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1. 发明申请

WO2010005480A9 CONTROLLED RELEASE COMPOSITIONS OF AGENTS THAT REDUCE CIRCULATING LEVELS OF PLATELETS AND METHODS THEREFOR 审中-公开
公开(公告)号：WO2010005480A9
公开(公告)日：2010-01-14
申请号：PCT/US2009/003632
申请日：2009-06-16
申请人： BIOVASCULAR, INC. , GLIDDEN, Paul, F. , PILGRIM, Alison, J. , HANSON, Stephen, R.
发明人： GLIDDEN, Paul, F. , PILGRIM, Alison, J. , HANSON, Stephen, R.
IPC分类号： A61K31/519 , A61K9/00 , A61K9/48 , A61K9/20 , A61K47/32 , A61K47/26 , A61P9/00 , A61P7/00
摘要： Provided are prophylactic and therapeutic methods of treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by administering agents, including anagrelide and anagrelide derivatives, which reduce the number of circulating platelets to low normal or to below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.

2. 发明申请

WO2007038749A3 METHODS AND COMPOSITIONS FOR BLOCKING PLATELET AND CELL ADHESION, CELL MIGRATION AND INFLAMMATION 审中-公开
公开(公告)号：WO2007038749A3
公开(公告)日：2007-04-05
申请号：PCT/US2006/038141
申请日：2006-09-28
申请人： BIOVASCULAR, INC. , GLIDDEN, Paul, F.
发明人： GLIDDEN, Paul, F.
IPC分类号： C08L89/00 , C09J189/00
摘要： The present invention provides compositions of saratin and methods of use thereof. One aspect of the invention is a method of prevention or mitigation of the development of adhesions, keloids and scars. The adhesions, keloids and scars can be due to surgery, such as plastic surgery or orthopedic surgery, or can be pre-existing scars. Another aspect of the invention is a method for treatment of flexor tendon injuries.

3. 发明申请

WO2006016217A1 tRNA SYNTHETASE FRAGMENTS 审中-公开
标题翻译： tRNA合成酶片段
公开(公告)号：WO2006016217A1
公开(公告)日：2006-02-16
申请号：PCT/IB2005/002180
申请日：2005-07-21
申请人： PFIZER INC. , GLIDDEN, Paul, F.
发明人： GLIDDEN, Paul, F.
IPC分类号： A61K38/53
CPC分类号： A61K38/53 , C12N9/93
摘要： The present invention relates to compositions and methods for treating conditions associated with angiogenesis. In particular the present invention relates to multi-unit complexes of tRNA synthetase fragments and uses thereof; diverse multi-unit complexes including a tRNA synthetase fragment; compositions and methods for modulating angiogenesis; polynucleotides encoding tRNA synthetase fragments and uses thereof; antibodies and epitopes specific to tRNA synthetase fragments; variants of tRNA synthetase fragments and uses thereof; methods for treating angiogenesis; methods for screening for anti-angiogenic agents; methods of modulating angiogenesis; kits for modulating angiogenesis; and business methods for modulating angiogenesis. Preferably the tRNA synthetase fragments are tryptophanyl tRNA synthetase fragments, and more preferably human tryptophanyl tRNA synthetase fragments.
摘要翻译：本发明涉及用于治疗与血管发生相关的病症的组合物和方法。特别地，本发明涉及tRNA合成酶片段的多单元复合物及其用途; 不同的多单位复合物，包括tRNA合成酶片段; 用于调节血管生成的组合物和方法; 编码tRNA合成酶片段的多核苷酸及其用途; 针对tRNA合成酶片段特异性的抗体和表位; tRNA合成酶片段的变体及其用途; 治疗血管生成的方法; 筛选抗血管生成剂的方法; 调节血管发生的方法; 用于调节血管发生的试剂盒; 和调节血管发生的商业方法。优选地，tRNA合成酶片段是色氨酰tRNA合成酶片段，更优选人色氨酰tRNA合成酶片段。

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