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1. 发明申请

WO2013040164A1 COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢障碍的组合物和方法
公开(公告)号：WO2013040164A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/055088
申请日：2012-09-13
申请人： BIOMED VALLEY DISCOVERIES, INC. , HALSE, Reza , ROIX, Jeffrey James , SAHA, Saurabh
发明人： HALSE, Reza , ROIX, Jeffrey James , SAHA, Saurabh
IPC分类号： A61K31/40 , C07D207/08
CPC分类号： A61K31/40 , A61K31/4985 , A61K2300/00
摘要： The present invention provides, inter alia, compositions containing enantiomerically pure (R)(+)-amisulpride or enantiomerically pure (R)(+)-sulpiride, optionally with dopamine receptor modulators. The present invention also provides compositions containing racemic (RS)-amisulpride or (RS)-sulpiride in combination with dopamine receptor modulators. Methods for preventing, treating, or ameliorating the effects of a metabolic disorder or key element thereof, for modulating blood glucose levels, and for preventing, treating, or ameliorating the effects of diabetes in a subject are also provided. Additionally, the present invention provides methods for counter-acting the dopamine antagonist activity of (S)-amisulpride in racemic (RS)-amisulpride, or the dopamine antagonist activity of (S)-sulpiride in racemic (RS)-sulpiride, administered to a subject to prevent, treat, or ameliorate the effects of a metabolic disorder.
摘要翻译：本发明尤其提供含有对映异构纯的（R）（+） - 氨磺酸或对映体纯的（R）（+） - 舒必利，任选与多巴胺受体调节剂组合的组合物。本发明还提供了与多巴胺受体调节剂组合含有外消旋（RS） - 马可福酯或（RS）-Sulpiride的组合物。还提供了用于预防，治疗或改善代谢紊乱或其关键要素的作用，用于调节血糖水平以及预防，治疗或改善受试者中糖尿病的作用的方法。另外，本发明提供了在外消旋（RS） - 米沙夫定反作用（S） - 阿米替丁的多巴胺拮抗剂活性或外消旋（RS）-Sulpiride中（S）-Sulpiride的多巴胺拮抗剂活性的方法）预防，治疗或改善代谢紊乱的影响的主题。

2. 发明申请

WO2013049045A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS 审中-公开
标题翻译：组合物和治疗玻璃体的方法
公开(公告)号：WO2013049045A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057085
申请日：2012-09-25
申请人： BIOMED VALLEY DISCOVERIES, INC. , HALSE, Reza , SAHA, Saurabh , ROIX, Jeffrey, James
发明人： HALSE, Reza , SAHA, Saurabh , ROIX, Jeffrey, James
IPC分类号： A61K45/00
CPC分类号： A61K38/08 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/197 , A61K31/235 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/42 , A61K31/433 , A61K31/4422 , A61K31/472 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/675 , A61K38/12 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a glioma. Methods of this invention include administering to a subject in need thereof an effective amount of a first active agent, such as e.g., an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1 ) inhibitor, a cyclooxygenase inhibitor, an α2δ voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an a2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, or combinations thereof, and a second active agent, which is a chemotherapeutic agent. Compositions for treating or ameliorating the effects of a glioma are also provided.
摘要翻译：本发明尤其提供了用于治疗或改善胶质瘤的作用的方法。本发明的方法包括向有需要的受试者施用有效量的第一活性剂，例如血管紧张素受体阻断剂，抗真菌剂，双膦酸盐，催产素抑制剂，白细胞介素-1（IL-1）抑制剂，环氧合酶抑制剂，α2delta电压依赖性钙通道（VDCC）抑制剂，二氢乳清酸脱氢酶抑制剂，钙通道阻断剂，肾钠氯化合物抑制剂，a2肾上腺素能激动剂，吩噻嗪抗精神病药，钙调磷酸酶抑制剂， 5-HT激动剂，血管紧张素转换酶（ACE）抑制剂，直接肾素抑制剂或其组合，以及作为化学治疗剂的第二活性剂。还提供了用于治疗或改善胶质瘤的作用的组合物。

3. 发明申请

WO2014152220A1 IDENTIFICATION OF CANDIDATE TARGET GENES FOR TREATING NEOPLASIA 审中-公开
标题翻译：鉴定用于治疗NEOPLASIA的候选靶基因
公开(公告)号：WO2014152220A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027087
申请日：2014-03-14
申请人： BIOMED VALLEY DISCOVERIES, INC.
发明人： HALSE, Reza , SAHA, Saurabh , ROIX, Jeffrey
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , G01N33/5748
摘要： The present invention provides, inter alia, a method for identifying a target for treating a neoplasia. This method includes: (a) generating a second neoplastic cell line having a single gene knockdown from a first neoplastic cell line; (b) growing cells from the first and second neoplastic cell lines in vitro and in vivo ; (c) determining whether there is a difference with respect to a cancer marker between the first and second neoplastic cell lines grown in vitro; (d) determining whether there is a difference with respect to the same cancer marker in step (c) between the first and second neoplastic cell lines grown in vivo , wherein (i) if there is no difference in step (c) between the first and second neoplastic cell lines grown in vitro with respect to the cancer marker and (ii) there is a difference in step (d) between the first and second neoplastic cell lines grown in vivo with respect to the cancer marker, then the gene that is knocked down in the second cancer cell line is a target for treating a neoplasia. Methods and kits for identifying a candidate agent that may be useful for treating a neoplasia are also provided.
摘要翻译：本发明尤其提供了用于鉴定用于治疗瘤形成的靶的方法。该方法包括：（a）产生具有来自第一肿瘤细胞系的单个基因敲除的第二肿瘤细胞系; （b）体外和体内从第一和第二肿瘤细胞系生长细胞; （c）确定在体外生长的第一和第二肿瘤细胞系之间是否存在与癌症标志物的差异; （d）确定在体内生长的第一和第二肿瘤细胞系之间是否在步骤（c）中相同的癌症标志物是否存在差异，其中（i）如果在第一和相对于癌症标志物在体外生长的第二肿瘤细胞系和（ii）在体内生长的第一和第二肿瘤细胞系之间在癌症标志物上的步骤（d）之间存在差异，则基因是在第二癌细胞系中被击倒是治疗瘤形成的靶标。还提供了用于鉴定可用于治疗瘤形成的候选药物的方法和试剂盒。

4. 发明申请

WO2008067527A1 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS 审中-公开
标题翻译：蛋白酪氨酸磷酸酯酶抑制剂治疗肌肉痉挛和相关疾病
公开(公告)号：WO2008067527A1
公开(公告)日：2008-06-05
申请号：PCT/US2007/086058
申请日：2007-11-30
申请人： NOVARTIS AG , PAUL, Angelika Christina , HALSE, Reza , DUTTAROY, Alokesh , HOLTON, Laura Elizabeth , KEMP, Daniel , GLASS, David J. , BARNES, David Weninger
发明人： PAUL, Angelika Christina , HALSE, Reza , DUTTAROY, Alokesh , HOLTON, Laura Elizabeth , KEMP, Daniel , GLASS, David J. , BARNES, David Weninger
IPC分类号： A61K31/433 , A61P19/10 , A61P21/06
CPC分类号： A61K31/433
摘要： The invention relates to the use of protein tyrosine phosphatase inhibitors for the treatment of musculoskeletal diseases, particularly for the treatment of muscle atrophy.
摘要翻译：本发明涉及蛋白酪氨酸磷酸酶抑制剂用于治疗肌肉骨骼疾病，特别是用于治疗肌肉萎缩的用途。

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