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1. 发明申请

WO2007081835A2 MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES 审中-公开
标题翻译： HYPOXIA诱导因子-1的调节剂及相关用途
公开(公告)号：WO2007081835A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000340
申请日：2007-01-09
申请人： BIONAUT PHARMACEUTICALS, INC. , KHODADOUST, Mehran , HESS, Hans-jurgen , HUSSON, Sajjat , BRUENING, Reimar, C. , GARDINER, Gregory, E.
发明人： KHODADOUST, Mehran , HESS, Hans-jurgen , HUSSON, Sajjat , BRUENING, Reimar, C. , GARDINER, Gregory, E.
CPC分类号： C07J19/00 , C07J19/005 , C07J41/0005 , C07J41/0038 , C07J43/003
摘要： The invention features compounds of formulas I or II: and pharmaceutically acceptable salts and prodrugs thereof, as well methods for modulating the effects of local and systemic hypoxic events using the compounds.
摘要翻译：本发明具有式I或II化合物及其药学上可接受的盐和前药，以及使用该化合物调节局部和全身缺氧事件的作用的方法。

2. 发明申请

WO2006074192A3 TREATMENT OF INFLAMMATORY DISORDERS 审中-公开
公开(公告)号：WO2006074192A3
公开(公告)日：2006-07-13
申请号：PCT/US2006/000132
申请日：2006-01-03
申请人： BIONAUT PHARMACEUTICALS, INC. , AN, Wenqian, Frank , PARK, Jun, Young , KHODADOUST, Mehran , HESS, Hans-Jurgen , HUSSOIN, Md., Sajjat
发明人： AN, Wenqian, Frank , PARK, Jun, Young , KHODADOUST, Mehran , HESS, Hans-Jurgen , HUSSOIN, Md., Sajjat
IPC分类号： A61K31/09 , A61K31/415 , A61K31/19 , A61K31/365 , A61K31/343 , A61K31/165 , A61K31/56 , A61K31/498 , A61K31/05 , A61K31/37 , A61P29/00 , A61P19/02
摘要： Methods of treating an inflammatory disorder include administering an effective amount of a compound represented by Structural Formula (I). Ring A is optionally substituted, contains zero, one, two, or three double bonds, and is optionally fused to an aliphatic, aryl or heteroaryl ring; X is an optionally substituted 1 to 3 carbon aliphatic chain that is optionally fused to a monocyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring, wherein one or two carbons in X are optionally replaced with -O-, -S-, or -NR e -; Y is carbon or nitrogen; R 1 and R 2 are independently -H, -OH, -CN, -NO 2 , -NR f R g , halogen, optionally substituted alkyl, or optionally substituted alkoxy; or R 1 and R 2 together link the carbons to which they are bonded with a bond, -O-, -S-, or -NR h -; R 3 and R 4 are independently -H, -OH, -CN, -NO 2 , -NR i R j , halogen, optionally substituted alkyl, or optionally substituted alkoxy, or R 4 is =0; or R 3 and R 4 , taken together with the atoms to which they are bonded, form a monocyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring that is optionally fused to a monocyclic or bicyclic, optionally substituted, aliphatic, heterocyclic, aryl, or heteroaryl ring; R e -R j are independently -H or optionally substituted alkyl; and each of the OSM signaling inhibitor compounds has at least one hydrogen atom bonded to an oxygen, nitrogen, or sulfur atom. The OSM signaling inhibitor compounds also include pharmaceutically acceptable salt or solvates of the compounds represented by Structural Formula (I).

3. 发明申请

WO2006044916A2 USE OF NA+/ K+-ATPASE INHIBITORS AND ANTAGONISTS THEREOF 审中-公开
标题翻译：使用NA + / K + -ATPASE抑制剂及其拮抗剂
公开(公告)号：WO2006044916A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037486
申请日：2005-10-18
申请人： BIONAUT PHARMACEUTICALS, INC. , KHODADOUST, Mehran , SHARMA, Ajay
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K31/58 , A61K31/704 , A61K31/7048
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach for treating hypoxia-related pathological conditions, such as Alzheimer's Disease, and those involving excessive angiogenesis, especially those non-cancer pathological conditions. The invention provides the use of Na + /K + -ATPase inhibitors, such as cardiac glycosides (e.g. ouabain and proscillaridin, etc.), either alone or in combination with other standard therapeutic agents for treating such conditions. The invention also relates to the use of cardiac glycoside inhibitors / antagonists as reagents, pharmaceutical formulations, or in kits and methods for treating conditions arising from excessive amount of cardiac glycosides, including all symptoms of digitalis poisoning, depression, hypertension, etc. The pharmaceutical formulation of the invention may be delivered to a patient either systemically or locally, or both. The pharmaceutical formulations of the invention may be delivered either in one dose, or continuously over a sustained period of time using, for example, sustained drug delivery devices.
摘要翻译：本发明的试剂，药物制剂，试剂盒和方法提供了治疗缺氧相关病理状况（例如阿尔茨海默氏病）和涉及过度血管生成的那些的新方法，特别是那些非癌症病理状况。本发明提供了Na

