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1. 发明申请

WO2009125925A3 GROWTH FACTOR-MIMICKING PEPTIDES AND USES THEREOF 审中-公开
标题翻译：生长因子模拟肽及其用途
公开(公告)号：WO2009125925A3
公开(公告)日：2009-12-17
申请号：PCT/KR2009001134
申请日：2009-03-06
申请人： CAREGEN CO LTD , CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , CHOI JUN YOUNG
发明人： CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , CHOI JUN YOUNG
IPC分类号： C07K14/71
CPC分类号： C07K14/475 , A61K8/64 , A61K38/00 , A61Q7/02 , A61Q19/00 , A61Q19/02 , A61Q19/06 , C07K14/50
摘要： The present invention relates to growth factor-mimicking peptides, and a method and a composition containing the same for improving skin condition or treating a wound. The disclosed growth factor-mimicking peptides have the same functions or activities as a natural human growth factor. Additionally, the peptides ensure excellent stability and skin permeability. Accordingly, the composition containing the peptides exhibits excellent effects on treatment, prevention or improvement of diseases or conditions which are required for activities of the growth factor. Also, the excellent activities and stability of the peptides allow the peptides to be applied to medicines, sanitary aids and cosmetics.
摘要翻译：本发明涉及生长因子模拟肽，以及含有其的用于改善皮肤状况或治疗伤口的方法和组合物。所公开的生长因子模拟肽具有与天然人生长因子相同的功能或活性。此外，这些肽可确保出色的稳定性和皮肤渗透性。因此，含有肽的组合物对于生长因子活性所需的疾病或病症的治疗，预防或改善显示出优异的效果。而且，肽的优异活性和稳定性使肽可以应用于药物，卫生用品和化妆品。

2. 发明申请

WO2010085039A3 NOGGIN-DERIVED PEPTIDE AND USE THEREOF 审中-公开
标题翻译： NOGGIN衍生肽及其用途
公开(公告)号：WO2010085039A3
公开(公告)日：2010-09-16
申请号：PCT/KR2009006930
申请日：2009-11-24
申请人： CAREGEN CO LTD , CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , SONG SANG SU , HONG IL , CHO KYOUNG MI , KIM SU MI , HAN SANG MIN
发明人： CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , SONG SANG SU , HONG IL , CHO KYOUNG MI , KIM SU MI , HAN SANG MIN
IPC分类号： C07K7/08 , C07K7/06 , C07K14/47
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： The present invention relates to a noggin-derived peptide and to a composition containing same for promoting hair growth, enhancing the condition of the skin, providing an anti-inflammatory function, or preventing or treating bone diseases. The noggin-derived peptide of the present invention performs a function identical or similar to that of natural human noggin, and has a superior stability and skin permeability as compared to the natural human noggin. The composition containing the peptide of the present invention as an active ingredient exhibits remarkably superior effects in treating, preventing, or improving growth factor-related symptoms, e.g. hair loss, skin conditions or stab wounds, and in treating, preventing, or improving symptoms of growth factor over-expression. Therefore, the superior activity and stability of the peptide of the present invention are greatly advantageous for using the peptide of the present invention in medicine, quasi-drugs, and cosmetics.
摘要翻译：本发明涉及一种头蛋白衍生肽及其含有促进毛发生长，增强皮肤状态，提供抗炎功能，或预防或治疗骨病的组合物。本发明的来源于肽的肽具有与天然人头蛋白相同或相似的功能，与天然人头蛋白相比具有优异的稳定性和皮肤透过性。含有本发明的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着优异的效果。脱发，皮肤状况或刺伤，以及治疗，预防或改善生长因子过表达的症状。因此，本发明的肽的优异活性和稳定性对于在医药，准药物和化妆品中使用本发明的肽是非常有利的。

3. 发明申请

WO2007102686A8 PEPTIDES HAVING ACTIVITIES OF INSULIN LIKE GROWTH FACTOR-1 AND THEIR USES 审中-公开
标题翻译：胰岛素样生长因子-1及其用途的活性肽
公开(公告)号：WO2007102686A8
公开(公告)日：2010-03-04
申请号：PCT/KR2007001086
申请日：2007-03-06
申请人： CAREGEN CO LTD , CHUNG YONG JI , KIM YOUNG DEUG , KIM EUN MI
发明人： CHUNG YONG JI , KIM YOUNG DEUG , KIM EUN MI
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-I) and derived from IGF-I, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-I mimicking peptides of this invention have identical functions or actions to natural- occurring IGF-I and much better stability and skin permeation than natural-occurring IGF-I. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-I activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有胰岛素样生长因子-1（IGF-I）的活性并且衍生自IGF-I的肽，用于改善皮肤病症或治疗包含该肽的牙周病的组合物。本发明的IGF-I模拟肽对天然存在的IGF-I具有相同的功能或作用，并且比天然存在的IGF-I具有更好的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要IGF-I活性的疾病或病症方面表现出优异的功效。此外，本发明的肽可以有利地应用于药物组合物，准药物和化妆品。

