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1. 发明申请

WO1995024701A1 STEREODIRECTED PROCESS FOR SYNTHESIS OF 'alpha'-N-ACETYLGALACTOSAMINIDES 审中-公开
标题翻译：用于合成α-N-乙酰胆碱酯酶的立体过程
公开(公告)号：WO1995024701A1
公开(公告)日：1995-09-14
申请号：PCT/US1995002777
申请日：1995-03-09
申请人： BIOMIRA, INC. , MCINNIS, Patricia, G. , KOGANTY, R., Rao , GANDHI, Sham
发明人： BIOMIRA, INC. , MCINNIS, Patricia, G.
IPC分类号： G07H13/04
CPC分类号： C07H13/04 , C07H15/04 , C07H15/18 , Y02P20/55
摘要： A stereodirected process for synthesizing alpha -N-acetylgalactosaminides from N-acetylgalactosamine which, in a preferred embodiment, comprises: reacting N-acetylgalactosamine with a dialkyl acetal of an aldehyde or ketone to form a 4,6-O-alkylidene derivative; reacting said 4,6-O-alkylidene derivative with a protecting group compound to attach a protecting group selectively to 3-OH of said derivative to form a 3-O- protected derivative; reacting said 3-O-protected derivative with an anomeric group to form a glycosyl donor; reacting said glycosyl donor with an alcohol to form an N-acetylgalactosaminide.
摘要翻译：在优选的实施方案中，由N-乙酰半乳糖胺合成α-N-乙酰半乳糖胺的立体定向方法，其中包括：使N-乙酰基半乳糖胺与醛或酮的二烷基缩醛反应以形成4,6-O-亚烷基衍生物; 使所述4,6-O-亚烷基衍生物与保护基化合物反应，将保护基选择性地连接到所述衍生物的3-OH上以形成3-O-保护的衍生物; 使所述3-O-保护的衍生物与端基异构基团反应以形成糖基供体; 使所述糖供体与醇反应以形成N-乙酰半乳糖胺。

2. 发明申请

WO1995029927A2 PROCESS FOR PREPARATION OF GLYCOSIDES OF TUMOR-ASSOCIATED CARBOHYDRATE ANTIGENS 审中-公开
标题翻译：制备与肿瘤相关的碳水化合物抗原的糖苷酶的方法
公开(公告)号：WO1995029927A2
公开(公告)日：1995-11-09
申请号：PCT/IB1995000363
申请日：1995-04-28
申请人： BIOMIRA, INC. , McINNIS, Patricia
发明人： BIOMIRA, INC. , McINNIS, Patricia , WONG, Ting, Chi , KOGANTY, R., Rao
IPC分类号： C07H15/10
CPC分类号： C07H9/06 , C07H3/06 , C07H15/04 , C07H15/10
摘要： Glycoconjugate antigens are prepared by preparing a hapten glycoside, especially an alpha glycoside prepared by the Fischer method, with an olefinic aglycon moiety, especially one having a non-terminal double bond, ozonolyzing the hapten glycoside with an olefinic aglycon moiety having a non-terminal double bond to form a hapten-glycoside derivative, preferably without producing Germaldehyde as a by-product, removing by-products of ozonolysis, and conjugating the hapten-glycoside derivative to a carrier.
摘要翻译：糖缀合物抗原通过制备半抗原糖苷，特别是通过费休法制备的α-糖苷，通过制备具有非末端双键的烯属糖苷配基部分，特别是具有非末端双键的半抗原糖苷，用具有非末端的烯属糖苷配基部分进行臭氧分解双键形成半抗原 - 糖苷衍生物，优选不产生作为副产物的甲醛，除去臭氧分解的副产物，并将半抗原 - 糖苷衍生物与载体缀合。

3. 发明申请

WO1995027505A1 CELLULAR IMMUNE RESPONSE-SPECIFIC ANTIGENS AND USES THEREFOR 审中-公开
标题翻译：细胞免疫反应特异性抗原及其用途
公开(公告)号：WO1995027505A1
公开(公告)日：1995-10-19
申请号：PCT/US1995004540
申请日：1995-04-12
申请人： BIOMIRA, INC. , LONGENECKER, B., Michael , DING, Lei , REDDISH, Mark, A. , KOGANTY, Raghupathi, Rao
发明人： BIOMIRA, INC.
IPC分类号： A61K39/00
CPC分类号： C07K14/70539 , A61K39/00 , C07K14/4727 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/476
摘要： A CMI-specific immunogenic composition, comprising: (a) a non-naturally occurring conjugate of a primary epitope which is substantially the same as a T cell epitope of a cancer-, microbial-, parasitic-, or virally infected cell-associated antigen, and of an immunomodulatory peptide, or (b) a mixture of (1) primary antigen bearing a primary epitope which is substantially the same as a T-cell epitope of a cancer-, microbial-, parasitic-, or virally infected cell-associated antigen, (2) an immunomodulatory peptide, where the conjugate of (a) and the immunomodulatory peptide of (b) have a molecular weight of less than 5,000 daltons, where said immunomodulatory peptide of (a) or (b) comprises an allopeptide moiety of at least five amino acids whose amino acid sequence corresponds essentially to that of a polymorphic region of an MHC-encoded polymorphic Class I or Class II antigen. The composition modulates a stronger cellular immune response than the humoral immune response and is useful for treatment of tumors.
摘要翻译：一种CMI特异性免疫原性组合物，其包含：（a）主要表位的非天然存在的缀合物，其与癌症，微生物，寄生虫或病毒感染的细胞相关抗原的T细胞表位基本相同，和免疫调节肽，或（b）（1）具有与癌，微生物，寄生虫或病毒感染细胞的T细胞表位基本上相同的主要表位的一级抗原的混合物，（2）免疫调节肽，其中（a）和（b）的免疫调节肽的缀合物具有小于5,000道尔顿的分子量，其中（a）或（b）的所述免疫调节肽包含异肽至少5个氨基酸的部分，其氨基酸序列基本上与MHC编码的多态性I类或II类抗原的多态性区域相符。该组合物调节比体液免疫应答更强的细胞免疫应答，并且可用于治疗肿瘤。

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