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1. 发明申请

WO2008108825A2 NEUROPROTECTIVE COMPOSITIONS AND METHODS 审中-公开
标题翻译：神经保护组合物和方法
公开(公告)号：WO2008108825A2
公开(公告)日：2008-09-12
申请号：PCT/US2007/021748
申请日：2007-10-10
申请人： BURNHAM INSTITUTE FOR MEDICAL RESEARCH , LIPTON, Stuart, A. , SATOH, Takumi
发明人： LIPTON, Stuart, A. , SATOH, Takumi
IPC分类号： A61K31/366
CPC分类号： C07C62/32 , C07C62/38 , C07C69/757 , C07C2602/26
摘要： Neurite outgrowth-promoting prostaglandins (NEPPs) and other electrophilic compounds bind to Keapl, a negative regulator of the transcription factor Nrf2, and prevent Keapl -mediated inactivation of Nrf2 and, thus, enhance Nrf2 translocation into the nucleus of neuronal cells. Therefore, neuroprotective compositions and related methods are provided that employ such neuroprotective compounds, and prodrugs of such compounds, to cause dissociation of Nrf2 from a Keapl /Nrf2 complex.
摘要翻译：神经突起促进前列腺素（NEPPs）和其他亲电子化合物与转录因子Nrf2的负调节物Keapl结合，并且防止了Keapl介导的Nrf2的失活，从而增强了Nrf2易位到神经元细胞核中。因此，提供了神经保护组合物和相关方法，其使用这种神经保护性化合物和这些化合物的前药引起Nrf2与Keap1 / Nrf2复合物的解离。

2. 发明申请

WO2011085213A2 PATHOLOGICALLY-ACTIVATED THERAPEUTICS 审中-公开
标题翻译：病理性激活的治疗药物
公开(公告)号：WO2011085213A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020536
申请日：2011-01-07
申请人： SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE , LIPTON, Stuart, A.
发明人： LIPTON, Stuart, A.
IPC分类号： G01N33/53
CPC分类号： G01N33/53
摘要： Disclosed are methods and compositions for identifying, producing, and using pathologically-activated targeting compounds. Pathologically- activated compounds are compound that only have an effect, or have a disproportionate effect, on a target molecule when a pathological condition exists.
摘要翻译：公开了鉴定，生产和使用病理活化的靶向化合物的方法和组合物。病理活性化合物是当病理状态存在时仅对靶分子具有作用或具有不成比例效应的化合物。

3. 发明申请

WO2005110468A3 TREATMENT OF INSULIN RESISTANCE/METABOLIC SYNDROME TO ALLEVIATE THE RISKS OF DEMENTIA 审中-公开
公开(公告)号：WO2005110468A3
公开(公告)日：2005-11-24
申请号：PCT/US2005/016248
申请日：2005-05-10
申请人： THE BURNHAM INSTITUTE , LIPTON, Stuart, A. , EINHORN, Daniel
发明人： LIPTON, Stuart, A. , EINHORN, Daniel
IPC分类号： C12Q1/00 , C12Q1/60 , G01N31/00
摘要： This invention relates to Applicant’s discovery that Metabolic Syndrome, a cluster of disorders stemming from a resistance to insulin, contributes directly to dementia, particularly Alzheimer’s disease. Applicant’s invention includes a screening method to determine susceptibility and diagnosis of dementia based on the risk factors for Metabolic Syndrome. Applicant’s invention further includes methods for the prevention or treatment of dementia and other neurological conditions based on (1) minimizing insulin resistance, thereby preventing excess biosynthesis of insulin; (2) modulating the activity of IDE such that insulin competes less efficiently with β-amyloid protein for the IDE; and (3) blocking the consequences of NMDA receptor activation, such as by minimizing the generation of NO and other harmful free radicals.

4. 发明申请

WO2003016479A2 EXCITATORY GLYCINE RECEPTORS AND METHODS 审中-公开
标题翻译：精氨酸受体和方法
公开(公告)号：WO2003016479A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/026022
申请日：2002-08-16
申请人： THE BURNHAM INSTITUTE , YALE UNIVERSITY , BRIGHAM AND WOMEN'S HOSPITAL , LIPTON, Stuart, A. , ZHANG, Dongxian , CHATTERTON, Jon, E. , AWOBULUYI, Marc , SEVARINO, Kevin, A.
发明人： LIPTON, Stuart, A. , ZHANG, Dongxian , CHATTERTON, Jon, E. , AWOBULUYI, Marc , SEVARINO, Kevin, A.
IPC分类号： C12N
CPC分类号： C07K14/70571 , A61K38/00
摘要： The invention provides isolated N-methyl-D- aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.
摘要翻译：本发明提供分离的N-甲基-D-天冬氨酸3B型（NR3B）多肽，功能片段和肽，编码核酸分子和多核苷酸以及特异性抗体。还提供了含有NR3B或NR3A多肽的兴奋性甘氨酸受体。还提供了检测兴奋性甘氨酸受体配体，激动剂和拮抗剂的方法。本发明还提供了相关的诊断和治疗方法。

