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1. 发明申请

WO2013055985A1 COMBINATORIAL COMPOSITIONS AND METHODS OF TREATING HEMOGLOBINOPATHIES 审中-公开
标题翻译：组合物组合物和治疗肝细胞病变的方法
公开(公告)号：WO2013055985A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/059861
申请日：2012-10-12
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , ORKIN, Stuart H. , XU, Jian , CONG, Peng
发明人： ORKIN, Stuart H. , XU, Jian , CONG, Peng
IPC分类号： A61K39/395 , A61K31/7088 , C12N15/11 , A61P7/06
CPC分类号： A61K39/3955 , A61K31/167 , A61K31/706 , A61K31/7105 , A61K35/28 , A61K45/06 , A61K2035/124 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/16 , C12N2320/31
摘要： Provided herein are compositions and methods for increasing fetal hemoglobin expression (HbF) for the treatment and/or amelioration of the symptoms of a hemoglobinpathy in a mammal. The compositions comprise a combination of one or more inhibitors of BCL11A expression or activity with epigenetic modifers, such as inhibitors of DNA methylation and/or one or more inhibitors of histone deacetylases.
摘要翻译：本文提供了用于增加胎儿血红蛋白表达（HbF）用于治疗和/或改善哺乳动物血红蛋白病症状的组合物和方法。组合物包含一种或多种BCL11A表达或活性抑制剂与表观遗传改良剂（例如DNA甲基化抑制剂）和/或一种或多种组蛋白脱乙酰酶抑制剂的组合。

2. 发明申请

WO2014085593A1 TARGETING BCL11A DISTAL REGULATORY ELEMENTS FOR FETAL HEMOGLOBIN REINDUCTION 审中-公开
标题翻译：瞄准BCL11A远端监管元件，用于局部HEMOGLOBIN吸收
公开(公告)号：WO2014085593A1
公开(公告)日：2014-06-05
申请号：PCT/US2013/072236
申请日：2013-11-27
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： ORKIN, Stuart H. , BAUER, Daniel E. , XU, Jian
IPC分类号： C12N5/10 , C12N5/0789 , C12N15/09
CPC分类号： C12N15/01 , A61K35/12 , A61K38/465 , C07K14/4702 , C07K14/805 , C12N9/22 , C12N15/102 , C12N15/63
摘要： Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.
摘要翻译：本文提供了通过在基因组水平上破坏BCL11A表达来增加细胞中胎儿血红蛋白水平的方法和组合物。本文还提供了通过重新产生胎儿血红蛋白水平来治疗血红蛋白病的方法和组合物。

3. 发明申请

WO2022051975A1 SYSTEMS AND METHODS OF DETERMINING HYGIENE CONDITION OF INTERIOR SPACE 审中-公开
公开(公告)号：WO2022051975A1
公开(公告)日：2022-03-17
申请号：PCT/CN2020/114438
申请日：2020-09-10
申请人： THE PROCTER & GAMBLE COMPANY , LIU, Jiquan , LAM, Tze Hau , ZHAO, He , VYAS, Rahul , CHAUHAN, Garima , XU, Jian , ZHU, Pengfei
发明人： LIU, Jiquan , LAM, Tze Hau , ZHAO, He , VYAS, Rahul , CHAUHAN, Garima , XU, Jian , ZHU, Pengfei
IPC分类号： C12Q1/68 , G06F3/048
摘要： A computer-implemented method for determining a hygiene condition of an interior space. The method has the steps of: a) obtaining relative abundance of at least one bacterium of human health concern in an interior space; b) generating a Microbial Index of Interior Space ("Microbial Index") for the interior space based on the relative abundance; and c) displaying an output indicative of the Microbial Index for determining a hygiene condition of the interior space. The Microbial Index is characterized by a function of the relative abundance of the at least one bacterium of human health concern defined by F (I), wherein N: Number of bacteria of human health concern identified in a microbial community in the interior space; P: Relative abundance of i-th bacteria of human health concern in the microbial community.

4. 发明申请

WO2014179965A1 BIOMARKER IDENTIFYING METHOD AND SYSTEM 审中-公开
标题翻译：生物识别识别方法与系统
公开(公告)号：WO2014179965A1
公开(公告)日：2014-11-13
申请号：PCT/CN2013/075406
申请日：2013-05-09
申请人： THE PROCTER & GAMBLE COMPANY , LI, Rui , HUANG, Shi , HE, Tao , LIU, Jiquan , XU, Jian
发明人： LI, Rui , HUANG, Shi , HE, Tao , LIU, Jiquan , XU, Jian
IPC分类号： G01N33/569
CPC分类号： G06F19/24 , C12Q1/689 , C12Q2600/112 , G01N33/569 , G06F19/18
摘要： A method of identifying a biomarker indicative of a subject mammal's condition is provided by designing a retrogression-progression model in combination with oral microbial community analysis, wherein the condition is selected from presence of the first disease, severity of the first disease, sensitivity to the first disease, and combinations thereof. A computer-aided system of identifying a biomarker indicative of a subject mammal's condition is further provided.
摘要翻译：通过设计与口腔微生物群落分析结合的倒退进展模型来提供识别指示受试者哺乳动物状况的生物标志物的方法，其中所述病症选自第一种疾病的存在，第一种疾病的严重性，对第一种疾病的敏感性第一种疾病及其组合。进一步提供了一种识别指示受试者哺乳动物状况的生物标志物的计算机辅助系统。

