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1. 发明申请

WO2008126974A1 COMPOSITION FOR PREVENTING AND TREATING OSSEOUS METABOLIC DISEASE 审中-公开
标题翻译：用于预防和治疗OSSEOUS代谢疾病的组合物
公开(公告)号：WO2008126974A1
公开(公告)日：2008-10-23
申请号：PCT/KR2007/006532
申请日：2007-12-14
申请人： BIORUNX CO., LTD. , LEE, Zang-Hee , RYOO, Hyun-Mo , BAE, Suk-Chul
发明人： LEE, Zang-Hee , RYOO, Hyun-Mo , BAE, Suk-Chul
IPC分类号： A61K31/40
CPC分类号： A61K31/40
摘要： The present invention relates to a pharmaceutical composition for preventing or treating metabolic bone diseases, comprising a pharmaceutically effective amount of a compound represented by the following Formula 1 or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及一种用于预防或治疗代谢性骨疾病的药物组合物，其包含药学有效量的由下式1表示的化合物或其药学上可接受的盐。

2. 发明申请

WO2006065075A1 METHOD TO ENHANCE THE BONE FORMATION ACTIVITY OF BMP BY RUNX2 ACETYLATION 审中-公开
标题翻译：通过RUNX2乙酰化增强BMP的骨形成活性的方法
公开(公告)号：WO2006065075A1
公开(公告)日：2006-06-22
申请号：PCT/KR2005/004307
申请日：2005-12-14
申请人： BAE, Suk-Chul , RYOO, Hyun-Mo
发明人： BAE, Suk-Chul , RYOO, Hyun-Mo
IPC分类号： A61K38/00
CPC分类号： A61K38/50 , A61K31/19 , A61K38/005 , A61K38/45 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method to enhance the activity of Runx2, a major target protein of Bone Mophogenetic Protein (BMP), by Runx2 acetylation, more precisely, a method to activate BMP-mediated bone formation pathway by protecting Runx2 from ubiquitination, indicating that Runx2 is protected from degradation by the increase of Runx2 acetylation making the protein more stable. The method to enhance Runx2 activity of the present invention can be utilized for the prevention and the treatment of bone disease such as osteoporosis, osteogenesis imperfecta, periodontal disease and fracture, by inducing bone formation by inhibiting Runx2 degradation.
摘要翻译：本发明涉及通过Runx2乙酰化增强骨发育蛋白（BMP）的主要靶蛋白Runx2的活性的方法，更准确地说，通过保护Runx2从泛素化来激活BMP介导的骨形成途径的方法，表明通过Runx2乙酰化的增加，可以保护Runx2免受降解，使蛋白质更稳定。本发明的增强Runx2活性的方法可用于通过抑制Runx2降解来诱导骨形成来预防和治疗诸如骨质疏松症，成骨不全，牙周病和骨折等骨疾病。

3. 发明申请

WO2005115388A1 A THERAPEUTIC AGENT CONTAINING NICOTINIC ACID OR ITS DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR PREVENTION AND TREATMENT OF CANCER 审中-公开
标题翻译：含有NICOTINIC酸或其衍生物的治疗药物作为预防和治疗癌症的有效成分
公开(公告)号：WO2005115388A1
公开(公告)日：2005-12-08
申请号：PCT/KR2005/001399
申请日：2005-05-12
申请人： BIORUNX CO., LTD. , BAE, Suk-Chul , KIM, Won-Jae
发明人： BAE, Suk-Chul , KIM, Won-Jae
IPC分类号： A61K31/4406
CPC分类号： A61K31/4406
摘要： The present invention relates to a niacinamide or a derivatives therefrom, specifically, agents for preventing cancer and therapeutics comprising a niacinamide or a derivatives therefrom enhancing the expression of RUNX3 gene, cancer-suppressing gene which is inactivated by methylation. agents for preventing cancer and therapeutics of the present invention is used to cancer which relates to inactivation of RUNX3 such as gastric, lung, liver, larynx, colon, bladdar, prostate, pancreas, uterine and breast cancer.
摘要翻译：本发明涉及烟酰胺或其衍生物，具体地，涉及用于预防癌症的药物和治疗剂，其包含烟酰胺或其衍生物，从而增强RUNX3基因的表达，通过甲基化灭活的癌抑制基因。本发明的用于预防癌症和治疗剂的药剂用于与胃，肺，肝，喉，结肠，bladdar，前列腺，胰腺，子宫和乳腺癌等RUNX3失活有关的癌症。

4. 发明申请

WO2002061069A1 RUNX3 GENE SHOWING ANTI-TUMOR ACTIVITY AND USE THEREOF 审中-公开
标题翻译： RUNX3基因显示抗肿瘤活性及其用途
公开(公告)号：WO2002061069A1
公开(公告)日：2002-08-08
申请号：PCT/KR2001/000121
申请日：2001-01-30
申请人： BAE, Suk-Chul , ITO, Yoshiaki
发明人： BAE, Suk-Chul , ITO, Yoshiaki
IPC分类号： C12N15/00
CPC分类号： C07K14/4747
摘要： The present invention relates to a RUNX3 gene showing anti-tumor activity which is essentially involved in TGF-β dependent-programmed cell death (apoptosis) and use thereof. In addition, the present invention finds that the RUNX3 gene expression is suppressed in the various gastric cancer and lung cancer cell lines. The suppression of the RUNX3 gene expression is due to hyper-methylation of CpG island located around RUNX3 exon (1). The RUNX3 gene and its gene product of the present invention can be used effectively for the development of anti-cancer agents. CpG island around RUNX3 exon (1) could also be used not only for the development of anti-cancer agents which regulate the abnormal DNA methylation and there by induce RUNX3 expression but also for the development of methods for cancer diagnosis by measuring the abnormal DNA methylation.
摘要翻译：本发明涉及显示抗肿瘤活性的RUNX3基因，其基本上参与TGF-β依赖性程序性细胞死亡（细胞凋亡）及其用途。此外，本发明发现在各种胃癌和肺癌细胞系中RUNX3基因的表达被抑制。 RUNX3基因表达的抑制是由于位于RUNX3外显子周围的CpG岛的超甲基化（1）。本发明的RUNX3基因及其基因产物可以有效地用于抗癌剂的开发。 RUNX3外显子（1）周围的CpG岛也不仅可用于开发调节异常DNA甲基化的抗癌剂，还可以通过诱导RUNX3表达，也可用于通过测定异常DNA甲基化来开发癌症诊断方法。

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