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1. 发明申请

WO2013128217A1 ABCG2 TRANSPORTER ASSAY 审中-公开
标题翻译： ABCG2运输车测定
公开(公告)号：WO2013128217A1
公开(公告)日：2013-09-06
申请号：PCT/HU2013/000021
申请日：2013-02-28
申请人： CELLPHARMA LLC
发明人： SARKADI, Balázs , TELBISZ, Ágnes
IPC分类号： G01N33/566
CPC分类号： C12Q1/34 , G01N33/566
摘要： The invention relates to membrane preparations for use in an increased sensitivity ABCG2 protein activity assay, said preparations comprising liposomes and one or more bile acid compounds wherein the bile acid compounds reduce the basal ATPase activity in said liposomes. Said membrane preparations can be cell membrane preparations or a membrane protein preparations. The invention also relates to methods for obtaining said membrane preparations, either cell membrane preparations or, preferably, membrane protein preparations comprising a reconstituted, recombinant ABCG2 protein. The invention also relates to kits comprising said membrane preparations as well as uses said kits, membrane preparations or bile acid compounds in high sensitivity ABCG2 protein activity assays.˙
摘要翻译：本发明涉及用于增加敏感性ABCG2蛋白活性测定的膜制剂，所述制剂包含脂质体和一种或多种胆汁酸化合物，其中胆汁酸化合物降低所述脂质体中的基础ATP酶活性。所述膜制剂可以是细胞膜制剂或膜蛋白制剂。本发明还涉及获得所述膜制备物，细胞膜制剂或优选包含重组的重组ABCG2蛋白的膜蛋白制剂的方法。本发明还涉及包含所述膜制剂的试剂盒以及在高灵敏度ABCG2蛋白活性测定中使用所述试剂盒，膜制剂或胆汁酸化合物。

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