4. 发明申请

WO2006029020A2 TREATMENTS OF REFRACTORY CANCERS USING NA+/K+-ATPASE INHIBITORS 审中-公开
标题翻译：使用NA + / K + -ATPASE抑制剂治疗癌症患者
公开(公告)号：WO2006029020A2
公开(公告)日：2006-03-16
申请号：PCT/US2005/031421
申请日：2005-09-02
申请人： BIONAUT PHARMACEUTICALS, INC. , KHODADOUST, Mehran , SHARMA, Ajay
发明人： KHODADOUST, Mehran , SHARMA, Ajay
CPC分类号： A61K31/395 , A61K31/17 , A61K31/365 , A61K31/407 , A61K31/4745 , A61K31/505 , A61K31/513 , A61K31/70 , A61K31/7048 , A61K31/7068 , A61K31/7072 , A61K33/24 , A61K39/39541 , A61K2300/00
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach to treat refractory cancers using Na + /K + -ATPase inhibitors, such as cardiac glycosides (e.g. ouabain or proscillaridin, etc.).
摘要翻译：本发明的试剂，药物制剂，试剂盒和方法提供了使用Na

5. 发明申请

WO2006028969A1 PANCREATIC CANCER TREATMENT USING NA+/K+ ATPASE INHIBITORS 审中-公开
标题翻译：使用NA + / K + ATP酶抑制剂的胰腺癌治疗
公开(公告)号：WO2006028969A1
公开(公告)日：2006-03-16
申请号：PCT/US2005/031331
申请日：2005-09-02
申请人： BIONAUT PHARMACEUTICALS, INC. , KHODADOUST, Mehran , SHARMA, Ajay
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K31/704
CPC分类号： A61K31/704
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach for treating pancreatic cancers. The invention provides the use of Na + /K + -ATPase inhibitors, such as cardiac glycosides (e.g. ouabain and proscillaridin, etc.), either alone or in combination with other standard therapeutic agents (chemo- or radio-therapies, etc.) for treating pancreatic cancers.
摘要翻译：本发明的试剂，药物制剂，试剂盒和方法提供了治疗胰腺癌的新方法。本发明提供单独使用或与其它组合使用的Na + + / K + + / - ATP酶抑制剂，例如强心苷（例如哇巴因和前列腺素等）用于治疗胰腺癌的标准治疗剂（化疗或放射疗法等）。

6. 发明申请

WO2006029018A3 COMBINATORIAL CHEMOTHERAPY TREATMENT USING NA+/K+-ATPASE INHIBITORS 审中-公开
公开(公告)号：WO2006029018A3
公开(公告)日：2006-03-16
申请号：PCT/US2005/031418
申请日：2005-09-02
申请人： BIONAUT PHARMACEUTICALS, INC. , KHODADOUST, Mehran , SHARMA, Ajay
发明人： KHODADOUST, Mehran , SHARMA, Ajay
IPC分类号： A61K45/06 , A61P35/00 , A61K31/585
摘要： The reagent, pharmaceutical formulation, kit, and methods of the invention provides a new approach to alleviate or eliminate certain negative effects associated with the use of certain cancer treatment agents (e.g. chemotherapy therapeutics, etc.) or regimens (e.g. radio therapies, etc.) including stimulation of the hypoxic stress response in tumor cells.

7. 发明申请

WO2007016656A2 MODULATORS OF HYPOXIA INDUCIBLE FACTOR-1 AND RELATED USES FOR THE TREATMENT OF OCULAR DISORDERS 审中-公开
标题翻译： HYPOXIA诱导因子-1的调节因子及治疗眼病的相关应用
公开(公告)号：WO2007016656A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/030224
申请日：2006-08-01
申请人： BIONAUT PHARMACEUTICALS , KHODADOUST, Mehran
发明人： KHODADOUST, Mehran
IPC分类号： A61K31/704
CPC分类号： A61K31/704 , A61K31/7048 , A61K39/395 , A61K2300/00
摘要： The invention features methods for the treatment of ocular disorders using compounds that modulate the effects of local and systemic hypoxic events.
摘要翻译：本发明的特征在于使用调节局部和全身缺氧事件的作用的化合物治疗眼部疾病的方法。

8. 发明申请

WO2005060951A2 ANTI-NEOPLASTIC AGENTS, COMBINATION THERAPIES AND RELATED METHODS 审中-公开
标题翻译：抗神经药物，组合疗法及相关方法
公开(公告)号：WO2005060951A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/042589
申请日：2004-12-20
申请人： BIONAUT PHARMACEUTICALS , KHODADOUST, Mehran
发明人： KHODADOUST, Mehran
IPC分类号： A61K31/167
CPC分类号： G01N33/5011 , A61K31/122 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/4709 , A61K31/498 , A61K31/704 , A61K31/7048 , A61K45/06 , G01N2500/10 , A61K2300/00
摘要： In certain aspects, the invention relates to the discovery of novel compositions for use in the treatment of a neoplastic disorder. Further aspects of the invention relate to the discovery that cell signaling may be exploited to identify significant genes in cancer cell lines and to generate reporter gene systems that may be used, for example, to identify anti-neoplastic agents and effective combinations thereof.
摘要翻译：在某些方面，本发明涉及用于治疗肿瘤性疾病的新型组合物的发现。本发明的另外方面涉及可以利用细胞信号传导来鉴定癌细胞系中的重要基因并产生可用于例如鉴定抗肿瘤剂及其有效组合的报道基因系统的发现。

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