专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008048519A2 ANTIBODIES THAT BIND CXCR7 EPITOPES 审中-公开
标题翻译：结合CXCR7表位的抗体
公开(公告)号：WO2008048519A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/021927
申请日：2007-10-12
申请人： CHEMOCENTRYX, INC. , PREMACK, Brett , MIAO, Zhenhua , PENFOLD, Mark
发明人： PREMACK, Brett , MIAO, Zhenhua , PENFOLD, Mark
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , C07K2317/34 , C07K2317/76
摘要： Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described.
摘要翻译：描述了结合CXCR7表位的抗体以及鉴定CXCR7调节剂的方法。

2. 发明申请

WO2005112916A2 BIS-ARYL SULFONAMIDES 审中-公开
标题翻译：双-ARYL磺酰胺
公开(公告)号：WO2005112916A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/017501
申请日：2005-05-18
申请人： CHEMOCENTRYX, INC. , UNGASHE, Solomon , WEI, Zheng , WRIGHT, John, J. , PENNELL, Andrew , PREMACK, Brett , SCHALL, Thomas
发明人： UNGASHE, Solomon , WEI, Zheng , WRIGHT, John, J. , PENNELL, Andrew , PREMACK, Brett , SCHALL, Thomas
IPC分类号： A61K31/397
CPC分类号： C07D213/26 , A61K31/18 , A61K31/195 , A61K31/397 , A61K31/4245 , A61K31/433 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译：提供了作为趋化因子受体的有效拮抗剂的化合物。这些化合物通常是芳基磺酰胺衍生物，并且可用于药物组合物，治疗趋化因子受体介导的疾病的方法以及用于鉴定趋化因子拮抗剂的分析中的对照。

3. 发明申请

WO2005076891A2 CELL PROLIFERATION ASSOCIATED WITH CCX CKR EXPRESSION 审中-公开
标题翻译：细胞增殖与CCX CKR表达相关
公开(公告)号：WO2005076891A2
公开(公告)日：2005-08-25
申请号：PCT/US2005/003384
申请日：2005-02-04
申请人： CHEMOCENTRYX, INC. , WANG, Yu , PREMACK, Brett , SCHALL, Thomas
发明人： WANG, Yu , PREMACK, Brett , SCHALL, Thomas
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/5011 , G01N2333/715
摘要： Methods for screening agents to identify an agent that modulates CCX CKR proliferative activity are provided. Tissue generation methods are also disclosed that involve activating CCX CKR expression and activity levels, as are methods for promoting angiogenesis. Methods for treating various diseases associated with cell proliferation are also described.
摘要翻译：提供筛选试剂鉴定调节CCX CKR增殖活性的试剂的方法。还公开了包括活化CCX CKR表达和活性水平的组织产生方法，以及用于促进血管生成的方法。还描述了治疗与细胞增殖相关的各种疾病的方法。

4. 发明申请

WO2003096017A1 METHODS AND COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE 审中-公开
标题翻译：诱导免疫反应的方法和组合物
公开(公告)号：WO2003096017A1
公开(公告)日：2003-11-20
申请号：PCT/US2002/036206
申请日：2002-10-21
申请人： CHEMOCENTRYX, INC.
发明人： SCHALL, Thomas, J. , MIAO, Zhenhua , BERAHOVICH, Robert , WEI, Zheng , HOWARD, Maureen , PREMACK, Brett
IPC分类号： G01N33/53
CPC分类号： C07K14/523 , A61K38/00 , A61K39/39 , A61K2039/55522 , Y02A50/39 , Y02A50/401 , Y02A50/466 , Y02A50/484
摘要： This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.
摘要翻译：本申请一般涉及增强免疫应答。这种免疫应答可以通过疫苗施用引起。提供了诱导或增强对抗原的免疫应答的组合物和方法。组合物和方法可用于治疗和预防用途（免疫）和产生抗体的疫苗制剂。

5. 发明申请

WO2006135382A2 ENZYMATIC ACTIVITIES IN CHEMOKINE-MEDIATED INFLAMMATION 审中-公开
标题翻译： CHEMOKIN-MEDIATED INFLAMMATION中的酶活性
公开(公告)号：WO2006135382A2
公开(公告)日：2006-12-21
申请号：PCT/US2005/027728
申请日：2005-08-04
申请人： CHEMOCENTRYX, INC. , BERAHOVICH, Robert, D. , MIAO, Zhenhua , PREMACK, Brett , SCHALL, Thomas, J.
发明人： BERAHOVICH, Robert, D. , MIAO, Zhenhua , PREMACK, Brett , SCHALL, Thomas, J.
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7158 , C12Q1/37 , G01N2500/00 , G01N2800/52
摘要： Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.
摘要翻译：提供缺乏活化CCR1和/或FPRL1的N端区域的截短趋化因子和含有截短趋化因子的组合物。还公开了通过调节截短的趋化因子的产生或截短的趋化因子活化CCR1和/或FPRL1的能力来鉴定调节CCR1和/或FPRL1活性的药剂的方法。还公开了使用截短的趋化因子抑制或激活CCR1和/或FPRL1介导的生物活性的方法。

6. 发明申请

WO2003031603A1 COMPOSITIONS USEFUL AS LIGANDS FOR THE FORMYL PEPTIDE RECEPTOR LIKE 1 RECEPTOR AND METHODS OF USE THEREOF 审中-公开
标题翻译：作为甲基肽类受体的配体有用的组合物1受体及其使用方法
公开(公告)号：WO2003031603A1
公开(公告)日：2003-04-17
申请号：PCT/US2002/026339
申请日：2002-08-19
申请人： CHEMOCENTRYX, INC.
发明人： MIAO, Zhenhua , PREMACK, Brett , SCHALL, Thomas, J.
IPC分类号： C12N5/00
CPC分类号： C07K14/521
摘要： The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1(25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1.
摘要翻译：发明人已经发现，CKβ8-1截短变体CKβ8-1（25-116）是两种不同GPCR，趋化因子受体CCR1和甲酰肽受体1（FPRL1）的双功能配体。因此，本发明人发现除了其对CCR1的功能活性外，CKβ8-1（25-116）除了通过募集单核细胞以外，还涉及炎性反应和先天免疫的GPCR受体FPRL1的功能性配体，嗜中性粒细胞。此外，本发明人已经发现CK beta 8-1的可选剪接外显子，命名为SHAAGtide。 SHAAGTIDE及其母体趋化因子CK beta 8-1（25-116）在已知表达FPRL1的单核细胞和嗜中性粒细胞上都具有完全功能。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式