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1. 发明申请

WO2007128829A3 18,21-DIDESOXYMACBECIN DERIVATIVES FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的18,21-DIDESOXYMACBECIN衍生物
公开(公告)号：WO2007128829A3
公开(公告)日：2008-01-03
申请号：PCT/EP2007054476
申请日：2007-05-09
申请人： BIOTICA TECH LTD , MARTIN CHRISTINE , ZHANG MING , COATES NIGEL , VOUSDEN WILLIAM , MOSS STEVEN , GAISSER SABINE
发明人： MARTIN CHRISTINE , ZHANG MING , COATES NIGEL , VOUSDEN WILLIAM , MOSS STEVEN , GAISSER SABINE
IPC分类号： C07D225/06 , A61K31/395 , A61P35/00
CPC分类号： C07D225/06
摘要： The present invention relates to 18,21-didesoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pre-treatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular, in the treatment and/or prophylaxis of cancer or B-cell malignancies. Formula (I) wherein: R 1 represents H, OH, OMe; R 2 represents H or Me; R 3 represents H or CONH 2 ; R 4 and R 5 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); R 6 represents H or F; R 7 represents H or F; and R 8 represents H or F.
摘要翻译：本发明涉及有用的18,21-二氧杂氧化锍类似物。在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫性疾病和/或作为癌症的预防性预处理。本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是在治疗和/或预防癌症或B细胞恶性肿瘤中的用途。式（I）其中：R 1表示H，OH，OMe; R 2表示H或Me; R 3表示H或CONH 2 H; R 4和R 5都表示H或一起代表键（即C4至C5是双键）; R 6表示H或F; R 7表示H或F; R 8表示H或F.

2. 发明申请

WO2008104812A3 C21-DE0XY ANSAMYCIN DERIVATIVES AS ANTITUMOR AGENTS 审中-公开
标题翻译： C21-DE0XY ANSAMYCIN衍生物作为抗菌剂
公开(公告)号：WO2008104812A3
公开(公告)日：2008-10-30
申请号：PCT/GB2008050150
申请日：2008-03-03
申请人： BIOTICA TECH LTD , MOSS STEVEN , MARTIN CHRISTINE , ZHANG MING
发明人： MOSS STEVEN , MARTIN CHRISTINE , ZHANG MING
IPC分类号： C07D225/06 , A61K31/395 , A61P35/00
CPC分类号： C07D225/06
摘要： According to the invention there are provided derivatives of a C21-deoxy ansamycin or salt thereof which contain a 1-hydroxyphenyl moiety bearing at position 3 an aminocarboxy substituent, in which position 5 and the aminocarboxy substituent at position 3 are connected by an aliphatic chain of varying length characterised in that the 1-hydroxy position of the phenyl ring is derivatised by an aminoalkyleneaminocarbonyl group, which alkylene group (which may optionally be substituted by alkyl groups) has a chain length of 2 or 3 carbon atoms, a phosphoric acid, or a phosphoric acid ester (such as an alkyl ester) group, or a salt thereof, and which derivatising group increases the water solubility and/or the bioavailability of the parent molecule. Such compounds are useful in therapy eg in the treatment of cancer and B-cell malignancies.
摘要翻译：根据本发明，提供了一种C21-脱氧安莎霉素或其盐的衍生物，其含有在位置3具有氨基羧基取代基的1-羟基苯基部分，其中位置5和位置3上的氨基羧基取代基通过脂族链连接变化的长度，其特征在于苯环的1-羟基位置被氨基亚烷基氨基羰基衍生，该亚烷基（其可以任选被烷基取代）具有2或3个碳原子的链长，磷酸或磷酸酯（例如烷基酯）或其盐，并且该衍生基增加了母体分子的水溶性和/或生物利用度。这样的化合物可用于治疗，例如治疗癌症和B细胞恶性肿瘤。

3. 发明申请

WO2007113269A3 15-DESMETHOXYMACBECIN DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES 审中-公开
标题翻译：用于治疗癌症疾病的15-脱乙酰壳多糖衍生物
公开(公告)号：WO2007113269A3
公开(公告)日：2007-11-29
申请号：PCT/EP2007053130
申请日：2007-03-30
申请人： BIOTICA TECH LTD , GAISSER SABINE , MARTIN CHRISTINE , ZHANG MING , WILKINSON BARRIE , COATES NIGEL , NUR-E-ALAM MOHAMMED , GAITATZIS NIKOLAOS
发明人： GAISSER SABINE , MARTIN CHRISTINE , ZHANG MING , WILKINSON BARRIE , COATES NIGEL , NUR-E-ALAM MOHAMMED , GAITATZIS NIKOLAOS
IPC分类号： C07D225/06 , A61K31/395 , A61P35/00
CPC分类号： C07D225/06
摘要： The present invention relates to 15-desmethoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.
摘要翻译：本发明涉及15-脱甲氧基锍类似物，其可用于，例如，在治疗癌症，B细胞恶性疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