4. 发明申请

WO2011159092A9 NOVEL SOIL MICROORGANISM, NOVEL OXIDOREDUCTASE SEPARATED FROM THE SOIL MICROORGANISM, GENE ENCODING THE OXIDOREDUCTASE, AND METHOD FOR PRODUCING AGLYCONES USING THE MICROORGANISM, THE OXIDOREDUCTASE AND THE GENE 审中-公开
标题翻译：新型土壤微生物，从土壤微生物分离的新型氧化还原酶，编码氧化菌的基因，以及使用微生物，氧化还原酶和基因产生雄烯的方法
公开(公告)号：WO2011159092A9
公开(公告)日：2012-03-01
申请号：PCT/KR2011004361
申请日：2011-06-14
申请人： AMOREPACIFIC CORP , SNU R&DB FOUNDATION , PARK JUN SEONG , KIM DUCK HEE , KIM HAN KON , KIM EUN MI , KIM BYUNG GEE
发明人： PARK JUN SEONG , KIM DUCK HEE , KIM HAN KON , KIM EUN MI , KIM BYUNG GEE
IPC分类号： C12N1/20 , C12N9/02 , C12N15/53 , C12P17/06
CPC分类号： C12P33/20 , C12N1/20 , C12N9/0004 , C12P17/06 , C12P19/02 , C12P33/00 , C12R1/41 , Y02P20/52
摘要： The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.
摘要翻译：本发明涉及新根瘤菌属（Rhizobium sp。） GIN611KCTC11708BP或其细胞提取物，对具有糖酵解活性的新型氧化还原酶，与编码该氧化还原酶的基因相连，包含重组载体蛋白的重组菌株或编码重组蛋白的表达载体，以及糖酵解方法使用与生物催化剂相同的天然产物。本发明还涉及使用它们的各种天然产物制备糖苷配基的方法。从本发明的新型微生物分离的新型氧化还原酶不属于葡萄糖苷酶基团，属于氧化还原酶基团，对天然产物具有糖酵解活性。新型氧化还原酶氧化天然产物的糖苷配基中的糖，从而产生各种糖苷配基。

5. 发明申请

WO2011159092A2 NOVEL SOIL MICROORGANISM, NOVEL OXIDOREDUCTASE SEPARATED FROM THE SOIL MICROORGANISM, GENE ENCODING THE OXIDOREDUCTASE, AND METHOD FOR PRODUCING AGLYCONES USING THE MICROORGANISM, THE OXIDOREDUCTASE AND THE GENE 审中-公开
标题翻译：新型土壤微生物，从土壤微生物分离的新型氧化还原酶，编码氧化菌的基因，以及使用微生物，氧化还原酶和基因产生雄烯的方法
公开(公告)号：WO2011159092A2
公开(公告)日：2011-12-22
申请号：PCT/KR2011004361
申请日：2011-06-14
申请人： AMOREPACIFIC CORP , SNU R&DB FOUNDATION , PARK JUN SEONG , KIM DUCK HEE , KIM HAN KON , KIM EUN MI , KIM BYUNG GEE
发明人： PARK JUN SEONG , KIM DUCK HEE , KIM HAN KON , KIM EUN MI , KIM BYUNG GEE
IPC分类号： C12N1/20 , C12N9/02 , C12N15/53 , C12P17/06
CPC分类号： C12P33/20 , C12N1/20 , C12N9/0004 , C12P17/06 , C12P19/02 , C12P33/00 , C12R1/41 , Y02P20/52
摘要： The present invention relates to the novel Rhizobium sp. GIN611 KCTC11708BP or to cell extracts thereof, to a novel oxidoreductase which exhibits a glycolytic activity, to a gene encoding the oxidoreductase, to a recombinant strain comprising recombinant vector proteins or to an expression vector encoding recombinant proteins, and to a method for the glycolysis of natural products using same as a biocatalyst. The present invention also relates to a method for producing aglycones from a variety of natural products using same. The novel oxidoreductase separated from the novel microorganism of the present invention does not belong to a glucosidase group but belongs to an oxidoreductase group, and has a glycolytic activity for natural products. The novel oxidoreductase oxidizes the sugar in the aglycones of natural products, thereby producing a variety of aglycones.
摘要翻译：本发明涉及新根瘤菌属（Rhizobium sp。） GIN611KCTC11708BP或其细胞提取物，对具有糖酵解活性的新型氧化还原酶，与编码该氧化还原酶的基因相连，包含重组载体蛋白的重组菌株或编码重组蛋白的表达载体，以及糖酵解方法使用与生物催化剂相同的天然产物。本发明还涉及使用它们的各种天然产物制备糖苷配基的方法。从本发明的新型微生物分离的新型氧化还原酶不属于葡萄糖苷酶基团，属于氧化还原酶基团，对天然产物具有糖酵解活性。新型氧化还原酶氧化天然产物的糖苷配基中的糖，从而产生各种糖苷配基。

6. 发明申请

WO2017105161A3 PEPTIDE HAVING SKIN WHITENING ACTIVITY, AND USE THEREOF 审中-公开
标题翻译：具有皮肤美白活性的肽及其用途
公开(公告)号：WO2017105161A3
公开(公告)日：2017-08-10
申请号：PCT/KR2017001315
申请日：2017-02-06
申请人： CAREGEN CO LTD
发明人： CHUNG YONG JI , KIM EUN MI , LEE EUNG-JI , KIM JAN DI
IPC分类号： C07K7/08 , A61K8/64 , A61Q19/02
CPC分类号： A61K8/64 , A61Q19/02 , C07K7/08
摘要： The present invention provides a peptide having skin whitening activity. The present invention exhibits an excellent skin whitening effect by inhibiting melanin generation, inhibiting the activity of tyrosinase, inhibiting the expression of factors related to melanin formation, and inhibiting the movement of melanosomes. The peptide according to the present invention is small in size and thus has outstanding skin permeability. The superior activity and stability of the peptide according to the present invention can be very advantageously applied to cosmetics.
摘要翻译：本发明提供了具有皮肤美白活性的肽。本发明通过抑制黑色素生成，抑制酪氨酸酶的活性，抑制与黑色素形成有关的因子的表达以及抑制黑素体的移动而表现出优异的皮肤增白作用。根据本发明的肽尺寸小并因此具有出色的皮肤渗透性。根据本发明的肽的优越的活性和稳定性可以非常有利地应用于化妆品。

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