专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005123736A8 NOVEL 2-BENZYLAMINODIHYDROPTERIDINONES, METHOD FOR PRODUCING THEM AND USE THEREOF AS DRUGS 审中-公开
标题翻译：新的2 BENZYLAMINODIHYDROPTERIDINONE，方法及其及其作为药物
公开(公告)号：WO2005123736A8
公开(公告)日：2006-03-30
申请号：PCT/EP2005006404
申请日：2005-06-15
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , HOFFMANN MATTHIAS , STEEGMAIER MARTIN , GRAUERT MATTHIAS , LEHMANN-LINTZ THORSTEN , REDEMANN NORBERT , SOLCA FLAVIO
发明人： HOFFMANN MATTHIAS , STEEGMAIER MARTIN , GRAUERT MATTHIAS , LEHMANN-LINTZ THORSTEN , REDEMANN NORBERT , SOLCA FLAVIO
IPC分类号： A61K31/519 , A61P35/00 , C07D475/00
CPC分类号： C07D475/00
摘要： The invention relates to the novel 2-benzylaminodihydropteridinones of general formula (I), wherein the groups R
摘要翻译：本发明涉及新的2- Benzylaminodihydropteridinone通式（I）其中基团R1至R7，R10和R11具有权利要求书和说明书中给出的含义，它们的异构体，制备这些二氢喋啶酮和作为药物中的用途的处理。

2. 发明申请

WO2006021378A8 DIHYDROPTERIDINONE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译： DIHYDROPTERIDINONDERIVATE，方法及其及其作为药物
公开(公告)号：WO2006021378A8
公开(公告)日：2006-04-27
申请号：PCT/EP2005008990
申请日：2005-08-19
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , GRAUERT MATTHIAS , HOFFMANN MATTHIAS , STEEGMAIER MARTIN , EICKMEIER CHRISTIAN , SCHNAPP GISELA , REDEMANN NORBERT , SOLCA FLAVIO , QUANT JENS JUERGEN
发明人： GRAUERT MATTHIAS , HOFFMANN MATTHIAS , STEEGMAIER MARTIN , EICKMEIER CHRISTIAN , SCHNAPP GISELA , REDEMANN NORBERT , SOLCA FLAVIO , QUANT JENS JUERGEN
IPC分类号： C07D475/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D487/04 , C07D475/00 , Y02P20/55
摘要： The invention relates to novel dihydropteridinones of general formula (I), in which the radicals L, R
摘要翻译：本发明涉及通式（I）中，新颖的二氢喋啶酮其中基团L，R

3. 发明申请

WO2006021379A8 DIHYDROPTERIDINONE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：二氢蝶啶酮衍生物，其制备方法及其作为药物的用途
公开(公告)号：WO2006021379A8
公开(公告)日：2006-04-27
申请号：PCT/EP2005008991
申请日：2005-08-19
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , GRAUERT MATTHIAS , HOFFMANN MATTHIAS , STEEGMAIER MARTIN , SOLCA FLAVIO , QUANT JENS JUERGEN
发明人： GRAUERT MATTHIAS , HOFFMANN MATTHIAS , STEEGMAIER MARTIN , SOLCA FLAVIO , QUANT JENS JUERGEN
IPC分类号： C07D475/04 , A61K31/4375 , A61P35/00
CPC分类号： C07D295/155 , C07D487/04 , Y02P20/55
摘要： The invention relates to novel dihydropteridinones of general formula (I), in which the radicals L, R
摘要翻译：本发明涉及通式（I）的新的二氢喋啶酮，其中基团L，R

4. 发明申请

WO2006008028A8 NOVEL 6-FORMYLTETRAHYDROPTERIDINES METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENT AGAINST CANCER AMONGST OTHER THINGS 审中-公开
标题翻译：新的6-甲酰基 - 四氢蝶啶，其制备方法以及它们作为药物的用途，U.A. 反对癌症
公开(公告)号：WO2006008028A8
公开(公告)日：2006-03-30
申请号：PCT/EP2005007532
申请日：2005-07-12
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , HOFFMANN MATTHIAS , GRAUERT MATTHIAS , STEEGMAIER MARTIN , SOLCA FLAVIO
发明人： HOFFMANN MATTHIAS , GRAUERT MATTHIAS , STEEGMAIER MARTIN , SOLCA FLAVIO
IPC分类号： C07D475/00 , A61K31/519
CPC分类号： C07D475/00
摘要： The invention relates to novel 6-formyltetrahydropteridines of general formula (I), where the groups R
摘要翻译：本发明涉及其中基团R