4. 发明申请

WO2007128827A8 17-OXYMACBECIN DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND/OR B-CELL MALIGNANCIES 审中-公开
标题翻译： 17-OXYMACBECIN衍生物及其在治疗癌症和/或B细胞恶性肿瘤中的应用
公开(公告)号：WO2007128827A8
公开(公告)日：2008-01-03
申请号：PCT/EP2007054473
申请日：2007-05-09
申请人： BIOTICA TECH LTD , MARTIN CHRISTINE , ZHANG MING , GAISSER SABINE , COATES NIGEL
发明人： MARTIN CHRISTINE , ZHANG MING , GAISSER SABINE , COATES NIGEL
IPC分类号： C07D225/06 , A61K31/395
CPC分类号： C07D225/06
摘要： The present invention relates to 17-oxymacbecin analogues according to the formula (IA) or (IB) below, or a pharmaceutically acceptable salt thereof, wherein: R 1 represents H, OH or OCH 3 ; R 2 represents H or CH 3 R 3 represents H or CONH 2 R 4 and R 5 either both represent H or together they represent a bond (i.e. C4 to C5 is a double bond); and R 6 represents H or OH; and R 7 represents H or CH 3 . that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.
摘要翻译：本发明涉及根据下式（IA）或（IB）的17-氧基锍类似物或其药学上可接受的盐，其中：R 1表示H，OH或OCH 3 ; R 2表示H或CH 3 R 3 R 3表示H或CONH 2 R 4 S / >和R 5都表示H或一起表示键（即C4至C5是双键）; R 6表示H或OH; 且R 7表示H或CH 3。这是有用的，例如。在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。本发明还提供了这些化合物的制备方法及其在医药中的用途，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。

5. 发明申请

WO2007113266A3 NOVEL COMPOUNDS AND METHODS FOR THEIR PRODUCTION 审中-公开
标题翻译：新型化合物及其生产方法
公开(公告)号：WO2007113266A3
公开(公告)日：2007-12-21
申请号：PCT/EP2007053124
申请日：2007-03-30
申请人： BIOTICA TECH LTD , GAISSER SABINE , MARTIN CHRISTINE , ZHANG MING , WILKINSON BARRIE , SHEEHAN LESLEY , COATES NIGEL , NUR-E-ALAM MOHAMMED , VOUSDEN WILLIAM , GAITATZIS NIKOLAOS
发明人： GAISSER SABINE , MARTIN CHRISTINE , ZHANG MING , WILKINSON BARRIE , SHEEHAN LESLEY , COATES NIGEL , NUR-E-ALAM MOHAMMED , VOUSDEN WILLIAM , GAITATZIS NIKOLAOS
IPC分类号： C07D225/06 , A61K31/395 , A61P35/00
CPC分类号： C07D225/06
摘要： The present invention relates to 11-O-desmethylmacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and / or prophylaxis of cancer or B-cell malignancies.
摘要翻译：本发明涉及有用的例如11-O-去甲基麦克菌素类似物。治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经退行性疾病，依赖于血管生成的疾病，自身免疫疾病和/或作为癌症的预防性预处理。本发明还提供了用于生产这些化合物及其在医学中的用途的方法，特别是用于治疗和/或预防癌症或B细胞恶性肿瘤。

6. 发明申请

WO2008056188A2 NOVEL COMPOUNDS AND METHODS FOR THEIR PRODUCTION 审中-公开
标题翻译：新型化合物及其生产方法
公开(公告)号：WO2008056188A2
公开(公告)日：2008-05-15
申请号：PCT/GB2007050679
申请日：2007-11-09
申请人： BIOTICA TECH LTD , MARTIN CHRISTINE
发明人： MARTIN CHRISTINE
IPC分类号： C07D225/06 , A61K31/395
CPC分类号： C07D225/06
摘要： The present invention relates to ansamycin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies, malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases or a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine.
摘要翻译：本发明涉及可用于例如安莎霉素类似物的安莎霉素类似物。在治疗癌症，B细胞恶性肿瘤，疟疾，真菌感染，中枢神经系统疾病和神经变性疾病，依赖于血管发生的疾病，自身免疫性疾病或癌症的预防性预处理。本发明还提供了这些化合物的制备方法及其在医药中的应用。

7. 发明申请

WO9414967A3 CS31A PROTEIN CAPSULE SUBUNIT MODIFIED BY AT LEAST ONE HETEROLOGOUS PEPTIDE, CS31A PROTEIN CAPSULE COMPRISING SAID SUBUNIT, MICRO-ORGANISMS HAVING SUCH SUBUNITS ON THEIR OUTER MEMBRANE, AND METHODS FOR PREPARING AND USING SAME 审中-公开
标题翻译：至少一个异位肽修饰的CS31A蛋白胶囊亚胺，包含所述子囊的CS31A蛋白胶囊，在其外膜上具有这样的亚类的微量组分，以及其制备和使用方法
公开(公告)号：WO9414967A3
公开(公告)日：1994-09-29
申请号：PCT/FR9301281
申请日：1993-12-21
申请人： AGRONOMIQUE INST NAT RECH , GIRARDEAU JEAN PIERRE , MARTIN CHRISTINE , MECHIN MARIE CLAIRE , VARTANIAN MAURICE , BOUSQUET FRANCOIS
发明人： GIRARDEAU JEAN-PIERRE , MARTIN CHRISTINE , MECHIN MARIE-CLAIRE , DER VARTANIAN MAURICE , BOUSQUET FRANCOIS
IPC分类号： A61K39/00 , C07K14/09 , C07K14/105 , C07K14/14 , C07K14/17 , C07K14/245 , C12N15/62 , A61K39/108 , A61K39/12 , C07K13/00 , C12N1/21 , C12N15/31 , C12N15/40 , G01N33/569
CPC分类号： C07K14/005 , A61K39/00 , C07K14/245 , C07K2319/00 , C12N2720/12322 , C12N2770/20022 , C12N2770/32122 , C12N2770/32622
摘要： A CS31A protein capsule subunit having an aminoacid sequence modified by at least one heterologous peptide, the CS31A protein capsule comprising said subunit, and micro-organisms having the CS31A protein capsule with its subunit aminoacid sequence modified by at least one heterologous peptide, are disclosed. Methods for preparing said subunits, CS31A protein capsules comprising same, and micro-organisms having CS31A protein capsules, as well as the use thereof for preparing vaccines, producing peptides and preparing immunoassays, are also disclosed.

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