专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012123493A3 ISOXAZOLIDINE DERIVATIVES 审中-公开
公开(公告)号：WO2012123493A3
公开(公告)日：2012-09-20
申请号：PCT/EP2012/054455
申请日：2012-03-14
申请人： CHIESI FARMACEUTICI S.P.A. , GHIDINI, Eleonora , CAPELLI, Anna Maria
发明人： GHIDINI, Eleonora , CAPELLI, Anna Maria
IPC分类号： C07J71/00 , A61K31/58 , A61P5/44 , A61P11/06 , A61P37/08
摘要： The present invention relates to novel anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, methods of preparing such compounds, pharmaceutical compositions comprisingthem, combinations and therapeutic uses thereof. More particularly, the invention relates to glucocorticosteroids that are derivatives of isoxazolidine.

2. 发明申请

WO2013017374A1 ANTI -INFLAMMATORY STEROIDS CONDENSED IN POSITION 16,17 WITH PYRROLIDINE RING 审中-公开
标题翻译：含有吡咯烷环的16,17位抗炎炎症甾体
公开(公告)号：WO2013017374A1
公开(公告)日：2013-02-07
申请号：PCT/EP2012/063239
申请日：2012-07-06
申请人： CHIESI FARMACEUTICI S.P.A. , GHIDINI, Eleonora , CAPELLI, Anna Maria
发明人： GHIDINI, Eleonora , CAPELLI, Anna Maria
IPC分类号： C07J71/00 , A61K31/58 , A61P5/44
CPC分类号： C07J71/0052 , A61K31/58
摘要： The present invention relates to novel anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, methods of preparing such compounds, pharmaceutical compositions comprising them, combinations and therapeutic uses thereof. More particularly, the invention relates to glucocorticosteroids that are derivatives of pyrrolidine.
摘要翻译：本发明涉及糖皮质激素系列的新型抗炎和抗过敏化合物，制备这些化合物的方法，包含它们的药物组合物，其组合和治疗用途。更具体地说，本发明涉及作为吡咯烷衍生物的糖皮质激素。

3. 发明申请

WO2022128853A1 DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS 审中-公开
公开(公告)号：WO2022128853A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/085380
申请日：2021-12-13
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： RANCATI, Fabio , ACCETTA, Alessandro , CAPELLI, Anna Maria , PALA, Daniele , MAZZUCATO, Roberta , EDWARDS, Christine , PASQUA, Adele Elisa
IPC分类号： C07D491/048 , A61K31/506 , A61P11/00 , A61P11/06
摘要： The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

4. 发明申请

WO2019048479A1 TYROSINE ANALOGUES DERIVATIVES AS RHO- KINASE INHIBITORS 审中-公开
公开(公告)号：WO2019048479A1
公开(公告)日：2019-03-14
申请号：PCT/EP2018/073872
申请日：2018-09-05
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： ACCETTA, Alessandro , CAPELLI, Anna Maria , RANCATI, Fabio , BHALAY, Gurdip , CHEGUILLAUME, Arnaud Jean Francois Auguste , EDWARDS, Christine , TISSELLI, Patrizia
IPC分类号： C07D471/04 , A61K31/437 , A61P11/00
CPC分类号： C07D471/04 , A61K31/437 , A61K2300/00
摘要： The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

5. 发明申请

WO2018138293A1 TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS 审中-公开
公开(公告)号：WO2018138293A1
公开(公告)日：2018-08-02
申请号：PCT/EP2018/052009
申请日：2018-01-26
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： ACCETTA, Alessandro , RANCATI, Fabio , CAPELLI, Anna Maria , CLARK, David Edward , TISSELLI, Patrizia , EDWARDS, Christine , CHEGUILLAUME, Arnaud Jean Francois Auguste , BHALAY, Gurdip
IPC分类号： C07D471/04 , A61K31/437 , A61K31/519 , C07D487/04 , C07D519/00 , A61P11/06
摘要： The invention relates to compounds of formula (I) inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

6. 发明申请

WO2022128851A1 DIHYDROFUROPYRIDINE DERIVATIVES AS RHO- KINASE INHIBITORS 审中-公开
公开(公告)号：WO2022128851A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/085378
申请日：2021-12-13
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： RANCATI, Fabio , ACCETTA, Alessandro , CAPELLI, Anna Maria , PALA, Daniele , EDWARDS, Christine , PASQUA, Adele Elisa , KAPADNIS, Prashant Bhimrao , CHEGUILLAUME, Arnaud Jean Franҫois Auguste
IPC分类号： C07D491/048 , A61K31/506 , A61P11/00 , A61P11/06
摘要： The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

7. 发明申请

WO2022128848A1 DIHYDROFUROPYRIDINE DERIVATIVES AS RHO-KINASE INHIBITORS 审中-公开
公开(公告)号：WO2022128848A1
公开(公告)日：2022-06-23
申请号：PCT/EP2021/085375
申请日：2021-12-13
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： RANCATI, Fabio , ACCETTA, Alessandro , CAPELLI, Anna Maria , PALA, Daniele , EDWARDS, Christine , PASQUA, Adele Elisa , KAPADNIS, Prashant Bhimrao , CHEGUILLAUME, Arnaud Jean Franҫois Auguste , CLARK, David Edward
IPC分类号： C07D491/048 , A61K31/506 , A61P11/00 , A61P11/06
摘要： The invention relates to compounds of formula (I) inhibiting Rho Kinase that are dihydrofuropyridine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

