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1. 发明申请

WO2008140863A2 CELL TRAINING FOR LOCAL FIELD STIMULATION 审中-公开
标题翻译：本地场刺激的细胞培养
公开(公告)号：WO2008140863A2
公开(公告)日：2008-11-20
申请号：PCT/US2008058144
申请日：2008-03-25
申请人： CARDIAC PACEMAKERS INC , KENKNIGHT BRUCE , GIROUARD STEVEN D
发明人： KENKNIGHT BRUCE , GIROUARD STEVEN D
IPC分类号： A61K35/34 , A61M37/00 , A61N1/362 , A61P9/04 , C12N5/077
CPC分类号： C12N5/0657 , A61B17/3468 , A61B2017/00247 , A61B2017/00256 , A61B2018/00392 , A61K35/12 , A61M37/0069 , A61N1/326 , A61N1/362
摘要： A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
摘要翻译：提供用于刺激一个或多个细胞的系统，其中所述刺激是亚阈值的，并且可以改变所述一个或多个细胞的跨膜电位。对于一些细胞群体，可能影响跨膜电位以获得治疗益处。由于跨膜电位的缓慢去极化，主要由于心房中心的细胞自发去极化。本系统可以向中心细胞提供局部场刺激，尽管不引起动作电位也可能改变局部跨膜电位。跨膜电位的这种改变可以允许去极化率的增加或减少，从而改变心率。

2. 发明申请

WO2007014134A3 TANDEM CARDIAC PACEMAKER SYSTEM 审中-公开
标题翻译： TANDEM CARDIAC PACEMAKER系统
公开(公告)号：WO2007014134A3
公开(公告)日：2007-07-26
申请号：PCT/US2006028625
申请日：2006-07-21
申请人： UNIV COLUMBIA , UNIV NEW YORK STATE RES FOUND , ROSEN MICHAEL R , BRINK PETER R , ROBINSON RICHARD B , GIROUARD STEVEN D , KENKNIGHT BRUCE H , COHEN IRA S
发明人： ROSEN MICHAEL R , BRINK PETER R , ROBINSON RICHARD B , GIROUARD STEVEN D , KENKNIGHT BRUCE H , COHEN IRA S
IPC分类号： A61N1/368 , A61K48/00 , C12N5/077 , C12N5/0775
CPC分类号： A61N1/372 , C12N5/0657 , C12N2502/1329 , C12N2502/1358 , C12N2510/00
摘要： This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.
摘要翻译：本发明提供了起搏器系统，其包括（1）电子起搏器和（2）生物起搏器，其中生物起搏器包括功能性表达嵌合超极化激活的环核苷酸门控（HCN）离子通道的细胞，其水平有效以诱导细胞中的起搏器电流。本发明还提供了相关的生物起搏器，房室桥，其制造方法以及治疗患有心律紊乱的受试者的方法。

3. 发明申请

WO2005084751A3 IMPLANTABLE SYSTEM FOR CONTROLLING GENE EXPRESSION 审中-公开
标题翻译：用于控制基因表达的可植入系统
公开(公告)号：WO2005084751A3
公开(公告)日：2005-12-15
申请号：PCT/US2005006069
申请日：2005-02-28
申请人： CARDIAC PACEMAKERS INC , GIROUARD STEVEN D , ROSS JEFFREY
发明人： GIROUARD STEVEN D , ROSS JEFFREY
IPC分类号： A61K47/48 , A61K48/00 , A61M5/142 , A61M5/172 , A61N1/32 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3627 , A61K47/6957 , A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61N1/326 , A61N1/362 , A61N1/36514 , A61N1/3962
摘要： A gene regulatory system controls gene therapy by emitting one or more forms of energy that regulate gene expression by triggering promoters. The system includes a sensor to sense a signal indicative of a need for the gene therapy as well as responses to the gene therapy. The regulation of the gene expression is controlled based on the sensed signal and/or a user command. In one embodiment, the system delivers one or more electrical therapies in conjunction with the gene therapy.
摘要翻译：基因调控系统通过发射通过触发启动子调节基因表达的一种或多种形式的能量来控制基因治疗。该系统包括感测指示基因治疗需要的信号以及对基因治疗的反应的传感器。基于感测信号和/或用户命令来控制基因表达的调节。在一个实施方案中，系统与基因治疗结合递送一种或多种电疗法。

