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1. 发明申请

WO1996033281A1 HIGH EFFICIENCY EX VIVO TRANSDUCTION OF HEMATOPOIETIC STEM CELLS BY RECOMBINANT RETROVIRAL PREPARATIONS 审中-公开
标题翻译：通过重组逆转录病毒制备HEMATOPOIETIC干细胞的高效转录
公开(公告)号：WO1996033281A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005432
申请日：1996-04-19
申请人： CHIRON VIAGENE, INC. , SYSTEMIX
发明人： CHIRON VIAGENE, INC. , SYSTEMIX , JOLLY, Douglas, J. , ROBBINS, Joan, M. , KERR, William, G.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K38/2013 , A61K38/217 , A61K38/37 , A61K48/00 , C07K14/55 , C07K14/555 , C07K14/755 , C12N2740/13043 , C12N2840/44
摘要： Compositions and methods for the efficient ex vivo introduction of nucleic acid into hematopoietic stem cells mediated by recombinant retrovirus particles is described. The recombinant vector constructs carried by the recombinant retrovirus particles code for the production of a desired gene product having a therapeutic application from a gene of interest. Upon re-introduction into a patient, the transduced hematopoietic stem cells produce a desired gene product in an amount sufficient to treat a particular disease state.
摘要翻译：描述了将核酸有效地离体引入由重组逆转录病毒颗粒介导的造血干细胞的组合物和方法。由重组逆转录病毒颗粒载带的重组载体构建体编码从目的基因生产具有治疗应用的所需基因产物。在重新引入患者体内时，转导的造血干细胞以足以治疗特定疾病状态的量产生所需的基因产物。

2. 发明申请

WO1997024446A2 GENE DELIVERY VEHICLE-TARGETING LIGANDS 审中-公开
标题翻译：基因交付车辆目标配对
公开(公告)号：WO1997024446A2
公开(公告)日：1997-07-10
申请号：PCT/US1996020295
申请日：1996-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , CHADA, Sunil , BANKS, Theresa , MOORE, Margaret, D. , CHANG, Stephen, M., W.
IPC分类号： C12N15/62
CPC分类号： C07K16/2881 , A61K38/00 , A61K48/00 , C07K14/005 , C07K14/505 , C07K14/70539 , C07K2319/00 , C12N2710/16222 , C12N2740/13043
摘要： Fusion proteins composed of an MHC Class I molecule, MHC Class II molecule, or beta 2 microglobulin, and a targeting ligand are disclosed. Also disclosed are nucleic acid molecules which encode such fusion proteins as well as suitable expression cassettes and host cells. Also provided are methods for targeting a gene delivery vehicle to a selected cell type utilizing gene delivery vehicles which contain on their surfaces one of the above-mentioned fusion proteins.
摘要翻译：公开了由MHC I类分子，MHC II类分子或β2微球蛋白组成的融合蛋白和靶向配体。还公开了编码这种融合蛋白以及合适的表达盒和宿主细胞的核酸分子。还提供了使用基因递送载体将基因递送载体靶向所选细胞类型的方法，所述基因递送载体在其表面上含有上述融合蛋白之一。

3. 发明申请

WO1996017072A2 RECOMBINANT ALPHAVIRUS VECTORS 审中-公开
标题翻译：重组ALPHAVIRUS矢量
公开(公告)号：WO1996017072A2
公开(公告)日：1996-06-06
申请号：PCT/US1995015490
申请日：1995-11-30
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , DUBENSKY, Thomas, W., Jr. , POLO, John, M. , IBANEZ, Carlos, E. , CHANG, Stephen, M., W. , JOLLY, Douglas, J. , DRIVER, David, A. , BELLI, Barbara, A.
IPC分类号： C12N15/86
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/705 , C07K14/755 , C12N15/1131 , C12N15/86 , C12N2310/111 , C12N2310/122 , C12N2710/10322 , C12N2730/10122 , C12N2740/15022 , C12N2740/16222 , C12N2830/002 , C12N2840/203 , C12N2840/206
摘要： The present invention provides composition and methods for utilizing recombinant alphavirus vectors.
摘要翻译：本发明提供了利用重组甲病毒载体的组合物和方法。