8. 发明申请

WO2018115383A1 BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO-KINASE INHIBITORS 审中-公开
公开(公告)号：WO2018115383A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084271
申请日：2017-12-21
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： ACCETTA, Alessandro , RANCATI, Fabio , CAPELLI, Anna Maria , CLARK, David Edward , TISSELLI, Patrizia , EDWARDS, Christine , BHALAY, Gurdip
IPC分类号： C07D487/04 , A61K31/519 , A61P37/00 , A61P11/00
摘要： The invention relates to compounds of formula (I) inhibiting Rho Kinase that are bicyclic dihydropyrimidine-carboxamide derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

9. 发明申请

WO2016038140A1 PYRIDAZINONE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS 审中-公开
标题翻译：吡咯烷酮衍生物作为磷酸三辛酯抑制剂
公开(公告)号：WO2016038140A1
公开(公告)日：2016-03-17
申请号：PCT/EP2015/070715
申请日：2015-09-10
申请人： CHIESI FARMACEUTICI S.P.A.
发明人： BIAGETTI, Matteo , CAPELLI, Anna Maria , GUALA, Matilde
IPC分类号： C07D487/04 , C07D403/12 , C07D473/34 , A61K31/519 , A61P11/00 , A61P37/00 , A61P29/00
CPC分类号： C07D487/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D403/12 , C07D473/34 , Y02A50/409
摘要： The invention relates to compounds of formula (I) inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them, and to therapeutic uses thereof in the treatment of disorders associated with PI3K enzymes such as respiratory diseases, allergic diseases, autoimmune diseases or inflammatory disorders.
摘要翻译：本发明涉及抑制磷酸肌醇3-激酶（PI3K）的式（I）化合物，包含它们的药物组合物及其治疗用途，用于治疗与PI3K酶相关的疾病，例如呼吸系统疾病，过敏性疾病，自身免疫疾病或炎症性疾病。

10. 发明申请

WO2007022936A1 TRIAZOLYL DERIVATIVES OF AZABICYCLO [3.1.0] HEXANE AS DOPAMINE D3 RECEPTOR MODULATORS 审中-公开
标题翻译： AZABICYCLO的三唑衍生物[3.1.0] HEXANE作为DOPAMINE D3受体调节剂
公开(公告)号：WO2007022936A1
公开(公告)日：2007-03-01
申请号：PCT/EP2006/008203
申请日：2006-08-18
申请人： GLAXO GROUP LIMITED , CAPELLI, Anna Maria , FAZZOLARI, Elettra , MICHELI, Fabrizio , TEDESCO, Giovanna , TERRENI, Silvia
发明人： CAPELLI, Anna Maria , FAZZOLARI, Elettra , MICHELI, Fabrizio , TEDESCO, Giovanna , TERRENI, Silvia
IPC分类号： C07D413/14 , A61K31/422 , A61P25/18
CPC分类号： C07D413/14
摘要： The present invention relates to novel compounds of formula (IC) or a salt thereof, wherein p is an integer ranging from 0 to 4; R 1 is independently selected from a group consisting of: halogen, hydroxy, cyano, C 1 - 4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkoxy, C 1-4 alkanoyl or SF 5 ; or corresponds to a group R 5 ; m 1 , m 2 , m 3 , and m 4 are 0; m 5 , m 6 and m 7 are each independently 0, 1 or 2 wherein the sum of m 5 , m 6 and m 7 is 1 or 2; R 6 is C 1-6 alkyl; R 7 is halogen, C 1-6 alkyl or haloC 1-6 alkyl; R 2 is hydrogen or C 1-4 alkyl; n is 2 or 3; X is S or -CH 2 -; R 3 is C 1-4 alkyl; R 4 is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1 , 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy and C 1-4 alkanoyl; R 5 is isoxazolyl, -CH 2 -N-pyrrolyl, 1 ,1 -dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl or 2-pyrrolidinonyl, wherein each group is optionally substituted by one or two substituents selected from: halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, C 1-4 alkoxy and C 1-4 alkanoyl; with the proviso that when m 5 =m 6 =1 , R 7 is not chlorine; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D 3 receptors, e.g. to treat substance related disorders, as antipsychotic agents, premature ejaculation or cognition impairment.
摘要翻译：本发明涉及式（IC）的新化合物或其盐，其中p为0至4的整数; R 1独立地选自：卤素，羟基，氰基，C 1 -C 4 - 烷基，卤代C 1 - C 1-4烷基，C 1-4烷氧基，卤代C 1-4烷氧基，C 1-4烷酰基或C 1-4烷氧基， 5 ; 或对应于基团R 5; m 1，m 2，m 3和m 4是0; m 5，m 6和m 7各自独立地为0,1或2，其中m为5〜 m 6和m 7是1或2; R 6是C 1-6烷基; R 7是卤素，C 1-6烷基或卤代C 1-6烷基; R 2是氢或C 1-4烷基; n为2或3; X是S或-CH 2 - ; R 3是C 1-4烷基; R 4是氢或苯基，杂环基，5或6元杂芳族基团或8至11元双环基团，其中任何基团任选被 1,2,3或4个选自以下的取代基：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1 -4个烷氧基和C 1-4烷酰基; R 5是异恶唑基，-CH 2 - N-吡咯基，1,1-二氧代-2-异噻唑烷基，噻吩基，噻唑基，吡啶基或2-吡咯烷基，其中各基团任选地被一个或两个选自以下的取代基取代：卤素，氰基，C 1-4烷基，卤代C 1-4烷基，C 1-4 - 烷氧基和C 1-4烷酰基; 条件是当m 5 = m 6 = 1时，R 7不是氯; 其制备方法，这些方法中使用的中间体，含有它们的药物组合物及其在治疗中的用途，作为多巴胺D 3受体的调节剂，例如。治疗与物质相关的疾病，作为抗精神病药，早泄或认知障碍。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式