitted by the tag in response to the electromagnetic signals. For example, the tag may include photodiodes coupled to the switch that transforms the optical signals to alternately short the antenna to modulate the backscatter signals. Alternatively, the tag may include a smart circuit that harvests electrical energy from the optical signals to power the smart circuit and/or modulate the backscatter signals, e.g., to include data related to the tag and/or alternate the tag between an information mode and a distance mode.

2. 发明申请

WO2017151808A1 IMPLANTABLE MARKERS, AND SYSTEMS AND METHODS FOR USING THEM 审中-公开
标题翻译：可植入标记以及使用它们的系统和方法
公开(公告)号：WO2017151808A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020260
申请日：2017-03-01
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John, E. , RULKOV, Nikolai
IPC分类号： A61B90/00
CPC分类号： A61B90/39 , A61B90/06 , A61B90/08 , A61B2017/00115 , A61B2017/00199 , A61B2017/00411 , A61B2034/2051 , A61B2090/061 , A61B2090/0807 , A61B2090/306 , A61B2090/3908 , A61B2090/3925 , A61B2090/3945 , A61B2090/3966 , A61B2090/3975 , A61B2090/3987
摘要： Markers, probes, and related systems and methods are provided for localizing locations within a patient's body, e.g., a lesion within a breast. The marker includes an energy converter e.g., one or more photodiodes, for transforming light energy striking the marker into electrical energy, a storage device coupled to the energy converter for storing the electrical energy, a threshold element that closes a switch when the electrical energy reaches a predetermined threshold to discharge the electrical energy and cause the antenna to transmit a radio frequency (RF) signal. The system includes a probe that transmits light into the patient's body and a processor that correlate the frequency of the RF signals to a distance from the probe to the marker.
摘要翻译：标记物，探针以及相关的系统和方法被提供用于定位患者体内的位置，例如乳房内的病变。该标记包括能量转换器，例如一个或多个光电二极管，用于将撞击标记的光能转换成电能，耦合到能量转换器以存储电能的存储设备，当电能到达时关闭开关的阈值元件预定阈值以释放电能并使天线发射射频（RF）信号。该系统包括一个将光线传输到患者体内的探头和一个处理器，该处理器将RF信号的频率与从探头到标记器的距离相关联。

3. 发明申请

WO2020051236A1 SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING REFLECTORS USING ORTHOGONAL SEQUENCES OF REFLECTORS SWITCHING 审中-公开
公开(公告)号：WO2020051236A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/049583
申请日：2019-09-04
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John, E. , RULKOV, Nikolai
IPC分类号： A61B17/34 , A61B90/00 , A61B10/00
摘要： Systems and methods are provided for identifying and locating a plurality of reflector markers implanted within a target tissue region within a patient's body. A probe is provided that is activated to transmit electromagnetic signals into the patient's body, receive reflected signals from the patient's body, and in synchronization with transmitting the electromagnetic signals, deliver light pulses into the patient's body. The markers reflector tags modulate reflected signals from the respective markers based on orthogonal code sequences opening and closing respective switches of the markers to modulate the reflective properties of the markers. The probe processes the return signals to separate the reflected signals based at least in part on the code sequences to identify and locate each of the plurality of reflector tags substantially simultaneously.

4. 发明申请

WO2023004236A1 NEEDLE LOCALIZATION REFLECTORS, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：WO2023004236A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/073610
申请日：2022-07-11
申请人： CIANNA MEDICAL, INC.
发明人： CHI SING, Eduardo , GREENE, John E. , RULKOV, Nikolai
IPC分类号： A61B34/20 , A61B90/00 , A61B17/00
摘要： Apparatus, systems, and methods are provided for localization of a needle within a patient's body using markers. In an exemplary embodiment, a probe includes a distal end for placement against a surface of the region and one or more antennas for transmitting electromagnetic signals into and receiving reflected signals from the region. A processor processes the modulated reflected signals at one or more of the surface locations to determine marker locations along the needle and generate a three-dimensional model of the body region and needle.

5. 发明申请

WO2017177074A1 REFLECTOR MARKERS AND SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING THEM 审中-公开
公开(公告)号：WO2017177074A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026468
申请日：2017-04-06
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John, E. , RULKOV, Nikolai , WHITE, Jonathan
IPC分类号： A61B34/20 , A61B90/00 , A61B17/00
摘要： Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

6. 发明申请

WO2021092032A1 SYSTEMS AND METHODS FOR IMAGING A BODY REGION USING IMPLANTED MARKERS 审中-公开
公开(公告)号：WO2021092032A1
公开(公告)日：2021-05-14
申请号：PCT/US2020/058912
申请日：2020-11-04
申请人： CIANNA MEDICAL, INC.
发明人： RULKOV, Nikolai , GREENE, John E.
IPC分类号： A61B90/00 , A61B34/20 , A61B10/00 , A61B5/05
摘要： Apparatus, systems, and methods are provided for localization of a region within a patient's body using markers implanted within the region. In an exemplary embodiment, a probe includes a distal end for placement against a surface of the region; one or more antennas for transmitting electromagnetic signals into and receiving reflected signals from the region; a light source for delivering light pulses into the region whereupon the markers modulate reflected signals. A processor of the probe processes the modulated reflected signals at one or more of the surface locations to determine marker locations within the region to obtain a reference frame, determine distance values corresponding to distances from the respective markers to the distal end at each of the surface locations, and determine coordinates of the surface locations relative to the reference frame to generate a three dimensional model of the body region.

