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1. 发明申请

WO2004062646A1 STABILIZED LYOPHILIZED COMPOSITIONS COMPRISING TISSUE FACTOR PATHWAY INHIBITOR OR TISSUE FACTOR PATHWAY INHIBITOR VARIANTS 审中-公开
标题翻译：包含组织因子途径抑制剂或组织因子途径抑制剂变体的稳定化LYOPHILED组合物
公开(公告)号：WO2004062646A1
公开(公告)日：2004-07-29
申请号：PCT/US2004000235
申请日：2004-01-08
申请人： CHIRON CORP , CHEN BAO-LU , HORA MANINDER
发明人： CHEN BAO-LU , HORA MANINDER
IPC分类号： A61K9/19 , A61K31/715 , A61K38/17 , A61K38/57 , A61K47/18 , A61K47/26
CPC分类号： A61K9/19 , A61K38/57 , A61K47/183 , A61K47/26
摘要： Lyophilized compositions of TFPI or a TFPI variant suitable for long-term storage can be formed by lyophilizing an aqueous formulation of the TFPI or TFPI variant having a pH from about 4 to about 8 with a carbohydrate or amino acid glass forming agent. These lyophilized compositions are stable for greater than three months when stored at 40°C.
摘要翻译：通过用碳水化合物或氨基酸玻璃形成剂将具有pH约4至约8的TFPI或TFPI变体的水性制剂冻干，可以形成适于长期储存的TFPI或TFPI变体的冻干组合物。这些冻干组合物在40℃储存时稳定3个月以上。

2. 发明申请

WO0149274A3 METHODS FOR PULMONARY DELIVERY OF INTERLEUKIN-2 审中-公开
标题翻译：脉络膜递送方法2
公开(公告)号：WO0149274A3
公开(公告)日：2002-02-14
申请号：PCT/US0035452
申请日：2000-12-27
申请人： CHIRON CORP
发明人： CHEN BAO-LU , HORA MANINDER
IPC分类号： A61K9/08 , A61K9/10 , A61K9/14 , A61K9/16 , A61K9/19 , A61K38/00 , A61K38/20 , A61K47/18 , A61K47/26 , A61K47/34 , A61P31/00 , A61P35/00 , A61P43/00 , A61K9/72
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/008 , A61K9/1617 , A61K9/19 , A61K38/2013 , A61K47/183 , A61K47/26
摘要： Methods for administering interleukin-2 (IL-2) or variants thereof via pulmonary inhalation are provided. The methods comprise preparing a pharmaceutical composition comprising IL-2 or variants thereof for subsequent delivery as an aqueous or nonaqueous solution or suspension or a dry powder form. These compositions may further comprise a surfactant in an amount sufficient to enhance absorption of the composition following pulmonary inhalation of the composition. When used in the delivery methods of the invention, these highly absorbable compositions result in enhanced bioavailability of IL-2.
摘要翻译：提供了通过肺部吸入给予白细胞介素-2（IL-2）或其变体的方法。所述方法包括制备包含IL-2或其变体的药物组合物，用于随后作为水或非水溶液或悬浮液或干粉形式递送。这些组合物还可以包含足以在肺部吸入组合物后增强组合物吸收量的表面活性剂。当用于本发明的递送方法时，这些高度可吸收的组合物导致增加的IL-2的生物利用度。

3. 发明申请

WO0226212A3 MICROPARTICLE COMPOSITIONS AND METHODS FOR THE MANUFACTURE THEREOF 审中-公开
标题翻译：微生物组合物及其制备方法
公开(公告)号：WO0226212A3
公开(公告)日：2003-03-27
申请号：PCT/US0130541
申请日：2001-09-28
申请人： CHIRON CORP
发明人： FANG JIA-HWA , SINGH MANMOHAN , O'HAGAN DEREK , HORA MANINDER
IPC分类号： A61K9/16 , A61K39/00 , A61K39/145 , A61K39/21 , A61K45/00 , A61K47/18 , A61K47/32 , A61K47/34 , A61P31/16 , A61P31/18 , C08L101/16
CPC分类号： A61K9/1676 , A61K9/1647
摘要： Microparticles with adsorbed complexes of macromolecule and detergent, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly( alpha -hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surfaces of the microparticles have absorbed thereon a complex of biologically active macromolecules, such as nucleic acids, polypeptides, antigens, and adjuvants, and a detergent. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 30,000 Daltons to 70,000 Daltons. Preferred macromolecules are bacterial and viral antigens (such as HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens) as well as polynucleotides that encode for such antigens.
摘要翻译：公开了具有大分子和洗涤剂的吸附复合物的微粒，制备这种微粒的方法及其用途。微粒包括聚合物，例如聚（α-羟基酸），多羟基丁酸，聚己内酯，聚原酸酯，聚酐等，并且使用阳离子，阴离子或非离子型洗涤剂形成。微粒的表面在其上吸收了生物活性大分子如核酸，多肽，抗原和佐剂以及洗涤剂的复合物。优选的聚合物是聚（D，L-丙交酯 - 共 - 乙交酯），更优选丙交酯/乙交酯摩尔比范围为40:60至60:40且分子量范围为30,000道尔顿至70,000道尔顿的聚合物。优选的大分子是细菌和病毒抗原（例如HIV抗原，脑膜炎B抗原，B链球菌抗原和甲型流感血凝素抗原）以及编码这些抗原的多核苷酸。

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