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1. 发明申请

WO2012054166A1 MEDICAL IMPLANT INCLUDING A MAGNESIUM-BASED TIE LAYER 审中-公开
标题翻译：医疗植入物包括一个基于镁的层状物
公开(公告)号：WO2012054166A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/052486
申请日：2011-09-21
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GREGORICH, Daniel J. , MEYER, Michael P. , STINSON, Jonathan S.
发明人： GREGORICH, Daniel J. , MEYER, Michael P. , STINSON, Jonathan S.
IPC分类号： A61L27/04 , A61L27/30 , A61L27/54 , A61L31/02 , A61L31/08 , A61L31/16
CPC分类号： A61L31/022 , A61L27/04 , A61L27/306 , A61L27/54 , A61L31/088 , A61L31/16 , A61L2300/00
摘要： A medical implant includes a metallic base, a tie layer, and at least a first layer overlying an outer surface of the tie layer. The tie layer is bonded to at least a portion of a surface of the metallic base. The tie layer includes magnesium or a magnesium-based alloy. The tie layer can have an outer surface comprising dendritic grains. The tie layer can have a rough outer surface defined by pores, projecting grain structures, and/or projecting particles. A method of producing a tie layer on a medical device includes applying magnesium or a magnesium-based alloy to the medical device and cooling the magnesium or the magnesium-based alloy to produce a rough outer surface.
摘要翻译：医疗植入物包括金属基底，连接层，以及覆盖连接层的外表面的至少第一层。粘结层结合到金属基底表面的至少一部分上。连接层包括镁或镁基合金。连接层可以具有包括树枝状晶粒的外表面。连接层可以具有由孔，突出的颗粒结构和/或突出的颗粒限定的粗糙的外表面。在医疗装置上制造粘结层的方法包括将镁或镁基合金施加到医疗装置上并冷却镁或镁基合金以产生粗糙的外表面。

2. 发明申请

WO2006060534A1 MEDICAL DEVICES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：医疗器械及其制造方法
公开(公告)号：WO2006060534A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043410
申请日：2005-11-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , STINSON, Jonathan S. , GREGORICH, Daniel J.
发明人： STINSON, Jonathan S. , GREGORICH, Daniel J.
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2002/91575 , A61F2210/0004 , A61F2250/0031 , A61F2250/0043 , A61F2250/0071
摘要： Medical devices, such as stents, and methods of making the devices, are described. In some embodiments, the invention features a medical (16) device that includes a member having a first portion (26) and a second portion (28) that define an electrically conductive loop. The first portion is adapted to break or erode after expansion of the medical device, and the second portion is not adapted to break or erode after expansion of the medical device. The breaking or erosion of the first portion breaks the electrically conductive loop.
摘要翻译：描述诸如支架的医疗装置和制造装置的方法。在一些实施例中，本发明的特征在于包括具有限定导电环路的第一部分（26）和第二部分（28）的构件的医疗（16）装置。第一部分适于在医疗装置膨胀之后破裂或侵蚀，并且第二部分不适于在医疗装置膨胀之后破裂或侵蚀。第一部分的断裂或侵蚀破坏了导电环路。

3. 发明申请

WO2008036457A2 CONTROLLING BIODEGRADATION OF A MEDICAL INSTRUMENT 审中-公开
标题翻译：控制医用仪器的生物降解
公开(公告)号：WO2008036457A2
公开(公告)日：2008-03-27
申请号：PCT/US2007/073839
申请日：2007-07-19
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GIRTON, Timothy S. , GREGORICH, Daniel J. , MESSAL, Todd
发明人： GIRTON, Timothy S. , GREGORICH, Daniel J. , MESSAL, Todd
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/88 , A61F2/90 , A61F2/91 , A61F2250/003 , A61L31/148
摘要： An endoprothesis comprising a bioerodible body having local erosion rates of the body that vary as a continuous function of radial distance from the longitudinal axis.
摘要翻译：一种内部旋转体，其包括具有本体的局部侵蚀速率的生物可蚀性体，其作为与纵向轴线的径向距离的连续函数而变化。

4. 发明申请

WO2007028058A2 ADJUSTABLE STIFFNESS CATHETER 审中-公开
标题翻译：可调节的刚性导管
公开(公告)号：WO2007028058A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/034295
申请日：2006-09-01
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GREGORICH, Daniel J. , YOON, Soo-Young , MEYER, Michael P. , DAVIS, Liza J.
发明人： GREGORICH, Daniel J. , YOON, Soo-Young , MEYER, Michael P. , DAVIS, Liza J.
IPC分类号： A61M25/00
CPC分类号： A61M25/0051 , A61B1/00078 , A61M25/0045 , A61M25/0053 , A61M25/0054 , A61M25/0097 , A61M2025/0046 , A61M2025/0058 , A61M2025/0063 , A61M2025/0065
摘要： Medical devices such as catheters can include structure or provision that permit a physician or other health care professional to adjust the stiffness of at least a portion of the medical device. In some instances, the medical device may be adjusted prior to inserting the medical device into a patient. In some cases, the medical device may be adjusted while in use within the patient.
摘要翻译：诸如导管之类的医疗装置可以包括允许医师或其他健康护理专业人员调整医疗装置的至少一部分的刚度的结构或设置。在一些情况下，可以在将医疗装置插入患者之前调整医疗装置。在某些情况下，医疗设备可能在患者体内使用时进行调整。

