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1. 发明申请

WO2008091529A2 ISCHEMIA DETECTION USING PRESSURE SENSOR 审中-公开
标题翻译：使用压力传感器进行ISCHEMIA检测
公开(公告)号：WO2008091529A2
公开(公告)日：2008-07-31
申请号：PCT/US2008/000628
申请日：2008-01-17
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , SIEJKO, Krzysztof Z. , FOGOROS, Richard , PATANGAY, Abhilash
发明人： ZHANG, Yi , SIEJKO, Krzysztof Z. , FOGOROS, Richard , PATANGAY, Abhilash
IPC分类号： A61B5/021
CPC分类号： A61B5/0215 , A61B5/02028 , A61B5/0205 , A61B5/145
摘要： This document discusses, among other things, a system and method for sensing a pulmonary artery pressure ("PAP") signal of a pulmonary artery ("PA") and computing an indication of a reduction of blood supply to at least a portion of a heart using information from the PAP signal. The reduction of blood supply to at least a portion of the heart can be detected using a PAP signal characteristic or measurement, using a change in the PAP, using an interval between multiple PAP signal features, using a mitral valve performance, or using information from the PAP and information from a different physiological signal, including a cardiac signal, a heart sound signal, right ventricular pressure signal, a left ventricular pressure signal, a blood pressure signal, and an oxygen saturation signal.
摘要翻译：本文件尤其涉及用于感测肺动脉（“PA”）的肺动脉压（“PAP”）信号的系统和方法，并且计算血液供应减少至少一部分的指示心脏使用来自PAP信号的信息。使用PAP信号特征或测量可以使用PAP信号特征或多个PAP信号特征之间的间隔，使用二尖瓣性能来使用PAP信号特征或测量来检测对心脏的至少一部分的血液供应，或使用来自 PAP和来自不同生理信号的信息，包括心脏信号，心音信号，右心室压力信号，左心室压力信号，血压信号和氧饱和度信号。

2. 发明申请

WO2010033928A1 CONGESTIVE HEART FAILURE DECOMPENSATION DETECTION 审中-公开
标题翻译：焦虑心脏衰竭检测
公开(公告)号：WO2010033928A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057710
申请日：2009-09-21
申请人： CARDIAC PACEMAKERS, INC. , SIEJKO, Krzysztof Z. , AVERINA, Viktoria A. , PATANGAY, Abhilash
发明人： SIEJKO, Krzysztof Z. , AVERINA, Viktoria A. , PATANGAY, Abhilash
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0002 , A61B5/7264 , G06F19/00
摘要： In an example, physiologic information about a patient can be obtained and mapped to a first set of fuzzy logic membership functions, and a symptom status can be derived from the mapping of the physiologic information using a first fuzzy logic inference. In an example, the symptom status can be mapped to a second set of fuzzy logic membership functions, and a disease status can be derived from the mapping of the symptom status to the second set of fuzzy logic membership functions using a second fuzzy logic inference.
摘要翻译：在一个示例中，可以获得关于患者的生理信息并将其映射到第一组模糊逻辑隶属函数，并且可以使用第一模糊逻辑推断从生理信息的映射导出症状状态。在一个示例中，症状状态可被映射到第二组模糊逻辑隶属函数，并且可以使用第二模糊逻辑推理从症状状态与第二组模糊逻辑隶属函数的映射导出疾病状态。

3. 发明申请

WO2008130532A1 HEART SOUND TRACKING SYSTEM AND METHOD 审中-公开
标题翻译：心音追踪系统及方法
公开(公告)号：WO2008130532A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/004832
申请日：2008-04-14
申请人： CARDIAC PACEMAKERS, INC. , PATANGAY, Abhilash , SIEJKO, Krzysztof Z. , CARLSON, Gerrard M.
发明人： PATANGAY, Abhilash , SIEJKO, Krzysztof Z. , CARLSON, Gerrard M.
IPC分类号： A61B7/00
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, or S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, or S4, respectively.
摘要翻译：一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。特定的心音可以包括S1，S2，S3或S4中的一个的至少一部分。此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3或S4中的一个的至少一部分。

