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1. 发明申请

WO2006005022A2 DYNAMIC CHEMICAL IMAGING OF BIOLOGICAL CELLS AND OTHER SUBJECTS 审中-公开
标题翻译：生物细胞和其他物质的动态化学成像
公开(公告)号：WO2006005022A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/023638
申请日：2005-06-30
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
发明人： MAIER, John, S. , TREADO, Patrick, J. , VOIGT, Thomas, C. , TUSCHEL, David
IPC分类号： G01J3/44
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像的方法，包括细胞成像的方法。该方法包括用基本上单色的光照射单元的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。拉曼位移光可以在每个离散时间的多个拉曼位移（RS）值处被评估，并且RS值可以被选择为在每个离散时间处的预选分量的特征。由此获得的图像的拉曼光谱特征的多变量分析可以产生组件在视场中的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见的显微图像）组合或覆盖。

2. 发明申请

WO2007101279A2 METHOD AND APPARATUS FOR COMPACT SPECTROMETER WITH FIBER ARRAY SPECTRAL TRANSLATOR 审中-公开
标题翻译：具有光纤阵列光谱转换器的紧凑光谱仪的方法和装置
公开(公告)号：WO2007101279A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/063348
申请日：2007-03-05
申请人： CHEMIMAGE CORPORATION , GARDNER, Charles, W. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , WANG, Chenhul , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H.
发明人： GARDNER, Charles, W. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , WANG, Chenhul , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H.
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator ("FAST") for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间上准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

3. 发明申请

WO2007092010A2 SYSTEM AND METHOD FOR ELECTROSTATIC DETECTION AND IDENTIFICATION OF THREAT AGENTS 审中-公开
标题翻译：用于静电检测和识别故障代理的系统和方法
公开(公告)号：WO2007092010A2
公开(公告)日：2007-08-16
申请号：PCT/US2006/004566
申请日：2006-02-09
申请人： CHEMIMAGE CORPORATION , SARNOFF CORPORATION , TREADO, Patrick, J. , GARDNER, Charles, W., Jr. , MAIER, John, S. , KELLER, David
发明人： TREADO, Patrick, J. , GARDNER, Charles, W., Jr. , MAIER, John, S. , KELLER, David
CPC分类号： G01J3/44 , G01N21/65
摘要： A system and method for detecting aerosol threats comprising electrostatic collection and deposition of a threat agent onto a substrate. The threat agent deposited on the substrate is illuminated with a plurality of photons to thereby produce Raman scattered photons. The Raman scattered photons are analyzed in order to identify the threat agent.
摘要翻译：一种用于检测气溶胶威胁的系统和方法，包括将威胁剂静电收集和沉积到基底上。沉积在基板上的威胁剂被多个光子照射，由此产生拉曼散射的光子。分析拉曼散射光子以识别威胁剂。

4. 发明申请

WO2007055981A2 INVASIVE AND NON-INVASIVE CHEMOMETRY 审中-公开
标题翻译：入侵和非入侵化学
公开(公告)号：WO2007055981A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/042538
申请日：2006-11-01
申请人： CHEMIMAGE CORPORATION , TREADO, Patrick, J. , MAIER, John, S. , COHEN, Jeffrey, K. , DEMUTH, Joseph, E.
发明人： TREADO, Patrick, J. , MAIER, John, S. , COHEN, Jeffrey, K. , DEMUTH, Joseph, E.
IPC分类号： A61B5/00
CPC分类号： G06F19/10 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1459 , A61B5/415 , A61B5/418 , A61B5/4519
摘要： The invention relates to methods and devices for assessing one or more components of blood or a selected tissue in an animal. The present invention permits non-invasive assessment of blood or tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the blood or the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood or tissue component for one or more regions that exhibit the optical characteristic of the blood or the tissue of interest.
摘要翻译：本发明涉及用于评估动物中血液或选定组织的一种或多种组分的方法和装置。本发明通过评估动物身体的多个区域以获得血液或感兴趣的组织的光学特征，并且分别评估一种或多种光学（例如，血液或组织）的身体结构中的血液或组织成分的非侵入性评估。，拉曼或NIR）特征，其表现出血液或感兴趣的组织的光学特征的一个或多个区域。

5. 发明申请

WO2007021485A2 RAMAN SPECTRAL ANALYSIS OF PATHOGENS 审中-公开
标题翻译：拉曼光谱分析病原体
公开(公告)号：WO2007021485A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/029187
申请日：2006-07-27
申请人： CHEMIMAGE CORPORATION , STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
发明人： STEWART, Shona , MAIER, John, S. , TREADO, Patrick, J.
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B18/20 , G01J3/10 , G01J3/44 , G01N21/31 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N21/658 , G01N2021/6423 , G01N2021/656
摘要： Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.
摘要翻译：使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。该方法可用于检测使用其他方法（如原生动物）难以检测的病原体。使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。本文描述的方法具有重要的应用，例如用于在市政水系统中检测隐孢子虫生物体。

