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1. 发明申请

WO2014131719A1 CHROMATOGRAPHIC PROCESS FOR ENRICHMENT AND ISOLATION 审中-公开
标题翻译：用于增强和分离的色谱方法
公开(公告)号：WO2014131719A1
公开(公告)日：2014-09-04
申请号：PCT/EP2014/053511
申请日：2014-02-24
申请人： CHROMACON AG
发明人： MÜLLER-SPÄTH, Thomas , AUMANN, Lars , STRÖHLEIN, Guido , BAVAND, Michael , ULMER, Nicole
IPC分类号： B01D15/18 , G01N30/46
CPC分类号： C07K1/165 , B01D15/1864 , B01D15/40 , C11B3/008 , G01N30/461 , G01N30/466 , G01N30/468
摘要： A chromatographic process for the enrichment of at least one compound of interest (X) from a mixture (F) comprising said at least one compound of interest (X) as well as at least one further compound (W, C, S), which is not of interest, is proposed, using at least two chromatographic columns, wherein said process at least involves a sequence of the following steps: (i) a cyclic accumulation phase, in which the at least two chromatographic columns are alternatingly operated in an interconnected phase (IC), followed by a disconnected phase (B), wherein after these two phases the first and second column or group of columns exchange places; wherein said two phases are carried out sequentially M times with M > 1; (ii) a cyclic separation phase, in which the at least two chromatographic columns are alternatingly operated in an interconnected phase (IC), followed by a disconnected phase (B), wherein after these two phases the first and second column or group of columns exchange places to undergo the next interconnected (IC) and disconnected phases (B); wherein said two phases are carried out sequentially N times with N > 0; (iii) an elution phase, in which from the column or group of columns, which at the end of phase (i) or, in case of N>0 at the end of phase (ii) contains the at least one compound of interest (X), said at least one compound of interest (X) is extracted via the outlet.
摘要翻译：用于从包含所述至少一种目标化合物（X）的混合物（F）以及至少一种其它化合物（W，C，S）富集至少一种目的化合物（X）的色谱方法，其中提出使用至少两个色谱柱，其中所述方法至少涉及以下步骤的顺序：（i）循环累积阶段，其中所述至少两个色谱柱交替地在互连的操作中相位（IC），之后是断开相位（B），其中在这两个阶段之后，第一和第二列或一组列交换位置; 其中所述两相按M> 1顺序执行M次; （ii）循环分离阶段，其中至少两个色谱柱在互连相（IC）中交替操作，随后是断开相（B），其中在这两相之后，第一和第二列或一组柱交换场所进行下一个互连（IC）和断开阶段（B）; 其中所述两相按N> 0顺序进行N次执行; （iii）洗脱阶段，其中在阶段（i）结束时或在阶段（ii）结束时的N> 0的情况下从柱或组列中含有至少一种目标化合物（X），所述至少一种感兴趣的化合物（X）经由所述出口提取。

2. 发明申请

WO2014166799A1 CHROMATOGRAPHIC PURIFICATION METHOD 审中-公开
标题翻译：色谱纯化方法
公开(公告)号：WO2014166799A1
公开(公告)日：2014-10-16
申请号：PCT/EP2014/056656
申请日：2014-04-03
申请人： CHROMACON AG
发明人： MÜLLER-SPÄTH, Thomas , AUMANN, Lars , STRÖHLEIN, Guido , BAVAND, Michael , ULMER, Nicole
IPC分类号： B01D15/18 , G01N30/42 , G01N30/46 , G01N30/86
CPC分类号： B01D15/1871 , B01D15/1807 , B01D15/1864 , B01D15/3804 , B01D15/3809 , G01N30/02 , G01N30/26 , G01N30/34 , G01N30/38 , G01N30/44 , G01N30/46 , G01N30/461 , G01N30/462 , G01N30/463 , G01N30/468
摘要： The invention relates to a chromatographic purification method for the isolation of a desired product fraction from a mixture using 2 chromatographic columns, it relates to methods for setting up such a process, and it also relates to control and/or monitoring and/or optimization processes in this context. The method comprises, within one cycle to be carried out at least once, the following steps: a first batch step (Bl), wherein during a batch timespan said columns are disconnected and a first column (1) is loaded with feed via its inlet using a first flow rate and its outlet is directed to waste, and from a second column (2) desired product is recovered via its outlet and subsequently the second column (2) is regenerated; a first interconnected step (IC1), wherein the outlet of the first column (1) is connected to the inlet of the second column (2) during an interconnected timespan, the first column (1) is loaded beyond its dynamic breakthrough capacity with feed via its inlet using a second flow rate which is the same or larger than the first flow rate, and the outlet of the second column (2) is directed to waste, a second batch step (B2) analogous to the first batch step (Bl) but with exchanged columns; a second interconnected step (IC2), analogous to the first interconnected step (IC1) but with exchanged columns.
摘要翻译：本发明涉及一种使用2个色谱柱从混合物中分离所需产物级分的色谱纯化方法，涉及用于建立这种方法的方法，并且还涉及控制和/或监测和/或优化方法在这种情况下该方法包括在一个循环内进行至少一次的步骤：第一批次步骤（B1），其中在批次间隔期间，所述柱断开，并且第一塔（1）通过其入口使用第一流量并且其出口被引导到废物，并且从第二塔（2）通过其出口回收期望的产物，随后再生第二塔（2）; 第一相互连接的步骤（IC1），其中第一列（1）的出口在互连时间段期间连接到第二塔（2）的入口，第一塔（1）被加载超过其动态穿透能力通过其入口使用与第一流量相同或更大的第二流量，并且第二塔（2）的出口被引导废物;第二批次步骤（B2），类似于第一批次步骤（B1 ）但交换列; 第二互连步骤（IC2），类似于第一互连步骤（IC1），但具有交换的列。

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