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1. 发明申请

WO2017192753A1 MULTIPHASE GEL 审中-公开
标题翻译：多相凝胶
公开(公告)号：WO2017192753A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/030892
申请日：2017-05-03
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas
IPC分类号： A61L31/12 , A61L31/14 , A61L31/16
摘要： Disclosed are hydrogels polymerized with or around a solid biofunctional moiety, biodegradable or permanent, designed to be implantable in a mammalian body, intended to block or mitigate the formation of tissue adhesions, and intended to aid in functional healing. The hydrogels of the present invention comprise multiphasic structural elements: a) at least one gel phase, b) at least one solid phase, c) optional polymeric chains connecting gel and solid phases, d) optional shape designs that provide for an interpenetrating geometry between gels and solids, e) optional shape designs that enhance a tissue-hydrogel interface, and f) optional shape designs that provide a biofunctional aspect. The hydrophobicity of the various phases is chosen to reduce tissue adhesion and enhance tissue healing. The gel phase polymer morphology is typically of high molecular weight and has morphology that encourages entanglement. Useful polymeric structures include branching chains, comb or brush, and dendritic morphologies.
摘要翻译：公开了与固体生物功能部分聚合的水凝胶，所述固体生物功能部分可生物降解或永久性设计成可植入哺乳动物体内，旨在阻断或减轻组织粘连的形成，并旨在帮助功能性愈合。本发明的水凝胶包含多相结构元件：a）至少一个凝胶相，b）至少一个固相，c）任选的连接凝胶相和固相的聚合物链，d）任选形状设计，其提供互穿几何凝胶和固体，e）增强组织 - 水凝胶界面的可选形状设计，以及f）提供生物功能方面的任选形状设计。选择各个相的疏水性以减少组织粘连并增强组织愈合。凝胶相聚合物形态通常具有高分子量并且具有鼓励缠结的形态。有用的聚合物结构包括分支链，梳子或刷子，以及树枝状形态。

2. 发明申请

WO2017190144A1 SPIN TRAP ANTI-ADHESION HYDROGELS 审中-公开
标题翻译：自旋捕获抗粘附水凝胶
公开(公告)号：WO2017190144A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/030441
申请日：2017-05-01
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas
IPC分类号： A61L27/18 , A61L27/52 , A61L31/06 , A61L31/14
摘要： Disclosed are hydrogels polymerized with a free radical scavenger, for example a spin trap. The hydrogels are biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) spin trap end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the free radical scavenging aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.
摘要翻译：公开了用自由基清除剂例如自旋捕集器聚合的水凝胶。水凝胶是可生物降解和永久性的，被设计为可植入哺乳动物体内并旨在阻断或减轻组织粘连的形成。本发明的水凝胶的特征在于包含四个结构单元：a）限定总体聚合物形态的聚合物主链，b）连接基团，c）侧链，和d）自旋捕获端基。选择各种结构元件的疏水性以减少组织粘附并增强端基的自由基清除方面。这些聚合物的形态通常具有高分子量并且具有促进缠结的形状。有用的结构包括分支链，梳子或刷子，以及树枝状形态。

3. 发明申请

WO2013052779A3 COPOLYMERS OF HYDROPHOBIC AND HYDROPHILIC SEGMENTS THAT REDUCE PROTEIN ADSORPTION 审中-公开
公开(公告)号：WO2013052779A3
公开(公告)日：2013-04-11
申请号：PCT/US2012/058921
申请日：2012-10-05
申请人： BVW HOLDING AG , BLUECHER, Lukas , MILBOCKER, Michael
发明人： BLUECHER, Lukas , MILBOCKER, Michael
IPC分类号： C08G18/64 , A61L31/10 , C08G18/66 , C08G18/12
摘要： The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.

4. 发明申请

WO2018126238A1 STENTS WITH IMPROVED FIXATION 审中-公开
公开(公告)号：WO2018126238A1
公开(公告)日：2018-07-05
申请号：PCT/US2017/069150
申请日：2017-12-30
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas , TRIP, Roel
IPC分类号： A61F2/07 , A61F2/90 , A61F2/04
摘要： The present disclosure provides stents, particularly self-expanding stents, useful for the GI tract, and more particularly, useful for treating esophageal strictures. Preferably, a portion of the stent comprises a textured surface for contact with the esophageal wall tissue to resist stent migration. The elastomer coated medial region provides a barrier to tissue ingrowth, and has an enhanced radial restoring force to maintain an open passageway in a body lumen. Optionally, the stent includes an exterior sheath with a surface pattern, to which the stent couples. A low durometer sleeve, between the stent and body lumen, axial positioning of the stent relative to the body lumen. Consequently, precision in stent placement is provided without tissue damage that could result if positioning motion occurred between the surface texture and the body lumen.