6. 发明申请

WO2006135628A2 CYTOLOGICAL METHODS FOR DETECTING A DISEASE CONDITION SUCH AS MALIGNANCY BY RAMAN SPECTROSCOPIC IMAGING 审中-公开
标题翻译：用于通过拉曼光谱成像检测疾病状态如恶性肿瘤的细胞学方法
公开(公告)号：WO2006135628A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022083
申请日：2006-06-06
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , STEWART, Shona , TREADO, Patrick, J.
发明人： MAIER, John, S. , STEWART, Shona , TREADO, Patrick, J.
IPC分类号： C12Q1/00 , C12Q1/70 , C12Q1/68 , G06F19/00 , G01J3/44
CPC分类号： G01N21/65 , G01N2021/656
摘要： Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment benign and malignant lesions of bladder and other tissues can be distinguished, including epithelial tissues such as lung, prostate, kidney, breast, and colon, and non-epithelial tissues, such as bone marrow and brain. Raman scattering data relevant to the disease state of cells or tissue can be combined with visual image data to produce hybrid images which depict both a magnified view of the cellular structures and information relating to the disease state of the individual cells in the field of view. Also, RMI techniques may be combined with visual image data and validated with other detection methods to produce confirm the matter obtained by RMI.
摘要翻译：拉曼分子成像（RMI）用于检测特定表型的哺乳动物细胞。例如，本公开包括使用RMI来区分正常和患病细胞或组织，例如癌细胞，以及确定所述癌细胞的等级。在一个优选实施方案中，可以区分膀胱和其他组织的良性和恶性病变，包括上皮组织如肺，前列腺，肾，乳腺和结肠以及非上皮组织，例如骨髓和脑。可以将与细胞或组织的疾病状态相关的拉曼散射数据与视觉图像数据组合，以产生描绘细胞结构的放大视图和与视野中的各个细胞的疾病状态有关的信息的混合图像。此外，RMI技术可以与可视图像数据组合，并用其他检测方法验证，以确定RMI获得的事项。

7. 发明申请

WO2005060380A2 WIDE FIELD METHOD FOR DETECTING PATHOGENIC MICROORGANISMS 审中-公开
标题翻译：用于检测致病微生物的广域方法
公开(公告)号：WO2005060380A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/020266
申请日：2004-06-24
申请人： CHEMIMAGE CORPORATION , GARDNER, Charles, W., Jr. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , VANNI, G., Steven , WOLFE, Julianne
发明人： GARDNER, Charles, W., Jr. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , VANNI, G., Steven , WOLFE, Julianne
IPC分类号： G01J3/02 , G01J3/10 , G01J3/44 , G01N21/35 , G01N21/64 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0272 , G01J3/10 , G01N21/35 , G01N21/3577 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N2021/6417 , G01N2021/6423 , G01N2021/656 , G01N2201/0221
摘要： Pathogenic microorganisms are detected in a wide field of view and classified by Raman light scattered light from these organisms together with digital pattern recognition of their spectral patterns.
摘要翻译：在广泛的视野中检测致病微生物，并通过来自这些生物体的拉曼光散射光以及其光谱图案的数字模式识别进行分类。

8. 发明申请

WO2007050602A2 AUTOMATED ACQUISITION OF SPECTRAL DATA AND IMAGE DATA 审中-公开
标题翻译：自动采集光谱数据和图像数据
公开(公告)号：WO2007050602A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/041471
申请日：2006-10-24
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , NELSON, Matthew , MCCLELLAND, Lindy , STEWART, Shona
发明人： MAIER, John, S. , TREADO, Patrick, J. , NELSON, Matthew , MCCLELLAND, Lindy , STEWART, Shona
IPC分类号： H04B10/08 , H04B17/00
CPC分类号： G01N21/65 , G01J3/28 , G01J3/2823 , G01J3/44 , G01N21/274 , G01N2021/656
摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.
摘要翻译：自动获取样品光谱的系统和方法。该方法涉及包括光漂白相和光谱采集阶段的两相过程。在漂白漂白阶段，收集样品的一系列光谱数据集。在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

9. 发明申请

WO2005010474A2 METHOD AND APPARATUS FOR MULTIWAVELENGTH IMAGING SPECTROMETER 审中-公开
标题翻译：多波长成像光谱仪的方法和装置
公开(公告)号：WO2005010474A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/022712
申请日：2004-07-19
申请人： CHEMIMAGE CORPORATION , MAIER, John, S. , TREADO, Patrick, J. , WANG, Chenhui
发明人： MAIER, John, S. , TREADO, Patrick, J. , WANG, Chenhui
IPC分类号： G01J
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for multi-wavelength imaging spectrometer. More specifically, in one embodiment, the disclosure relates to an optical filter for passing photons therethrough. The filter includes a first filter stage and a second filter stage. The first filter stage may include a first retarder element and a first liquid crystal cell. The first element may include an input face and an output face. One of the first element faces is not oriented substantially normal to the trajectory of photons passing through the filter.
摘要翻译：本公开一般涉及用于多波长成像光谱仪的方法和装置。更具体地，在一个实施例中，本发明涉及一种用于使光子通过其的滤光器。该滤波器包括第一滤波器级和第二滤波级。第一滤波器级可以包括第一延迟元件和第一液晶单元。第一元件可以包括输入面和输出面。第一元件面之一不是基本上垂直于通过过滤器的光子的轨迹。

10. 发明申请

WO2007103897A2 METHOD AND APPARATUS FOR COMPACT SPECTROMETER FOR MULTIPOINT SAMPLING OF AN OBJECT 审中-公开
标题翻译：用于多目标采样的紧凑型光谱仪的方法和装置
公开(公告)号：WO2007103897A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/063346
申请日：2007-03-05
申请人： CHEMIMAGE CORPORATION , GARDNER, Charles, W., JR. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H. , WANG, Chenhui
发明人： GARDNER, Charles, W., JR. , MAIER, John, S. , NELSON, Matthew, P. , SCHWEITZER, Robert, C. , TREADO, Patrick, J. , VANNI, G., Steven , WOLFE, Julianne , DEMUTH, Joseph, E. , NEISS, Jason, H. , WANG, Chenhui
IPC分类号： G06F19/00
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
摘要翻译：本公开涉及通过使用便携式或手持式装置对样品进行多点光谱分析来评估样品中一种或多种危险剂的发生的方法和装置。公开了采用拉曼光谱法和其他分光光度法的方法。还公开了适于执行这种多点方法的设备和系统。

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