4. 发明申请

WO2008143884A3 MEDIA AND DEVICES FOR COLD STORAGE OF THERAPEUTIC CELLS 审中-公开
标题翻译：用于贮存治疗细胞的媒体和装置
公开(公告)号：WO2008143884A3
公开(公告)日：2009-09-03
申请号：PCT/US2008006164
申请日：2008-05-14
申请人： CARDIAC PACEMAKERS INC , STOLEN CRAIG , GIROUARD STEVEN D
发明人： STOLEN CRAIG , GIROUARD STEVEN D
IPC分类号： A01N1/02 , A61F2/82 , A61K38/18 , A61L31/04 , A61L31/16
CPC分类号： A01N1/02 , A01N1/0226 , A01N1/0231 , A61F2/82 , A61L31/043 , A61L31/16 , A61L2300/252 , A61L2300/414
摘要： The invention provides a composition for cold storage of cells which includes a population of isolated stem cells, a cell medium, and isolated trophic factors, as well as devices having a plurality of the trophic factors.
摘要翻译：本发明提供了用于冷藏细胞的组合物，其包括分离的干细胞群，细胞培养基和分离的营养因子，以及具有多种营养因子的装置。

5. 发明申请

WO2004050180A3 METHOD AND APPARATUS FOR CELL AND ELECTRICAL THERAPY OF LIVING TISSUE 审中-公开
标题翻译：细胞和生活组织电疗法的方法和装置
公开(公告)号：WO2004050180A3
公开(公告)日：2004-11-11
申请号：PCT/US0338085
申请日：2003-11-26
申请人： CARDIAC PACEMAKERS INC
发明人： GIROUARD STEVEN D , SALO RODNEY W , KENKNIGHT BRUCE H
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the exogenous cells are conditioned in vitro before their administration into tissue. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD or DDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译：一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。在一个应用中，外源细胞在其施用到组织中之前在体外调节。在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。在一个应用中，与内部房室延迟相比，在房室延迟与房室延迟保持相对较短的VDD或DDD模式下使用可植入起搏器。

6. 发明申请

WO0128609A3 DRUG DELIVERY SYSTEM FOR IMPLANTABLE CARDIAC DEVICE 审中-公开
标题翻译：用于可植入心脏装置的药物递送系统
公开(公告)号：WO0128609A3
公开(公告)日：2001-11-01
申请号：PCT/US0041214
申请日：2000-10-18
申请人： CARDIAC PACEMAKERS INC
发明人： SCHEINER AVRAM , HERNER MARK , HEIL RONALD W JR , GIROUARD STEVEN D
IPC分类号： A61N1/30 , A61N1/362 , A61B5/00 , A61N1/39
CPC分类号： A61N1/30 , A61N1/3621 , Y10S128/12 , Y10S128/13
摘要： A drug delivery system incorporated into a cardiac device (Fig. 1) for delivering a dose (133) of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link (40, 140) with a drug delivery device (Fig. 2). The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.
摘要翻译：一种药物递送系统，其结合到心脏装置（图1）中，用于在检测到特定医疗状况时将药物的剂量（133）递送给患者。心脏装置可以是例如通过射频链路（40,140）与药物递送装置（图2）进行通信的可植入式心律转复器/除颤器，心脏起搏器或组合装置。药物递送装置优选是经电调制的透皮药物递送装置，用于根据从心脏装置接收的信号透皮地递送药物。

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