7. 发明申请

WO2018175667A1 REFLECTOR MARKERS AND SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING THEM 审中-公开
公开(公告)号：WO2018175667A1
公开(公告)日：2018-09-27
申请号：PCT/US2018/023669
申请日：2018-03-21
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John, E. , RULKOV, Nikolai , WHITE, Jonathan
IPC分类号： A61B34/20 , A61B90/00 , G01S13/84 , G01S7/41 , G01S13/75 , H01Q15/00 , A61B17/00 , G01S7/35 , H01Q1/22 , H01Q19/24
摘要： Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.

8. 发明申请

WO2017177074A9 REFLECTOR MARKERS AND SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING THEM 审中-公开
标题翻译：反射标记和用于识别和定位它们的系统和方法
公开(公告)号：WO2017177074A9
公开(公告)日：2017-10-12
申请号：PCT/US2017/026468
申请日：2017-04-06
申请人： CIANNA MEDICAL, INC.
发明人： GREENE, John, E. , RULKOV, Nikolai , WHITE, Jonathan
IPC分类号： A61B34/20 , A61B90/00 , A61B17/00
摘要： Markers and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes one or more photosensitive diodes for transforming light pulses striking the marker into electrical energy, one or more antennas, and a switch coupled to the photodiodes and antennas such that the light pulses cause the switch to open and close and modulate radar signals reflected by the marker back to a source of the signals. The antenna(s) may include one or more wire elements extending from a housing, one or more antenna elements printed on a substrate, or one or more chip antennas. Optionally, the marker may include a processor coupled to the photodiodes for identifying signals in the light pulses or one or more coatings or filters to allow selective activation of the marker.
摘要翻译：提供标记物和相关系统和方法用于定位患者体内的病灶，例如在乳房内。该标记包括一个或多个用于将撞击标记的光脉冲转换成电能的光敏二极管，一个或多个天线以及耦合到光电二极管和天线的开关，使得光脉冲导致开关打开和关闭并调制反射的雷达信号通过标记返回到信号的来源。天线可以包括从外壳延伸的一个或多个导线元件，印刷在衬底上的一个或多个天线元件或者一个或多个芯片天线。可选地，标记可以包括耦合到光电二极管的处理器，用于识别光脉冲中的信号或一个或多个涂层或过滤器，以允许选择性激活标记。

9. 发明申请

WO2016197008A1 PASSIVE TAGS, AND SYSTEMS AND METHODS FOR USING THEM 审中-公开
标题翻译：被动标签，以及使用它们的系统和方法
公开(公告)号：WO2016197008A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035846
申请日：2016-06-03
申请人： CIANNA MEDICAL, INC.
发明人： RULKOV, Nikolai , LOPEZ, Michael, John , GREENE, John, E.
IPC分类号： A61B90/00 , A61B5/05 , H01L23/60 , A61B90/98
CPC分类号： A61B90/39 , A61B5/062 , A61B5/064 , A61B90/04 , A61B90/37 , A61B90/98 , A61B2034/2051 , A61B2034/2072 , A61B2090/3908 , A61B2090/3941 , A61B2090/3945 , A61B2090/397 , A61B2090/3975 , A61B2090/3979 , A61B2090/3987 , H01L23/60 , H01L2224/48091 , H01L2924/00014
摘要： Markers, microwave probes, and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes an energy converter e.g., one or more photodiodes, for transforming energy pulses striking the marker into electrical energy, a switch, e.g., FET, coupled to the photodiodes such that light from a probe cause the switch to open and close. A pair of antenna wires are coupled to the switch to provide an antenna, the switch configured to open and close when light strikes the photodiodes to modulate signals from the probe reflected by the antenna back to the probe to identify the location of the marker. The marker also includes an electro static discharge (ESD) protection device coupled to the switch to provide protection against an electrostatic discharge event.
摘要翻译：提供标记物，微波探针以及相关的系统和方法用于定位患者体内的损伤，例如在乳房内。标记包括能量转换器，例如用于将撞击标记的能量脉冲转换成电能的一个或多个光电二极管，耦合到光电二极管的开关，例如FET，使得来自探针的光使开关打开和关闭。一对天线线耦合到开关以提供天线，该开关被配置为当光照射光电二极管时打开和闭合，以将来自由天线反射的探针的信号反馈回探头以识别标记的位置。标记还包括耦合到开关的静电放电（ESD）保护装置，以提供防止静电放电事件的保护。

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