5. 发明申请

WO2011126708A1 ENDOPROSTHESIS 审中-公开
标题翻译：内置假体
公开(公告)号：WO2011126708A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/029002
申请日：2011-03-18
申请人： BOSTON SCIENTIFIC SCIMED, INC. , WEBER, Jan , ATANASOSKA, Liliana , SHIPPY III, James Lee , SCHEUERMANN, Torsten , GREGORICH, Daniel J. , MEYER, Michael P.
发明人： WEBER, Jan , ATANASOSKA, Liliana , SHIPPY III, James Lee , SCHEUERMANN, Torsten , GREGORICH, Daniel J. , MEYER, Michael P.
IPC分类号： A61L31/08 , A61L31/14
CPC分类号： A61L31/088 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/148 , A61L31/16 , Y10T29/49826 , C08L67/04
摘要： Among other things, a bio-erodible implantable endoprosthesis comprises a member that includes (a) a core having a surface, and (b) a bio-erodible metal on a least a portion of the surface of the core, wherein the bio-erodible metal erodes more slowly than the core and includes openings through which physiological fluids can access the core upon implantation.
摘要翻译：除其他之外，生物可蚀刻的可植入内用假体包括一种构件，其包括（a）具有表面的芯，和（b）芯的表面的至少一部分上的生物可侵蚀金属，其中生物可蚀刻金属腐蚀比核心更慢，并且包括生理流体在植入时可通过其进入核心的开口。

6. 发明申请

WO2009108816A1 BALLOON CATHETER WITH DURABLE TIP PORTION 审中-公开
标题翻译：具有耐用提示部分的气泡导管
公开(公告)号：WO2009108816A1
公开(公告)日：2009-09-03
申请号：PCT/US2009/035350
申请日：2009-02-26
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GREGORICH, Daniel J. , GUNDALE, Ben
发明人： GREGORICH, Daniel J. , GUNDALE, Ben
IPC分类号： A61M29/02
CPC分类号： A61M25/104 , A61M2025/1093 , Y10T29/49826
摘要： A durable distal tip structure for an intravascular catheter that may include a distal portion comprising a ring of durable material configured to provide a durable distal tip to the catheter, and a proximal portion extending proximally from the distal portion and configured for connecting the distal tip structure to the catheter, wherein the proximal portion of the distal tip structure is more laterally flexible than the distal portion. In some cases, the durable distal tip structure comprises a metal or metal alloy, and in some cases, the distal ring portion and proximal portion of the durable distal tip structure comprise a single monolith of material. Also, catheters including such durable distal tip structures, and methods of making and using such catheters. In some cases, the catheter is a balloon catheter. In some other embodiments, the catheter is a stent delivery catheter for a self expanding stent.
摘要翻译：一种用于血管内导管的耐久的远侧末端结构，其可包括远侧部分，所述远端部分包括耐久材料环，构造成向导管提供耐久的远端尖端，以及近端部分，其从远端部分向近侧延伸并且构造成用于连接远端尖端结构导管，其中远端尖端结构的近端部分比远侧部分更侧向地柔性。在一些情况下，耐用的远侧末端结构包括金属或金属合金，并且在一些情况下，耐久的远侧末端结构的远端环部分和近端部分包括单个整料材料。此外，包括这种耐久的远端尖端结构的导管以及制造和使用这种导管的方法。在一些情况下，导管是球囊导管。在一些其他实施例中，导管是用于自扩张支架的支架输送导管。

7. 发明申请

WO2006105192A1 ENDOPROSTHESES 审中-公开
标题翻译：用假体
公开(公告)号：WO2006105192A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/011457
申请日：2006-03-29
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GREGORICH, Daniel J.
发明人： GREGORICH, Daniel J.
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2230/0054 , A61F2250/0036
摘要： Medical devices, such as endoprostheses, are disclosed. In some embodiments, an endoprosthesis includes a circumferentially-oriented band (22) including two curved portions (26) and a first portion (28) connecting the two curved portions, the first portion having a first width and at least one curved portion having a second width; and a connector extending from the band; wherein the second width is greater than the first width.
摘要翻译：公开了医疗装置，例如内用假体。在一些实施例中，内假体包括周向定向的带（22），包括两个弯曲部分（26）和连接两个弯曲部分的第一部分（28），第一部分具有第一宽度和至少一个弯曲部分，第二宽以及从所述带延伸的连接器; 其中所述第二宽度大于所述第一宽度。

