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    • 2. 发明申请
    • BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
    • 苯并噻唑和氰基苯并噻唑化合物可用作激酶抑制剂
    • WO2007016392A2
    • 2007-02-08
    • PCT/US2006/029520
    • 2006-07-28
    • BRISTOL-MYERS SQUIBB COMPANYLIU, ChunjianLEFTHERIS, KaterinaLIN, James
    • LIU, ChunjianLEFTHERIS, KaterinaLIN, James
    • C07D417/04C07D513/04A61K31/428
    • C07D513/04C07D417/04
    • A compound of Formula (I), or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: (a); (b); (c); or (d), further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein. Also disclosed is a compound of Formula (II), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: (a); (b); (c); (d); or (e), further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.
    • 式(I)的化合物或其对映异构体,非对映异构体或药学上可接受的盐,其中A独立地选自:(a); (B); (C); 或(d)中,进一步地,其中R 1,R 2,R 3,R 4,R 5,R 6,R 7和W如本文所述。 还公开了式(II)的化合物或其对映异构体,非对映异构体或药学上可接受的盐,其中G,X和Y各自独立地为CH或N,其中在每次出现时,G,X 或者Y是N而G,X或Y中的另外两个是CH; 和B独立地选自:(a); (B); (C); (d); 或(e)中,进一步其中R 1,R 2,R 3,R 4,R 5,R 8,R 9和Z如本文所述。 还公开了含有式(I)和式(II)化合物的药物组合物,以及治疗与p38激酶活性相关的病症的方法。