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1. 发明申请

WO1997014812A2 METHOD OF SCREENING FOR FACTORS THAT MODULATE GENE EXPRESSION 审中-公开
标题翻译：筛选调节基因表达因子的方法
公开(公告)号：WO1997014812A2
公开(公告)日：1997-04-24
申请号：PCT/US1996016318
申请日：1996-10-11
申请人： CHIRON CORPORATION
发明人： CHIRON CORPORATION , CEN, Hui , WILLIAMS, Lewis, T. , ESCOBEDO, Jamie
IPC分类号： C12Q01/68
CPC分类号： C07K14/475 , C12Q1/6897
摘要： The invention describes a method of screening for factors that modulate gene expression, by detection of factors including factors that stimulate or inhibit cell growth, differentiation or proliferation, factors involved in one or more signal transduction pathways, or factors involved in protein-protein interactions. Identification of such factors that modulate gene expression is accomplished by detection of an intracellular event mediated by the factor. The intracellular event can be an increase or decrease in transcription or translational activities. Detection of the intracellular event is accomplished by any highly sensitive assay targeting a transcription or translation product, including, for example, a bDNA assay to the nascent transcript induced by the factor.
摘要翻译：本发明描述了通过检测包括刺激或抑制细胞生长，分化或增殖的因子，参与一个或多个信号转导途径的因子或涉及蛋白质 - 蛋白质相互作用的因子的因素来筛选调节基因表达的因子的方法。通过检测由因子介导的细胞内事件来实现调节基因表达的这些因子的鉴定。细胞内事件可以是转录或翻译活动的增加或减少。通过靶向转录或翻译产物的任何高度敏感的测定来实现细胞内事件的检测，包括例如由该因子诱导的新生转录物的bDNA测定。

2. 发明申请

WO1997022690A2 SIGNALING INOSITOL POLYPHOSPHATE 5-PHOSPHATASES (SIPs) 审中-公开
标题翻译：信号核糖核酸多磷酸5-磷酸酯（SIPs）
公开(公告)号：WO1997022690A2
公开(公告)日：1997-06-26
申请号：PCT/US1996019515
申请日：1996-12-06
申请人： CHIRON CORPORATION
发明人： CHIRON CORPORATION , KAVANAUGH, W., Michael , POT, David , WILLIAMS, Lewis, T.
IPC分类号： C12N09/16
CPC分类号： C12N9/16 , A61K38/00 , C07K16/40
摘要： Novel polypeptides called signaling inositol polyphosphate 5-phosphatases are described called SIP-130, SIP-125, and SIP-N. SIP-130 is capable of binding to a PTB domain of SH2 and collagen containing protein (SHC). Also provided are polynucleotide sequences encoding the novel polypeptides, as well as vectors and host cells containing the polynucleotides. Further provided are modulators including agonists and antagonists of the novel polypeptides for use as therapeutics, including antibodies, polypeptides, small molecules, and polynucleotides and methods of using the therapeutics in treatment of diseases associated with abnormal cell growth. Methods of making the polypeptides, polynucleotides, vectors, host cells, antibodies, and small molecules are also provided. Gene delivery vehicles including SIP and SIP activity-modulating polynucleotides are described.
摘要翻译：称为信号多聚磷酸肌醇5磷酸酶的新型多肽被称为SIP-130，SIP-125和SIP-N。 SIP-130能够结合到SH2和含胶原蛋白（SHC）的PTB结构域。还提供了编码新多肽的多核苷酸序列以及含有多核苷酸的载体和宿主细胞。还提供了包括用作治疗剂的新型多肽的激动剂和拮抗剂的调节剂，包括抗体，多肽，小分子和多核苷酸以及使用治疗剂治疗与异常细胞生长有关的疾病的方法。还提供了制备多肽，多核苷酸，载体，宿主细胞，抗体和小分子的方法。描述了包括SIP和SIP活性调节多核苷酸的基因递送载体。

