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1. 发明申请

WO2022034557A1 INTRAVENOUS AND ORAL INHALATION ANTI-VIRAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2022034557A1
公开(公告)日：2022-02-17
申请号：PCT/IB2021/057499
申请日：2021-08-13
申请人： BLUACT TECHNOLOGIES GMBH , ETH ZURICH
发明人： PALIKA, Archana , RAHIMI, Akram , BOLISETTY, Sreenath , MEZZENGA, Raffaele
IPC分类号： A61K33/24 , A61K38/17 , A61P31/12
摘要： A pharmaceutical composition for the prevention or treatment of a viral infection in a mammal that includes hybrid antiviral metal-associated amyloid fibrils having metal nanoparticles on a surface of amyloid fibrils. The pharmaceutical composition is an intravenous pharmaceutical composition or inhalation composition and is not buccally administered or enterically administered.

2. 发明申请

WO2022034556A1 ANTI-VIRAL COMPOSITIONS AND METHOD OF KILLING VIRUS 审中-公开
公开(公告)号：WO2022034556A1
公开(公告)日：2022-02-17
申请号：PCT/IB2021/057498
申请日：2021-08-13
申请人： BLUACT TECHNOLOGIES GMBH
发明人： PALIKA, Archana , RAHIMI, Akram , BOLISETTY, Sreenath , MEZZENGA, Raffaele
IPC分类号： A01N59/16 , A01N63/50 , D06M11/49 , D06M11/83 , A01P1/00 , A62B23/02 , B01D46/00 , C02F1/00 , D06M15/15 , F24F8/108 , A01N25/34
摘要： A method of inactivating a virus that includes the step of contacting a virus with an antiviral composition comprising a hybrid antiviral metal-associated amyloid fibril comprising metal nanoparticles on a surface of an amyloid fibril to contact a virus and an antiviral composition comprising metal nanoparticles on a surface of an amyloid fibril wherein the antiviral composition removes virus and bacterial contaminants in water or air to non-detectable levels when water or air comes into contact with the antiviral composition.

3. 发明申请

WO2021037915A1 LIGHT GOLD 审中-公开
公开(公告)号：WO2021037915A1
公开(公告)日：2021-03-04
申请号：PCT/EP2020/073857
申请日：2020-08-26
申请人： ETH ZURICH
发明人： VAN 'T HAG, Leonie , MEZZENGA, Raffaele
IPC分类号： B22F1/00 , C07K14/47 , C08L89/00 , C22C32/00 , C08H1/00 , C08J3/075 , C08J3/24 , C08L25/06 , C08K3/08
摘要： The present invention relates to novel composite materials comprising elemental gold in the form of single crystals, amyloid fibrils and a polymer. This composite material is similar to glassy plastics yet lighter than aluminum and has a golden shining similar to 18K gold. Due to its unique properties, this composite is termed "light gold". This composite material suits, for example, watches, jewelry, radiation shielding, catalysis and electronics. The invention further provides for environmentally friendly methods to manufacture such composite materials.

4. 发明申请

WO2015185504A1 LIQUID CRYSTAL BIOSENSORS 审中-公开
标题翻译：液晶生物传感器
公开(公告)号：WO2015185504A1
公开(公告)日：2015-12-10
申请号：PCT/EP2015/062151
申请日：2015-06-01
申请人： ETH ZURICH
发明人： MEZZENGA, Raffaele , VALLOORAN, Jijo
IPC分类号： C12Q1/06 , C12Q1/26 , C12Q1/28 , G01N21/23
CPC分类号： C12Q1/26 , C12Q1/06 , C12Q1/28 , G01N21/23 , G01N2201/0221 , Y02A50/58
摘要： The invention relates to a method for visually detecting a reaction from a reactant to a product, and comprises the steps of providing a liquid crystal in bicontinuous cubic mesophase comprising said reactant, further providing conditions in which the reactant is converted into the product in a reaction step, wherein said product is insoluble in the mesophase, and measuring a birefringence value of said mesophase. The invention is particularly suitable for detecting enzymatic conversions of analytes into products. E.g. glucose or cholesterol conversions by means of oxidase/peroxidase systems. The invention further relates to an apparatus (10) for use in a method of the invention, which comprises a volume (11) delimited by transparent optical elements (12) and (13) that are orthogonal to an axis (15) passing through said volume (11), and wherein the axis of polarization (16) and (17) of the optical elements is rotated by 90°, and bicontinuous cubic mesophase is present in said volume.
摘要翻译：本发明涉及一种从反应物到产品的视觉检测方法，包括以下步骤：在包含所述反应物的双连续立方中间相中提供液晶，进一步提供反应物在反应中转化成产物的条件步骤，其中所述产物不溶于中间相，并测量所述中间相的双折射值。本发明特别适用于检测分析物到产品中的酶转化。例如。葡萄糖或胆固醇转化通过氧化酶/过氧化物酶系统。本发明还涉及一种在本发明的方法中使用的装置（10），其包括由透明光学元件（12）和（13）界定的体积（11），所述体积（11）与穿过所述体积（11），并且其中光学元件的偏振轴（16）和（17）旋转90°，并且所述体积中存在双连续立方中间相。

