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1. 发明申请

WO2006032828A1 ADDITIONAL IMPROVEMENTS IN POWDER COMPACTION AND ENROBING 审中-公开
标题翻译：粉末压实和增强的附加改进
公开(公告)号：WO2006032828A1
公开(公告)日：2006-03-30
申请号：PCT/GB2005/001077
申请日：2005-03-22
申请人： BIOPROGRESS TECHNOLOGY LIMITED , TECKOE, Jason , MERWOOD, Colin , DANN, Michael , KESSEL, Stephen, Ronald , POVEY, Ian , GOOD, Martin
发明人： TECKOE, Jason , MERWOOD, Colin , DANN, Michael , KESSEL, Stephen, Ronald , POVEY, Ian , GOOD, Martin
IPC分类号： A61J3/10
CPC分类号： A61J3/10 , A61J3/005 , A61K9/2893 , B30B11/027 , B30B11/10 , B30B11/34
摘要： An apparatus and method is disclosed for forming a compacted powder slug (7) coated with a film. The powder (6), e.g. of a medicament, is compacted and enrobed to produce compacted powder slugs (7) by preferably mechanically compacting a powder (6) and forming a film (8) of a material, preferably hydroxy propyl methyl cellulose, by vacuum or pressure differential, about the surface of the powder (6) thus compacted.
摘要翻译：公开了一种用于形成涂覆有薄膜的压实粉末块（7）的装置和方法。粉末（6），例如通过优选机械压实粉末（6）并通过真空或压差差形成材料（优选羟丙基甲基纤维素）的膜（8），压制并包裹以产生压实的粉末块塞（7）粉末（6）的表面被压实。

2. 发明申请

WO2005030116A1 IMPROVEMENTS IN POWDER COMPACTION AND ENROBING 审中-公开
标题翻译：粉末压实和增强的改进
公开(公告)号：WO2005030116A1
公开(公告)日：2005-04-07
申请号：PCT/GB2004/004097
申请日：2004-09-24
申请人： BIOPROGRESS TECHNOLOGY LIMITED , TECKOE, Jason , MERWOOD, Colin , DANN, Michael , KESSEL, Stephen, Ronald , POVEY, Ian , GOOD, Martin
发明人： TECKOE, Jason , MERWOOD, Colin , DANN, Michael , KESSEL, Stephen, Ronald , POVEY, Ian , GOOD, Martin
IPC分类号： A61J3/10
CPC分类号： B30B15/304 , A61J3/005 , A61J3/10 , B30B11/34 , Y10T428/24116
摘要： An apparatus and method is disclosed for forming a compacted powder slug (7) coated with a film (1). The powder (6), e.g. of a medicament, is compacted and enrobed to produce compacted powder slugs (7) by preferably mechanically compacting a powder (6) and forming a film (1) of a material, prefer ably hydroxy propyl methyl cellulose, by vacuum or pressure differential, about the surface of the powder thus compacted.
摘要翻译：公开了一种用于形成涂覆有膜（1）的压实粉末块（7）的装置和方法。粉末（6），例如通过优选机械压实粉末（6）并形成材料的膜（1），优选羟丙基甲基纤维素，通过真空或压力差约约粉末的表面如此压实。

3. 发明申请

WO2005030115A1 APPARATUS FOR COMPACTING POWDER 审中-公开
标题翻译：用于调节粉末的装置
公开(公告)号：WO2005030115A1
公开(公告)日：2005-04-07
申请号：PCT/GB2004/004092
申请日：2004-09-24
申请人： BIOPROGRESS TECHNOLOGY LIMITED , TECKOE, Jason , MERWOOD, Colin , KESSEL, Stephen, Ronald
发明人： TECKOE, Jason , MERWOOD, Colin , KESSEL, Stephen, Ronald
IPC分类号： A61J3/10
CPC分类号： B30B15/304 , A61J3/005 , A61J3/10 , B30B11/34 , Y10T428/24116
摘要： An apparatus for compacting a powder comprises: i) a die (2) including a piston chamber (4) having an entrance for receiving a piston; ii) dosing means (20) adapted to dispense a free flowing powder through said entrance and into said piston chamber; and iii) a piston (9) having a cross-sectional area reciprocal with the piston chamber (4) and being adapted such that in use the piston enters said chamber, thereby to compact any powder in said chamber, and then exits said chamber. The dosing means (20) comprises a plurality of juxtaposed components (22, 23) between which components is formed a dosing cavity (21) for receiving and dispensing powder. The volume of the cavity (21) and at least the cross-sectional area of the cavity perpendicular to the direction of flow of the powder when the powder is dispensed into the piston chamber (4) are variable by adjustment of the respective positions of the juxtaposed components (22, 23) such that when powder is received into the dosing cavity (21) said volume and cross-sectional area is greater than when powder is dispensed from said cavity into said piston chamber (4). The apparatus is useful for reducing dust in powder compaction processes.
摘要翻译：用于压实粉末的设备包括：i）包括具有用于接收活塞的入口的活塞室（4）的模具（2） ii）适于将自由流动粉末分配通过所述入口并进入所述活塞室的计量装置（20）; 以及iii）活塞（9），其具有与所述活塞室（4）往复的横截面积，并且适于使得在使用中所述活塞进入所述室，由此压缩所述室中的任何粉末，然后离开所述室。计量装置（20）包括多个并置部件（22,23），在该部件之间形成有用于接收和分配粉末的计量腔（21）。当粉末分配到活塞室（4）中时，空腔（21）的体积和至少垂直于粉末流动方向的空腔的横截面面积可以通过调节粉末的相应位置而变化并置部件（22,23），使得当粉末被接收到配量腔（21）中时，所述体积和横截面面积大于当粉末从所述空腔分配到所述活塞室（4）中时。该设备可用于减少粉末压实过程中的粉尘。