3. 发明申请

WO2004037972A2 ENDOGENOUS RETROVIRUS UP-REGULATED IN PROSTATE CANCER 审中-公开
标题翻译：在前列腺癌中上调的内源性RETROVIRUS
公开(公告)号：WO2004037972A2
公开(公告)日：2004-05-06
申请号：PCT/US2002/039136
申请日：2002-12-09
申请人： CHIRON CORPORATION , HARDY, Stephen, F. , GARCIA, Pablo , WILLIAMS, Lewis, T. , ESCOBEDO, Jaime
发明人： HARDY, Stephen, F. , GARCIA, Pablo , WILLIAMS, Lewis, T. , ESCOBEDO, Jaime
IPC分类号： C12N
CPC分类号： C07K14/4748 , C07K14/005 , C12N7/00 , C12N2740/10021 , C12N2740/10022 , C12Q1/6886 , C12Q1/702 , C12Q2600/136 , G01N33/57434 , G01N2333/15
摘要： A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an expression product of the virus. The virus has five features not seen in other HERV-K members: (1) its own specific nucleotide sequence, and consequently amino acid sequences; (2) tandem 5' LTRs; (3) a fragmented 3' LTR; (4) an env gene interrupted by an alu insertion; and (5) unique gag sequences.
摘要翻译：已经发现，在20.428兆比特（22q11.2）的位于22号染色体上的HERV-K家族的特异成员在前列腺肿瘤中优先显着上调。本发明提供了诊断前列腺癌的方法，包括在患者样品中检测病毒表达产物的存在或不存在的步骤。该病毒在其他HERV-K成员中没有看到五个特征：（1）其自身的特异核苷酸序列，因此是氨基酸序列; （2）串联5'LTR; （3）碎片3'LTR; （4）由alu插入中断的env基因; 和（5）独特的gag序列。

4. 发明申请

WO2000038706A3 METHODS FOR TREATING CANCER AND FOR MEDIATING CHEMOTAXIS OF DENDRITIC CELLS 审中-公开
公开(公告)号：WO2000038706A3
公开(公告)日：2000-07-06
申请号：PCT/US1999/031096
申请日：1999-12-28
申请人： CHIRON CORPORATION , CHU, Keting , XIN, Hong , CHAN, Vivien, W., F. , KOTHAKOTA, Srinivas , WILLIAMS, Lewis, T. , WINTER, Jill, A.
发明人： CHU, Keting , XIN, Hong , CHAN, Vivien, W., F. , KOTHAKOTA, Srinivas , WILLIAMS, Lewis, T. , WINTER, Jill, A.
IPC分类号： A61K38/19
摘要： The invention is based on the novel observation, reported herein, that SLC inhibits the growth of tumors in vivo and is a potent chemokine for Dendritic Cells (DC). Thus, the invention provides a method of treating cancer or hyperproliferative disorder in a mammalian subject, comprising: administering a therapeutically effective amount of an SLC to said subject. SLCs useful in the methods of the invention include SLC polypeptides, variants and fragments and related nucleic acids. The methods of the invention are useful in the treatment of cancer and hyperproliferative disorders. In addition, the invention provides methods for modulating dendritic cell function in a mammal, said method comprising administering a therapeutically effective amount of an SLC agent to said mammal, said agent selected from the group consisting of: SLC plypeptides, SLC polypeptide variants, SLC polypeptide fragments, polynucleotides encoding SLC polypeptides, variants and fragments, anti-SLC antibodies and ligands for the CCR7 receptor. Such methods can be used to increase or decrease an immune response, particularly a primary immune response, in a mammal. The methods are particularly useful in the prevention of graft rejection and in the treatment of autoimmune disease. Alternatively, the methods may be used to enhance an immune response.

5. 发明申请

WO1997013857A1 COMBINATION PDGF, KGF, IGF AND IGFBP FOR WOUND HEALING 审中-公开
标题翻译：组合PDGF，KGF，IGF和IGFBP用于治疗
公开(公告)号：WO1997013857A1
公开(公告)日：1997-04-17
申请号：PCT/US1996015623
申请日：1996-09-27
申请人： CHIRON CORPORATION
发明人： CHIRON CORPORATION , WILLIAMS, Lewis, T.
IPC分类号： C12N15/12
CPC分类号： C07K14/49 , A61K9/06 , A61K9/127 , A61K9/4825 , A61K9/7015 , A61K38/00 , A61K38/1754 , A61K38/1825 , A61K38/30 , A61K48/00 , A61L26/0047 , A61K2300/00
摘要： The invention provides a therapeutic composition for epithelial wound repair that is a combination of PDGF and KGF. Further, the invention provides a composition for epithelial wound repair that is a therapeutic combination of PDGF, KGF and IGF. Additionally, the invention provides a therapeutic composition of PDGF, KGF, IGF and IGFBP for epithelial wound repair.
摘要翻译：本发明提供了作为PDGF和KGF的组合的上皮创伤修复的治疗组合物。此外，本发明提供了用于上皮创伤修复的组合物，其是PDGF，KGF和IGF的治疗组合。另外，本发明提供了用于上皮创伤修复的PDGF，KGF，IGF和IGFBP的治疗组合物。

