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1. 发明申请

WO2003094086A3 ANALYSIS OF GENE EXPRESSION DATA FOR MULTI-CLASS PREDICTION 审中-公开
公开(公告)号：WO2003094086A3
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001258
申请日：2003-03-24
申请人： BIOTECH RESEARCH VENTURES PTE LIMITED , DENISON, Christopher , TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
发明人： TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
IPC分类号： G06F19/00
摘要： The invention provides a method for identifying, from a pool of parameters whose values are known for a plurality of samples ("training samples") which are classified into multiple classes, a subset of parameters whose values in a sample of unknown class are likely to be predictive of the class of that sample. The invention also provides related uses, computer programs, apparatuses and systems. The invention is particularly applicable to the classification of biological samples on the basis of gene expression data. The classifier is preferably a maximum likelihood classifier.

2. 发明申请

WO2003094086A2 ANALYSIS OF GENE EXPRESSION DATA FOR MULTI-CLASS PREDICTION 审中-公开
标题翻译：用于多级预测的基因表达数据分析
公开(公告)号：WO2003094086A2
公开(公告)日：2003-11-13
申请号：PCT/GB2003/001258
申请日：2003-03-24
申请人： BIOTECH RESEARCH VENTURES PTE LIMITED , DENISON, Christopher , TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
发明人： TAN, Patrick, Boon, Ooi , OOI, Chia, Huey
IPC分类号： G06F19/00
CPC分类号： G06K9/6231 , G06F19/20 , G06F19/24 , G06N3/126
摘要： The invention provides a method for identifying, from a pool of parameters whose values are known for a plurality of samples ("training samples") which are classified into multiple classes, a subset of parameters whose values in a sample of unknown class are likely to be predictive of the class of that sample, the method comprising: (a) providing a first generation population of individuals, each individual representing a candidate subset of parameters; (b) for each individual, evaluating its fitness to predict the class of a sample of unknown class by determining its ability to predict the class of a plurality of test samples of known class;(c) generating a second generation population of individuals from selected individuals in the first generation population, wherein said selected individuals are selected according to their fitness as evaluated in step (b); (d) repeating steps (b) and (c) to evaluate the fitness of the individuals of the second generation population and to generate and evaluate further generations until a termination condition is reached; and(e) selecting the fittest individual, as evaluated in step (b) or step (d), from the final generation or from among the fittest individuals of a plurality of generations, wherein the class prediction in step (b) uses a discriminant-based classifier. The invention also provides related uses, computer programs, apparatuses and systems. The invention is particularly applicable to the classification of biological samples on the basis of gene expression data. The classifier is preferably a maximum likelihood classifier.
摘要翻译：本发明提供了一种用于从被分类为多个类的多个样本（“训练样本”）已知值的参数池中识别未知类样本中的值很可能的参数子集的方法预测该样本的类别，该方法包括：（a）提供第一代个体群体，每个个体代表参数的候选子集; （b）对于每个人，通过确定其预测已知类别的多个测试样本的类别的能力来评估其适合度来预测未知类别的样本的类别;（c）从所选择的生成第二代个体群体第一代人群中的个体，其中所述选择的个体根据其在步骤（b）中评估的适合度来选择; （d）重复步骤（b）和（c）以评估第二代人群的个体的适应度，并产生和评估进一步的代数，直到达到终止条件; 以及（e）从步骤（b）或步骤（d）中评估的最适合的个体中选择多代人中最适合的个体之间的适合个体，其中步骤（b）中的类预测使用判别式的分类器。本发明还提供了相关用途，计算机程序，设备和系统。本发明特别适用于基于基因表达数据的生物样品的分类。分类器优选地是最大似然分类器。

3. 发明申请

WO2003070979A2 MATERIALS AND METHODS RELATING TO CANCER DIAGNOSIS 审中-公开
标题翻译：与癌症诊断相关的材料和方法
公开(公告)号：WO2003070979A2
公开(公告)日：2003-08-28
申请号：PCT/GB2003/000755
申请日：2003-02-20
申请人： NCC TECHNOLOGY VENTURES PTE LIMITED , CRIPPS, Joanna, E. , TAN, Patrick , KUN, Yu , AGGARWAL, Amit , OOI, Chia, Huey
发明人： TAN, Patrick , KUN, Yu , AGGARWAL, Amit , OOI, Chia, Huey
IPC分类号： C12Q1/68
CPC分类号： G01N33/57415 , C12Q2600/158
摘要： The invention provides a number of genetic identifiers (genesets) which may be used as diagnostic tools to determine the presence or risk of breast cancer in a patient. The invention also provides genesets which may be used to classify a breast tumour cell as to its molecular subgroup. Each of the identified genesets may be used to product customised specific nucleic acid microarrays for use in diagnosis and classification of breast tumour cells.
摘要翻译：本发明提供了许多遗传标识符基因组，其可以用作诊断工具来确定患者中乳腺癌的存在或风险。本发明还提供可用于将乳腺肿瘤细胞分类为其分子亚组的基因。每个鉴定的基因组可用于产生用于乳腺肿瘤细胞诊断和分类的定制的特异性核酸微阵列。

4. 发明申请

WO2003070979A3 MATERIALS AND METHODS RELATING TO CANCER DIAGNOSIS 审中-公开
公开(公告)号：WO2003070979A3
公开(公告)日：2003-08-28
申请号：PCT/GB2003/000755
申请日：2003-02-20
申请人： NCC TECHNOLOGY VENTURES PTE LIMITED , CRIPPS, Joanna, E. , TAN, Patrick , KUN, Yu , AGGARWAL, Amit , OOI, Chia, Huey
发明人： TAN, Patrick , KUN, Yu , AGGARWAL, Amit , OOI, Chia, Huey
IPC分类号： C12Q1/68
摘要： The invention provides a number of genetic identifiers (genesets) which may be used as diagnostic tools to determine the presence or risk of breast cancer in a patient. The invention also provides genesets which may be used to classify a breast tumour cell as to its molecular subgroup. Each of the identified genesets may be used to product customised specific nucleic acid microarrays for use in diagnosis and classification of breast tumour cells.

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