5. 发明申请

WO2015140074A1 HEAVY METAL RECYCLING PROCESS AND MATERIAL USEFULL IN SUCH PROCESS 审中-公开
标题翻译：重金属循环过程和材料在此过程中有效
公开(公告)号：WO2015140074A1
公开(公告)日：2015-09-24
申请号：PCT/EP2015/055323
申请日：2015-03-13
申请人： ETH ZURICH
发明人： BOLISETTY, Sreenath , MEZZENGA, Raffaele
IPC分类号： B01D39/20
CPC分类号： C02F1/288 , B01D39/02 , B01D39/14 , B01D39/2058 , B01D2239/086 , C02F1/283 , C02F1/285 , C02F2101/10 , C02F2101/20
摘要： The present invention relates to the field of water treatment / metal recovery and to materials / devices useful in such processes. Specifically the invention provides for composite materials comprising amyloid fibrils; activated carbon; optionally a support material; whereby said amyloid fibrils and said activated carbon are in intimate contact. The invention further provides for the treatment of water using such composite materials.
摘要翻译：本发明涉及水处理/金属回收领域以及在这些方法中有用的材料/装置。具体地，本发明提供了包含淀粉样蛋白原纤维的复合材料; 活性炭; 任选的支撑材料; 由此所述淀粉样蛋白原纤维和所述活性炭紧密接触。本发明还提供了使用这种复合材料处理水的方法。

6. 发明申请

WO2022238244A1 BIOPLASTICS BASED ON AMYLOID FIBRILS AND BIODEGRADABLE POLYMERS 审中-公开
公开(公告)号：WO2022238244A1
公开(公告)日：2022-11-17
申请号：PCT/EP2022/062215
申请日：2022-05-05
申请人： ETH ZURICH
发明人： BAGNANI, Massimo , PEYDAYESH, Mohammad , MEZZENGA, Raffaele
IPC分类号： C08L89/00 , B65D65/00 , C08L29/04 , B65D65/466 , C08L2205/16 , C09D129/04
摘要： The present invention relates to novel methods to manufacture composite materials comprising amyloid fibrils and a biodegradable polymer. The methods described herein prove to be environmentally friendly and allow the use of starting materials of low quality / purity. Specifically, amyloid fibrils may be obtained from food waste. The invention further provides for novel composite materials comprising specific amyloid fibrils and a biodegradable polymer, to articles comprising such composite materials and to the use of such composite materials. The composite materials described herein show unexpected beneficial properties, when compared to the individual constituents. These beneficial properties include improved mechanical properties, improved biodegradation, improved antioxidant properties, and beneficial optical properties.

7. 发明申请

WO2020104125A1 FLUORIDE REMOVAL PROCESS 审中-公开
公开(公告)号：WO2020104125A1
公开(公告)日：2020-05-28
申请号：PCT/EP2019/078541
申请日：2019-10-21
申请人： ETH ZURICH
发明人： ZHANG, Qingrui , MEZZENGA, Raffaele , BOLISETTY, Sreenath
IPC分类号： B01J20/06 , B01D39/08 , B01D39/20 , B01J20/20 , B01J20/24 , B01J20/28 , B01J20/32 , B01D67/00 , B01D69/12 , B01D69/14 , B01D71/02 , B01D71/74 , B01J20/02 , C02F1/28 , C02F1/44 , C02F101/14
摘要： The present invention relates to the field of water treatment / fluoride removal and to materials / devices useful in such processes. Specifically, the invention provides for hybrid materials comprising amyloid fibrils and ZrO2; and to composite materials further comprising a support material. The invention further provides for the treatment of water using such hybrid or composite materials.

8. 发明申请

WO2018166947A1 COMPOSITE MATERIALS COMPRISING AMYLOID FIBRILS AND NANOPARTICULATE NUTRITIONAL MINERALS 审中-公开
公开(公告)号：WO2018166947A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/056023
申请日：2018-03-12
申请人： ETH ZURICH
发明人： BOLISETTY, Sreenath , ZIMMERMANN, Michael , SHEN, Yi , MEZZENGA, Raffaele
IPC分类号： C07K14/47 , G01N33/68 , A23L5/00
摘要： The present invention relates to the use of amyloid fibrils for providing nutritional minerals to the human body, particularly as a component in a food product, a dietary supplement or in a pharmaceutical product. The invention further provides for new compositions comprising composite materials of amyloid fibrils and nutritional minerals. The invention further relates to the use of such composite materials in the treatment of diseases and disorders and to the fortification of food and dietary supplements with nutritional minerals.

9. 发明申请

WO2014124546A1 HYBRID NANOCOMPOSITE MATERIALS OF AMYLOID FIBRILS AND GOLD 审中-公开
标题翻译： AMYLOID FIBRILS和GOLD的混合纳米复合材料
公开(公告)号：WO2014124546A1
公开(公告)日：2014-08-21
申请号：PCT/CH2014/000014
申请日：2014-02-03
申请人： ETH ZURICH
发明人： LI, Chaoxu , BOLISETTY, Sreenath , MEZZENGA, Raffaele
IPC分类号： C09D5/00 , C09D7/12 , C08L89/00 , C08K3/08
CPC分类号： C08K3/08 , B82Y30/00 , C07K14/4711 , C08K2003/0831 , C08K2201/011 , C08L89/00 , C09D5/38 , C09D7/61
摘要： The present invention relates to novel hybrid nanocomposite materials containing amyloid fibrils and elemental single crystals of gold; to environmentally friendly ("green") methods for manufacturing such materials; to shaped articles comprising such materials as well as to the use of such materials.
摘要翻译：本发明涉及含有淀粉样蛋白原纤维和金元素单晶的新型杂合纳米复合材料; 以环保（“绿色”）制造这种材料的方法; 包括这种材料的成型制品以及这种材料的使用。

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