5. 发明申请

WO2005113515A8 PYRIMIDINES FOR USE AS PLK INHIBITORS 审中-公开
标题翻译：嘧啶，其PLK抑制剂
公开(公告)号：WO2005113515A8
公开(公告)日：2006-11-02
申请号：PCT/EP2005052214
申请日：2005-05-13
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , STADTMUELLER HEINZ , ENGELHARDT HARALD , REISER ULRICH , ZAHN STEPHAN KARL , HAUPTMANN RUDOLF , STEEGMAIER MARTIN , GUERTLER ULRICH , HOFFMANN MATTHIAS , GRAUERT MATTHIAS
发明人： STADTMUELLER HEINZ , ENGELHARDT HARALD , REISER ULRICH , ZAHN STEPHAN KARL , HAUPTMANN RUDOLF , STEEGMAIER MARTIN , GUERTLER ULRICH , HOFFMANN MATTHIAS , GRAUERT MATTHIAS
IPC分类号： C07D239/48 , A61K31/505 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07D401/12 , C07D403/12
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： The invention relates to the compounds of formula (1), wherein A, X, Y, Z, R a , R b , R c , R 1 , R 2 and R 3 are defined as in claim 1. These compounds are suitable for use in the treatment of diseases which are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of these compounds in the production of a drug having the above-mentioned properties.
摘要翻译：本发明包括通式（1）化合物，其中A，X，Y，Z，R ^{一，R ^{B'/ SUP>，R ^{C ，R ^{1 ，R ^{2 和R ^{3 是如权利要求1中所定义，对于疾病的治疗特征为过度或异常细胞增殖的是合适的，并且其用于生产具有上述特性的药物。}}}}}}

6. 发明申请

WO2007057399A2 TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症
公开(公告)号：WO2007057399A2
公开(公告)日：2007-05-24
申请号：PCT/EP2006068461
申请日：2006-11-14
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , SOMMERGRUBER WOLFGANG , KRAUT NORBERT , SCHWEIFER NORBERT , RETTIG WOLFGANG , HILBERG FRANK , SOLCA FLAVIO , STEEGMAIER MARTIN
发明人： SOMMERGRUBER WOLFGANG , KRAUT NORBERT , SCHWEIFER NORBERT , RETTIG WOLFGANG , HILBERG FRANK , SOLCA FLAVIO , STEEGMAIER MARTIN
IPC分类号： A61P35/00 , A61K31/404
CPC分类号： A61K31/404
摘要： The invention is based on the finding that indolinones are useful for the therapy of diseases which result from aberrant activity of a kinase selected from the group comprising AXL, FLT3, MEK1, and RET.
摘要翻译：本发明基于以下发现：吲哚啉酮可用于治疗由选自包括AXL，FLT3，MEK1和RET的组的激酶的异常活性引起的疾病。

7. 发明申请

WO2006018182A8 COMBINATIONS FOR THE TREATMENT OF DISEASES INVOLVING CELL PROLIFERATION 审中-公开
标题翻译：用于治疗涉及细胞增殖的疾病的组合
公开(公告)号：WO2006018182A8
公开(公告)日：2006-06-08
申请号：PCT/EP2005008623
申请日：2005-08-09
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , MUNZERT GERD , STEEGMAIER MARTIN , BAUM ANKE
发明人： MUNZERT GERD , STEEGMAIER MARTIN , BAUM ANKE
IPC分类号： A61K31/4985 , A61K31/435 , A61K31/4409 , A61K31/519
CPC分类号： A61K31/4985 , A61K31/435 , A61K31/4409 , A61K31/519
摘要： The present invention relates to a pharmaceutical composition for the treatment of diseases which involve cell proliferation. The invention also relates to a method for the treatment of said diseases, comprising co-administration of a compound 1 of Formula (I) wherein the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, optionally in form of its tautomers, racemates, enantiomers, diastereomers and the mixtures thereof and optionally in form of the pharmacologically acceptable acid addition salts, solvates, hydrates, polymorphs, physiologically functional derivatives or prodrugs thereof, and of an effective amount of an active compound 2 and/or co-treatment with radiation therapy, in a ratio which provides an additive and synergistic effect, and to the combined use of a compound 1 of Formula (I) and of an effective amount of an active compound 2 and/or radiotherapy for the manufacture of corresponding pharmaceutical combination preparations.
摘要翻译：本发明涉及用于治疗涉及细胞增殖的疾病的药物组合物。本发明还涉及治疗所述疾病的方法，包括共同给予式（I）化合物1，其中基团L，R 1，R 2，R 3，R 4和R 5具有权利要求书和说明书中给出的含义，任选以其互变异构体，外消旋体，对映异构体，非对映体及其混合物的形式，并且任选呈药理学上可接受的酸加成盐，溶剂合物，水合物，多晶型物，生理功能衍生物或前药的形式，以及有效量的活性化合物2和/或以放射疗法共同治疗，以提供添加剂和协同效应的比例，以及组合使用式（I）化合物1和有效量的活性化合物2和/或放射治疗用于制造相应的药物组合制剂。