5. 发明申请

WO2014029099A1 I-VECTOR BASED CLUSTERING TRAINING DATA IN SPEECH RECOGNITION 审中-公开
标题翻译：基于I-VECTOR的群集训练数据在语音识别中的应用
公开(公告)号：WO2014029099A1
公开(公告)日：2014-02-27
申请号：PCT/CN2012/080527
申请日：2012-08-24
申请人： MICROSOFT CORPORATION , HUO, Qiang , YAN, Zhijie , ZHANG, Yu , XU, Jian
发明人： HUO, Qiang , YAN, Zhijie , ZHANG, Yu , XU, Jian
IPC分类号： G10L15/14 , G10L15/22 , G10L15/06
CPC分类号： G10L15/063 , G10L15/14 , G10L2015/0631
摘要： Methods and systems for i-vector based clustering training data in speech recognition are described. An i-vector may be extracted from a speech segment of a speech training data to represent acoustic information. The extracted i-vectors from the speech training data may be clustered into multiple clusters using a hierarchical divisive clustering algorithm. Using a cluster of the multiple clusters, an acoustic model may be trained. This trained acoustic model may be used in speech recognition.
摘要翻译：描述了基于i矢量的聚类训练数据在语音识别中的方法和系统。可以从语音训练数据的语音段中提取i向量以表示声学信息。来自语音训练数据的提取的i向量可以使用分级分割聚类算法聚类成多个聚类。使用多个群集的群集，可以训练一个声学模型。该训练的声学模型可用于语音识别。

6. 发明申请

WO2013012219A1 METHOD AND APPARATUS FOR PERFORMING CLOSED SUBSCRIBER GROUP GROUPING IN WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：在无线通信系统中执行封闭订户组分组的方法和装置
公开(公告)号：WO2013012219A1
公开(公告)日：2013-01-24
申请号：PCT/KR2012/005628
申请日：2012-07-13
申请人： LG ELECTRONICS INC. , XU, Jian , RYU, Jin Sook , PARK, Kyung Min , LEE, Young Dae , JUNG, Sung Hoon
发明人： XU, Jian , RYU, Jin Sook , PARK, Kyung Min , LEE, Young Dae , JUNG, Sung Hoon
IPC分类号： H04W88/18 , H04W92/12 , H04W36/08
CPC分类号： H04W8/186 , H04W36/08 , H04W48/16 , H04W84/045 , H04W92/12
摘要： A method and apparatus for grouping home eNodeBs (HeNBs) in a wireless communication system is provided. The method includes grouping a plurality of HeNBs into at least one closed subscriber group (CSG) group, and transmitting an identifier (ID) of a specific CSG group to HeNBs included in the specific CSG group.
摘要翻译：提供了一种用于在无线通信系统中对归属eNodeB（HeNB）进行分组的方法和装置。该方法包括将多个HeNB分组成至少一个封闭用户组（CSG）组，并将特定CSG组的标识符（ID）发送到特定CSG组中包括的HeNB。

7. 发明申请

WO2011119449A1 ENERGY HARVESTER FOR LED LUMINAIRE 审中-公开
标题翻译： LED灯具能量收割机
公开(公告)号：WO2011119449A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029117
申请日：2011-03-19
申请人： MASCO CORPORATION , XU, Jian , BARNETT, Thomas, Alan
发明人： XU, Jian , BARNETT, Thomas, Alan
IPC分类号： F21S9/04 , H01L35/00 , F21Y101/02
CPC分类号： F21S9/04 , F21Y2115/10 , H01L35/00
摘要： A light-emitting diode luminaire includes at least one light-emitting diode and at least one thermoelectric generator in contact with a portion of the luminaire. The at least one thermoelectric generator is operable to harvest energy from heat dissipated by the at least one light-emitting diode. An energy management module is operable to receive energy harvested by the at least one thermoelectric generator.
摘要翻译：发光二极管灯具包括至少一个发光二极管和至少一个与灯具的一部分接触的热电发电机。所述至少一个热电发电机可操作以从由所述至少一个发光二极管消散的热量中收集能量。能量管理模块可操作以接收由至少一个热电发电机收集的能量。