5. 发明申请

WO2003103608A3 NEUROPROTECTIVE SYNERGY OF ERYTHROPOIETIN AND INSULIN-LIKE GROWTH FACTOR 审中-公开
公开(公告)号：WO2003103608A3
公开(公告)日：2003-12-18
申请号：PCT/US2003/018645
申请日：2003-06-11
申请人： THE BURNHAM INSTITUTE , DIGICAYLIOGLU, Murat , LIPTON, Stuart, A.
发明人： DIGICAYLIOGLU, Murat , LIPTON, Stuart, A.
IPC分类号： G01N33/53
摘要： The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuropotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a does of at most 200 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathicpain, migraine, glaucoma, drug addition, drug withdrawal, drug dependency, depression or anxiety.

6. 发明申请

WO2003103608A2 NEUROPROTECTIVE SYNERGY OF ERYTHROPOIETIN AND INSULIN-LIKE GROWTH FACTOR 审中-公开
标题翻译：红细胞生成素和胰岛素样生长因子的神经保护性协同
公开(公告)号：WO2003103608A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/018645
申请日：2003-06-11
申请人： THE BURNHAM INSTITUTE , DIGICAYLIOGLU, Murat , LIPTON, Stuart, A.
发明人： DIGICAYLIOGLU, Murat , LIPTON, Stuart, A.
IPC分类号： A61K
CPC分类号： A61K38/30 , A61K2300/00
摘要： The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuropotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a does of at most 200 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathicpain, migraine, glaucoma, drug addition, drug withdrawal, drug dependency, depression or anxiety.
摘要翻译：本发明提供了一种通过在兴奋性侮辱时或之后诱导神经元细胞中促红细胞生成素（EPO）信号通路来提供急性神经保护作用的方法; 并在兴奋性侮辱时间附近或之后在神经元细胞中诱导胰岛素样生长因子（IGF）信号通路，从而在神经元细胞中产生协同的急性神经保护作用。本发明还提供了一种通过以至多200U / kg的剂量给予受试者EPO或其活性片段或类似物来预防或降低受试者神经系统病症的严重性的方法; 并向受试者施用IGF或其活性片段或类似物，由此提供神经病症。这种方法可用于预防或减轻例如阿尔茨海默氏病，帕金森病，亨廷顿病，癫痫，肌萎缩性侧索硬化，多发性硬化，运动障碍，HIV相关性痴呆，HIV相关神经病，神经病理性疼痛，偏头痛，青光眼，药物添加，戒毒，药物依赖，抑郁或焦虑。

7. 发明申请

WO2005019166A2 METHOD OF TARGETING A THERAPEUTIC AGENT 审中-公开
标题翻译：治疗药物的方法
公开(公告)号：WO2005019166A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/019045
申请日：2004-06-14
申请人： NEUROMOLECULAR, INC. , WENT, Gregory, T. , WASLEY, Jan, W., F. , LIPTON, Stuart, A. , LARRICK, James, W. , MEYERSON, Laurence, R. , STAMLER, Jonathan, S.
发明人： WENT, Gregory, T. , WASLEY, Jan, W., F. , LIPTON, Stuart, A. , LARRICK, James, W. , MEYERSON, Laurence, R. , STAMLER, Jonathan, S.
IPC分类号： C07D
CPC分类号： A61K31/40 , A61K47/51
摘要： Disclosed are conjugates in which an aminoadamantane derivative, such as amantadine, memantine, or rimantadine is linked to a therapeutic agent. The conjugate can then be used to target the therapeutic agent to an injured neuron.
摘要翻译：公开了其中氨基金刚烷衍生物如金刚烷胺，美金刚或金刚烷胺与治疗剂连接的缀合物。然后可以将缀合物用于将治疗剂靶向损伤的神经元。

8. 发明申请

WO2003016479A3 EXCITATORY GLYCINE RECEPTORS AND METHODS 审中-公开
公开(公告)号：WO2003016479A3
公开(公告)日：2003-02-27
申请号：PCT/US2002/026022
申请日：2002-08-16
申请人： THE BURNHAM INSTITUTE , YALE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , LIPTON, Stuart, A. , ZHANG, Dongxian , CHATTERTON, Jon, E. , AWOBULUYI, Marc , SEVARINO, Kevin, A.
发明人： LIPTON, Stuart, A. , ZHANG, Dongxian , CHATTERTON, Jon, E. , AWOBULUYI, Marc , SEVARINO, Kevin, A.
IPC分类号： C12N1/21 , C12N1/15 , C12N5/10 , C12N15/12 , C12N15/63
摘要： The invention provides isolated N-methyl-D- aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also provided are excitatory glycine receptors, containing either NR3B or NR3A polypeptides. Further provided are methods for detecting excitatory glycine receptor ligands, agonists and antagonists. The invention also provides related diagnostic and therapeutic methods.

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