4. 发明申请

WO1997024452A2 TOXIC-PROTEIN EXPRESSING VIRUSES AND PRODUCER CELL LINES 审中-公开
标题翻译：毒素蛋白表达病毒和生产细胞系
公开(公告)号：WO1997024452A2
公开(公告)日：1997-07-10
申请号：PCT/US1996020587
申请日：1996-12-20
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , CHADA, Sunil , DePOLO, Nicholas, J. , SAUTER, Sybille , ROBBINS, Joan , JOLLY, Douglas, J. , MANNING, William, C. , MURPHY, John, E. , RALSTON, Robert, O., II
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , C12N2740/13043 , C12N2760/20222 , C12N2830/00 , C12N2830/003 , C12N2840/105
摘要： Expression vectors are provided which have a tightly controllable promoter which directs the expression of a fusogenic protein. Also provided are nucleic acid molecules which encode toxic of fusogenic proteins, wherein one or more cysteine residues in the nucleic acid molecule has been altered to an opal termination codon.
摘要翻译：提供了表达载体，其具有指导融合蛋白的表达的可控启动子。还提供了编码融合蛋白毒性的核酸分子，其中核酸分子中的一个或多个半胱氨酸残基已被改变为蛋白石终止密码子。

5. 发明申请

WO1996021035A3 RETROVIRAL DELIVERY OF FULL LENGTH FACTOR VIII 审中-公开
公开(公告)号：WO1996021035A3
公开(公告)日：1996-07-11
申请号：PCT/US1995016582
申请日：1995-12-18
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , BODNER, Mordechai , DE POLO, Nicholas, J. , CHANG, Stephen , CHI-TANG HSU, David
IPC分类号： C12N15/86

6. 发明申请

WO1996020731A1 DIRECT ADMINISTRATION OF GENE DELIVERY VEHICLES AT MULTIPLE SITES 审中-公开
标题翻译：基因交付机构在多个站点的直接管理
公开(公告)号：WO1996020731A1
公开(公告)日：1996-07-11
申请号：PCT/US1995016471
申请日：1995-12-15
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , IRWIN, Michael, J. , WARNER, John, F.
IPC分类号： A61K48/00
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/51 , A61K2039/545 , C07K14/005 , C12N2740/13043 , C12N2740/16134 , C12N2740/16222
摘要： Methods of stimulating an immune response, either humoral or cell-mediated, in a warm-blooded animal through the administration at multiple sites of one or more gene delivery vehicles is provided. Each of the gene delivery vehicles directs the expression of at least one substance in host cells modified with the vehicle, such that an immune response is generated. Within preferred embodiments, the expressed substance elicits a cell-mediated immune response, preferably an HLA Class I-restricted immune response.
摘要翻译：提供了通过在一种或多种基因递送载体的多个位点施用来刺激温血动物体液或细胞介导的免疫应答的方法。基因递送载体中的每一种引导至少一种物质在用载体修饰的宿主细胞中的表达，使得产生免疫应答。在优选实施方案中，所表达的物质引发细胞介导的免疫应答，优选HLA I类限制性免疫应答。

7. 发明申请

WO1996033282A2 HIGH EFFICIENCY EX VIVO TRANSDUCTION OF CELLS BY HIGH TITER RECOMBINANT RETROVIRAL PREPARATIONS 审中-公开
标题翻译：高效率转录重组体高效率转染细胞
公开(公告)号：WO1996033282A2
公开(公告)日：1996-10-24
申请号：PCT/US1996005638
申请日：1996-04-19
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , JOLLY, Douglas, J.
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/57 , C07K14/755 , C12N2740/13043 , C12N2840/44
摘要： Compositions and methods for the efficient ex vivo introduction of nucleic acid into T cells, non-dividing cells, and cells resistant to standard transduction techniques mediated by high titer recombinant retroviral preparations is described. The recombinant vector constructs carried by the recombinant retrovirus particles code for the production of one or more desired gene products from one or more corresponding genes of interest, at least one of the gene products having a therapeutic application. Upon re-introduction into a patient, the transduced cells produce a desired gene product in an amount sufficient to treat a particular disease state.
摘要翻译：描述了将核酸有效地离体导入T细胞，非分裂细胞和耐高效滴度重组逆转录病毒制剂介导的标准转导技术的细胞的组合物和方法。由重组逆转录病毒颗粒承载的重组载体构建体编码用于从一个或多个相应的目的基因产生一种或多种所需基因产物，至少一种基因产物具有治疗应用。在重新引入患者体内时，转导的细胞产生足以治疗特定疾病状态的量的所需基因产物。