8. 发明申请

WO2011087679A1 LOW VOLTAGE CONTROL SYSTEMS AND ASSOCIATED METHODS 审中-公开
标题翻译：低电压控制系统及相关方法
公开(公告)号：WO2011087679A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/060417
申请日：2010-12-15
申请人： MASCO CORPORATION , XU, Jian , BARNETT, Thomas Alan , IOTT, Jeffrey , BUSLEPP, James Allen
发明人： XU, Jian , BARNETT, Thomas Alan , IOTT, Jeffrey , BUSLEPP, James Allen
IPC分类号： H05B33/08 , H05B37/02 , G05B15/02
CPC分类号： H05B37/0245 , G05B15/02 , H05B33/0842 , H05B37/0227 , H05B37/0254 , Y10T307/25
摘要： A low voltage control system includes a controller having at least one DC power bus and a plurality of discrete control line outputs. A plurality of DC lighting loads each includes at least one DC lighting element, an associated switch and control input. Each switch controls whether its associated at least one DC lighting element receives DC power from the power bus, and each control input controls its associated switch. At least one first input device includes at least one of a light intensity sensor, an occupancy sensor, or a programmable digital timer. The controller selectively controls the associated switches in response to sensor data received from the at least one first input device or commands received from at least one wired or wireless switch in communication with the controller. At least one second input device includes at least one of a chromatic light sensor, a light intensity sensor, or an occupancy sensor. The at least one second input device is operable to control the associated switches independently of the controller.
摘要翻译：低压控制系统包括具有至少一个DC电源总线和多个离散控制线路输出的控制器。多个DC照明负载各自包括至少一个DC照明元件，相关联的开关和控制输入。每个开关控制其相关联的至少一个DC照明元件是否从电力总线接收直流电力，并且每个控制输入控制其相关联的开关。至少一个第一输入装置包括光强度传感器，占用传感器或可编程数字定时器中的至少一个。控制器响应于从至少一个第一输入设备接收的传感器数据或从与控制器通信的至少一个有线或无线交换机接收的命令来选择性地控制相关联的开关。至少一个第二输入装置包括彩色光传感器，光强度传感器或占用传感器中的至少一个。至少一个第二输入装置可操作以独立于控制器来控制关联的开关。

9. 发明申请

WO2011087677A1 LOW VOLTAGE CONTROL SYSTEMS AND ASSOCIATED METHODS 审中-公开
标题翻译：低电压控制系统及相关方法
公开(公告)号：WO2011087677A1
公开(公告)日：2011-07-21
申请号：PCT/US2010/060413
申请日：2010-12-15
申请人： MASCO CORPORATION , XU, Jian , BARNETT, Thomas Alan , IOTT, Jeffrey , BUSLEPP, James Allen
发明人： XU, Jian , BARNETT, Thomas Alan , IOTT, Jeffrey , BUSLEPP, James Allen
IPC分类号： H05B33/08 , H05B37/02 , G05B15/02
CPC分类号： H05B37/0245 , G05B15/02 , H05B33/0842 , H05B37/0227 , H05B37/0254 , Y10T307/25
摘要： A low voltage control system includes a controller having a plurality of switched power lines and a plurality of DC lighting loads. Each DC lighting load includes at least one DC lighting element. Each DC lighting load has an associated switch downstream from the controller that selectively connects the at least one DC lighting element to one of the plurality of switched power lines. At least one first input device includes at least one of an occupancy sensor, a light intensity sensor, or a programmable digital timer. The controller selectively powers the switched power lines in response to sensor data received from the first input device or commands received from at least one wired or wireless switch in communication with the controller. At least one second input device includes at least one of a light intensity sensor or an occupancy sensor. The second input device controls the associated switches of the DC lighting loads to selectively connect and disconnect the DC lighting loads from the switched power lines independently of the controller.
摘要翻译：低压控制系统包括具有多个开关电源线和多个DC照明负载的控制器。每个DC照明负载包括至少一个DC照明元件。每个DC照明负载具有从控制器下游的相关联的开关，其选择性地将至少一个DC照明元件连接到多个开关电力线中的一个。至少一个第一输入装置包括占用传感器，光强度传感器或可编程数字定时器中的至少一个。控制器响应于从第一输入设备接收的传感器数据或从与控制器通信的至少一个有线或无线交换机接收到的命令来选择性地为切换的电力线供电。至少一个第二输入装置包括光强度传感器或占用传感器中的至少一个。第二输入设备控制DC照明负载的相关开关，以便与控制器独立地选择性地连接和断开来自开关电源线的DC照明负载。

10. 发明申请

WO2010151372A1 SYSTEM AND METHOD FOR PROTECTING A CIRCUIT 审中-公开
标题翻译：用于保护电路的系统和方法
公开(公告)号：WO2010151372A1
公开(公告)日：2010-12-29
申请号：PCT/US2010/033348
申请日：2010-05-03
申请人： LIBERTY HARDWARD MANUFACTURING CORP. , XU, Jian
发明人： XU, Jian
IPC分类号： H02H3/07 , H02H3/093
CPC分类号： H02H3/07 , H02H3/0935
摘要： A method of protecting a circuit includes measuring a value associated with a circuit having a current flowing through a switch to a load and comparing the measured value to a threshold. If the measured value meets or exceeds the threshold, the switch is turned OFF and a counter is incremented. If the counter is less than the counter limit, and a predefined time period has elapsed, the switch is turned back ON.
摘要翻译：一种保护电路的方法包括测量与具有流过开关的电流的电路相关联的电路到负载并将测量值与阈值进行比较。如果测量值达到或超过阈值，则开关关闭，计数器递增。如果计数器小于计数器限制，并且预定义的时间段已经过去，则开关转为ON。

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