5. 发明申请

WO2017190149A1 MICROSTRUCTURED HAPTOTAXIC IMPLANT 审中-公开
标题翻译：微结构HAPTOTAXIC植入
公开(公告)号：WO2017190149A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/030463
申请日：2017-05-01
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas
IPC分类号： A61L27/50 , A61L31/14 , A61F2/30
摘要： The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.
摘要翻译：本发明涉及组织工程和再生医学领域，特别涉及利用三维印刷技术的三维仿生组织支架。通过精确地放置具有不同表面化学性质的聚合物，并使用表面结构和本体组合物来模拟可吸收和不可吸收的聚合物，以促进哺乳动物体内的功能愈合来控制表面能。

6. 发明申请

WO2017062424A1 LOW NORMAL FORCE RETRACTING DEVICE COMPRISING A MICROSTRUCTURED SURFACE 审中-公开
标题翻译：包含微结构表面的低正常力退回装置
公开(公告)号：WO2017062424A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/055453
申请日：2016-10-05
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas
IPC分类号： A61B17/02 , A61B17/00
CPC分类号： A61B17/0218 , A61B17/02 , A61B2017/00557 , A61B2017/00858 , A61B2017/00938 , A61B2017/0096 , A61B2017/0225 , A61B2017/0237 , A61B2017/0243 , A61B2217/005
摘要： The present disclosure provides surgical retractors comprising microtextured surfaces. The surgical retractors comprise a microtextured surface on one or more portions of the retractor, thereby advantageously providing immobilizing or positioning forces to a wet tissue surface while preventing or minimizing damage or trauma to the tissue.
摘要翻译：本公开提供了包括微结构表面的手术牵开器。手术牵开器包括在牵开器的一个或多个部分上的微观结构表面，由此有利地向湿组织表面提供固定或定位力，同时防止或最小化对组织的损伤或创伤。

7. 发明申请

WO2013126718A1 ANTI-EROSION SOFT TISSUE REPAIR DEVICE 审中-公开
标题翻译：防腐软组织修复装置
公开(公告)号：WO2013126718A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/027345
申请日：2013-02-22
申请人： BVW HOLDING AG , BLUECHER, Lukas , MILBOCKER, Michael
发明人： BLUECHER, Lukas , MILBOCKER, Michael
IPC分类号： A61L31/04 , A61L31/10 , A61L31/14
CPC分类号： A61F2/0063 , A61L31/04 , A61L31/10 , A61L31/148 , A61L2430/34 , C08L67/04
摘要： The present disclosure relates to surgical implants comprising a bioabsorbable incision reinforcement element, a long-term mesh, and a bioabsorbable coating disposed on the mesh. The surgical implants disclosed herein are useful in a variety of surgical procedures, particularly surgeries involving the pelvic floor. More particularly, the present disclosure relates to surgical implants, wherein an incision reinforcement element comprises a bioabsorbable material that degrades during a first time period, and the coating comprises a bioabsorbable material that degrades in a second time period, and the first time period is shorter than the second time period.
摘要翻译：本公开涉及包括生物可吸收切口加强元件，长期网和设置在网上的生物可吸收涂层的外科植入物。本文公开的手术植入物可用于各种外科手术，特别是涉及骨盆底的手术。更具体地，本公开涉及外科植入物，其中切口加强元件包括在第一时间段内降解的生物可吸收材料，并且所述涂层包括在第二时间段内降解的生物可吸收材料，并且所述第一时间段较短比第二时期。

8. 发明申请

WO2023049510A1 CAPILLARY BRIDGE ENHANCED FLUID GRIP DEVICE 审中-公开
公开(公告)号：WO2023049510A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/044897
申请日：2022-09-27
申请人： BVW HOLDING AG
发明人： MILBOCKER, Michael , BLUECHER, Lukas , TRIPP, Roel
IPC分类号： B01L3/00 , B32B3/30
摘要： A microstructured surface is disclosed capable of immobilizing or resisting displacement forces with respect to a target surface. The microstructured surface is capable of generating capillary bridges with a target surface. The capillary bridges can be further stabilized to generate a novel liquid enhanced adhesion mechanism.

9. 发明申请

WO2020028230A2 PATTERNED SURFACES WITH SUCTION 审中-公开
公开(公告)号：WO2020028230A2
公开(公告)日：2020-02-06
申请号：PCT/US2019/043879
申请日：2019-07-29
申请人： BVW HOLDING AG
发明人： BLUECHER, Lukas , MILBOCKER, Michael
摘要： A microstructured pressure- sensitive surface (102) is described comprising a Wenzel-Cassie hydrophilic- hydrophobic zone structure and capillary action with improved peel strength. The capillary action is enhanced by the Wenzel-Cassie zone creation, and the barrier energy to disruption of the Wenzel-Cassie zone is increased by the capillary action. The micro-structured surfaces of the present invention create water zones of exclusion, where entropic effects reinforce Wenzel-Cassie zone stability, creating a suction effect that conforms the micro structure surface to a target surface.

10. 发明申请

WO2019089960A1 MICROSTRUCTURED PHASE INTERFACIAL DEVICE 审中-公开
公开(公告)号：WO2019089960A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058754
申请日：2018-11-01
申请人： BVW HOLDING AG , MILBOCKER, Michael
发明人： MILBOCKER, Michael , BLUECHER, Lukas
IPC分类号： B81B1/00 , C09J7/10 , B29C59/00 , B32B7/04 , B32B3/30
摘要： The present disclosure relates to gripping surfaces and devices comprising the same, wherein the gripping surface comprises a shape tunable surface microstructure, wherein the height, width and spatial periodicity of the microstructures corresponds to an integer multiple of Schallamach wave amplitudes and wavelengths of a target surface, wherein the device microstructures and induced Schallamach waves are entrained by applying strain to the device.

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