8. 发明申请

WO2006018185A2 DIHYDROPTERIDINONES FOR THE TREATMENT OF CANCER DISEASES 审中-公开
标题翻译：用于治疗癌症的止痛药
公开(公告)号：WO2006018185A2
公开(公告)日：2006-02-23
申请号：PCT/EP2005008626
申请日：2005-08-09
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , MUNZERT GERD , STEEGMAIER MARTIN
发明人： MUNZERT GERD , STEEGMAIER MARTIN
IPC分类号： A61K31/525 , A61K31/5377 , A61P1/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P31/10 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00
CPC分类号： A61K31/525 , A61K31/5377
摘要： The present invention relates to the use of a compound of general Formula (1), optionally in form of its tautomers, racemates, enantiomers, diastereomers and the mixtures thereof and optionally in form of the pharmacologically acceptable acid addition salts, solvates, hydrates, polymorphs, physiologically functional derivatives or prodrugs thereof, for the preparation of a pharmaceutical composition for the treatment of diseases characterized by abnormal cell proliferation in a human or non-human mammalian body by inhibition of polo like kinases as mitotic regulators.
摘要翻译：本发明涉及通式（1）的化合物，任选以其互变异构体，外消旋物，对映异构体，非对映异构体及其混合物的形式，并且任选呈药理学上可接受的酸加成盐，溶剂合物，水合物，多晶型物，其生理功能衍生物或前药，用于通过抑制马球状激酶作为有丝分裂调节剂来制备用于治疗特征在于人或非人哺乳动物体内异常细胞增殖的疾病的药物组合物。

9. 发明申请

WO2009003998A3 ANTIPROLIFERATIVE COMPOUNDS BASED ON 5-MEMBERED HETEROCYCLES 审中-公开
标题翻译：基于5个成员的杂环化合物的抗菌化合物
公开(公告)号：WO2009003998A3
公开(公告)日：2009-02-26
申请号：PCT/EP2008058432
申请日：2008-07-01
申请人： BOEHRINGER INGELHEIM INT , SAPOUNTZIS IOANNIS , ETTMAYER PETER , KLEIN CHRISTIAN , MANTOULIDIS ANDREAS , STEEGMAIER MARTIN , STEURER STEFFEN , WAIZENEGGER IRENE
发明人： SAPOUNTZIS IOANNIS , ETTMAYER PETER , KLEIN CHRISTIAN , MANTOULIDIS ANDREAS , STEEGMAIER MARTIN , STEURER STEFFEN , WAIZENEGGER IRENE
IPC分类号： C07D401/04 , A61K31/41 , A61K31/4427 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D417/04
摘要： The present invention encompasses compounds of general formula (1) wherein the groups R2 to R4, L, Q and n are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 2至R 4，L，Q和n基团如权利要求1中所定义，其适用于治疗以细胞增殖过度或异常为特征的疾病，制备具有上述性质的药物组合物。

10. 发明申请

WO2006018185A8 Dihydropteridinones for the treatment of cancer diseases 审中-公开
标题翻译：用于治疗癌症疾病的二氢蝶呤酮
公开(公告)号：WO2006018185A8
公开(公告)日：2006-06-01
申请号：PCT/EP2005008626
申请日：2005-08-09
申请人： BOEHRINGER INGELHEIM PHARMA , MUNZERT GERD , STEEGMAIER MARTIN
发明人： MUNZERT GERD , STEEGMAIER MARTIN
IPC分类号： A61K31/525 , A61K31/5377 , A61P1/00 , A61P3/10 , A61P17/06 , A61P19/02 , A61P31/10 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00
CPC分类号： A61K31/525 , A61K31/5377
摘要： The present invention relates to the use of a compound of general Formula (1), for the treatment of diseases characterized by abnormal cell proliferation in a human or non-human mammalian body by inhibition of polo like kinases as mitotic regulators like cancer selected from the group consisting of carcinomas, sarcomas, melanomas, myeloma, hematologic neoplasias, lymphomas, childhood cancers and leukemia, autoimmune disorders selected from the group consisting of amyloidosis, systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease, multiphe sclerosis, systemic sclerosis (scleroderma), mixed connective tissue disease, Sjögren's syndrome, ankylosing spondylitis, autoimmune vasculitis, Behcet's syndrome, psoriasis, autoimmune arthritis, sarcoidosis, diabetes mellitus and fungous diseases.
摘要翻译：本发明涉及通式（1）化合物在人或非人哺乳动物体内通过抑制作为有丝分裂调节剂如癌症的人类或非人哺乳动物体内异常细胞增殖的疾病的用途，由癌组织，肉瘤，黑素瘤，骨髓瘤，血液肿瘤，淋巴瘤，儿童期癌症和白血病组成的组，选自淀粉样变性，系统性红斑狼疮，类风湿性关节炎，克罗恩病，多发性硬化症，全身性硬化症（硬皮病）混合性结缔组织病，Sjögren综合征，强直性脊柱炎，自身免疫性血管炎，贝切特综合征，牛皮癣，自身免疫性关节炎，结节病，糖尿病和真菌性疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式