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1. 发明申请

WO2008106606A3 CAROTENOID ANALOGS AND DERIVATIVES IN THE TREATMENT OF PROSTATE CANCER 审中-公开
标题翻译： CAROTENOID ANALOGS AND DERIVATIVES IN THE ADVESTING OF PROSTATE CANCER
公开(公告)号：WO2008106606A3
公开(公告)日：2009-07-02
申请号：PCT/US2008055334
申请日：2008-02-28
申请人： CARDAX PHARMACEUTICALS INC , KING TIMOTHY J , LOCKWOOD SAMUEL F , HIEBER ANDREW DAVID , SHUBIN NICHOLAS J , JACKSON HENRY J , NADOLSKI GEOFFRY T
发明人： KING TIMOTHY J , LOCKWOOD SAMUEL F , HIEBER ANDREW DAVID , SHUBIN NICHOLAS J , JACKSON HENRY J , NADOLSKI GEOFFRY T
IPC分类号： A61K31/221 , A61K31/01 , A61K31/047 , A61K31/225 , A61K31/341 , A61P35/00
CPC分类号： A61K31/01 , A61K31/047 , A61K31/221 , A61K31/225 , A61K31/341
摘要： The presently described embodiments are directed to compositions that include one or more carotenoid analogs or derivatives for use in the treatment of prostate cancer, BPH or prostatitis. Certain embodiments provide for the use of said carotenoid analogs or derivatives in preparing compositions suitable for use in such treatments. Further embodiments provide for pharmaceutical compositions that include one or more carotenoid analogs or derivatives in combination with one or more additional compositions or medicaments suitable for the treatment of prostate cancer. Yet further embodiments provide for methods of treating prostate cancer that include administering to a subject who would benefit from such treatment pharmaceutical compositions suitable for inhibiting or reducing one or more components of NF-?B signaling in the subject undergoing said treatments, and that include carotenoid analogs or derivatives, optionally in combination with one or more additional compositions or medicaments suitable for the treatment of prostate cancer.
摘要翻译：目前描述的实施方案涉及包含用于治疗前列腺癌，BPH或前列腺炎的一种或多种类胡萝卜素类似物或衍生物的组合物。某些实施方案提供了使用所述类胡萝卜素类似物或衍生物制备适用于这种治疗的组合物。另外的实施方案提供包含一种或多种类胡萝卜素类似物或衍生物与一种或多种适合于治疗前列腺癌的其它组合物或药物组合的药物组合物。另外的实施方案提供了治疗前列腺癌的方法，其包括对受益于受治疗的受试者施用适合于抑制或减少经历所述治疗的受试者中NF-κB信号传导的一种或多种成分的药物组合物，并且包括类胡萝卜素类似物或衍生物，任选地与一种或多种适合于治疗前列腺癌的另外的组合物或药物组合。

2. 发明申请

WO2006057957A3 SYSTEM AND METHOD FOR A VARIABLE HOME POSITION DISPENSE SYSTEM 审中-公开
标题翻译：用于可变的家庭位置调节系统的系统和方法
公开(公告)号：WO2006057957A3
公开(公告)日：2007-11-15
申请号：PCT/US2005042127
申请日：2005-11-21
申请人： ENTEGRIS INC , LAVERDIERE MARC , CEDRONE JAMES , GONNELLA GEORGE , GASHGAEE IRAJ , MAGOON PAUL , KING TIMOTHY J
发明人： LAVERDIERE MARC , CEDRONE JAMES , GONNELLA GEORGE , GASHGAEE IRAJ , MAGOON PAUL , KING TIMOTHY J
IPC分类号： F04B49/00 , B67D7/30 , F04B49/06
CPC分类号： F04B43/02 , F04B13/00 , F04B49/065 , F04B2201/0201 , F04B2205/09
摘要： Embodiments of the present, invention provide a system and method for reducing the hold-up volume of a pump. More particularly, embodiments of the present invention provide a system and method for determining a home position to reduce hold-up volume at a dispense pump and/or a feed pump. The home position for the diaphragm can be selected such that the volume of the chamber at the dispense pump and/or feed pump contains sufficient fluid to perform the various steps of a dispense cycle while minimizing the hold-up volume. Additionally, the home position of the diaphragm can be selected to optimize the effective range of positive displacement.
摘要翻译：本发明的实施例提供了一种用于减小泵的保持容积的系统和方法。更具体地，本发明的实施例提供了一种用于确定原始位置以减少分配泵和/或进料泵的滞留体积的系统和方法。可以选择膜片的原始位置，使得在分配泵和/或进料泵处的室的体积包含足够的流体，以在最小化保持体积的同时执行分配循环的各个步骤。另外，可以选择隔膜的原始位置来优化正位移的有效范围。

