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1. 发明申请

WO2009158333A3 MEDICAL DEVICES FOR DELIVERY OF THERAPEUTIC AGENT IN CONJUNCTION WITH GALVANIC CORROSION 审中-公开
标题翻译：用于与治疗性腐蚀相关的用于输送治疗药物的医疗装置
公开(公告)号：WO2009158333A3
公开(公告)日：2010-08-19
申请号：PCT/US2009048242
申请日：2009-06-23
申请人： BOSTON SCIENT SCIMED INC , ATANASOSKA LILIANA , WEBER JAN , GROSSO PAUL , WARNER ROBERT W , SEETHAMRAJU KASYAP V
发明人： ATANASOSKA LILIANA , WEBER JAN , GROSSO PAUL , WARNER ROBERT W , SEETHAMRAJU KASYAP V
IPC分类号： A61L31/02 , A61L31/16
CPC分类号： A61L31/022 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16 , A61L2300/00
摘要： According to an aspect of the present invention, at least one ionic therapeutic agent is delivered from an implantable or insertable medical device that comprises an ion-conductive polymeric region that is disposed on a metallic region. The metallic region is in electrical contact with a dissimilar metallic region, such that a galvanic current is generated by the dissimilar metals when the device is implanted or inserted into a patient. Delivery of the ionic therapeutic agent from the ion-conductive polymeric region may be, for example, either accelerated or retarded by the galvanic current. According to another aspect of the present invention, implantable or insertable medical devices are provided which comprise: (a) a first metallic region having a first corrosion potential, (b) a second metallic region in electrical contact with the first metallic region and having a second corrosion potential that is greater than the first corrosion potential, and (c) a solid ion-conductive polymeric region, comprising an ion conducting polymer and an ionic therapeutic agent, disposed on the first metallic region, the second metallic region, or both.
摘要翻译：根据本发明的一个方面，至少一种离子治疗剂从可植入或可插入的医疗装置输送，其包括设置在金属区域上的离子导电聚合物区域。金属区域与异种金属区域电接触，使得当器件植入或插入患者体内时，异种金属产生电流。离子导电聚合物区域的离子治疗剂的递送可以例如由电流加速或延迟。根据本发明的另一方面，提供了可植入或可插入的医疗装置，其包括：（a）具有第一腐蚀电位的第一金属区域，（b）与第一金属区域电接触的第二金属区域，第二腐蚀电位大于第一腐蚀电位，和（c）固体离子传导聚合物区域，其包含离子导电聚合物和离子治疗剂，设置在第一金属区域，第二金属区域或两者上。

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