4. 发明申请

WO2003096963A1 POWDER COMPACTION AND ENROBING 审中-公开
标题翻译：粉末压实和消毒
公开(公告)号：WO2003096963A1
公开(公告)日：2003-11-27
申请号：PCT/GB2003/002145
申请日：2003-05-19
申请人： BIOPROGRESS TECHNOLOGY INTERNATIONAL, INC. , KESSEL, Stephen, Ronald , TECKOE, Jason
发明人： KESSEL, Stephen, Ronald , TECKOE, Jason
IPC分类号： A61J3/10
CPC分类号： B30B11/027 , A61J3/005 , A61J3/10
摘要： Powder, e.g. of a medicament, is compacted and enrobed to produce compacted powder slugs by preferably mechanically compacting a powder and forming a film of material, preferably hydroxy propyl methyl cellulose, by vacuum or pressure differential, about the surface of the powder thus compacted.
摘要翻译：粉末，例如通过优选机械压实粉末并通过真空或压差差来形成如此压实的粉末的表面的材料膜，优选羟丙基甲基纤维素，来压制和包埋以产生压实的粉末块。

5. 发明申请

WO2007052012A2 APPARATUS FOR TABLET COATING 审中-公开
标题翻译：用于片剂涂料的装置
公开(公告)号：WO2007052012A2
公开(公告)日：2007-05-10
申请号：PCT/GB2006/004062
申请日：2006-10-31
申请人： BIOPROGRESS TECHNOLOGY LIMITED , TECKOE, Jason , LEE, Stephen , BEALE, David
发明人： TECKOE, Jason , LEE, Stephen , BEALE, David
IPC分类号： A61J3/00
CPC分类号： A61J3/005
摘要： The present invention relates to apparatus for use in a method of tablet coating, that is coating ingestible tablets with a film. In particular, the invention relates to apparatus for transferring tablets, apparatus for mermoforming a film on at least part of a tablet and apparatus for sealing overlapping film layers formed on a tablet. The present invention also relates to a tablet produced by using the apparatus of the present invention.
摘要翻译：本发明涉及用于片剂包衣方法的装置，即用薄膜包衣可摄入片剂。特别地，本发明涉及用于转移片剂的装置，用于在至少部分片剂上成形薄膜的装置和用于密封形成在片剂上的重叠薄膜层的装置。本发明还涉及通过使用本发明的装置制造的片剂。

6. 发明申请

WO2007052003A1 SEALED TABLET 审中-公开
标题翻译：密封片
公开(公告)号：WO2007052003A1
公开(公告)日：2007-05-10
申请号：PCT/GB2006/004051
申请日：2006-10-31
申请人： BIOPROGRESS TECHNOLOGY LIMITED , TECKOE, Jason
发明人： TECKOE, Jason
IPC分类号： A61K9/28
CPC分类号： A61K9/2893 , A61K9/2886
摘要： The present invention relates to a coated tablet and a method for making a coated tablet and in particular the present invention provides a tablet having a coating formed from at least 2 separate film layers, wherein the film layers overlap and the overlapping film layers are sealed so that there is at least one non-sealed region.
摘要翻译：本发明涉及一种包衣片及其制造方法，特别是本发明提供具有由至少2个分开的膜层形成的涂层的片剂，其中膜层重叠并且重叠的膜层被密封至少有一个非密封区域。

7. 发明申请

WO2007113568A1 A CONTAINER 审中-公开
标题翻译：集装箱
公开(公告)号：WO2007113568A1
公开(公告)日：2007-10-11
申请号：PCT/GB2007/001254
申请日：2007-04-04
申请人： BIOPROGRESS TECHNOLOGY LTD , TREVILLION, Richard, Ian , TECKOE, Jason
发明人： TREVILLION, Richard, Ian , TECKOE, Jason
IPC分类号： A61B19/02
CPC分类号： A61B50/37 , A61B2050/0056 , A61B2050/3005
摘要： A container (1) comprising an outer sealable chamber (2) comprising an outer sealable opening (4) that in an open position allows material to be placed within the outer chamber (2), and a liquid emitting device (9) that is only operable when the outer sealable opening (4) is closed; and an inner sealable chamber (3) connected to the outer chamber (2) by an inner sealable opening (10) that in an open position allows material to pass from the outer chamber (2) into the inner chamber (3), wherein control elements interconnect the inner sealable opening (10) and the outer sealable (4) opening to ensure that they are not simultaneously open.
摘要翻译：一种容器（1），包括外密封室（2），其包括外部可密封开口（4），所述外密封开口（4）在打开位置允许材料被放置在所述外室（2）内;以及液体排放装置（9）当所述外部可密封开口（4）关闭时可操作; 以及通过内部可密封开口（10）连接到外部腔室（2）的内部可密封腔室（3），所述内部可密封开口（10）在打开位置允许材料从外部腔室（2）进入内部腔室（3），其中控制元件将内部可密封开口（10）和外部可密封（4）开口互连，以确保它们不是同时打开。

