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1. 发明申请

WO2014049447A3 A WHOLE, LEECH SALIVA EXTRACT 审中-公开
标题翻译：全文，LELLAL SALIVA EXTRACT
公开(公告)号：WO2014049447A3
公开(公告)日：2014-06-19
申请号：PCT/IB2013002848
申请日：2013-09-17
申请人： BIOPEP SOLUTIONS INC
发明人： MERZOUK AHMED , GHAWI ABBAS MOHAMMAD , ABDUALKADER ABDUALRAHMAN M , ALAAMA MOHAMED
IPC分类号： A61K35/62 , A01K67/033 , A61K9/19 , C07K1/14
CPC分类号： A61K35/62 , A01K67/033 , A01N63/00 , A61K9/0014 , A61K31/282 , A61K31/4745 , A61K31/555 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0°C; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5°C to about 40°C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about -20°C, the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.
摘要翻译：提供了分离和使用全唾液水蛭提取物的方法。所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。该方法可包括通过在约5℃至约40℃的温度范围内对其进行升温来振兴水蛭。还提供稳定的，冻干的全唾液提取物，所述提取物在低于约-20℃的温度下储存使用时具有稳定的活性，所述提取物保持至少6个月的活性的至少70％。提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。

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