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    • 1. 发明申请
    • ENHANCED TRANSMUCOSAL COMPOSITION AND DOSAGE FORM
    • 增强转运组合物和剂型
    • WO2009114192A3
    • 2010-07-08
    • PCT/US2009001626
    • 2009-03-13
    • CEPHALON INCHOLL RICHARD JLENTZ MATTHEW J
    • HOLL RICHARD JLENTZ MATTHEW J
    • A61K9/00
    • A61K9/006A61K9/0007
    • The invention provides a transmucosal pharmaceutical composition comprising an active compound, a bile salt and an osmolality adjusting ingredient, wherein the osmolality adjusting ingredient generates a localized hyperosmotic environment and maintains an osmolality level for a period of time sufficient to produce hypertonicity- facilitated transmucosal transport of said active compound across the mucosal tissue. The invention also provides a solid transmucosal dosage form containing the composition, as well as a method of treatment comprising administering the same. In one embodiment, the active compound is a triptan compound, e.g., sumatriptan and zolmitriptan.
    • 本发明提供了包含活性化合物,胆汁盐和重量摩尔渗透压浓度调节成分的透粘膜药物组合物,其中所述重量克分子渗透浓度调节成分产生局部高渗环境并保持渗透压浓度足以产生高渗性促进的经粘膜转运 所述活性化合物穿过粘膜组织。 本发明还提供了含有该组合物的固体透粘膜剂型,以及一种治疗方法,其包括施用该组合物。 在一个实施方案中,活性化合物是曲坦类化合物,例如舒马曲坦和佐米曲坦。