8. 发明申请

WO2010132205A1 FILM COATINGS CONTAINING FINE PARTICLE SIZE DETACKIFIERS AND SUBSTRATES COATED THEREWITH 审中-公开
标题翻译：包含精细颗粒尺寸的胶片包装和基材
公开(公告)号：WO2010132205A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/032749
申请日：2010-04-28
申请人： BPSI HOLDINGS, LLC. , FARRELL, Thomas, P. , TECKOE, Jason , FRIEND, Barry , GULIAN, Scott
发明人： FARRELL, Thomas, P. , TECKOE, Jason , FRIEND, Barry , GULIAN, Scott
IPC分类号： A61K9/28 , A23G3/02 , A61J3/00
CPC分类号： A61K47/32 , A61K9/284 , C08K5/103 , C08K5/41
摘要： The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a fine particle size detackifier. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is either polyvinyl alcohol or a copolymer of polyvinyl alcohol. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译：本发明涉及用于口服剂型例如压缩片剂和其它含有细颗粒尺寸防粘剂的可口服摄取底物的薄膜包衣组合物。膜涂层组合物可以直接施加到基底上，或者在基底已经被底涂层涂覆之后。在优选的方面，聚合物是聚乙烯醇或聚乙烯醇的共聚物。还公开了包含本发明的薄膜涂料组合物的水性悬浮液，将涂料施加到基材和涂布的基材本身上的方法。

9. 发明申请

WO2010132204A1 ENHANCED MOISTURE BARRIER IMMEDIATE RELEASE FILM COATING SYSTEMS AND SUBSTRATES COATED THEREWITH 审中-公开
标题翻译：增强水分阻隔膜立即释放薄膜涂层系统及其涂层
公开(公告)号：WO2010132204A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/032748
申请日：2010-04-28
申请人： BPSI HOLDINGS, LLC. , FARRELL, Thomas P. , TECKOE, Jason
发明人： FARRELL, Thomas P. , TECKOE, Jason
IPC分类号： A61K9/48
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/2846 , A61K47/02
摘要： The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
摘要翻译：本发明涉及用于口服剂型例如压缩片剂和具有改善的防潮性能的其它可口服摄取的底物的立即释放膜包衣系统。膜涂层系统可以直接施加到基底上，或者在基底涂覆有底涂层之后。在优选的方面，防潮膜涂层被制备为含有聚乙烯醇，具有pH依赖性溶解度的聚合物，增塑剂，助流剂和任选的防粘剂，碱化剂和颜料的干粉混合物。还公开了含有粉末混合物的水性悬浮液的薄膜包衣组合物，将涂料施加到基材和涂布的基材上的方法。

10. 发明申请

WO2004103338A1 ADHESIVES AND FILM MODIFYING COMPOSITIONS 审中-公开
标题翻译：粘合剂和薄膜改性组合物
公开(公告)号：WO2004103338A1
公开(公告)日：2004-12-02
申请号：PCT/GB2004/002167
申请日：2004-05-18
申请人： BIOPROGRESS PLC , NOWAK, Edward, Zbygniew , TECKOE, Jason
发明人： NOWAK, Edward, Zbygniew , TECKOE, Jason
IPC分类号： A61K9/00
CPC分类号： A61K9/2893 , A61K9/282 , A61K9/2866 , A61K9/2886 , A61K9/4891
摘要： A surface modifier, film modifier, adhesive or glue is used in connection with non-gelatin films to achieve strong tamper proof and leak free welds. Products thus produced include capsules, pouches and other packaging constructions. Other products include tablets, powders and compacted powders enrobed by films and using the adhesives /film modifying compositions disclosed. The films, adhesives and film modifying compositions used can be safe for human consumption and may find use as a wall material of an ingestible delivery capsule, e.g. containing a dose of a pharmaceutical preparation.
摘要翻译：与非明胶膜相结合使用表面改性剂，膜改性剂，粘合剂或胶水，以实现强大的防篡改和无泄漏焊接。如此生产的产品包括胶囊，小袋和其他包装结构。其他产品包括由薄膜和使用所公开的粘合剂/膜改性组合物涂覆的片剂，粉末和压实粉末。所用的膜，粘合剂和改良膜的组合物可以安全地用于人类消费，并且可以用作可摄入递送胶囊的壁材料，例如，含有一定剂量的药物制剂。

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