3. 发明申请

WO2008079533A2 FUEL VAPOR RECOVERY CANISTER 审中-公开
标题翻译：燃油蒸汽回收罐
公开(公告)号：WO2008079533A2
公开(公告)日：2008-07-03
申请号：PCT/US2007083938
申请日：2007-11-07
申请人： STANT MFG INC , KING TIMOTHY J
发明人： KING TIMOTHY J
IPC分类号： F02M25/08
CPC分类号： B01D53/0415 , B01D2253/102 , B01D2259/40086 , B01D2259/402 , B01D2259/4146 , B01D2259/4516 , B01D2259/4566 , F02M25/0809 , F02M25/0854 , F02M25/089
摘要： A vehicle fuel system includes a fuel vapor recovery canister containing a carbon bed configured to capture hydrocarbon material associated with fuel vapor discharged from the fuel tank into the canister. A purge vacuum is applied to the canister to draw fuel vapor carrying reclaimed hydrocarbon material from the canister into an intake manifold coupled to an engine so that the reclaimed hydrocarbon material can be burned in the engine.
摘要翻译：车辆燃料系统包括燃料蒸气回收罐，其包含碳床，该碳床被配置为捕获与从燃料箱排放到罐中的燃料蒸汽相关联的烃类材料。吹扫真空被施加到罐上以将携带有回收的碳氢化合物材料的燃料蒸汽从罐吸入到与发动机相连的进气歧管中，使得回收的烃材料可以在发动机中燃烧。

4. 发明申请

WO0172120A3 A STRATEGY FOR MAINTAINING PREGNANCY 审中-公开
标题翻译：维护孕妇的策略
公开(公告)号：WO0172120A3
公开(公告)日：2002-02-14
申请号：PCT/US0109403
申请日：2001-03-23
申请人： GERON CORP , KING TIMOTHY J
发明人： KING TIMOTHY J
IPC分类号： A61K35/12 , C12N5/073 , A01K67/027 , A61K35/54
CPC分类号： C12N5/0604 , A61K35/12 , A61K2035/122 , C12N2510/00
摘要： Pregnancy in animals such as the pig usually does not continue to term when there are only a few embryos in the uterus. Currently available technology for maintaining pregnancy involves a series of hormone injections, and the failure rate is high. It has now been discovered that pregnancy can be maintained by complementing fertile embryos in the uterus with additional embryos that aren't expected to survive the full term of the pregnancy. Particularly suitable are parthenogenetic embryos, formed by activating and diploidizing unfertilized oocytes. The carrier embryos are engrafted into the uterus of a surrogate female, and the pregnancy continues to term without further intervention - even if the number of fertile embryos is below the minimum litter size. This provides valuable biological material that can be used for transplantation, the production of pharmaceuticals, and for agricultural use.
摘要翻译：动物如猪的妊娠通常在子宫中只有少数胚胎时不能持续。目前用于维持怀孕的技术涉及一系列激素注射，失败率高。现在已经发现，通过补充子宫中的可育胚胎可以维持怀孕，另外的胚胎预计不会在怀孕的全期生存。特别合适的是通过激活和二倍体化未受精的卵母细胞形成的孤雌胚胎。载体胚胎被移植到代孕女性的子宫中，怀孕继续进行而无需进一步干预 - 即使可育胚胎的数量低于最小产仔数。这提供了可用于移植，药物生产和农业用途的有价值的生物材料。

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