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1. 发明申请

WO2008121231A3 SYSTEMS AND LEADS FOR THERMAL NEUROINHIBITION 审中-公开
公开(公告)号：WO2008121231A3
公开(公告)日：2008-10-09
申请号：PCT/US2008/003545
申请日：2008-03-18
申请人： CARDIAC PACEMAKERS, INC. , LOVETT, Eric G. , LIBBUS, Imad , WALKER, Joseph
发明人： LOVETT, Eric G. , LIBBUS, Imad , WALKER, Joseph
IPC分类号： A61H39/06
摘要： Disclosed herein, among other things, is system for thermal neuroinhibition. According to an embodiment, the system includes at least one implantable fluid-filled conduit adapted to be placed adjacent to a neural target. The system also includes an implantable housing including a power source, a heat pump deriving power from the source and connected to the conduit, and a controller within the housing. The controller is connected to the heat pump, and is adapted to control the heat pump to effect fluid flow in the conduit to cool the neural target using electromechanical refrigeration to reversibly inhibit neural activity as part of a medical treatment.

2. 发明申请

WO2008143814A2 SYSTEMS AND METHODS FOR STIMULATING NEURAL TARGETS 审中-公开
标题翻译：用于刺激神经目标的系统和方法
公开(公告)号：WO2008143814A2
公开(公告)日：2008-11-27
申请号：PCT/US2008/006023
申请日：2008-05-12
申请人： CARDIAC PACEMAKERS, INC. , AMURTHUR, Badri , LIBBUS, Imad
发明人： AMURTHUR, Badri , LIBBUS, Imad
IPC分类号： A61N1/05 , A61N1/36 , A61B5/00
CPC分类号： A61N1/36017 , A61B5/021 , A61B5/02405 , A61B5/02416 , A61B5/026 , A61B5/14532 , A61B5/1455 , A61B5/4041 , A61B5/6815 , A61B5/6826 , A61B5/6838 , A61B8/06 , A61N1/0452 , A61N1/0456 , A61N1/0492 , A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a method for stimulating neural targets in the vicinity of a human ear. According to an embodiment, a device is clipped on a patient ear lobe, the device including a neural stimulation electrode. A neural stimulation signal is applied to the electrode to transcutaneously stimulate neural targets in the vicinity of the ear lobe, according to an embodiment. A physiological parameter is sensed using a sensor connected to the device. According to an embodiment, the neural stimulation signal is adjusted in response to the sensed parameter. The method is used is a variety of treatment regimens, including anti-hypertensive and cardiac improvement therapy.
摘要翻译：本文公开了一种用于刺激人耳附近的神经靶的方法。根据实施例，将装置夹在患者耳垂上，该装置包括神经刺激电极。根据实施例，神经刺激信号被施加到电极以经皮刺激耳垂附近的神经靶。使用连接到该装置的传感器感测生理参数。根据实施例，响应于所感测的参数来调整神经刺激信号。使用的方法是多种治疗方案，包括抗高血压和心脏改善治疗。

3. 发明申请

WO2008115507A1 SELECTIVE NERVE STIMULATION INCLUDING CLOSED-LOOP CAPABILITIES 审中-公开
标题翻译：选择性神经刺激包括闭环能力
公开(公告)号：WO2008115507A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/003574
申请日：2008-03-19
申请人： CARDIAC PACEMAKERS, INC. , SMITH, David J. , WESTLUND, Randy , LIBBUS, Imad
发明人： SMITH, David J. , WESTLUND, Randy , LIBBUS, Imad
IPC分类号： A61N1/05 , A61N1/36 , A61N1/34
CPC分类号： A61N1/36139 , A61N1/36071 , A61N1/36114 , A61N1/36185
摘要： Systems and methods for steering one or more stimulation fields to a selected nerve target, thereby optimizing one or a combination of low stimulation thresholds, desired therapy outcomes, or a minimization of adverse stimulation side-effects. An array of electrodes disposed, at least in part, on two or more neural stimulation leads are used for steering the stimulation fields to the selected nerve target and are positioned adjacent the selected target. The stimulation may be titrated based on, among other things, a detected physiologic response to the applied stimulation.
摘要翻译：用于将一个或多个刺激场转向所选择的神经靶的系统和方法，从而优化低刺激阈值，期望的治疗结果或不利刺激副作用的最小化中的一个或组合。使用至少部分地设置在两个或更多个神经刺激引线上的电极阵列，用于将刺激场转向所选择的神经靶，并且定位成与所选择的靶相邻。基于对所施加的刺激的检测到的生理反应，刺激可以被滴定。