6. 发明申请

WO1997040173A2 PI 3-KINASE FUSION MUTANTS AND USES THEREOF 审中-公开
标题翻译： PI 3激酶融合突变体及其用途
公开(公告)号：WO1997040173A2
公开(公告)日：1997-10-30
申请号：PCT/US1997005573
申请日：1997-04-03
申请人： CHIRON CORPORATION
发明人： CHIRON CORPORATION , KLIPPEL, Anke , KAVANAUGH, Michael , HARRISON, Stephen, D. , WILLIAMS, Lewis, T.
IPC分类号： C12N15/54
CPC分类号： C12N9/1205 , A01K67/0339 , A01K2217/05 , A61K48/00 , C07K2319/00 , C12P9/00 , C12P19/44
摘要： Polynucleotide constructs encoding growth factor independent catalytically active membrane targeted PI 3-kinase mutants useful for therapeutic and research purposes are described. In addition, a method for using the polynucleotide constructs to screen for inhibitors of PI 3-kinase, a method for making 3' phosphorylated inositol phospholipids, methods of reducing cell death after trauma, and methods of overcoming insulin resistance are described.
摘要翻译：描述了用于治疗和研究目的的编码不依赖于生长因子的催化活性膜靶向PI3-激酶突变体的多核苷酸构建体。此外，描述了使用多核苷酸构建体筛选PI 3激酶抑制剂的方法，制备3'磷酸化肌醇磷脂的方法，减少创伤后细胞死亡的方法以及克服胰岛素抵抗的方法。

7. 发明申请

WO1996035787A1 NUCLEIC ACIDS FOR TREATING OBESITY 审中-公开
标题翻译：用于治疗肥胖的核酸
公开(公告)号：WO1996035787A1
公开(公告)日：1996-11-14
申请号：PCT/US1996006609
申请日：1996-05-08
申请人： CHIRON CORPORATION
发明人： CHIRON CORPORATION , GIESE, Klaus, W. , WILLIAMS, Lewis, T.
IPC分类号： C12N15/12
CPC分类号： C07K14/5759 , A61K38/00 , C07K14/43563 , C07K14/72 , C07K2319/00 , C07K2319/02 , C12N2799/026
摘要： A nucleic acid molecule is provided that can be expressed in a host cell to produce a biologically active ob polypeptide that can effectively inhibit food intake and/or weight gain. Vectors and host cells containing the nucleic acid molecule are also provided, as well as methods for producing the ob protein and other ob polypeptides, methods of induction of the production of the ob polypeptides, such as by in vivo or ex vivo gene therapy, and methods for inhibition of food intake and/or weight gain. Further provided are antibodies to the ob polypeptides and methods of using such antibodies, such as for identification or detection of other ob polypeptides or homologs thereof, and for inhibition of ob polypeptide activity. A method for identification, detection, or isolation of an ob receptor is provided as well as methods for production of antibodies to the ob receptor. The antibodies and polypeptides herein can be incorporated in kits for immunoassays. Pharmaceutical compositions containing the ob polypeptide and antibodies to the ob polypeptide or to the ob receptor can be used for administration to animals and humans.
摘要翻译：提供了可以在宿主细胞中表达以产生可以有效抑制食物摄取和/或体重增加的生物活性的ob多肽的核酸分子。还提供了含有核酸分子的载体和宿主细胞，以及用于产生ob蛋白和其它ob多肽的方法，例如通过体内或离体基因治疗诱导ob多肽的产生的方法，以及抑制食物摄取和/或体重增加的方法。进一步提供的是针对ob多肽的抗体和使用此类抗体的方法，例如用于鉴定或检测其它ob多肽或其同系物，以及抑制ob多肽活性。提供了用于鉴定，检测或分离ob受体的方法以及用于产生针对ob受体的抗体的方法。本文的抗体和多肽可并入用于免疫测定的试剂盒中。含有ob多肽的药物组合物和对ob多肽或ob受体的抗体可用于给予动物和人类。

8. 发明申请

WO1998025959A2 SECRETED HUMAN PROTEINS 审中-公开
标题翻译：分泌人类蛋白质
公开(公告)号：WO1998025959A2
公开(公告)日：1998-06-18
申请号：PCT/US1997022787
申请日：1997-12-11
申请人： CHIRON CORPORATION
发明人： CHIRON CORPORATION , ESCOBEDO, Jaime , HU, Quianjin , GARCIA, Pablo , WILLIAMS, Lewis, T. , KOTHAKOTA, Srinivas
IPC分类号： C07K14/00
CPC分类号： C12N15/1051 , C07K14/47 , C07K2319/00 , C12N15/1034
摘要： Secreted proteins can be identified using a method which exploits the ability of microsomes to modify proteins post-translationally. Nineteen human secreted proteins and full-length cDNA sequences encoding the proteins have been identified using this method. The proteins and cDNA sequences can be used, inter alia, for targeting other proteins to the membrane or extracellular milieu.
摘要翻译：可以使用利用微粒体在翻译后修饰蛋白质的能力的方法鉴定分泌的蛋白质。已经使用该方法鉴定了19种人分泌蛋白和编码蛋白质的全长cDNA序列。蛋白质和cDNA序列特别可用于将其它蛋白质靶向膜或细胞外环境。

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