8. 发明申请

WO2015057518A1 PRESSURE SENSING GUIDEWIRE AND METHODS FOR CALCULATING FRACTIONAL FLOW RESERVE 审中-公开
标题翻译：压力传感指南及计算流量储备的方法
公开(公告)号：WO2015057518A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/060117
申请日：2014-10-10
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： GREGORICH, Daniel J.
IPC分类号： A61B5/00 , A61B5/0215
CPC分类号： A61B5/02007 , A61B5/02154 , A61B5/6851 , A61B5/7225 , A61B5/7278
摘要： Medical devices and methods for making and using medical devices are disclosed. An example method may include a method for calculating fractional flow reserve including providing a pressure sensing guidewire, advancing the pressure sensing guidewire through a blood vessel to a first position distal of an intravascular occlusion, determining a distal pressure within the body lumen with the pressure sensing guidewire, proximally shifting the pressure sensing guidewire to a second position proximal of the occlusion, determining a proximal pressure within the body lumen with the pressure sensing guidewire, measuring an aortic pressure, and calculating a pressure drift. The pressure drift may be the difference between the aortic pressure and the proximal pressure. The method may also include calculating a drift-compensated fractional flow reserve. The drift-compensated fraction flow reserve may correspond to (the distal pressure + the pressure drift) divided by the aortic pressure.
摘要翻译：公开了用于制造和使用医疗装置的医疗装置和方法。示例性方法可以包括用于计算分数流量储备的方法，包括提供压力感测导线，将压力感测导线通过血管推进到血管内闭塞的远端的第一位置，利用压力感测确定体腔内的远侧压力导线，将压力感测导丝向近侧移动到闭塞附近的第二位置，使用压力感测导线确定体腔内的近侧压力，测量主动脉压力并计算压力漂移。压力漂移可能是主动脉压力和近端压力之间的差异。该方法还可以包括计算漂移补偿分数流量储备。漂移补偿分数流量储备可以对应于（远端压力+压力漂移）除以主动脉压力。

9. 发明申请

WO2014149688A1 PRESSURE SENSING GUIDEWIRE 审中-公开
标题翻译：压力感应指南
公开(公告)号：WO2014149688A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/020345
申请日：2014-03-04
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： GREGORICH, Daniel J.
IPC分类号： A61M25/09 , A61B5/00 , A61B5/0215 , A61M25/00
CPC分类号： A61B5/02154 , A61B5/0215 , A61B5/6851 , A61B5/6852 , A61M25/09 , A61M2025/0002 , A61M2025/09108 , A61M2025/09183
摘要： Medical devices and methods for making medical devices are disclosed. An example medical device (300) includes a pressure sensing guidewire. The pressure sensing guidewire may include a tubular member (312) having a proximal portion (349) and a distal portion (348). The distal portion may have a plurality of slots (318) formed therein. The distal portion may have a first wall thickness along a first region and a second wall thickness different from the first wall thickness along a second region. A pressure sensor (320) may be disposed within the distal portion of the tubular member.
摘要翻译：公开了用于制造医疗装置的医疗装置和方法。示例性医疗装置（300）包括压力感测导丝。压力感测导丝可以包括具有近端部分（349）和远端部分（348）的管状构件（312）。远侧部分可以具有形成在其中的多个狭槽（318）。远侧部分可以具有沿第一区域的第一壁厚度和沿第二区域不同于第一壁厚度的第二壁厚度。压力传感器（320）可以设置在管状构件的远端部分内。

10. 发明申请

WO2014005095A1 PRESSURE SENSING GUIDEWIRE 审中-公开
标题翻译：压力感应指南
公开(公告)号：WO2014005095A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/048720
申请日：2013-06-28
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： GREGORICH, Daniel J.
IPC分类号： A61B5/0215 , A61M25/09 , A61B5/00
CPC分类号： A61B5/02154 , A61B5/0084 , A61B5/0215 , A61B5/6851 , A61M2025/0915
摘要： Medical devices and methods for making and using medical devices are disclosed. An example medical device includes a pressure sensing guidewire. The pressure sensing guidewire may include a shaft having a proximal portion, a distal portion, and a distal tip portion. The distal portion may have a plurality of slots formed therein. A pressure sensor may be disposed within the distal portion of the shaft.
摘要翻译：公开了用于制造和使用医疗装置的医疗装置和方法。示例性医疗装置包括压力感测导丝。压力感测导丝可以包括具有近端部分，远侧部分和远侧末端部分的轴。远侧部分可以具有形成在其中的多个狭槽。压力传感器可以设置在轴的远端部分内。

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