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    • 3. 发明申请
    • HANDPIECE OF AN ELECTRIC TOOTHBRUSH AND CHARGING UNIT FOR THE SAME
    • 电动牙刷的一部分和为此装载的部分
    • WO2007022949A3
    • 2007-05-31
    • PCT/EP2006008230
    • 2006-08-22
    • BRAUN GMBHKRESSNER GERHARDHAAS MARTIN
    • KRESSNER GERHARDHAAS MARTIN
    • A61C17/22
    • A61C17/225A61C17/22A61C17/224
    • The invention relates to a handpiece of an electric toothbrush having a housing in which a drive unit is received. Said housing has a front or rear housing opening that can be closed by a cover in a preferably moisture- and liquid-proof manner. Snap-in means are provided on the housing and/or the cover for snap-locking the cover on the housing. The aim of the invention is to provide a combination of snap-in and threaded engagement for releasing the snap-in connection between the cover and the housing. For this purpose, at least one draft taper or curve, increasing in relation to the longitudinal axis of the housing, is provided on the housing and/or the cover. The cover can be axially lifted using said draft taper by twisting it about the longitudinal axis of the housing and the snap-in means are released. The draft taper or curve allows a threaded engagement of the cover with the housing and effects, for releasing the snap-in connection, a translation of a rotational movement of the cover into an axial movement of the same in a screw-on type manner. The snap-in means can be released in a power-saving manner by twisting the cover and they are forced to unlock by way of a restricted guidance having a threaded or curve engagement. The combination of snap-in connection of the cover and the housing and the draft taper or curve allowing a threaded or curve engagement for detaching the cover by twisting the same allows for a firm connection between the cover and the housing transmitting even high cleaning forces while facilitating a comparatively power-saving unlocking of the snap-in connection.
    • 本发明涉及一种具有外壳的电动牙刷,其中,驱动单元被容纳的手柄,所述具有面或后壳体开口壳体,优选地由盖水分和液密地封闭,其特征在于,在壳体上和/或 盖锁定装置被设置用于将盖锁定到壳体。 提出了用于释放盖和壳体之间的锁定的锁定和螺纹接合的组合。 根据本发明的壳体和/或盖的至少一个上升设置在壳体纵向轴线的锥形或曲线草案经由其通过绕壳体的纵向轴线的旋转盖在轴向上与外壳剥离和所述锁定装置是可拆卸的。 锥形或曲线草案允许所述盖和所述外壳之间的螺纹接合,并且使闩锁盖的旋转运动反应到相同的在螺杆的方式轴向运动的释放。 通过转动盖子,可以利用锁定装置来节省能量,这是通过用螺钉或凸轮接合进行的强制操作来解锁的。 由盖锁定到所述壳体和螺杆或凸轮随动件允许锥形或曲线草案通过接通实现一方面释放相同的盖,另一方面,然而,组合盖和壳体之间的固体,以及高清洁力传递连接相对省电 解锁Verrastun允许。
    • 4. 发明申请
    • MULTIPOTENT AMNIOTIC FETAL STEM CELLS (MAFSC) AND BANKING OF SAME
    • 多发性乳腺癌细胞(MAFSC)及其相应的药物
    • WO2005017117A3
    • 2009-04-09
    • PCT/US2004026304
    • 2004-08-13
    • HAAS MARTIN
    • HAAS MARTIN
    • C12N5/00A01N1/02C12N20060101C12N5/073C12N5/074G01N33/48G01N33/50G06F19/00
    • C12N5/0605C12N5/0607C12N2500/25C12N2501/11C12N2501/115C12N2501/135C12N2501/39
    • A source of multipotent amniotic fluid/fetal stem cells (MAFSCs) is disclosed. MAFSC are of fetal origin and have a normal diploid karyotype. These cells are characterized by the following cell surface markers: SSEA3, SSEA4, Tra-1-60, Tra-1-81, Tra-2-54, HLA class I, CD13, CD44, CD49b, CD105 and are distinguished by the absence of the antigen markers CD34, CD45, and HLA Class II, but are distinguished from mouse embryonic stem cells in that these cells do not express the cell surface marker SSEA1. MAFSC express the stem cell transcription factor Oct-4. MAFSC cells can be propagated for an indefinite period of time in continuous culture in an undifferentiated state. The MAFSCs have the ability to differentiate in culture in a regulated manner, into three or more subphenotypes. Cells can then be differentiated into endodermal, mesodermal and ectodermal derived tissues in vitro and in vivo. A method for isolating, identifying, expanding and differentiating MAFSCs is disclosed. Additionally, methods of banking MAFSCs derived from the amniotic fluid cells of pregnant individuals are disclosed. Amniotic fluid-derived cells are banked for the purpose of access to transplantation antigen-compatible or syngeneic multipotent stem cells.
    • 公开了多潜能羊水/胎儿干细胞(MAFSCs)的来源。 MAFSC是胎儿来源的,具有正常的二倍体核型。 这些细胞的特征在于以下细胞表面标志物:SSEA3,SSEA4,Tra-1-60,Tra-1-81,Tra-2-54,HLA I类,CD13,CD44,CD49b,CD105, 的抗原标记CD34,CD45和HLA II类,但与小鼠胚胎干细胞不同,因为这些细胞不表达细胞表面标志物SSEA1。 MAFSC表达干细胞转录因子Oct-4。 MAFSC细胞可以在未分化状态的连续培养中繁殖无限期。 MAFSC有能力以受监管的方式将文化区分成三个或更多个亚型。 然后可以在体外和体内将细胞分化成内胚层,中胚层和外胚层衍生的组织。 公开了一种用于隔离,识别,扩展和区分MAFSC的方法。 另外,公开了从怀孕个体的羊水细胞获得的银行MAFSC的方法。 为了获得移植抗原相容性或同基因多能干细胞而将羊水来源的细胞储存起来。