4. 发明申请

WO2008045598A1 TRANSCUTANEOUS NEUROSTIMULATOR FOR MODULATING CARDIOVASCULAR FUNCTION 审中-公开
标题翻译：用于调节心脏功能的经视神经调节剂
公开(公告)号：WO2008045598A1
公开(公告)日：2008-04-17
申请号：PCT/US2007/071288
申请日：2007-06-15
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , CAPARSO, Anthony V. , KRAMER, Andrew P.
发明人： LIBBUS, Imad , CAPARSO, Anthony V. , KRAMER, Andrew P.
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/36017 , Y10S128/907
摘要： A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient's body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient's body using surface stimulation electrodes placed on the body approximately over the stimulation target.
摘要翻译：神经刺激装置包括由患者佩戴的外部神经刺激器，其使用支撑患者身体的一部分的支撑元件。外部神经刺激仪提供神经刺激来调节患者的心血管功能。在一个实施例中，外部刺激器将神经刺激经皮递送到患者身体中的刺激目标，其中使用放置在身体上的表面刺激电极大致超过刺激目标。

5. 发明申请

WO2008042477A1 DISTRIBUTED NEUROMODULATION SYSTEM FOR TREATMENT OF CARDIOVASCULAR DISEASE 审中-公开
标题翻译：用于治疗心血管疾病的分布式神经调节系统
公开(公告)号：WO2008042477A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/070183
申请日：2007-06-01
申请人： CARDIAC PACEMAKERS, INC. , AMURTHUR, Badri , GIROUARD, Steven , LIBBUS, Imad
发明人： AMURTHUR, Badri , GIROUARD, Steven , LIBBUS, Imad
IPC分类号： A61N1/372 , A61N1/36 , A61N1/378
CPC分类号： A61N1/37288 , A61N1/36114 , A61N1/37247 , A61N1/3787
摘要： A distributed system is described that employs electrical neural stimulation to modulate autonomic activity and which allows titration of the neural stimulation therapy in accordance with physiological measurements reflective of autonomic activity and/or physiological variables affected by the neural stimulation. Such a system may include a plurality of implantable neuromodulation units that communicate with one another over a network.
摘要翻译：描述了一种使用电神经刺激来调节自主活动的分布式系统，并且其允许根据反映受神经刺激影响的自主活动和/或生理变量的生理测量来滴定神经刺激疗法。这样的系统可以包括通过网络彼此通信的多个可植入神经调节单元。

6. 发明申请

WO2007146490A3 PHYSICAL CONDITIONING SYSTEM 审中-公开
公开(公告)号：WO2007146490A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/066918
申请日：2007-04-19
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , SPINELLI, Julio C. , PASTORE, Joseph M. , KRAMER, Andrew P.
发明人： LIBBUS, Imad , SPINELLI, Julio C. , PASTORE, Joseph M. , KRAMER, Andrew P.
IPC分类号： A61N1/36 , A61N1/372
摘要： Various system embodiments comprise a neural stimulator and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to elicit sympathetic activity at a neural target. The controller is adapted to control the neural stimulator to provide a physical conditioning therapy. The controller is adapted to control the neural stimulator to intermittently elicit sympathetic activity at the neural target. Other aspects and embodiments are provided herein.

7. 发明申请

WO2006044025A1 SYSTEM FOR SUSTAINED BAROREFLEX STIMULATION 审中-公开
标题翻译：持续性BAROREFLEX刺激系统
公开(公告)号：WO2006044025A1
公开(公告)日：2006-04-27
申请号：PCT/US2005/029540
申请日：2005-08-19
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad
发明人： LIBBUS, Imad
IPC分类号： A61N1/05
CPC分类号： A61N1/36114
摘要： In various embodiments, the implantable medical device comprises a baroreflex stimulator (1626) and a controller (1623). The baroreflex stimulator (1626) is adapted to generate a stimulation signal to stimulate a baroreflex. The controller (1623) is adapted to communicate with the baroreflex stimulator (1626) and implement a baroreflex stimulation protocol (1628) to vary an intensity of the baroreflex stimulation provided by the stimulation signal to abate baroreflex adaptation. According to various embodiments, the controller (1623) is adapted to implement the baroreflex stimulation protocol (1628) to periodically modulate the baroreflex stimulation to produce an effect that mimics an effect of pulsatile pressure.
摘要翻译：在各种实施例中，可植入医疗装置包括压力反射刺激器（1626）和控制器（1623）。压力反射刺激器（1626）适于产生刺激信号以刺激压力反射。控制器（1623）适于与压力反射刺激器（1626）通信并实施压力反射刺激方案（1628），以改变由刺激信号提供的压力反射刺激的强度以减轻压力反射适应。根据各种实施例，控制器（1623）适于实施压力反射刺激方案（1628）以周期性地调节压力反射刺激以产生模拟脉动压力效应的效果。