4. 发明申请

WO2010042790A3 MULTI-SENSOR STRATEGY FOR HEART FAILURE PATIENT MANAGEMENT 审中-公开
公开(公告)号：WO2010042790A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060118
申请日：2009-10-09
申请人： CARDIAC PACEMAKERS, INC. , ZHANG, Yi , STAHMANN, Jeffrey E. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh , THOMPSON, Julie A. , HATLESTAD, John D. , BECK, Kenneth C.
发明人： ZHANG, Yi , STAHMANN, Jeffrey E. , SIEJKO, Krzysztof Z. , WARIAR, Ramesh , THOMPSON, Julie A. , HATLESTAD, John D. , BECK, Kenneth C.
IPC分类号： A61B5/02 , A61B5/00 , A61N1/39 , A61B5/085 , A61B5/0452 , A61B5/12 , A61B7/04 , A61B5/029 , A61B5/0215
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

5. 发明申请

WO2012087761A1 BIVENTRICULAR-TRIGGERED PACING FOR MULTI-SITE VENTRICULAR PACING 审中-公开
标题翻译：用于多地点静态PAC的双向触发式PAC
公开(公告)号：WO2012087761A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065260
申请日：2011-12-15
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , GILKERSON, James O. , SIEJKO, Krzysztof Z. , KALGREN, James , YU, Yinghong , BAKER, Kenneth L.
发明人： STAHMANN, Jeffrey E. , GILKERSON, James O. , SIEJKO, Krzysztof Z. , KALGREN, James , YU, Yinghong , BAKER, Kenneth L.
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/36592 , A61N1/3627 , A61N1/3684
摘要： Biventricular-triggered pacing is a pacing mode that can employ in cardiac resynchronization pacing at elevated heart rates. Described herein are methods and devices for implementing biventricular pacing in the context of multi-site left ventricular pacing.
摘要翻译：双心室触发起搏是起搏模式，可以在升高的心率下采用心脏再同步起搏。本文描述了在多局部左心室起搏背景下实现双心室起搏的方法和装置。

6. 发明申请

WO2012087758A2 LEFT VENTRICULAR PACING PROTECTION FOR MULTI-SITE LEFT VENTRICULAR PACING 审中-公开
标题翻译：左室心室起搏左室周围起搏保护
公开(公告)号：WO2012087758A2
公开(公告)日：2012-06-28
申请号：PCT/US2011/065255
申请日：2011-12-15
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , GILKERSON, James O. , SIEJKO, Krzysztof Z. , YU, Yinghong
发明人： STAHMANN, Jeffrey E. , GILKERSON, James O. , SIEJKO, Krzysztof Z. , YU, Yinghong
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684
摘要： In a pacing mode where the left ventricle is paced upon expiration of an escape interval that is reset by a right ventricular sense, there is the risk that the left ventricular pace may be delivered in the so-called vulnerable period that occurs after a depolarization and trigger an arrhythmia. To reduce this risk, a left ventricular protective period (LVPP) may be provided. Methods and devices for implementing an LVPP in the context of multi-site left ventricular pacing are described.
摘要翻译：
在左心室时由右心室感重置逃逸间隔期满节奏起搏模式，存在左心室起搏可以以所谓的待递送的风险在去极化之后发生并且引发心律失常的易损期。为了降低这种风险，可以提供左心室保护期（LVPP）。描述了在多部位左心室起搏情况下实施LVPP的方法和装置。

7. 发明申请

WO2008027242A2 CONTROLLED TITRATION OF NEUROSTIMULATION THERAPY 审中-公开
标题翻译：神经病理疗治疗的控制
公开(公告)号：WO2008027242A2
公开(公告)日：2008-03-06
申请号：PCT/US2007/018411
申请日：2007-08-20
申请人： CARDIAC PACEMAKERS, INC. , BROCKWAY, Marina V. , LIBBUS, Imad , SIEJKO, Krzysztof Z. , SWEENEY, Robert J.
发明人： BROCKWAY, Marina V. , LIBBUS, Imad , SIEJKO, Krzysztof Z. , SWEENEY, Robert J.
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译：本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。