8. 发明申请

WO1996021416A2 METHODS AND COMPOSITIONS FOR TREATMENT OF SOLID TUMORS IN VIVO 审中-公开
标题翻译：用于治疗体内实体肿瘤的方法和组合物
公开(公告)号：WO1996021416A2
公开(公告)日：1996-07-18
申请号：PCT/US1995016855
申请日：1995-12-22
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , BURROWS, Francis, J. , FONG, Timothy, C , POLO, John, M. , DUBENSKY, Thomas, W., Jr. , JOLLY, Douglas, J.
IPC分类号： A61K00/00
CPC分类号： C12N9/0069 , A61K38/00 , A61K48/00 , C07K14/57 , C07K14/705 , C07K14/745 , C07K14/8132 , C07K14/8146 , C12N9/1211 , C12N9/6491 , C12N2799/021 , C12N2799/027
摘要： The present invention provides compositions and methods for treatment of solid tumors with gene therapy utilizing recombinant viral vectors that express polypeptides which selectively initiate irreversible coagulation of blood in the tumor vasculature, inhibit tumor neovascularization, are capable of activating a non-toxic agent into a toxic agent within the tumor vascular wall causing destruction of the vascular bed and absorb or metabolize nutrients in the blood being supplied to the tumor. The production of these polypeptides by transduced cells in or adjacent to the blood vessels of the tumor result in the death of tumor cells.
摘要翻译：本发明提供了使用重组病毒载体的基因治疗用于治疗实体瘤的组合物和方法，所述重组病毒载体表达选择性地启动肿瘤脉管系统中的血液不可逆凝结，抑制肿瘤新生血管形成，能够将无毒物质活化成毒性的多肽肿瘤血管壁内的药剂导致血管床的破坏并吸收或代谢供应到肿瘤的血液中的营养物质。这些多肽通过在肿瘤血管中或邻近的转导细胞的产生导致肿瘤细胞的死亡。

9. 发明申请

WO1996021036A2 NUCLEIC ACID CONDENSING AGENTS WITH REDUCED IMMUNOGENICITY 审中-公开
标题翻译：具有降低免疫原性的核酸冷凝剂
公开(公告)号：WO1996021036A2
公开(公告)日：1996-07-11
申请号：PCT/US1995017005
申请日：1995-12-26
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , DE POLO, Nicholas, J. , HSU, David, Chi-Tang
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , A61K47/60 , A61K47/645
摘要： Nucleic acid condensing agents with reduced immunogenicity are generated either by conjugation of polycations or by selection of basic amino acid regions from proteins. Conjugation involves a chemical linkage between a polyalkylene glycol, such as polyethylene glycol, or a polysaccharide, such as dextran, and a polycation. Additionally, gene delivery vehicles, such as viral vectors, may be conjugated with polyalkylene glycol or polysaccharide, to reduce their immunogenicity. Basic amino acid regions of proteins are identified by isoelectric point, and amino acid composition. These condensing agents are complexed with nucleic acids and used to deliver genes to cells. Immunogenicity is assessed by whether neutralizing antibody is induced and by whether a serum component inactivates the complexes.
摘要翻译：具有降低的免疫原性的核酸缩合剂通过聚阳离子的缀合或通过从蛋白质中选择碱性氨基酸区域来产生。共轭涉及聚亚烷基二醇如聚乙二醇或多糖如葡聚糖和聚阳离子之间的化学键合。此外，基因递送载体如病毒载体可以与聚亚烷基二醇或多糖缀合，以降低其免疫原性。蛋白质的碱性氨基酸区域通过等电点和氨基酸组成鉴定。这些缩合剂与核酸复合并用于将基因递送至细胞。通过是否诱导中和抗体以及血清成分是否使复合物失活来评估免疫原性。

10. 发明申请

WO1996021015A3 COMBINATION GENE DELIVERY VEHICLES 审中-公开
公开(公告)号：WO1996021015A3
公开(公告)日：1996-07-11
申请号：PCT/US1995016964
申请日：1995-12-22
申请人： CHIRON VIAGENE, INC.
发明人： CHIRON VIAGENE, INC. , JOLLY, Douglas, J. , MONTISANO, Dominic
IPC分类号： C12N15/19

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