8. 发明申请

WO2008088798A1 SYSTEM AND DEVICES FOR ACUTE AUTONOMIC STIMULATION 审中-公开
标题翻译：急性自发性刺激的系统和设备
公开(公告)号：WO2008088798A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/000511
申请日：2008-01-15
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , NIKLES, Stefan
发明人： LIBBUS, Imad , NIKLES, Stefan
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0519 , A61B5/4035 , A61N1/0517 , A61N1/36007 , A61N1/3601 , A61N1/36017 , A61N1/36114 , A61N1/36185
摘要： Various system embodiments comprise a medical device, comprising a flexible tether, a neural stimulation circuit, and a controller. The flexible tether is adapted to be fed into a patient's throat. The flexible tether includes a plurality of electrodes. The neural stimulation circuit is adapted to deliver neural stimulation. The controller is adapted to control the neural stimulation circuit to provide a neural stimulation therapy using at least one electrode from the plurality of electrodes, and to implement a neural stimulation test routine. The neural stimulation test routine is adapted to assess neural stimulation efficacy for electrode subsets of the plurality of electrodes to identify a desired electrode subset for use in delivering the neural stimulation therapy to elicit a desired response.
摘要翻译：各种系统实施例包括医疗装置，包括柔性系绳，神经刺激电路和控制器。灵活的系绳适于喂入患者的喉咙。柔性系链包括多个电极。神经刺激电路适用于输送神经刺激。控制器适于控制神经刺激电路，以使用来自多个电极的至少一个电极提供神经刺激治疗，并实施神经刺激测试程序。神经刺激测试程序适于评估多个电极的电极子集的神经刺激功效，以识别用于递送神经刺激疗法以引出期望的响应的期望的电极子集。

9. 发明申请

WO2007078410A1 DEVICE FOR TREATING EPILEPSY AND RHYTHM DISORDERS 审中-公开
标题翻译：用于治疗癫痫病和恶心病的手段
公开(公告)号：WO2007078410A1
公开(公告)日：2007-07-12
申请号：PCT/US2006/042727
申请日：2006-11-01
申请人： CARDIAC PACEMAKERS, INC. , LIBBUS, Imad , KRAMER, Andrew P.
发明人： LIBBUS, Imad , KRAMER, Andrew P.
IPC分类号： A61N1/36 , A61N1/362
CPC分类号： A61N1/362 , A61N1/36064 , A61N1/36114 , A61N1/3622 , A61N1/3962
摘要： Various device embodiments comprise at least one pulse generator and a controller to communicate with the pulse generator(s). The pulse generator(s) is (are) adapted to deliver a first electrical signal through at least one electrode positioned proximate to a vagus nerve and to deliver a second electrical signal through at least one electrode positioned within or proximate to the heart. The controller includes a module to provide epilepsy therapy that includes delivering the first electrical signal though the at least one electrode proximate to the vagus nerve and a module to provide a cardiac rhythm management (CRM) therapy that includes delivering the second electrical signal through at least one electrode positioned within or proximate to the heart. The CRM therapy includes at least one therapy selected from an antitachycardia therapy and a cardiac resynchronization therapy (CRT).
摘要翻译：各种装置实施例包括至少一个脉冲发生器和与脉冲发生器通信的控制器。脉冲发生器适于通过位于迷走神经附近的至少一个电极传送第一电信号，并且通过位于心脏内或心脏附近的至少一个电极传送第二电信号。控制器包括提供癫痫治疗的模块，其包括通过靠近迷走神经的至少一个电极递送第一电信号，以及提供心律控制（CRM）治疗的模块，其包括至少递送第二电信号一个电极位于心脏内或靠近心脏。 CRM治疗包括至少一种选自抗心律失焦治疗和心脏再同步治疗（CRT）的治疗。

10. 发明申请

WO2006138069A1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 审中-公开
标题翻译：神经控制系统
公开(公告)号：WO2006138069A1
公开(公告)日：2006-12-28
申请号：PCT/US2006/021323
申请日：2006-06-01
申请人： CARDIAC PACEMAKERS, INC. , CAPARSO, Anthony , LIBBUS, Imad , BROOKE, M., Jason , LEE, Kent , KWOK, Jonathan , PU, Yachuan
发明人： CAPARSO, Anthony , LIBBUS, Imad , BROOKE, M., Jason , LEE, Kent , KWOK, Jonathan , PU, Yachuan
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

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