8. 发明申请

WO2012005991A3 CARDIAC MECHANICAL VIBRATION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 审中-公开
公开(公告)号：WO2012005991A3
公开(公告)日：2012-01-12
申请号：PCT/US2011/041868
申请日：2011-06-24
申请人： CARDIAC PACEMAKERS, INC. , SWEENEY, Robert J. , SHUROS, Allan C. , SIEJKO, Krzysztof Z. , OLSON, David C. , INGLE, Frank
发明人： SWEENEY, Robert J. , SHUROS, Allan C. , SIEJKO, Krzysztof Z. , OLSON, David C. , INGLE, Frank
IPC分类号： A61N1/365 , A61B5/026 , A61B5/11 , A61N1/08
摘要： Systems and methods to monitor cardiac mechanical vibrations using information indicative of lead motion are described. In an example, a system including an implantable medical device can include an excitation circuit configured to provide a non-tissue stimulating, non-therapeutic electrical excitation signal to a portion of an implantable lead. A receiver circuit can be configured to obtain information indicative of a mechanical vibration of the implantable lead due at least in part to one or more of an impact of at least a portion of the heart to the implantable lead, or friction contact between the implantable lead and cardiac tissue. The system can include a processor circuit configured to determine one or more of a lead mechanical status, or information indicative of valvular activity using the information indicative of the mechanical vibration of the implantable lead.

9. 发明申请

WO2008085308A1 BETWEEN-PATIENT COMPARISONS FOR RISK STRATIFICATION 审中-公开
标题翻译：风险分析的患者比较
公开(公告)号：WO2008085308A1
公开(公告)日：2008-07-17
申请号：PCT/US2007/025666
申请日：2007-12-17
申请人： CARDIAC PACEMAKERS, INC. , CAZARES, Shelley, M. , PETERSON, Jon , SACHANANDANI, Haresh G. , STALSBERG, Kevin J. , SWEENEY, Robert J. , SIEJKO, Krzysztof Z. , CARLSON, Gerrard M.
发明人： CAZARES, Shelley, M. , PETERSON, Jon , SACHANANDANI, Haresh G. , STALSBERG, Kevin J. , SWEENEY, Robert J. , SIEJKO, Krzysztof Z. , CARLSON, Gerrard M.
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： G06Q50/22 , A61B5/0031 , A61N1/37282 , G06F19/00 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70
摘要： A system comprises a patient device comprising: a communication module adapted to receive patient data associated with a patient; a reference group module adapted to select and store reference group data corresponding to the patient; and an analysis module adapted to: generate a model of the reference group data; and compare the patient data to the model to calculate an index for the patient.
摘要翻译：一种系统包括患者装置，包括：通信模块，其适于接收与患者相关联的患者数据; 适于选择和存储与患者对应的参考组数据的参考组模块; 以及分析模块，其适于：生成所述参考组数据的模型; 并将患者数据与模型进行比较，以计算患者的指标。

10. 发明申请

WO2012087760A1 LEFT VENTRICLE-ONLY AND RIGHT VENTRICULAR SAFETY PACING 审中-公开
标题翻译：左通风和右心室安全
公开(公告)号：WO2012087760A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065259
申请日：2011-12-15
申请人： CARDIAC PACEMAKERS, INC. , STAHMANN, Jeffrey E. , GILKERSON, James O. , SIEJKO, Krzysztof Z. , KALGREN, James , YU, Yinghong
发明人： STAHMANN, Jeffrey E. , GILKERSON, James O. , SIEJKO, Krzysztof Z. , KALGREN, James , YU, Yinghong
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： One way in which cardiac resynchronization therapy may be delivered is to only deliver paces to the left ventricle. If left ventricular pacing is inhibited during a cardiac cycle, it may be desirable to deliver a right ventricular safety pace to prevent asystole. Methods and devices for implementing right ventricular safety pacing in the context of multi-site left ventricular-only pacing are described.
摘要翻译：进行心脏再同步治疗的一种方法是仅向左心室输送步伐。如果在心动周期期间左心室起搏受到抑制，可能需要输送右心室安全步速以防止心搏停搏。描述了在多局部左心室起搏背景下实施右心室安全起搏的方法和装置。

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